5BO6,5BO7,5BO8,5BO9,5CXY


Conserved Protein Domain Family
GT29_ST8SIA3_oligo
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cd23970: GT29_ST8SIA3_oligo 
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).
Links
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Statistics
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PSSM-Id: 467698
Aligned: 15 rows
Threshold Bit Score: 474.575
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:5BO6: Human ST8SiaIII binds CDP, contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                  ###   
5BO6_A        35 FNRTAFLHQRQEILQHVDvIKNFSltknsvriGQLMHYDYSshkYVFSISnnfrSLLPDVSPImnkhyNICAVVGNSGIl 114 human
5BO7_A        35 FNRTAFLHQRQEILQHVDvIKNFSltknsvriGQLMHYDYSshkYVFSISnnfrSLLPDVSPImnkhyNICAVVGNSGIl 114
5BO8_A        55 FNRTAFLHQRQEILQHVDvIKNFSltknsvriGQLMHYDYSshkYVFSISnnfrSLLPDVSPImnkhyNICAVVGNSGIl 134 human
5BO9_A        35 FNRTAFLHQRQEILQHVDvIKNFSltknsvriGQLMHYDYSshkYVFSISnnfrSLLPDVSPImnkhyNICAVVGNSGIl 114
5CXY_A        35 FNRTAFLHQRQEILQHVDvIKNFSltknsvriGQLMHYDYSshkYVFSISnnfrSLLPDVSPImnkhyNICAVVGNSGIl 114
NP_001106903  86 FNRSAYAELSKEIAQHIDvPHNFTltknsvrvGQLMHYDYSshkYVFSIGenlrSLLPDASPVlnkryNTCAVVGNSGIl 165 zebrafish
CAP16255      31 VNQTALNHHRADIEQFVDaERNISlvrsevrvGQVMHFDYSeqkYVFPISaslySLIPEVVPFqnkhyNACAVVGSGGIl 110 Florida lancelet
NP_001268686  43 ANKTGLLQTRSEMRKFFNpYKMITmtsdddtrGQLKRFYSAkakAMTLIPpglrKLLPTKQLFsnqyfKTCSVVGNSGIl 122 purple sea urchin
XP_007901266  92 FNKTAYLKQREDIRHYIDvIQNFTlikknvrvGQLMHFDYSshkYVFSISnnfrMLLPEVSPLlkmhyNTCAVVGNSGIl 171 elephant shark
XP_022081721  91 FNKEAAEEARKDMKQYFNpFDVITmtsddvatGRLRRFYLSkklNVNVVPpglhRLLPKRLLFrnqhyRKCSLVGNSGVl 170 crown-of-thorns...

Feature 1                         ##                    #                                        
5BO6_A       115 tgsqCGQEIDKsDFVFRCNfAPTEAfqrDVGrKTNLTTFNPsilekyynnlltiqDRNNFFLSLKkl-dgAILWIPAff- 192 human
5BO7_A       115 tgsqCGQEIDKsDFVFRCNfAPTEAfqrDVGrKTNLTTFNPsilekyynnlltiqDRNNFFLSLKkl-dgAILWIPAff- 192
5BO8_A       135 tgsqCGQEIDKsDFVFRCNfAPTEAfqrDVGrKTNLTTFNPsilekyynnlltiqDRNNFFLSLKkl-dgAILWIPAff- 212 human
5BO9_A       115 tgsqCGQEIDKsDFVFRCNfAPTEAfqrDVGrKTNLTTFNPsilekyynnlltiqDRNNFFLSLKkl-dgAILWIPAff- 192
5CXY_A       115 tgsqCGQEIDKsDFVFRCNfAPTEAfqrDVGrKTNLTTFNPsilekyynnlltiqDRNNFFLSLKkl-dgAILWIPAff- 192
NP_001106903 166 tgsrCGPEIDKyDFVFRCNfAPTEVfrrDVGrRTNLTTFNPsilekyynnlltiqDRNNFFLSLKkl-dgAILWIPAff- 243 zebrafish
CAP16255     111 snsyCGNEIDEaDFVFRCNfAPIDKyksHVGsKTNFTTFNPsvlekyfnnlqtiyDRARFLNELRrl-kgAVLWIPAfs- 188 Florida lancelet
NP_001268686 123 inssCGAEIDAaDFAFRCNfATVKGyekDVGtKTDVITFNPsildrfygrlkkdtDKKSFEERLVsy-gkYVLWIPIfst 201 purple sea urchin
XP_007901266 172 rgsrCGDSIDKsDFVFRCNfAPTEFfekDVGrKTNLTTFNPsilekyynnlmaiqDRNKFFLNLKkl-dgAILWIPAff- 249 elephant shark
XP_022081721 171 rnssCGRQIDSsNFVVRCNfATLKGyekDVGtRTDVVTFNPsiiekyh-klstkaDMARFESDLRkyhekYVLWVPVfn- 248 crown-of-thorns...

Feature 1                                                             ###                 ##     
5BO6_A       193 fhTSATVTRTLVDFFVehrg--qlkVQLAWPgNIMQHVNRYWknkhl-spkrlSTGILMYTLASAiCEEIHLYGFWPFgf 269 human
5BO7_A       193 fhTSATVTRTLVDFFVehrg--qlkVQLAWPgNIMQHVNRYWknkhl-spkrlSTGILMYTLASAiCEEIHLYGFWPFgf 269
5BO8_A       213 fhTSATVTRTLVDFFVehrg--qlkVQLAWPgNIMQHVNRYWknkhl-spkrlSTGILMYTLASAiCEEIHLYGFWPFgf 289 human
5BO9_A       193 fhTSATVTRTLVDFFVehrg--qlkVQLAWPgNIMQHVNRYWknkhl-spkrlSTGILMYTLASAiCEEIHLYGFWPFgf 269
5CXY_A       193 fhTSATVTRTLVDFFVehrg--qlkVQLAWPgNIMQHVNRYWknkhl-spkrlSTGILMYTLASAiCEEIHLYGFWPFgf 269
NP_001106903 244 fhTSATVTRTLVDFFVehkg--qlkVQLAWPgNIMQYVNRYWktkql-spkrlSTGILMFTLASSlCEQVHLYGFWPFgw 320 zebrafish
CAP16255     189 fhGSNMVTRTLTDFFLeherqfnpkLNLAWPgNVMKYFSESFwktkglspkrlSTGMIVYTLATMfCDEVRLYGFWPYsv 268 Florida lancelet
NP_001268686 202 hyVSRTVHEILEYFNLnfkr--ftnVQLAFPgNILPDISDYWltqai-deeriSTGLLMFNIAATiCEEIHMYGFYPFpq 278 purple sea urchin
XP_007901266 250 fhSSALVTRTLVDFFVehrr--qlkVELAWPgNIMQYVNKYWktkql-spkrlSTGILMYTLASSvCEEIHLYGFWPFaw 326 elephant shark
XP_022081721 249 rpYVTVALRTLLDFFDkhlg-ssknIQLAFPgNVLPDISDYWaskgi-deeriSTGLLMYNMASAlCDEIHMYGFYPFpd 326 crown-of-thorns...

Feature 1                ###                    #                      
5BO6_A       270 dpntredLPYHYYDKKgtk----fttKWQesHQLPAEFQLLYRMHgeGLTKLTL 319 human
5BO7_A       270 dpntredLPYHYYDKKgtk----fttKWQesHQLPAEFQLLYRMHgeGLTKLTL 319
5BO8_A       290 dpntredLPYHYYDKKgtk----fttKWQesHQLPAEFQLLYRMHgeGLTKLTL 339 human
5BO9_A       270 dpntredLPYHYYDKKgtk----fttKWQesHQLPAEFQLLYRMHgeGLTKLTL 319
5CXY_A       270 dpntredLPYHYYDKKgtk----fttKWQesHQLPAEFQLLYRMHgeGLTKLTL 319
NP_001106903 321 dpntgkeLPYHYYDKKgtk----fttKWQesHQLPTEFKLLFKMHadGVLKLSL 370 zebrafish
CAP16255     269 ap-dhtpLSYHYYDKKgtt----ftmKWKqaHQLPEEFTLLQHLHkqGVLKLTV 317 Florida lancelet
NP_001268686 279 fq--etsIPYHYDDSRrnktrnnydyGYRrfHQLPDEFVLLKKLHkaGIVKLHL 330 purple sea urchin
XP_007901266 327 dpntgreLPYHYYDKKgtk----fntNWQetHQLPAEFKILFKMHtaGLTKLSL 376 elephant shark
XP_022081721 327 fk--grpIPYHYDHPLdrvgr-kfdyGYRrfHALPDEFVYLKKLHraGVVQLHL 377 crown-of-thorns starfish

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