Conserved Protein Domain Family
DUF6421

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pfam19985: DUF6421 
Family of unknown function (DUF6421)
This entry represents a member of a biosynthetic gene cluster (BGC). This BGC (BGC0000877) is described by MIBiG as an example of the following biosynthetic class, other (unspecified), in particular the polyoxin A biosynthetic gene cluster from Streptomyces cacaoi subsp. asoensis. This family appears to be predominantly found in Actinobacteria.
Statistics
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PSSM-Id: 437817
Aligned: 26 rows
Threshold Bit Score: 786.523
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
RJS45786      32 SAAWLSLKAAATALQPLQAQDGSVPDAAD----HAEARGHVAAITAAIEELRPLFPHDDAYLAASVRDFATWADGGFGVP 107
SNV19910      48 HPAWISIREAATSIQALQSSDGSITEATE----HAKARELITHITQGIEELAPLLPHDADYLTAVRSDLHTWANNGFTVP 123
RKT79574     205 DPAWLRLKAAVSELRLLQQKDGSLRDDVDea-gHERARTLVAEVVAGIRGLAPSLPHDAAYLEALVLDFGRWVDGGFGVP 283
OPC83798      15 HPQWPVLKEAVADLRPLQAKDGSIEPSG-----HAAARVLVADITAAIAALAPLFPYDEAYLDAVVADFHRWAEADFARP 89 
SFC83010       8 HPAWLRLRETVSDLRAHQRTDGSVDLGSIg---RERAEALLGTVRTAVAELAPSFPHDGDYLTALDKDLARWADDGFGVP 84 
PLW71668      22 NPAWAVLKRAVEAIRPHQSKDGSIDFAADgapaRADVEKELARVVEAVQELAPALPHDADYLQALVKDLVKWGESGFAVP 101
AKG46552      26 HPAWPRLKHAVEAVRPAQSPDGSIDFDAEgappRAAVERDIERVITELRTLSPLLPHDAAYHRALESDLRRWADEGFGVP 105
RAJ86695      27 HPAWPVLKDAVEEIRTWQEKDGSIDLDAEgapsVADAKEAVDRVVTAVERLAPLLPHDAAYLDALVGDLRRWADGGFAVP 106
BAJ27530      30 HPAWPRLKDAVEALRPLQSKDGSIDLAAVp---RATVDPLVATVRDAVAELAPLFPHDAAYLDAVRADLAKWADTGYRQP 106
WP_042452484  21 HPAWLRLKAAVEAMRPLQSKDGSIDLNSRgastKDEADAQLAAITAAIGELAPLFPHDKAYLDAVVLDLMRWAASGYAVP 100 Streptacidiphil...
RJS45786     108 DFLDSLVAFQPQEHRVDGLRHLVVFPMYTQNGSSDRHVEALLVEVIWPEFIAHLEAGDYGNRLFVPLRLLDFTSGYDTNS 187
SNV19910     124 DFLDSLVAFHPELHRVDGLVHLVVFPMYTQNGSSERHLEAVLIQVIWPDFVAALEAGDYTNAAFVPIRFIDFTAGYDTNS 203
RKT79574     284 DFLDSLNAFAPAQHRVDGLTHLVVFPMYTQNGNPDRMVEAVLLEVIWPDFVAELEAGDYSNRLFLPIRFLDFTAGYDTNS 363
OPC83798      90 DFLDSLVAFRPEQNRRDGLEHLVVFPMTTQNGNPNRNVEAVLLRVVWPQWLADLEATRYDNAMFVPLAFVDFTDGYDTDS 169
SFC83010      85 DFLDSLTQFQPSRGRADGRGHLVVFAMYTQNGNPDRNLEALLIHEVWPEWLAALEADRYDNPMFVPIRFDDFTAGYDTHS 164
PLW71668     102 DFLDSLLAFRPASQRVDGLEHLVVFPMYTQNGNPDRNLEAVALRVVWPEWLSELERTRYDNPLFVPITFQDFTAGYDTNS 181
AKG46552     106 DFLDSLLAFRPAEHRADGLQHLVLFPMYTQNGNPDRNLEAVVVRVVWPEWLAELERTRYDNPMFLGITFEDFTPGYDTNS 185
RAJ86695     107 DFLDSLLAFQPAAQRRDGLQHLVVFPMYTQNGNPDRNLEAVVLKMVWPDWLAELEATRYDNPLFCGITFEDFTSGYDTNS 186
BAJ27530     107 DFLDSLLAFRPNEQRVDGTGHLVVFPMYTQNGNPDRNLEAVLLKVVWPDWIAELERTRFDNPGYLGIAFEDFTAGYDTNS 186
WP_042452484 101 DFLDSLLAFQPAEQRVDGLAHLVVFPMYTQNGNPDRNLEAVLLHVVWPEWLSELERTRYDNPMFVPITFVDFTAGYDTNS 180 Streptacidiphil...
RJS45786     188 AVLFPETVAVRETP-QFTWGAIFQDREAARFRRVVGAASAITDLALPEGAARMLEDQALTEKAFVVWDLIHDRTHMRGDL 266
SNV19910     204 AVLFPETVAVRAIP-QFTWGGIFADREAARFRKVLAAACEITSLDPPEEARAFLDDQRLTEETFVMWDLIHDRTHMRGDL 282
RKT79574     364 AVLFPETVAMREVP-AFTWGGIFADREAARFRRVVAEAADVTRLSLPADAARLVADQQLAERTFVMWDLIHDRTHMHGDL 442
OPC83798     170 AVLFPETVAVREVP-RFTWGGIFCDREAARFRRVGTAAADTLGLELPPEAQALVESQQLAQNAFVLWDLIHDRSHMRGHM 248
SFC83010     165 AVLFPETVSVRETPsAYTWGAIFCDREAARFRQVTNAAADILRLDLPDQARALLSDQARCEEAFVLWDLIHDRTHSHGDL 244
PLW71668     182 AVLFPETVAVREVPdSFSWGGIFCDREAARFRAVSDAAVRTLGLELPEDAARLIADQELAMETFVLWDLVHDRTHSHGDL 261
AKG46552     186 AVLFPETIAVREAPeRFSWGGIFCDREAARFRKVVAAAGEVTSLALPEDAQGLLTDQERTQHTFVLWDMIHDRTHSHGDL 265
RAJ86695     187 AVLFPETIAVREAPeRFSWGGIFCDREAARFRRVTEAAVDILGVELPDDIRDMVGDQERCQQAFVLWDMVHDRTHSHGDL 266
BAJ27530     187 AVLFPETVAVREAPeRFTWGGIFCDREAARFRAVTTSAVRQLGLDIPADAAGLLGDQDRTQQTFVLWDLVHDRTHSHGDL 266
WP_042452484 181 AVLFPETVSVREVPeRFTWGGIFCDREAARFRAVSNASVNTLGLTIPEDAAALLADQELAQQTFVLWDLVHDRTHSHGDL 260 Streptacidiphil...
RJS45786     267 PFDPFMIKQRMPYFLYSLEELRCDLTAFRECVWVEQQltarrdesgsrdgvgglETIEVETLEHAKLVQYAVIFDRIFRF 346
SNV19910     283 PFDPFMIKQRMPYFLYSLEELRCDLTAFREALRIERIiaas----------pdvSDEQRSLARHARLVQYAVIFDRIFRF 352
RKT79574     443 PFDPFMVKQRMPFFLYALEELRCDLTAFRESVKLE-----------------------AEGHPYARMVQYAVLFDRIFRF 499
OPC83798     249 PFDPFMIKQRMPFWMYALEELRCDLTAFREAVALSA------------------EG-----EPTAPLVRYAVIFDRLFRF 305
SFC83010     245 PFDPFMIRQRQPFWMYGLEELRCDLTAFREAVRLAD------------------EG-----LPQAEDVQYAVLFDRLFRF 301
PLW71668     262 PFDPFMIKQRQPFWMYALEELRCDLTAFKEAVKLEA------------------EG-----YPQGRNVQYAILFDRLFRF 318
AKG46552     266 PFDPFMIKQRQPFWMYGLEELRCDLTAFHEAVRLER------------------EG-----LPQARDVQYAILLDRIFRF 322
RAJ86695     267 PFDPFMIKQRQPFWMYGLEELRCDLTAFKEAVKLEA------------------DG-----VPQARDVQYAVLFDRMFRF 323
BAJ27530     267 PFDPFMIKQRSPFWMYGLEELRCDLNTFKESVALEA------------------EG-----TPQGRDVQYAILFDRLFRF 323
WP_042452484 261 PFDPFMIKQRSPFWMYGLEELRCDLTAFKAAVELEA------------------EG-----NEHGRNVQYAILFDRMFRF 317 Streptacidiphil...
RJS45786     347 AITGSRVRNYDGLGGQLLFAWLHQRGVLHWTDTSLAFDWDDVPAAVVALGDAIDELYWRSIDRPKTAHWLAAYELIRSTL 426
SNV19910     353 TVTGGRNRNYDGLGGQLLFAWLHRKGVLHWTDTKLTFDWDRVPDMVNELGDAVNDLYWQSIDRPKVNHWFAAYDLVASVL 432
RKT79574     500 SITGSRVRNYDGLGGQLLFAWLHQRGVLHWTDNRLSVDWEAVTEPVLELGRAIEDLYWRSIDRPKASHWLAAYALVSSVV 579
OPC83798     306 PVTGGRVRNYDGLGGQLLFAYLHRAGVLDWSDNRLTIDWDRITDAVLGLFDEVDRLYREGVDRSKVGHWLAGYRLVAEYV 385
SFC83010     302 PVTGNRVRNYDGLGGQLLFAYLHKNGAVRWTDNRLSIDFDRARELTARLGEEIQRFYRDGIDRPKVVHWIAGHELVSRYL 381
PLW71668     319 PVTGDRVRNYDGLGGQLLFAYLHKHDAVRWTDNTLRIDWKLASEVTNRLCAEIETLYRDGIDRPKVVHWLAAYELVSTYV 398
AKG46552     323 PVTGARNRNYDGLGGQLLFAYLHQNGALQWTDNRLSIDWEHARALTVRLREEIETLYRLGIDRPKIVHWFKAYELVSAYL 402
RAJ86695     324 PVTGDRVKNYDGLGGQLLFAYLHKHDVLRWTDNKLLIDWQRAPEVTNQLCGEIEQLYRDGIDRPKLVHWFAAYDLVSTYL 403
BAJ27530     324 PVSGDRVRNYDGMGGQLLFAYLHKHDALRWRDNRLTIDWDRVAEVTNGLCAEIETLYRDGIDRPKTAHWIAAYQLVSRYL 403
WP_042452484 318 PVSGGRVRNYDGLGGQLLFAYLHKHDALRWTDNKLHIDWQRAPQVTNDLCAEIEKLYRDGIDRPKTAHWLAAYELVATYL 397 Streptacidiphil...
RJS45786     427 TPNPASVWA-R----GLPDEIL------AGPTKGYTDAVLDDEFPLSMFYESLDKKMRPVIESTAGIVGT 485
SNV19910     433 EPHVASKWAtR----DLP---L------NGTPRELTDAVLDDEFPLSMFFEAYEKKVRDVIASTKGITGE 489
RKT79574     580 TPHPSSAWA-RhaagDLTALPL------DGPPKGLTDAVLPDEFPLSMFFEALAKKMKPVIESTAGITGR 642
OPC83798     386 PSHPGSVWA-K----GTAALPM------DGPPKALVDAVLPDEFPLSMFYEALNRRLRDVIASTRGITAD 444
SFC83010     382 SAHPGSKWA-R----ARETLDF------SLPPRELVDEVLPDEFPLSMFYETLAKKLGGVVESTRGVTGK 440
PLW71668     399 SPHPASVWA-K----GPEALPL------DEPPRRLVDQVLADEFPLSMFYEALNKKLRDVIASTRGITAR 457
AKG46552     403 SPHPGSTWA-K----GPEALDL------SQPPRKLVDDVLPDEFPLSLFYEALAKKLRKVIESTRGITAD 461
RAJ86695     404 APHPGSRWA-K----GPDALDT------SLPPRKLVDEVLPDEFPLSMFYEALSKKLKNVIASTKGITAA 462
BAJ27530     404 TPHPASTWA-K----GPEALPLdla-ddRALRKALCDAVHPDEFPLSMFYEALSKKLRRVIAGTKGITGT 467
WP_042452484 398 TPHPASTWA-K----GAEALPFaqhteaKALNKALCDAVLPDEFPLSMFFEALSKKLSGVIASTSGMTGT 462 Streptacidiphilus jiangxi...
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