Conserved Protein Domain Family
PRK09277

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PRK09277: PRK09277 
aconitate hydratase AcnA
Statistics
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PSSM-Id: 236445
Aligned: 560 rows
Threshold Bit Score: 1226.91
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
121605915  19 ASTLQSFQTAS--------GKTGKLYSL--PSLAEQFPMVKRLPVSIRIVLESVLRNCDGK-KVTAEHVEQLANWVPQaE 87  
93006137    5 lvQPMNEPFKKpl-----pGTDLYYFDTreAIENIEAGAYDKLPFCSKVLCENLVRRCPPE-DLTAALKQHIEG-----K 73  
71065670    5 LVQPMNEPFKKpl-----pGTDLYYFDTreAIENIEAGAYDKLPFCSKVLCENLVRRCPPE-DLTAALEQHIYG-----K 73  
148653005  17 HPQPMNTEFKKplplpngeDSGLYYFDVeqAVNAIEPGAYAKLPFSSKVLCENLVRRCPP-----EDLTEALSQHIYR-K 90  
33600328    3 SRMTNRGYMNAsfl---hlGTPIHYADVa-AAAARSGVELASLPYVIRILLENLLRHRGRGrPVQEAEIEAVAHWQA--H 76  
33595801    3 SGMTNRGYMNAsfl---hlGTPIHYADVa-AAAARSGVELASLPYVIRILLENLLRHRGRGrPVQEAEIEAVAHWQA--H 76  
187477133   5 DILPVSLSMIQsfs---crGRVLRYADLs-AAAHAEGRDIRTYPYVIRVLLENLLRHRAWGaAVSEAEISRLWDWGK--H 78  
157736539   1 ---MTNEKYLKql-----dGLDVKYYDVksAVEDIKAGSFAKLNYTSRVLAENLLRKCPS--ADLKDSLIQLIEK----R 66  
160901292   1 ----MNHTHKKpl-----pGTTLHYIDAraAVDALSPGAWARMPYTARVHAENLVRRADP--AQLDSYLLQLIER----R 65  
296274253   1 ---MTNDKYLKkl-----eGFDTSYYDVkaAVEDITPGSFEKLNYTSRVLAENLIRKCPS--VDLKDSLIQLIEK----R 66  
121605915  88 RSAEIPFVVSRVVLQDFTGVPLLADLAAMRSVAARLGRNPKAIEPLVPVDLVVDHSIMVDYFG-TKDSMDLNMKLEFQRN 166 
93006137   74 QDLDFPWYPARVVCHDILGQTAFVDLAGLRDAIAEQGGDPSKVNPIVPTQLIVDHSLAVEHAGfEENAFEKNRAIEERRN 153 
71065670   74 QDLDFPWYPARVVCHDILGQTAFVDLAGLRDAIAEQGGDPSKVNPIVPTQLIVDHSLAVEHAGfEENAFEKNRAIEERRN 153 
148653005  91 QDIDFPWYPARVVCHDILGQTAFVDLAGLRDAIAAEGGDPAKVNPIVPTQLIVDHSLAVEHAGyEENAFEKNRAIEERRN 170 
33600328   77 ISEQISLHVERVILPDSSGLPVLQDLAALRDAVQAGGGDPARVDTRVPVDLIVDHSLQVDAWS-TADAVRRNLDAEFARN 155 
33595801   77 ISEQISLHVERVILPDSSGLPVLQDLAALRDAVQAGGGDPARVDTRVPVDLIVDHSLQVDAWS-TADAVRRNLDAEFARN 155 
187477133  79 IGADLPLHVARVILPDSSGLPVLQDLAALRDAVAQAGGDAAQVDTRIPVDLIVDHSLQVDYWG-DSGAVQRNLRREFERN 157 
157736539  67 TDKDFPWYPSRVICHDILGLTAFVDLAGLREAVAKEGGDPQKVNPVVPTQLIVDHSLAVECGGyDPDAFQKNRDIEDRRN 146 
160901292  66 RDIDFPWYPVRVVCHDILGQTALVDLAGLRDAIAAEGGDPAQVNPVVPVQLIVDHSLAVECGGfDPDAFVKNRAIEDRRN 145 
296274253  67 TDKDFPWFPSRVICHDILGLTAFVDLAGLREAVASKGGNPDKVNPVVPTQLIVDHSLAVECGGfDPDAFQKNRDIEDRRN 146 
121605915 167 RERYEFMKWGMQAFDTFGVVPPGFGIVHQVNLEFLARGVHRT-QDD------VYYPDTLVGTDSHTTMINGIGVVGWGVG 239 
93006137  154 DDRFHFINWCQYAFDNVNVVPPGNGIMHQINLEKMSPVVQVV--QNkag-eqVAFADTLVGTDSHTPMVDALGVISIGVG 230 
71065670  154 DDRFHFINWCQYAFDNVNVVPPGNGIMHQINLEKMSPVVQVV--KNkag-eeVAFADTLVGTDSHTPMVDALGVISIGVG 230 
148653005 171 EDRFHFINWCEYAFDNVNVVPPGNGIMHQINLEKMSPVVQVI--TDkndgtpVAYPDTLVGTDSHTPMVDALGVISIGVG 248 
33600328  156 EQRYRFLKWAQQAFDGLRVFAPGTGIIHQVNLEKLATVVSTSeHGGq----qWACPDFVIGGDSHTPMVNGLGVLGWGVG 231 
33595801  156 EQRYRFLKWAQQAFDGLRVFAPGTGIIHQVNLEKLATVVSTSeHGGq----qWACPDFVIGGDSHTPMVNGLGVLGWGVG 231 
187477133 158 DERYRFLKWAQQAYKGLRVITPGIGIIHQVNLEYLAPVVAHQtRPDg----eWAYPDFVIGGDSHTPMVNALGVLGWGVG 233 
157736539 147 ADRFHFINWAKEAFNNVDVIPPGNGIMHQINLEKMSPVVHNI--DG------IASPDTLVGTDSHTPHVDALGVIAVGVG 218 
160901292 146 EDRFHFIEWTKKAFANVDVIPAGNGIMHQINLEKMSPVVTVQ--DG------LAFPDTCVGTDSHTPHVDALGVIAVGVG 217 
296274253 147 ADRFHFINWTKEAFNNVDVIPPGNGIMHQINLEKMSPVVHNI--DG------IASPDTLVGTDSHTPHVDALGVIAVGVG 218 
121605915 240 GIEAEAAMLGQPVYFLTPDVVGMELTGKLREGVTATDLVLRVTETLRREKVVGKFVEFFGEGTRTLALPDRATIGNMAPE 319 
93006137  231 GLEAESVMLGNPSYMRLPDYVGVKLTGKLQRGITGTDLVLAMTEFLRDAGVVSTYIEFFGEGARQLSVGDRASISNMTPE 310 
71065670  231 GLEAESVMLGNPSYMRLPDYVGVKLTGKLQKGITGTDLVLAMTEFLRNAGVVSTYIEFFGEGARQLSVGDRASISNMTPE 310 
148653005 249 GLEAESVMLGNPSYMRLPDIIGLELTGKLQPGITGTDLVLAMTEFLRDEGVVSAYVECFGDGARSLSVGDRASISNMTPE 328 
33600328  232 GIDAESALLGRAYTFPIPEVVGVELKGAFRSPVTTTDAALLVTQRLRAEGVTGCMVEFFGEALPGLSVADRATIANMAPE 311 
33595801  232 GIDAESALLGRAYTFPIPEVVGVELKGAFRSPVTTTDAALLVTQRLRAEGVTGCMVEFFGEALPGLSVADRATIANMAPE 311 
187477133 234 GIDAEAALLGHAYTFPIPEVVGVRLHGAIQA--LTTDAALLVTQQLRAAGVVGSMVEFFGPAVAALAVPERATIANMAPE 311 
157736539 219 GLEAENVMLGNPSYMRVPEIIGVEITGTRAAGITATDIALSLTSFLRENNVISAYLEFYGSGIKYLDLGDRATISNMTPE 298 
160901292 218 GLEAENVMLGRACWMRLPEIVGVRLTGRRQGGITATDIVLALTEFLRQQKVVGAYVEFFGEGADSLSIGDRATISNMCPE 297 
296274253 219 GLEAENVMLGNPSYMRVPEIIGVEITGVRAEGITATDIALAMTSFLRENNVISAYLEFFGSGVQYLNLGDRATIANMTPE 298 
121605915 320 YGATMGFFPVDEKTIDYFRGTGRLDAEIEAFEAYFRAQGLFGva-aaGEIDYSHVVKLDLDDVRPSLAGPKRPQDRIELG 398 
93006137  311 YGATAAMFYIDEQTIDYLRLTGRSEAQIKLVEQYAKQTGLWAdg--mEKAEYARVLEFDLSAVVRNMAGPSRPHARVSTT 388 
71065670  311 YGATAAMFYIDEQTIDYLRLTGRSEAQIKLVEQYAKQTGLWAdg--mENAVYDRVLEFDLSAVVRNMAGPSRPHARVSTT 388 
148653005 329 YGATAVMFYIDEQTIDYLRLTGRTEKQINVVEAYAKHTGLWAdg--mQQAKYERVLRFDLSKVVRNIAGPSKPHARVSTT 406 
33600328  312 YGATCGFFPVDAQTLDYLRLTGRTAEHIELVRAYCQANGLWRadpaaSAVRYARVVRIDLAQAEPCMSGPRRPQDRLPIG 391 
33595801  312 YGATCGFFPVDAQTLDYLRLTGRTAEHIELVRAYCQANGLWRadpaaSAVRYARVVRIDLAQAEPCMSGPRRPQDRLPIG 391 
187477133 312 YGATCGFFPIDARTLDYARMTGRDEAQLALIEDYARANQLWRdt-aqAAPAYSRVIDIDLSAARLSLAGPRRPQDRMDVA 390 
157736539 299 YGASAAMFAIDNRTIDYLKITGREAKQVELVEKYAKANGLWAds--lNEATYARTLKFDLSTVTRSLAGPSKPHKLVPTS 376 
160901292 298 YGATAAMFSIDDQTLAYLRLTGRDEAQVRLVEAYARTAGFWSds--lADAQYERVLQFDLSTVVRNMAGPSNPHRRLPTS 375 
296274253 299 YGASAGIFAIDEQTIDYLTVTGRDAAQVKLVEAYAKANGLWAdq--fDNATYARTIEFDLSKVTRSLAGPSKPHKLVPTS 376 
121605915 399 DVARQ-FSslfskpNAENGFNQPAGMLGTrhlvrhtddgrpdavpaapptpmgaersvvemesnrptlamaheqggevas 477 
93006137  389 DLVAKgIAhgegd------------------------------------------------------------------- 401 
71065670  389 DLVAKgIAhaped------------------------------------------------------------------- 401 
148653005 407 DLVNKgIAqehy-------------------------------------------------------------------- 418 
33600328  392 QLAED-FRqrlprpAAEGGFGLDAAALARa-------------------------------------------------- 420 
33595801  392 QLAED-FRqrlprpAAEGGFGPDAAALARa-------------------------------------------------- 420 
187477133 391 DVAAD-FRrrlgapQSEGGFEVD---MGLa-------------------------------------------------- 416 
157736539 377 TLEAEgITkkie-------------------------------------------------------------------- 388 
160901292 376 ALAERgIAdaaklq------------------------------------------------------------------ 389 
296274253 377 TLRAEgIVk----------------------------------------------------------------------- 385 
121605915 478 asvpaahAAAQglTVGNGDVLIAAITSCTNTSNPSVLLAAGLLAKKAVEAGLGVQPHIKTSLAPGSRIVTEYLTQTGLLP 557 
93006137  402 ---klpePKDG--LMPDGAVIIAAITSCTNTSNPRNMVAAGLVARNANKKGLLRKPWVKSSLAPGSKTVKMYLEEAGLMP 476 
71065670  402 ---klpePKDG--LMPDGAVIIAAITSCTNTSNPRNMVAAGLVARNANAKGLLRKPWVKSSLAPGSKTVKMYLEEAGLMP 476 
148653005 419 ---dptaPADG--SMPDGAVIIAAITSCTNTSNPRNMVAAGIVARNALKKGLVRKPWVKSSLAPGSKAVKLYLEEADLLP 493 
33600328  421 -------PGSA--GLRHGSIVVAALTSCTNTSNPSVMLTAALVARAARQRGIAPPAWVKRSLAPGSRTVTDYLAATGLLQ 491 
33595801  421 -------PGSA--GLRHGSIVVAALTSCTNTSNPSVMLTAALVARAARQRGIAPPAWVKRSLAPGSRTVTDYLAATGLLQ 491 
187477133 417 -------AGRD--VVGHGSVALAAITSCTNTSNPSVMLAAGLIARKALDRGLTPPAWVKRSLAPGSRAVTRYLESAGLLT 487 
157736539 389 ---------itndVIPDGAVLIAAITSCTNTSNPRNVVAAGLLAKKANELGLTRKRWVKSSLAPGSKVAELYLKESGLLP 459 
160901292 390 --aaraqeAQG--LMPDGAVIIAAITSCTNTSNPRNVIAAALLARNANRLGLVRKPWVKSSLAPGSKAVELYLKEAGLLT 465 
296274253 386 ------eWKQDgdKIPDGGILIAAITSCTNTSNPRNVIAAGLLAKKANELGLTRKPWVKSSLAPGSKVIEVYLKEAGLLS 459 
121605915 558 YLQQLGFDLVGYGCTTCIGNSGDLTAELNDAINKSDLVCAAVLSGNRNFEARIHPNIKANFLGSPPLVVAYALAGTVMRD 637 
93006137  477 ELQEIGFDVVGFACTTCNGMSGALDPDIEKEIIDNDLFTTAVLSGNRNFDGRIHPYAKQAFLASPPLVIAYAIAGNIRFD 556 
71065670  477 ELQEIGFDVVGFACTTCNGMSGALDPDIEKEIIDNDLFTTAVLSGNRNFDGRIHPYAKQAFLASPPLVIAYAIAGNIRFD 556 
148653005 494 DLQTLGFDVVAFACTTCNGMSGALEPEIQQEIIDRDLFATAVLSGNRNFDGRIHPYAKQAFLASPPLVVAYAIAGSIRFD 573 
33600328  492 DLEALGFGVIGYGCTTCGGKSGPLAPEVAQDIADNQWVVCTVLSGNRNFEGRIHKLARANYIGSPPLVVAYALAGRIDID 571 
33595801  492 DLEALGFGVIGYGCTTCGGKSGPLAPEVAQDIADNQWVVCTVLSDNRNFEGRIHKLARANYIGSPPLVVAYALAGRIDID 571 
187477133 488 ALQAQGFHVIGYGCTTCGGKSGPLDAGVAEAIVEGGLVAAAVLSGNRNFEGRIHKLLRANYIGSPAMVVLYALAGRIDVD 567 
157736539 460 ELEKLGFGIVGFACTTCNGMSGALDPKLQKEAADSGVYTTAVLSGNRNFDGRIHPFIKEAFLASPPLVIAYAIAGSIRFN 539 
160901292 466 ELEQLGFGIVAFACTTCNGMSGALDPRIQQEIIERDLYATAVLSGNRNFDGRIHPQAKQAFLASPPLVVAYALAGTIHFD 545 
296274253 460 EMEKLGFGVVGFACTTCNGMSGALDPAIQKEVVDNDIYTTAVLSGNRNFDGRIHPYVKEAFLASPALVIAYALAGTIRFD 539 
121605915 638 LTTEPLGKGKDGQDVFLRDIWPGSDEIHALMKFAMNAEAFRANYAKVKTEPgQLWENIHGVA-GNTYNW-PLSTYIAEPP 715 
93006137  557 IEKDSLGKDQHGNDVYLKDIWFDDDEVDAIVAAAVKPEQFNAVYIPMFDEA----KKDTGKAlSPLYNWrDQTTYIRRPP 632 
71065670  557 IEKDSLGKDQNGNDVYLKDIWFDDDEVDAIVAKAVKPEQFNAVYIPMFD---EAKKDTGKAL-SPLYNWrDQTTYIRRPP 632 
148653005 574 IEKDPLGQDQDGNDVYLKDIWFDDAEVDAIVASAVKPEQYSKVYIPMFDEGkVDAERHDAVT-DPQYNWrEMSTYIRRPP 652 
33600328  572 FSREPIATDADGQPVWLHELWPGEAQLDEIMARALSPQGFRRVWGLEPEGA-SQWRALAEVS-GQHWQWd-DSNYLVEPP 648 
33595801  572 FSREPIATDADGQPVWLHELWPGEAQLDEIMARALSPQGFRRVWGLEPEGA-SQWRALAEVS-GQHWQWd-DSNYLVEPP 648 
187477133 568 FEREPLGPGADGAPVYLRDVWPSQEEIMALMPLASDPALFAEVYDPASLDS-AIWRDLAAPA-GLRFPWdPDSQYLVEPP 645 
157736539 540 IETDVLGKDKNGNDIKLKDIWPSDEEIDAVVNSAVKPEMFGKIYDPMFARN-----GLGAKKaEPFYKWnTKSTYINKPP 614 
160901292 546 IEQDVLAV-VDGREIRLKDLWPADEEIDAIVEQAVKPAQFRAVYEPMFAIRkDDGNKA-----SPQYDWrPQSTYIRRPP 619 
296274253 540 IENDVLGKDKEGNDIRLKDLWPSDAEINAVEKSCVRPEMYNNIYEPMFKRE-----LLDSIKiDPFYKWnPKSTYINRPP 614 
121605915 716 FF----N-----DFAMemkAPtASgtgENGqnnefsVQGARIMALFGDSITTDHISPAGSIKGSSPAGLWLQAHGVQKAD 786 
93006137  633 YW----E-----GKMA---AM-NK------------LKGMRPLAVLGDNITTDHLSPSNAILGDSAAGEYLDTMGLPSED 687 
71065670  633 YW----E-----GKMA---AM-NK------------LTGMRPLAVLGDNITTDHLSPSNAILGDSAAGEYLDTMGLPSED 687 
148653005 653 YW----E-----GSMA---EA-NQ------------LKGMRPLAVLGDNITTDHLSPSNAIMPDSAAGEYLDTMGLPAED 707 
33600328  649 FF----K-------AP------AQq-fGQR------LAGARVLGLYGDSLTTDHISPSGEIPAEAPAGRYLLGLGVAQRD 704 
33595801  649 FF----K-------AP------AQq-fGQR------LAGARVLGLYGDSLTTDHISPSGEIPAEAPAGRYLLGLGVAQRD 704 
187477133 646 FF----KtepgrDALA------DL---AAG------LARGRVLAAFGDSLTTDHISPSGEIPADTPAGSYLIAKGVAPRD 706 
157736539 615 YW----E---------------DEymqMPA------LKNMRPLGVFPDNITTDHLSPSNAILPTSASGEYCIKMGLPIED 669 
160901292 620 YW----DtegvgALAA---FP-RT------------LTGMRPLALLPDNITTDHLSPSNAILADSAAGEYLARMGLPEED 679 
296274253 615 YWedeyM-----QMPA--------------------LKGMRPLGVFPDNITTDHLSPSNAILPTSASGEYCLKMGLPVED 669 
121605915 787 FNSYGSRRGNHDVMMRGTFANVRIKNLMIPagkdgsreEGGVTLYHP-GHRtpesviekMPIYDAAMKYMAEGTPTVIFA 865 
93006137  688 YNSYATHRGDHLTAQRATFANPKLLNEMVRdekg-eviQGSLARVEPqGQV--------MRMWEAIETYMNREQPLIIIA 758 
71065670  688 YNSYATHRGDHLTAQRATFANPKLLNEMVRdekg-dviQGSLARVEPeGQV--------MRMWEAIETYMNREQPLIIIA 758 
148653005 708 YNSYATHRGDHLTAQRATFANPKLLNEMVRdeng-eviQGSLARVEPeGET--------MRMWEAIETYMKRNQPLIIIA 778 
33600328  705 FNTYVARRSNFEVMTRATFGNIRIRNLLVPg------tEGGYTRHFPsGEQ--------LSIYDASRRYMAAGTPTIVLA 770 
33595801  705 FNTYVARRSNFEVMTRATFGNIRIRNLLVPg------tEGGYTRHFPsGEQ--------LSIYDASRRYMAAGTPTIVLA 770 
187477133 707 FNTYVARRCNHHVMTRATFANIRIKNALTPg------mEGGVTRHYPsGRL--------MPIVDAATAYRDAGEACIILG 772 
157736539 670 LNSYATHRGDHHTASRATLANPKLFNEMVKdeng-nvkQGSLTKIMPeGKE--------SRMWEAIETYTQRKQPLIIIA 740 
160901292 680 FNSYATHRGDHLTAMRATFANPQLVNEMAVidg--vqhKGSLARIEPeGRV--------VRMWEAMETYLNRRQPLIIIA 749 
296274253 670 LNSYATHRGDHHTASRATLANPKLYNEMVKnedg-tvkQGSLTKIMPeGTE--------SRMWEAIETYTQRKQPLIIIA 740 
121605915 866 GEEYGTGSSRDWAAKGTQLLGIKAVVARSFERIHRSNLVGMGVLPLQFMPgESWQTLKLIGSEVVDVIPHPE-LKPQSEA 944 
93006137  759 GDGYGQGSSRDWAAKGVRLAGVEVVVAEDFERIHRQNLVGMGALPLQFEKgTTRNTLNIDGTEVFDVTGEV---SAGGMM 835 
71065670  759 GDGYGQGSSRDWAAKGVRLAGVEVVVAEDFERIHRQNLVGMGALPLQFEKgVTRNTLNIDGTEVFDVTGEV---SAGGMM 835 
148653005 779 GDGYGQGSSRDWAAKGVRLAGVECVVAEDFERIHRQNLVGMGALPVQFEAgTTRKTLNIDGTEVFDIEGEV---SAGGTM 855 
33600328  771 GEEYGTGSSRDWAAKGTALLGVRAVLAKSYERIHRANLVGMGVIPFQFERgQGWRELGLDGSETFEFFDVLDgIRQGRPV 850 
33595801  771 GEEYGTGSSRDWAAKGTALLGVRAVLAKSYERIHRANLVGMGVIPFQFERgQGWRELGLDGSETFEFFDVLDgIRQGRPV 850 
187477133 773 GKDYGMGSSRDWAAKGSALLGVRAVIAESFERIHRANLVGMGVLPLAFAPgQGWRQLGLTGAQTLRLENVANgVLKGEPI 852 
157736539 741 GTNYGQGSSRDWAAKGVRLAGVEVLIAESIERIHRTNLVGMGVLPLQFKEgETRHTYAIDGTEVFEIVGDI---TPRCDL 817 
160901292 750 GADYGQGSSRDWAAKGVRLAGVEAVVAEGFERIHRTNLIGMGVLPLQFVPgTNRKTLALDGTEVYGVEGER---TPGTQL 826 
296274253 741 GTNYGQGSSRDWAAKGVRLAGVEVLIAESIERIHRTNLVGMGVLPLQFKDgETRHTYNIDGSETFDIEGKI---TPRCDL 817 
121605915 945 RLVITRADG-TRQEVTVILRVDTPIEVDYYRNGGILPYVLRQLLAA 989 
93006137  836 TLVINRADG-STTETPIICRLDTADEVKMYNAGGMLQRFAKEFIDG 880 
71065670  836 ALVINRADG-SKLEVPIICRLDTADEVKMYNAGGMLQRFAKEFIDG 880 
148653005 856 TLVIHRKDG-SVDKAPVKCRLDTADEVKMYQSGGMLQRFAKEFLAG 900 
33600328  851 RVAASRDDG-MRVEFSVMPQALTESERELLLQGGIPASVLADYLQ- 894 
33595801  851 RVAASRDDG-MRVEFSVMPQALTESERELLLQGGIPASVLADYLQ- 894 
187477133 853 DVIA--EDGsRQVRFQAYAQVLTHAERKLMAEGGIPASVLNAFLTD 896 
157736539 818 TVVMTRANG-EVVKFSVLCRLDTSAEVEVYKNGGILQKFAKDVIAS 862 
160901292 827 TLVIERRGG-QTLRVPVTCRLDTAEEVSAYEAGGVLQRFAQDFLAQ 871 
296274253 818 TVVMTRANG-EVVKFPVLCRLDTSAEVDVYKNGGILQKFAKDVIAE 862 
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