1L8K


Conserved Protein Domain Family
PTPc-N2
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cd14607: PTPc-N2 
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catalytic domain of tyrosine-protein phosphatase non-receptor type 2
Tyrosine-protein phosphatase non-receptor type 2 (PTPN2), also called T-cell protein-tyrosine phosphatase (TCPTP), belongs to the family of classical tyrosine-specific protein tyrosine phosphatases (PTPs). PTPs (EC 3.1.3.48) catalyze the dephosphorylation of phosphotyrosine peptides. PTPN2, a tumor suppressor, dephosphorylates and inactivates EGFRs, Src family kinases, Janus-activated kinases (JAKs)-1 and -3, and signal transducer and activators of transcription (STATs)-1, -3 and -5, in a cell type and context-dependent manner. It is deleted in 6% of all T-cell acute lymphoblastic leukemias and is associated with constitutive JAK1/STAT5 signaling and tumorigenesis.
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Statistics
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PSSM-Id: 350455
Aligned: 5 rows
Threshold Bit Score: 543.02
Created: 14-Oct-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitecatalytic site
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1: active site [active site], 13 residue positions
Conserved feature residue pattern:x x x x x C x x x x x R xClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the binding of human PTBN1/PTP-1B to peptide substrates and peptide mimetic
  • Citation:PMID 9922143
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                     ####                                               
1L8K_A        19 QPLYLEIRNEShdyphRVAKFPENRNRNRYRDVSpYDHSRVKLqnaeNDYINASLVDIeeaQRSYILTQGPlpntCCHFW 98  human
P17706        19 QPLYLEIRNEShdyphRVAKFPENRNRNRYRDVSpYDHSRVKLqnaeNDYINASLVDIeeaQRSYILTQGPlpntCCHFW 98  human
NP_001086910  15 NSVYGDVRNESpslpiKIAKNPENKSRNRYRDVNpYDHSRVKLqnmdNDYINASLVVVeeaQRSYILTQGPlpntCCHFW 94  African clawed ...
NP_001186316  19 QARYLEIRHKSsdyphRVAKYPENRNRNRYRDVSpYDHSRVKLqnteNDYINASLVVIeeaQRYYILTQGPlpntCCHFW 98  chicken
NP_997819     15 QNIYLEIRNQShecafKVAKYPENRIRNRYRDVSpFDHSRVKLenteNDYINASLVVMeeaQRRYILTQGPlrntCGHFW 94  zebrafish

Feature 1                                                                                        
1L8K_A        99 LMVWQQktKAVVMLNRIvekesVKCAQYWPTddqeml-fketgFSVKLLSEDVKsyYTVHLLQLEninsgetRTISHFHY 177 human
P17706        99 LMVWQQktKAVVMLNRIvekesVKCAQYWPTddqeml-fketgFSVKLLSEDVKsyYTVHLLQLEninsgetRTISHFHY 177 human
NP_001086910  95 LMVWQQksKAIVMLNRIiekdaVKCAQYWPTpeeevlfyketgLCVKLLSEDIKsyYTVRLLQLQdiktgetRDIFHFHY 174 African clawed ...
NP_001186316  99 LMVWQQqtKAVVMLNRIvekdsVKCAQYWPTrgeevmvfsetgFRVRLVSEDIKsyYTVHLLQLEninsgesRMISHFHY 178 chicken
NP_997819     95 LMIWEQktKAVIMLNRViekgsEKCAQYWPTqeeremsfrdtrFVVTLVSEDVKsyYTTRVLELQnantgetREIYHFHY 174 zebrafish

Feature 1             #                                #######                                   
1L8K_A       178 TTWPDFGVPesPASFLNFLFKVRESgslnpdhGPAVIHCSAGIGRSGTFSLVDTCLVLMe---kGDDINIKQVLLNMRKY 254 human
P17706       178 TTWPDFGVPesPASFLNFLFKVRESgslnpdhGPAVIHCSAGIGRSGTFSLVDTCLVLMe---kGDDINIKQVLLNMRKY 254 human
NP_001086910 175 TTWPDFGVPqsPASFLNFLFKVRESrslslqnGPAVVHCSAGIGRSGTFSLVDTCLVLMekrkdPCSVHIKQVLLDMRKY 254 African clawed ...
NP_001186316 179 TTWPDFGVPesPASFLNFLFKVRESgclspehGPAVVHCSAGIGRSGTFSLVDSCLVLMek-kdPFSVDIKKVLLDMRKY 257 chicken
NP_997819    175 TTWPDFGVPesPASFLNFLFKVRESgslgmeqGPAVVHCSAGIGRSGTFSLVDTCLVLMdkrkdPLLVDIKKILLDMRKY 254 zebrafish

Feature 1             #            
1L8K_A       255 RMGLIQTPDQLRFSYMAI 272 human
P17706       255 RMGLIQTPDQLRFSYMAI 272 human
NP_001086910 255 RMGLIQTPGQLRFSYMAV 272 African clawed frog
NP_001186316 258 RMGLIQTPDQLRFSYMAV 275 chicken
NP_997819    255 RMGLIQTPDQLRFSYMAV 272 zebrafish

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