Conserved Protein Domain Family
p53-inducible11
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pfam14936: p53-inducible11 
Tumour protein p53-inducible protein 11
TP53 is a tumour suppressor gene, when switched on it suppresses tumour development by inducing stable growth arrest or cell apoptosis. The tumour protein TP53 inducible protein 11 encoded for by the gene TP53I11, has a protein sequence of 189 amino acids in length and 21 kDa in mass. The role of this protein is thought to negatively regulate cell proliferation in response to stress, and therefore suppress tumour formation.
Links
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Statistics
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PSSM-Id: 464386
Aligned: 5 rows
Threshold Bit Score: 248.984
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EEN53909      46 LRKESCGDLQSRLKTRKMLGV-GEDDDGEIHRSKISQILGRSEHLKTRLPPGLRTWQVLSAATITALALTMLVFPDTATQ 124
XP_003967569  10 MKKHSQTDLISRLKSRKILGVgGEDDEGEVHRSKISQVLGNEIKFAGREPIGLRLWILISAIGFTVMALMALVFPNQLYE 89 
XP_021323333  10 MKKHSQTDLVSRLKTRKILGVgGEDDDGEVHRSKISQMLGNEIKFAVREPVGLRLWILFSAVVFTVMALMALAFPNQLYE 89 
XP_006642539  10 MKKHSQTDLVSRLKTRKILGVgGEDDDGEVHRSKISQVLGNEIKFAVREPLGLRVWLLVSAVLFTAVALMALTFPNQLYD 89 
OCA36137      10 MKKHSQTDLVSRLKTRKILGVgGEDDDGEVHRSKISQVLGNEIKFAVREPLGLRLWQFLSAVIFTGIAVMALTFPDQLYA 89 

EEN53909     125 TVLSTSVADVRTGScsslngRLHGTALAAVALLLWSAATAPEKLLIRWGLLMEASFLLFQAVATEMSVWgESErpGLSWA 204
XP_003967569  90 VVFEEELSTTNISV------RLYGGALLSLALIMWNCLYTAEKIVIQWTLLSEACYFTVQFLVTSITLI-EIG--ILPNA 160
XP_021323333  90 VVFDQEQTVTSVSI------RLYGGAILSLSLIMWNGLYTAEKVIIQWTLLSEACYFAIQFLVTSVTLV-ELG--SLPNA 160
XP_006642539  90 AVFDEELSGTKISI------RLYGGALLSISLIMWNGLYTAEKAIIQWTLLTEACYFGVQFLVTAITLV-ENG--SVSNG 160
OCA36137      90 AVFDSGPVSSKTST------RLYGGALFSISLIIWNSMYTAEKVIIRWTLLTEACYLGIQLLVTAVTVI-ESGtpSLTTA 162

EEN53909     205 PVVQIA-RLLGAMTSMVFYRLTGAPPRK 231
XP_003967569 161 AVLLLLsRVLFLVVTMAYYYHLGRKPKK 188
XP_021323333 161 AILLLLsRIFFLTVTLSYYYHLGRRPKK 188
XP_006642539 161 AILLLLsRVLSIVISLAYYHHLGRRAKK 188
OCA36137     163 AVLSIC--LLFALISVYFYYQVGRRPKK 188
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