2KRH


Conserved Protein Domain Family
Costars

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pfam14705: Costars 
Costars
This domain is found both alone and at the C-terminus of actin-binding Rho-activating protein (ABRA). It binds to actin, and in muscle regulates the actin cytoskeleton and cell motility. It has a winged helix-like fold consisting of three alpha-helices and four antiparallel beta strands. Unlike typical winged helix proteins it does not bind to DNA, but contains a hydrophobic groove which may be responsible for interaction with other proteins.
Statistics
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PSSM-Id: 464274
Aligned: 61 rows
Threshold Bit Score: 76.7653
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2KRH_A          9 HIYREIMELCFVIRTMARHRRD-GKIqVTFGELF--DRYVRISD--KVVGILMRARKHGLVHFEGEMLWQGKDDHVVITL 83  
XP_004995417  500 FVADELEKLVAAIKRIGRLDKPtGQYnVTFGVLF--EKTEDVFAasDVDGILLTARSVGLITYLGGLLFPGRDDLVLITL 577 
XP_001744036  381 WVRDQIQHVVHAIMAHGVa-TEyNTSaVTFGVLY--EKLCDTVQatDVNAVLEVARDYAIVAYSGAHLDPIRMASTEIHL 457 
XP_002505679    4 NVEEEVAQLREEIRRLGSEGPD-GKIaVKFGVLFadDRCANIFE--ALVGTLRAAKKRKVIHFEGEMLLQGVHDDVDVVL 80  
XP_010231394    2 NVEEEVGKLKEEIQRLGQQQPD-GSYkVKFGVLFndDRCANIFE--ALVGTLRAAKKRKFVTYDGELLLQGVHDNVEITL 78  
XP_003387508    2 NVEHEVELLVGEIKRLGTQNAD-GQYvVTFGTLFadDKCANLFE--ALVGTLKAAKRKKIVKYDAEILLQGVHDGVEITL 78  
XP_002131888    2 NVDHEVKLLVEEIKRLGKQNAD-GQFvVTFGVLFsdDRCANIFE--ALVGTLRAAKRKKIVTYTGELLLQGVHDNVEVIL 78  
XP_004992837   37 DIDHEVGLLVKCMKRIGKEGDD-GKIqVTFGEIFrdEVLEQQLE--SLVGTMKAARKRGLIDFKGQILLQGAHDDVVVTL 113 
EDQ92351        2 DIDHEISLLVACLKRIAEPGPD-GKLqTTFGKIFtdEILEQQLE--SLVGTMKAAKKRGIISFEGQMLLQGAHDHVVVTL 78  
XP_004999053  127 WMDVGIRKLLKIIFREGTIDGE-GHShISFGRLR--RKASRVFWgqALVGHLKAAKVKGAVDFAGDRLIQGASDSVDIIG 203 
2KRH_A         84 L 84  
XP_004995417  578 V 578 
XP_001744036  458 L 458 
XP_002505679   81 L 81  
XP_010231394   79 L 79  
XP_003387508   79 L 79  
XP_002131888   79 L 79  
XP_004992837  114 L 114 
EDQ92351       79 L 79  
XP_004999053  204 I 204 
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