Conserved Protein Domain Family
PHAF1

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pfam03676: PHAF1 
Phagosome assembly factor 1
PHAF1 and BCAS3 form a complex that affects the recruitment of several core autophagy proteins to the phagophore assembly site.
Statistics
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PSSM-Id: 461013
Aligned: 21 rows
Threshold Bit Score: 352.771
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001949946  15 EQWEFVLGMHFCQAVAIIQSQVGIIKGVQVLYSDKNPLDIDLILDLPQDGIRFIFHPVFQRLKMIEIVNLKNIKLKYCGM 94 
ESO04072      15 EYWEFILGMPLYQAIALIKSQDDLLKNIQLMYNQHNALANDIVLDLAQDCIRLHFDSYLQRLKVIEVYDMSKIKLKYLNE 94 
P34692        33 SQFEFVLGMPINQCIAMIQQHPRMLTKVELKYSKKDPFYQDIIIYIGSTGIRLYFDGLSQLIKLIEVDNLSMITLTYNDT 112 Caenorhabditis ...
CDQ02366      15 DYIELLLGMPINQAIAAIQNASRHIQNVELTYSSKEPLSRDVMIRLAKDGVRLYFEPNSQLLKLIEVYDLSNIILQYGGV 94 
XP_002905255  13 GVGPFRLGASVAEVLHALKSRLP-VRPFEIAYDAVEPYKRDVVIESAEDGLRLHFDPVRQTLKVIEFYDVNRVALKFGRV 91 
XP_011272825  57 gfndITLGSSLYDVLNQLTSQG---YHLNLIFSSKNPINVPYIIFIKELSTRLIFNGSNQILQFIEFTSFQNLRLHYQNH 133
EFC43326      11 SMGSFRIGMPISEAIQHLKHLDDKPNAVEILYNEKDPLNNDTIVKIVEEDIVLYFESKTQRLKLIQINNVKKVKLSYGAS 90 
EFJ28090      13 GIGAFSLGMPVCEALAYIEQHHSVFDVVHIKFNDEDPLQFDLVISFPEHGFHLRFEPRTQRLRLIEVYDVQRLQMRYATS 92 
Q9SD33        37 GIGPFSIGMPICEAFAQIEQQPNIYDVVHVKYYDEDPLKLDVVISFPDHGFHLRFDPWSQRLRLVEIFDVKRLQMRYATS 116 thale cress
XP_006657342  50 GVGPFTLGMPISDAFAQIESQPTLYDVVHVKYFDEEPLKLDFVISFPDHGFHLRFDPWSQRLRLIEIYDMKRLQLRYAKS 129
XP_001949946  95 VFNSPEVMPTIQQVEHTFGATHPGVFDAEKQTFTLNFRGISFCFNVDS-------KFQAGSAQCg-------LGSLQFAS 160
ESO04072      95 YFNSPSTLPTITQIDNCFGATHPAKYNADKTIFSLNFRGLTFIFKILDg-----sSYE---------------------- 147
P34692       113 IFSDPNNMATLDRVNEFFGSTHPGSYDDKHNIYVQSWPGLSFCFPYGGens--nlEVRPGFGGN--------LRSLKYDA 182 Caenorhabditis ...
CDQ02366      95 VFSSPKDEADVNKVEGCFGATHPGVYVAEQSLYELSWKGLSFSFPTLNevs--kvQTSSVDATG--------LGSLQFRS 164
XP_002905255  92 VIFGGDISATFMSVYNLFGPTFPGRYDASEQSYVLGYEGGCVKFPIPAeyrnlyqNGID--------------LPMEFPN 157
XP_011272825 134 KISSLGLKTIY---NNSFGPTYPGEIDGS--IYILSYPGISFRFKIPQtikdqeqDQNKIFIKIldeniefdTLVIHNEK 208
EFC43326      91 IFSGPNVDASFVNIYNVFGPTYPGEFDTKSNTYKLTYPGLTFVFPIPPmfshlysDGKE--------------LPIEFPN 156
EFJ28090      93 SIGGPSVAATFVAVYALFGPTFPGSFDAKRNIYTLFYPGLAFTFPIPGqytnccqDREAE-------------LPIEFPD 159
Q9SD33       117 MIGGPSTLATFVAVYALFGPTFPGIYDKERGIYSLFYPGLSFEFPIPNqytdcchDGEAA-------------LPLEFPD 183 thale cress
XP_006657342 130 LIGGPSTLATFVAVYGLFGPTFPGIYDKERGIYTLFYPGLSFAFPIPSqytnlftNGEVAD------------LPLEFPD 197
XP_001949946 161 GTSPNVSRVI--------IFSGSPLPg-----------qDILNiPSH--PL--SCYKGLTYLERLEVQRDLKN-TKGFMI 216
ESO04072     148 -TSPVVTSLF--------IYSGQSLT-------------DAIV-PSI--PS--SCFYAGLYLEKFD----------GDRL 190
P34692       183 NSQPKLTKMS--------IYRGPNPS-------------EPES-VDT--PF--SCYCGQNRTRKVEAIWENGN-IVGIDI 235 Caenorhabditis ...
CDQ02366     165 NSPPLLAKMA--------IYPDSYNS--------------PKP-PRI--SA--ASLCGVICPVEVKSISDGSR-ISGLFF 216
XP_002905255 158 GATPAATGFV--------VFVGG----------------DYRS-PGL--PG----PTKKHYFEEVAVDIAEKKtS----L 202
XP_011272825 209 NWNDVYEKIIninqdgyeLFDNKDIK------------------PRInkPS------SDISIDRIDINMPKGKiL----- 259
EFC43326     157 NTTPIATTIY--------LFHGHDLAk-----------------PKL--PPvkSESTPDSYYEPIIVNLGRG-------I 202
EFJ28090     160 GTTPVMSRVC--------IYDGALGGnveaganlaalikKAIP-PQL--PS------GSLYMEEVHAKLAED-------L 215
Q9SD33       184 GTTPVTCRVS--------IYDNSSDKkvgvg----klmdRASV-PPL--PP------GSLYMEEVHVKPGKE-------L 235 thale cress
XP_006657342 198 GTTPVTCRVS--------IYDSSTDSkvgvg----slmdKAVV-PAL--PA------GSLYMEEVHAKLGEE-------L 249
XP_001949946 217 QLYLEGsg----sNRG----RKVTYNREINFGMSC------------QDVTSMLGTPSQIFYKSEDKMKIHSPNVHRHIS 276
ESO04072     191 MQAADEas----pYSSi---HYATILQEINFGDTT------------QDVISKIGSPSRMHYKDYDKMKIHCPKKHNMCY 251
P34692       236 QFDTQNg------RIVdgeyDVSTYTRQIYFGDSV------------SDVQSILGAPTKVFYKSDDKMKIHRGLHKETLY 297 Caenorhabditis ...
CDQ02366     217 IFAAETplpdsssRKQa--fGLRKIEQSIFFGDTA------------ESVLSSLGAPSKVFYTKADRMLIHRGEDSRKLR 282
XP_002905255 203 VFSGR--------------------KQCIRLGWSP------------QEVISELGAPVSVFRKSED------PNDGATVA 244
XP_011272825 260 ----------------------------INFNDSTkpfeieinktyqQDILLKLGPPDDIFIKNDSRLKIHQTNQ----- 306
EFC43326     203 ELSYS--------------------KKKIKFGYST------------QDVLMILGAPDKIYYKRNDKLRIHAIGAGQSQT 250
EFJ28090     216 FFTTS--------------------KKRLPFGASP------------QDVWAELGRPDGIHQKQVDPMVIHSASDPRPNS 263
Q9SD33       236 YFTVG--------------------GQHMPFGASP------------QDVWTELGRPCGIHPKQVDQMVIHSASDPRPKT 283 thale cress
XP_006657342 250 LFTTG--------------------GQHIPFGASP------------QDVWTELGRPCGIHQKQVDQMVIHSASDPRPRT 297
XP_001949946 277 vPRRSDYFFNYFTLGFDILFDAKTH---KIKKFIVHTNFPGHYNFNIYHRCEFNIALTSEKskfnlsndckkydkkskpi 353
ESO04072     252 --NTSDYFFNYLNYGVDILFDARTH---VVKKLVMHTNFPNHFNFNIYYRCHFQIPLSVSRnlssfdsd----elvlnnn 322
P34692       298 -GP-PNFFFNYFVMGLDILFDFVSK---RVVKFVLHTNAPGHCDFGMYSRCNFSIFLNDKQy------------------ 354 Caenorhabditis ...
CDQ02366     283 -GPRPNYFFNYFSLGLDILFDCITN---RVQKFVLHTNLPGHFDFGIYARCNFCVTINGGPt------------------ 340
XP_002905255 245 gGLVGEYFHNYPHLGLDILYN-SMH---RVSKVILKTNALGHPDFGAYNKCNFRLTFQSSSalqksgi------skrtsl 314
XP_011272825 307 -TSDSEVFHNYFKFGIDILYNISSKngsRVKKFIIHNNLPNSLNFQKYKKCIWRMLGYPQQpqttsednw--dwirdknq 383
EFC43326     251 --VGNDYFYNYFSMGFDIMFGGNTH---TVQKIMLHTNFPGSVDFNTYSKCNFSIPVSQFEfqekr-----------enq 314
EFJ28090     264 -ALCGDYFYNYFARGLDILFDGQTH---RIKKFVLHTNFPAHTDFNSYIKCNFVIHCPLTGsdekd-----------shy 328
Q9SD33       284 -TICGDYFYNYFTRGLDILFDGETH---KVKKFVLHTNYPGHADFNSYIKCNFVISAGADAaeanr-----------sgn 348 thale cress
XP_006657342 298 -TLCGDYFYNYFSRGIDILFDGQTH---RIKKFVLHTNFPGHSDFNSYMKCNFVIYdteaegtdq--------pgnipkn 365
XP_001949946 354 tVNTFTKWDEISEKL-KH--SERPVVLNRGS---SENST--------------NPFGSTFCYG-YQDMVFEVMQ-NQHIA 411
ESO04072     323 fITFDTKWSSVMKYLiTP--HTKPVVRNRMY------DN--------------QLFREIHCFG-CNEFIFEVMS-CDQIA 378
P34692       355 eIRTDSKFDEFSHAFmNDsnPPRPVVLARQE-------Q--------------QPFGSTFCYG-IKQIIVERTE-NGFLT 411 Caenorhabditis ...
CDQ02366     341 -ITPSSKREDFFGAFcGDt-AVQPVVLSRSG------TE--------------NPFGSTFCYG-TDQVIVEVMD-NGFIA 396
XP_002905255 315 eITPQTPWEDIRLVFkSSs-DLRPIVLDNGL------GL--------------HPFGASLCYSpTPGCTFEVMK-NGFIA 372
XP_011272825 384 fITSEMYFNEIPKNYkTNg-SNLPIILNRFDlinNLDQSieiiddmdekgdqgDNHGQSLIYA-YKRCIWEIID-NAAIN 460
EFC43326     315 fIGPDEKFSNVQKILdGTp-CSKPIVHDHTK------AN--------------NPFGGTKFFA-FRNCIFEVISrNDHIN 372
EFJ28090     329 vITGDTKWPQIQQLLgDA---GRAAIQTQGS------VS--------------NPFGPTFVYG-YRNIAFEVMK-NGHIA 383
Q9SD33       349 kITPSTNWDQVKEILgEC---GPAAIQTQGS------TS--------------NPFGSTYVYG-YQNVAFEVMK-NGHIA 403 thale cress
XP_006657342 366 cITPRTKWEQVKEILgDC---GRAAIQTQGS------MN--------------NPFGSTFVYG-YQNIAFEVMK-NGYIA 420
XP_001949946 412 SITFY 416
ESO04072     379 SVTVY 383
P34692       412 SVTIY 416 Caenorhabditis elegans
CDQ02366     397 SVTLF 401
XP_002905255 373 SVTLT 377
XP_011272825 461 SVTLY 465
EFC43326     373 SLTLF 377
EFJ28090     384 TVTLF 388
Q9SD33       404 TITLF 408 thale cress
XP_006657342 421 TVTLF 425
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