Conserved Protein Domain Family
PyrB

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COG0540: PyrB 
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]
Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis
Statistics
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PSSM-Id: 440306
Aligned: 762 rows
Threshold Bit Score: 229.555
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_083305054   4 A---TW-TRRHILALADFTPDEYNTVLQTAASFREVLsRr----TKKV--PALQ----GHVVANLFFEPSTRTRSSFELA 69 
NP_970746      3 N---KF-MGRSLTVIDDLSIDERKYLFDKTKRLKKAI-Qed--dQKVM--DEFRindkDFGIYEVFLEPSTRTKESFRNA 73 
NP_229442      3 R---DF-LGRTLAVIEDLSVEEQMFLYEKTRELKQRW-Ys----GEDV--SDFRikkrNVGIYIVFVEPSTRTKESFINA 71 
WP_012002187   2 R---SF-RGRTLALIRDFTIDEQLFLYQKTKELKQKW-Ln----REDM--SEFQik-gDVNIYIVFVEPSTRTKESFINA 69 
WP_004102325   3 N---DF-LGRSLTVIEDFSVDEQMFLYAQTRKLKKLW-Ke----KSDI--SEFQik-kNVGIYIVFVEPSTRTKESFINA 70 
WP_013254024   4 N---TF-QGRTLAVIRDFSQEERLYLFSHTRRLKQAL-Leg--dRKTV--DEYRiddgDFGIYEVFLEDSTRTKESFKNA 74 
WP_014271539   5 S---VF-AGRSLCVIDDFTIEERKYLFEEVKVLKQAM-Ekn--dLSVM--DRYRindkDFGIYEVFLEDSTRTKESFRNA 75 
WP_041638731   3 H---DF-LGRTLAVINDLSIQEQLFLYEKTKQLKKKW-Le----KQDL--SEFMin-kNVGIYIVFIEPSTRTKESFINA 70 
WP_045088475   3 N---DF-LGRSLNVMSDFTIEEEMFLYHQTNRLKKKW-Kn----KEDC--SEFEiklpSVGIYIVFTEPSTRTKESFINA 71 
WP_069691232   1 MqrpNYpSGKDLLGADSVSRDDLDDIFARAERFLAEEdEedspgDQPArlHLIRr--rPKVIATLFDQRSTRTRLGFQAA 78 
WP_083305054  70 AKRL---SADILNFA---PGTSSLSKGETILDTAKTYLAMGt-NMMVIRHRQAGVPQIIATEMnrl------gvQVSVLN 136
NP_970746     74 AKFH---QVKLSDLA---AESSSFNKGESYADTFNTLAGYQn-SIFIVRSKVEGVCRWLEDEAqafyqrnnlkrKPAFIN 146
NP_229442     72 AKFHsgpNVKVNVFD---SEHSSFNKQESYTDTFSMLTGYSdySIFVVRTRLEGVCRLLERRIsefas-rngieVPSFIN 147
WP_012002187  70 AKFHk--NARVNIFD---AEHSSFNKNESYVDTFNMLTGYGiySIFVVRTRLEGVPRLLERKVgefaq-rhgieRPAFIN 143
WP_004102325  71 ARFHk--NAKVNIFD---SEHSSFNKKESYLDTFNMLTGYSdySIFVLRTRLEGTCKYLDEKVsefae-rhgveKPAFIN 144
WP_013254024  75 AQFH---GVKLNSLD---VGHSSINKKESYADTFNTLCGYDn-KIFIVRSTLEGVCRWLEENGkefarrnglsvPPAFIN 147
WP_014271539  76 ANFH---HVKVSELN---SDSSSFNKGESFADTFNTLSGYSn-TIFIVRSKIEGVCRWLEDECheyalrnklwrKPSFIN 148
WP_041638731  71 AKFHk--KAKVTIFD---SNHSSFNKKESYLDTFNMLTGYSdySIFVIRSKLEGTCRYLEQSVskfal-rnglpIPSFIN 144
WP_045088475  72 AKFHk--NAKTNIFE---SEHSSFNKSESYIDTFNMLTGYSdhSIFVVRTKLEGTCKLLDEKVsdyaf-rhslnKPSFIN 145
WP_069691232  79 ALRL---GHQSLDVYdtdRSRMGSATGETLDDHIRTVEAYS--DLIVVRSHTESLPYQIGRLS-----------YLPVVN 142
WP_083305054 137 AGDGQHEHPSQGLLDLFTICSCLdwdnpriE-LLAGKKITIVGDILHSRVARSNIWSLLAT-GAEVHLAG-PPTLL--PQ 211
NP_970746    147 AGDGKHEHPTQELLDEFTFIEDN-------NwSFDKIHIALVGDLYHGRTVHSKADGLKIFkSVKVDLIA-PAELAm-PE 217
NP_229442    148 AGDGKHEHPTQELLDEYTFLEQN-------GfDNSFIHVALVGDLLHGRTVHSKVNGLKIFkNVKVDLVA-PEELMm-PE 218
WP_012002187 144 GGDGKHEHPTQELLDEFTFLEQN-------NfDNSHIRIALIGDLLHGRTVHSKVDGLKIFkNVEVDLIA-PQQIQm-PQ 214
WP_004102325 145 AGDGKHEHPTQELLDEYTFLEQM-------DfDNSFIHIALVGDLLHGRTVHSKVNGLKIFkNVLVDLIA-PEEISm-PP 215
WP_013254024 148 AGDGKHEHPTQELLDEFSFLEQL-------DwDESRLHIALVGDLYHGRTVHSKVDGLKLFgSVSVDLIA-PKELAm-PE 218
WP_014271539 149 AGDGKHEHPTQELLDEFTFMEDN-------TwQTDSIHLALVGDLYHGRTVHSKAAGLRIFeKVRVDLIA-PPELAm-PE 219
WP_041638731 145 AGDGKHEHPTQELLDEFTFLEQN-------NfDNSFIHIALVGDLLHGRTVHSKVNGLKIFkNVKVDLIA-PQEISm-PS 215
WP_045088475 146 AGDGKHEHPTQEILDEYTFLEQL-------NfDNSYIHIALVGDLLHGRTVHSKVSGLRIFkNVLVDLIA-PEELQm-PR 216
WP_069691232 143 AGNGADEHPTQALIDLFAIRKLR-------G-DVKDLSIALSSDTR-ARFALSFVKMLRLSpPRRFTLCSlPd-VPinPP 212
WP_083305054 212 --LF----AEYSstrlqqprekqqqqllaksslahqrqytetplilkttvpitsqashsltstqqlpishpkLYVHWDIE 285
NP_970746    218 --YYkvrmQENGf----------------------------------------------------------tVREFSSIE 237
NP_229442    219 --HYvekmKKNGf----------------------------------------------------------eVRIFSSIR 238
WP_012002187 215 --HYiekmKSNGf----------------------------------------------------------eVRKFSSID 234
WP_004102325 216 --HYikkmKENGf----------------------------------------------------------eVRIFDSIE 235
WP_013254024 219 --YYvrkmEENDf----------------------------------------------------------aVRTFSSIE 238
WP_014271539 220 --NYllemKKNGf----------------------------------------------------------dIRQFSSIE 239
WP_041638731 216 --HYisqmKENGf----------------------------------------------------------eVRIFESID 235
WP_045088475 217 --HYvnamKENKf----------------------------------------------------------eVRIFDSIE 236
WP_069691232 213 mrEAiallASLGc----------------------------------------------------------kVSFVHDVR 234
WP_083305054 286 AALKD----ADFVMTLRLQKERMTSHLl----pSLREYHQRYGITGERLQLCQPNVHILHPGPVn-rGVEISSELMDDPQ 356
NP_970746    238 EYLRQad-vALIWYFTRPQLERMGEQVl----kKQDELRRSITFRKEFIEKLPENTRFYHPLPRhrvHPTIPTFLDATPL 312
NP_229442    239 EYLDQkd-vAKIWYFTRLQLERMGEDIl----eKVHVLREAVTFKKEYLDALPEGVKFYHPLPRhkvYPTIPNFLDTLPL 313
WP_012002187 235 EYLSNkd-vAKIWYFTRLQLERMGEDIl----eKEHILRKAVTFRKDMLDKVKEGTKFYHPLPRpkiDPEIPTFLDELPL 309
WP_004102325 236 SYLKStdkvAKIWYFTRLQLERMGEDIl----eKEHVLRKSVTFRKEFLEYIPQDVKFYHPLPRhkiYPTIPTFLDNLPL 311
WP_013254024 239 EYLSQsn-tAPIWYFTRPQLERMGDDIl----kRQDELRSKIVFRREFLSKIADGTKFYHPLPRhkeHPTIPTFLDDTEL 313
WP_014271539 240 EYLKQsd-iADKWYFTRPQLERMGDRIl----qRQDELRNSITFRKEFMGKLPENTKFYHPLPRhkvTPTIPTFLDNTSL 314
WP_041638731 236 SYLKYgd-vANIWYFTRLQLERMGEDIl----eKEHILRKAVTFQKSYLEKIPDNIKFYHPLPRhklYPTIPTFLDDLPL 310
WP_045088475 237 NYLKQeq-iAPIWYFTRLQLERMGEDIl----eKEPLLRKSVTFRKDFLNLLPEKVKFYHPLPRhkiYPTIPTFLDPLPL 311
WP_069691232 235 DTL-E----HDVLIIQMQDMSRFAHASlgseaiDKEIETEPFTLTAKKILDAKSDTLILNPLPR---FAELDVSCDALPN 306
WP_083305054 357 iSLIPQQVTSGVAVRMALLYLIG-SG-------K 382
NP_970746    313 -NGWERQSINGMYVRMVLLSMIA-GKigddykgP 344
NP_229442    314 -NGWETQARNGYWVRIVLLSMFG-GAleapfdtS 345
WP_012002187 310 -NGWEIQARNGFWVRVVLLSLLG-GAvemecdqS 341
WP_004102325 312 -NGWEQQAINGYWTRTVLLSMLG-GAlkanfdtS 343
WP_013254024 314 -NGWENQSINGKLIRIVLLSLIA-GKighdfvpK 345
WP_014271539 315 -NAWERQSINGMYVRIALLALIG-GKigsgfvpS 346
WP_041638731 311 -NGWERQAINGYWTRIILLSMFG-GAlkadfdtS 342
WP_045088475 312 -NGWENQAINGYWTRIILLSMFG-GAisapfdtS 343
WP_069691232 307 -AGYFRQVKLSLPVRMAILERMLlGipwtg---- 335
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