1ZR4,1GDT,1GDT,2RSL


Conserved Protein Domain Family
SR_ResInv
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cd03768: SR_ResInv 
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Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.
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Statistics
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PSSM-Id: 239737
Aligned: 210 rows
Threshold Bit Score: 77.9051
Created: 12-Jun-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic nucleophile [active site]
Evidence:
  • Structure:1ZR4; Escherichia coli Synaptic Gamma-Delta Resolvase forms a phosphoserine linkage to the 5' end of cleaved DNA
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  • Comment:When cleavage occurs, a phosphodiester bond is replaced by a phosphoserine bond between a 5' phosphate group at the DNA cleavage site and a Ser hydroxyl group of the resolvase.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                                                                        
1ZR4_D        3 LFGYARVSTSq--QSLDIQVRALKdagv----kanRIFTDKASGss---sDRKGLDLLRMKVk--eGDVILVKKLDRLGR 71  Escherichia coli
AAR25035      5 AAIYCRVSTAd--QSCERQEFDLRafagcagydvvGIFKETGSGtk---lDRAERKKVLALAqsrqIDAILVTELSRWGR 79  Escherichia coli
AAW39063      3 VALYARVSTKdkeQNPELQLAALRkycadngweiyREYTDEASAsd--ftGRKAWTALMKEAqlkkFNVLLVWKLDRAFR 80  Dehalococcoides ...
AAW40462      3 VALYARVSTRdknQDPEVQLMELRkycqengmeitREYIDHASAnd--fvRRTAWKQLLVDAsarkFRGLLVWKLDRAFR 80  Dehalococcoides ...
ZP_00520460  35 AGLYARVSTNd-qQTVPLQTRALReytvrrgwtvaLQVKEVRSGa----sERQLREKLLAAArrgeIDVVLVWRLDRWDR 109 Solibacter usita...
CAI82871      4 TAIYARVSTDk--QTEANQLLALTqwansrgweihEVYQEADTSwk--agHQKELARLKTDAqhrkFDTVLVWALDRMSR 79  Dehalococcoides ...
ABA55979     34 AALYLRVSTPd--QKPDLQYDGLRayaeragltivGEYCDIAVSgr--reGRPKLNALMTRArnreLDCVLVWKFDRFAR 109 Sinorhizobium me...
YP_464677     9 AAVYHRVSTLd--QNPALARDELRaaagrlgaelvLDIEETGSGar---nDRPGLQRLMDAArrgkLDTVLVWKLDRFGR 83  Anaeromyxobacter...
YP_510838    12 AAIYARVSTGe--QTPENQLIRLRevaeragwavvCEYVETASGtk---rARPALDAMVKDAarrrFDVVMAWDVSRLGR 86  Jannaschia sp. CCS1
ZP_01196676   9 VALYLRVSTSe--QTTENQRRELRavaekagwevvAVFEDAGISgakgrdQRPGYDAMLKAVtrreVDMVAAWSVDRLGR 86  Xanthobacter aut...

Feature 1                                                                      
1ZR4_D       72 Dt-aDMIQLIKEFDaQGVSIRFi-dDGISTDSyi---gkMVVTILSAVAQAERQRILQRTNEG 129 Escherichia coli
AAR25035     80 St-lDLLNTLRELEnWKVSVIAmngMAFDLSSpy---grMLATFLSGIAEFERDLISERVKSG 138 Escherichia coli
AAW39063     81 Sv-iHAVNSMQMLNsYNVGFKSymdSGIDTTTpm---gnFVFSIMTAAAELEQSTIRQRVNAG 139 Dehalococcoides ethenogenes 195
AAW40462     81 Di-tVATSSVKMLRnAGIDFIVttvPVLSVQGpa---gdLMFNIYAAFAQFEKDTIIERVNAG 139 Dehalococcoides ethenogenes 195
ZP_00520460 110 Sv-aDLLATLQELEhLGVGFVSl-tEALDLTTpa---grAMAALLAVFAEFEREILRERVRAG 167 Solibacter usitatus Ellin6076
CAI82871     80 EgalVTLSLVDQLKaYGCRLISy-qEPWTEAPgaa--geVMYAIAGWVAKMESQRRSERTKAG 139 Dehalococcoides sp. CBDB1
ABA55979    110 St-rHLLTALEEFDhLGVRFISl-qDQIDTASpm---grAMFTIIGAMAELESSLISERVTAG 167 Sinorhizobium meliloti
YP_464677    84 Sa-lDVLANIRDLDaAGVRFIAt-tQGIDIRPggdamsrLILGVLASVAEFERDLIRERTRLG 144 Anaeromyxobacter dehalogenans 2CP-C
YP_510838    87 Sl-rDLVDLFEMLRsVGCDLFLe-qQALDTSTpa---grALLQMSGVFAEFERAMIVERTKAG 144 Jannaschia sp. CCS1
ZP_01196676  87 Sm-aDLVAFLGELHaRGADLYLh-qQALDTTTps---grAMFQMMGVFAEYERAMIRERVNAG 144 Xanthobacter autotrophicus Py2

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