Conserved Protein Domain Family
PL48

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pfam15903: PL48 (this model, PSSM-Id:464930 is obsolete and has been replaced by 464930)
Filopodia upregulated, FAM65
PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.
Statistics
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PSSM-Id: 464930
Aligned: 14 rows
Threshold Bit Score: 495.764
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005469764   16 IHRSRSFTGFSS-LT--GRQRTSSVRNSLRVKAmtgNKASRAPvSPRRSSGAIWSLQPEQVDRVFQALRKGLKDYLEGHQ 92  
XP_021244499   45 IIRSQSFAGFSGlQErrSRCNSFIENSSALKKPq--aKVKKMHnLGHKNSTTPKEPQPKRMEEVYRALKNGLDEYLEVHQ 122 
XP_004074425   49 IIRSQSFAGFSTlQErrSRCNSFMGNSAVPKKPq--sKPKKPHlSGHKGGSSSREPQPKRLEEVYNALKQGLDEYLEVHQ 126 
Q4FZU8         17 VSRSQSFAGVLGsQErgPRNFTVFSPPGPQRKPlvlSRVSRMFsVAH---PAPKVPQPERLDLVYAALKRGLTAYLEVHQ 93   Norway rat
XP_023811302   16 ITRSQSFTGVNSqDKl-YRNLAVFSTPGLSRKPs---RASRMFtMSTKSNAPPKVPQPERLDEIYEALKKGLQSYLHLCQ 91  
XP_003224034   16 INRSCSFAGFSNaHN--RKLTKSISKGSTRSKTs--lKSAKMY-PSLQKGTVIWDPKPQQVKRIFEALKKGLNDYLEMKQ 90  
Q96MK2         19 VGRSASFAGFSSaQS--RRIAKSINRNSVRSRMp--aKSSKMY-GTLRKGSVCADPKPQQVKKIFEALKRGLKEYLCVQQ 93   human
XP_007475803   16 MGRSSSFAGFSSmQR--RNIVKSLNRNSMRSKVp--mKSSKIY-ATLRRGTPCLDPKPQQVKKIFEALKKGLKEYLCAQQ 90  
XP_028906817   31 VSRSQSFAGVVSaQErgPRSLPVFSPPIPPRKPpavSRVSRMFsMAHKT-PPPKVPQPERLDQVYEALKRGLTAYLEVHQ 109  platypus
XP_006639810   16 VRRSRSFAGFGTpLS--RHARVSSVRSSVRSRGf-sGKSPRMP----HSSRSPVASQPEQVERVFQTLRRGLKEYLEGHQ 88   spotted gar
XP_005469764   93 AEMDFLSSQQRETKRNSRLAFLYDLEKEIRSLERYIRRLEFQISKveelyetyciqwrlcqgavnmkraf-slspstras 171 
XP_021244499  123 TELDKLTAQLKDMRRNSRLGVLYDLDKQIKAVERYMRRLEFHISKvdelyeayciqrrlcdgaskmkqaf-amspaskaa 201 
XP_004074425  127 TELDKLMCLMKDMKRNSRLGVLYDLDKQIKSIERYMRRLEFHISKvdelyeafciqsrlrdgasrmkqaf-ssspstkgt 205 
Q4FZU8         94 QEQEKLQRQIKESKRNSRLGFLYDLDKQVKSIERFLRRLEFHASKidelyeaycvqrrlrdgaynmvraystgspgsrea 173  Norway rat
XP_023811302   92 KDLDGINRQIKKSKRNSRLGFLYEQDKQVKVMERFIRRLEFHLSKveehhetyclvrrlrdgadkmikay-taspgskea 170 
XP_003224034   91 AELDYLLECHKDTRRNSRLAFYYDLDKQIRYVERYIRKLEFHISKveelyeaysiqcrlrdgasnmkhaf-slspstkas 169 
Q96MK2         94 AELDHLSGRHKDTRRNSRLAFYYDLDKQTRCVERHIRKMEFHISKvdelyedyciqcrlrdgassmqraf-arcppsraa 172  human
XP_007475803   91 AELDYLSGRHKDTRRNSRLAFYYDLDKQTRSVERHIRKMEFHISKveelyegyciqwrlrdgasnmqqaf-slspltkas 169 
XP_028906817  110 LEQEKLNIQIRESKRNSRLGFVYDLDKQVKSIERFLRRLEFHASKidelyegyciqrrlrdgaqnmvraystgspgsrea 189  platypus
XP_006639810   89 AELDFLTAQQRDSKRISRLAFLYDLEKEIRALERYIRRLEFHISKveelheayaiqwrlctgaanmkraf-alspstras 167  spotted gar
XP_005469764  172 resllelnrnhrhslqDMSTMEGELEILLGELHIKMKGLIGFARLCPGDQYEVLVRLGRQRWKIRGRIESDDSQSWDEEE 251 
XP_021244499  202 reslteinrsykeyteNMCTIEAELENLLGEFCIKMKGLAGFARLCPGDQYEIFMRYGRQRWKLKGKIEVNGKQSWDGEE 281 
XP_004074425  206 kesiaevnrrykeyteNMSTFEVELENLLGEFHIKMKGLAGFARLCPGDQYEIFMRYGRQRWKLKGRIEVNSRQSWDGDE 285 
Q4FZU8        174 rdslaeatrghreyteSMCLLENELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIESSGKQVWDSEE 253  Norway rat
XP_023811302  171 keslaeanksykeyteRMCVLENELESQLGEFHIRMKGLAGFARLCTGDQYEVLLKYGRQRWKLRGQMEMNDKQVWDGEK 250 
XP_003224034  170 reslvelyknlqdcteDMCLIEGTLEVHLGEFHLKMKGLVGYARLCPGDQYEVFVRLGRQKWKLRGKILTDDSQTWDEEE 249 
Q96MK2        173 reslqelgrslhecaeDMWLIEGALEVHLGEFHIRMKGLVGYARLCPGDHYEVLMRLGRQRWKLKGRIESDDSQTWDEEE 252  human
XP_007475803  170 reslvelyrnlqecteDMCLIEGALEVHLGEFHVKMKGLVGYARICPGDQYEVFIRLGRQRWKLKGKIETDNSQTWDEEE 249 
XP_028906817  190 rdslaeasrghreyteSMCLLESELEGQLGEFHIKMKGLAGFARLCAGDQYEICMKYGRQRWKLRGRIEGSGKQVWDSEE 269  platypus
XP_006639810  168 resllqlgrsqrqcleDMFMMEGELELLLGELHIKMKGLIGFARLCPGDQYEVLIRLGRQRWKLKGKIEADDRQSWDEEE 247  spotted gar
XP_005469764  252 MVFLPHIHHNFEIKVTEAKGLSW-LLVGTVTCASADFFVARPQVMLVDITELGTIKLQLEVTWNPFDGTEKLRPLS-GNK 329 
XP_021244499  282 MVFLPLIVGLISIKVTEVKGLAThILVGSVTCETKDLFAARPQVVAVDINDLGTIKLNLEITWYPFDVEDLTPSTGnVSK 361 
XP_004074425  286 MIFMPLISDLINIKVTELKGLAThMLVGSVICETKELFTAMPQVVAVDVNDLGTIKLNLEVTWYPFDVEDLTLSSGnLSK 365 
Q4FZU8        254 TVFLPLLTEFLSIKVTELKGLANhVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVIWSPFDKDDQPSAAStVNK 333  Norway rat
XP_023811302  251 MLFVPLIGEFLSVKVTELKSLANhVVVGNVSCDMKDLFAPLPQMVAVDINDLGTIKLSLEVNWNPFDTEEPGGPISpMIK 330 
XP_003224034  250 KVFIPNLHEKFEIKVTELRGLST-LLVGVVTCDSIDFFTTRPQIIVVDITELGTIKLQLEVLWNPFDNESVILSPGsTAK 328 
Q96MK2        253 KAFIPTLHENLDIKVTELRGLGS-LAVGAVTCDIADFFTTRPQVIVVDITELGTIKLQLEVQWNPFDTESFLVSPSpTGK 331  human
XP_007475803  250 KVFIPILHEHFEIKVIELRGLST-LLVGTVTCQLEDFFTTRPQIIVVDITELGTIKLQLEVIWNPFDTESFLVSPG-ISK 327 
XP_028906817  270 MVFLPLLTEFLSIKVTELKSLANhVVVGSVACETRDLFAARPQVVAVDINDLGTIKLSLEVTWNPFDKDDQPSAAStVTK 349  platypus
XP_006639810  248 MVFLPHIQENFEIKVTEVKGLGS-VLVGVVTCESLDFFQARPHIMVVDITELGTIKLQMEVMWdPFDSGETRPMSTsTSK 326  spotted gar
XP_005469764  330 QSVSSRKSSV-YSWTAPSTPSFTEKYFISMVRE 361 
XP_021244499  362 ASALQRRMSM-YSQGTPETPTFKDHSFFKWLHP 393 
XP_004074425  366 ATALQRRVSV-YSQGTPETPTFQDNSFFMQPYP 397 
Q4FZU8        334 ASTVTKRFST-YSQSPPDTPSLREQAFYNMLRR 365  Norway rat
XP_023811302  331 PTHDSSRFSIhVNPLPPDATSPPEQRFPKLIPN 363 
XP_003224034  329 FSVGSRKNSI-YSWTPPNTPSFREKYYLSVLQP 360 
Q96MK2        332 FSMGSRKGSL-YNWTPPSTPSFRERYYLSVLQQ 363  human
XP_007475803  328 FSVGSRKGSL-YNWTPPSTPSFREKYYLSLFQQ 359 
XP_028906817  350 ASTVSKRLSA-YSQSPPDTPSLREQAFYNMLRR 381  platypus
XP_006639810  327 LSVPSRKGSL-YSWTPPSTPSFTEKYFISVARR 358  spotted gar
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