Conserved Protein Domain Family
AKR_KCAB1B_AKR6A3-like
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cd19159: AKR_KCAB1B_AKR6A3-like 
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins
KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Links
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Statistics
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PSSM-Id: 381385
Aligned: 13 rows
Threshold Bit Score: 702.568
Created: 5-Apr-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) binds cortisone and cofactor NADPH.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          ###     #                     #    #                          
Q14722        89 MPHRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVIT 168 human
Q9PWR1        71 MKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAEQLMTIAYESGVNLFDTAEVYAAGKAEVILGNILKKKGWRRSSLVIT 150 chicken
XP_007887032   1 MLYRNLGKSGLRVSCLGLGTWVTFGGQITDEVAEQLMTIAYENGVNLFDTAEVYAAGKAEVILGNIIRKKAWRRSSLVIT 80  elephant shark
NP_001014376  68 MKYRNLGKSGLRVSCLGLGTWVTFGGQISDDVAEQLMTIAYESGVNLFDTAEVYAAGKAEVILGNIIKKKGWRRSSLVIT 147 zebrafish
NP_001016986  70 MKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAEQLMTIAYENGVNLFDTAEVYAAGKAEIILGNIIRKKNWRRSSLVIT 149 western clawed ...
P63143        71 MKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVIT 150 house mouse
NP_034727     71 MKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVIT 150
Q28528        78 MAYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVIT 157 European polecat
AAD37854      78 MAYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVIT 157
AAD37853      71 MKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVIT 150
AAC48462      78 MAYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVIT 157
P63144        71 MKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVIT 150 Norway rat
OCT80862      70 MKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAEQLMTIAYENGVNLFDTAEVYAAGKAEIILGNIIRKKNWRRSSLVIT 149 African clawed ...

Feature 1         #                                       #                             ##       
Q14722       169 TKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEeIVRAMTHVINQGMAMYWGTSRWSAMEIM 248 human
Q9PWR1       151 TKLYWGGKAETERGLSRKHIIEGLRASLQRLQLEYVDVVFANRPDNNTPMEeIVRAMTHVINQGMAMYWGTSRWSAMEIM 230 chicken
XP_007887032  81 TKLYWGGKAETERGLSRKHIIEGLKASLQRMQLEYVDVVFANRPDTNTPMEeIVRAMTYVINQGMAMYWGTSRWSAMEIM 160 elephant shark
NP_001014376 148 TKLYWGGKAETERGLSRKHIIEGLKGSLQRMQMEYVDVVFANRPDSNTPMEeIVRAMTYVINQGMSMYWGTSRWTAMEIM 227 zebrafish
NP_001016986 150 TKLYWGGKAETERGLSRKHIIEGLKASLQRMQLEYVDVVFANRPDNNTPMEeIVRAMSYVINQGMAMYWGTSRWSAMEIM 229 western clawed ...
P63143       151 TKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEeIVRAMTHVINQGMAMYWGTSRWSAMEIM 230 house mouse
NP_034727    151 TKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEeIVRAMTHVINQGMAMYWGTSRWSAMEIM 230
Q28528       158 TKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEeIVRAMTHVINQGMAMYWGTSRWSAMEIM 237 European polecat
AAD37854     158 TKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEeIVRAMTHVINQGMAMYWGTSRWSAMEIM 237
AAD37853     151 TKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEeIVRAMTHVINQGMAMYWGTSRWSAMEIM 230
AAC48462     158 TKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEeIVRAMTHVINQGMAMYWGTSRWSAMEIM 237
P63144       151 TKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEeIVRAMTHVINQGMAMYWGTSRWSAMEIM 230 Norway rat
OCT80862     150 TKLYWGGKAETERGLSRKHIIEGLKASLQRMQLEYVDVVFANRPDNNTPMEeIVRAMSYVINQGMAMYWGTSRWSAMEIM 229 African clawed ...

Feature 1                         #                            ######   # #       ###            
Q14722       249 EAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKER 328 human
Q9PWR1       231 EAYSVARQFNLIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRAALKCYQWLKEK 310 chicken
XP_007887032 161 EAYSVARQFNLIPPVCEQAEYHLFQREKIEAQLPELYHKIGVGAMTWSPLACGIISGKYENGVPDNSRASLKCYQWLKDK 240 elephant shark
NP_001014376 228 EAYSVARQFNLIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIITGKYENGIPDSSRASMKSYQWLKEK 307 zebrafish
NP_001016986 230 EAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYENGVPESTRASLKCYQWLKDK 309 western clawed ...
P63143       231 EAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKER 310 house mouse
NP_034727    231 EAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKER 310
Q28528       238 EAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKER 317 European polecat
AAD37854     238 EAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKER 317
AAD37853     231 EAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKER 310
AAC48462     238 EAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKER 317
P63144       231 EAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKER 310 Norway rat
OCT80862     230 EAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIITGKYENGVPESARASLKCYQWLKDK 309 African clawed ...

Feature 1                                   #                #####   #  ##                       
Q14722       329 IVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILR 408 human
Q9PWR1       311 IISEEGRKQQTKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSNPEQLIENLGAIQVLPKMTSHIVNEIDNILG 390 chicken
XP_007887032 241 ICSEEGRKQQAKLKDLIPIAERLSCTLPQLAVAWCLRNEGVSSVLLGSSNVEQLVENLGAIQVLPKMSSQTVNEIDTILG 320 elephant shark
NP_001014376 308 IVSEDGRKQQAKLKELGHIAEKLGCTLPQLAVAWCLRNEGVSSVLLGTSNAEQLTENLGAIQVLPKMTSHVVSDIDHILG 387 zebrafish
NP_001016986 310 ILSEEGRKQRTKLRDLMPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSNPEQLIENLGAIQVLPKMTSHIVNEVDNILG 389 western clawed ...
P63143       311 IVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILR 390 house mouse
NP_034727    311 IVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILR 390
Q28528       318 IVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILR 397 European polecat
AAD37854     318 IVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILR 397
AAD37853     311 IVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILR 390
AAC48462     318 IVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILR 397
P63144       311 IVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILR 390 Norway rat
OCT80862     310 IISEEGRKQQTKLRDLMPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSNPEQLVENLGAIQVLPKMTSHIVNEVDNILG 389 African clawed ...

Feature 1           
Q14722       409 NKP 411 human
Q9PWR1       391 NKP 393 chicken
XP_007887032 321 NKP 323 elephant shark
NP_001014376 388 NKP 390 zebrafish
NP_001016986 390 NKP 392 western clawed frog
P63143       391 NKP 393 house mouse
NP_034727    391 NKP 393
Q28528       398 NKP 400 European polecat
AAD37854     398 NKP 400
AAD37853     391 NKP 393
AAC48462     398 NKP 400
P63144       391 NKP 393 Norway rat
OCT80862     390 NKP 392 African clawed frog

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