Conserved Protein Domain Family
SmAKAP

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pfam15127: SmAKAP 
Small membrane A-kinase anchor protein
SmAKAP is a small membrane-bound PKA-RI-specific protein kinase A-anchoring protein, referred to as small membrane-AKAP. It is probably tethered to the plasma membrane most through a dual acylation of its N-terminal Met-Gly-Cys- motif (myristoylation and palmitoylation, respectively). It specifically targets PKA-RI isoforms to the plasma membrane. It localizes to plasma membranes, is enriched at cell-cell junctions and associates with filopodia.
Statistics
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PSSM-Id: 464517
Aligned: 13 rows
Threshold Bit Score: 107.98
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_008765367   1 MGCMKSKETFPF-PTTLdiDKLHESEEAFMPGDTCqYRTPst--------------dEQQQVQEEVK------------- 52 
EGW14480       1 MGCMKSKQTFPF-PNTL--DKLHESEETFMPDDSCqHRTPs---------------pGKPGDQEEAK------------- 49 
P0C8Y7         1 MGCIKSKQECNL-HKTIrlKRNKENDEMHNKEKVC-------------------------LVQANQE------------- 41  tropical clawed...
XP_015214771   1 MGCIKSKQNNLT-QNASsmEKADGKPKKYLDENAA-------------------------LVNSETR------------- 41 
P0C8S0         1 MGCMKSKRRDPT-QNSDssEKVDGKPGKH-GEKAV-------------------------LVFSEIG------------- 40  zebrafish
XP_006807689   1 MGCVKSKRSDSVaQNANstEKVEGKSKGTRGEKAY-------------------------LVHSEMG------------- 42 
1_pfamImport   1 MGCVKSKRSHSAsQTANstDRNDGKGKKMKGEKAY-------------------------LVQSETG------------- 42 
XP_003339078   1 MGCMKSKQTFPF-PTIYegEKQHESEEPFMPEERClPRMA-----------------SPVNVKEEVK------------- 49 
XP_003801094   1 MGCMKSKQTFPF-PTPLeaEKQRDNEVGIRPEERS--KMV-----------------SSAGVKQEVK------------- 47 
EHB08423       1 MGCMKSKQTSPF-PTNFemERQCGSEERFMPEDRL-CRLS-----------------SPCNAQGDMK------------- 48 
XP_010601016   1 MGCMKSKQTFPF-PTTLenEKRHSSEENFMPEERFlPRMP-----------------SPV-VEENVK------------- 48 
XP_019649252   1 MGCMKSKQTFPF-PTTFesEKRHASEESFMSEERFlPRMP-----------------SPVNV-EEVK------------- 48 
XP_023617913   1 MGCMKSKQTFPF-PTTI---------------ERCePRvptpvtrdgedvedvegveeveAVEEEVQaveeakveevqav 64  little brown bat
XP_008765367  53 ---KPPVPgaviGSVILEFADRLANEIVEDALQQWACENIQYYNIPYIESES 101
EGW14480      50 ---KLPEA----SPVVLEFAERLAKEIVQDALQQWACENIKYYNIPYIESEG 94 
P0C8Y7        42 ---DSKFCsctaSPLLLEYAHRLSEDIVNKAVRQWAEVDSKYSDIPYIESDA 90  tropical clawed frog
XP_015214771  42 ---QGEEGslrvNPGLLDYAQRLSEEIVAKAVQQWAEVDSRYSDIPYIESDV 90 
P0C8S0        41 ----SMEDsvriNPVLLDYAQRLSEEIVARAVQQWAEVDSRYSDIPYIECDV 88  zebrafish
XP_006807689  43 ----SPESspqvNPVLLEYAQKLSEEIVARAVQQWVEVDRRYSDIPYIECDV 90 
1_pfamImport  43 ----SVENsapaNPVLLEYAQRLSEEIVARAVQQWVEIDSRYSDIPYIECDV 90 
XP_003339078  50 ---EPPGT----NIVILEYAHRLSQDILCDALQQWACNNIKYHDIPYIESEG 94 
XP_003801094  48 ---GSSGT----STVILEYAHHLSQEILRDALKQWAFANVQYSDVPYIESEE 92 
EHB08423      49 ---AEPR--------VTEYADCLSREILRDALQQWARNSIKYQDIPYIESEG 89 
XP_010601016  49 ---TPPEP----SVVVLEYAHRLSQEILNDALQQWACNNIKYCDIPYIESEG 93 
XP_019649252  49 ---EPPGP----ETVVFEFAHRLSQEILSDALQQWAGNNIKYYDIPYIESEG 93 
XP_023617913  65 eeaEEPAQpaepKVVVSQFAHRLSQEILSGALQQWADSNAKYADIPFIESDG 116 little brown bat
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