1A4M,2ADA


Conserved Protein Domain Family
ADA_AMPD

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cd00443: ADA_AMPD 
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Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase catalyzes a similar reaction leading to the hydrolytic removal of an amino group at the 6 position of the adenine nucleotide ring, a branch point in the adenylate catabolic pathway.
Statistics
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PSSM-Id: 238250
Aligned: 16 rows
Threshold Bit Score: 216.83
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active site
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1A4M; adenosine deaminase with bound metal and substrate analog (6-hydroxy-1,6-dihydro purine nucleoside)

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              # #                                                                      
1A4M_A        6 KPKV-ELHVHLDGAIKPETILYFGKKrgialpadtveel----------------------------------------- 43  house mouse
ZP_00110911  64 MPKGgDIHSHLSGAVYAEHYLEWAATdgycvnpkvgalvepkacgqdssyfpase---------------llnrtsvyds 128 Nostoc punctiforme
AAD52851    100 MPKGgALHLHALGSVSPEWIIKNITYlpglkkcinranapvltfrpnaephmckfdytdvnderksenaeeydkklaaaf 179 Glossina morsita...
NP_494973   313 IRKV-DTHIHAASSMNQKHLLRFIKKkikteadtvvlnnngtkvtmkevfkkmgiday---------dlsvdmldvhadr 382 Caenorhabditis e...
NP_296818    34 LPKA-DIHVHLPGTISPETAWELGVRnglikwknnqwvspafsngnphksyaei-----------------frnfesiry 95  agent of mouse p...
2ADA          9 KPKV-ELHVHLDGAIKPETILYFGKKrgialpadtveel----------------------------------------- 46  house mouse
NP_488458     2 ALYA-ELHRHLGGSVVPRVLWRYFERhsselisrfaeype---------------------------------------- 40  Nostoc sp. PCC 7120
CAE65987      8 MPKI-ELHAHLSGSLSPGTISKLVGNkdkciqtiak-------------------------------------------- 42  Caenorhabditis b...
NP_714149     2 KPYA-DLHNHLYGSITSEFLYELGKSnpsprweiftssylqcfgkkistet------------------------ffqdy 56  Leptospira inter...
NP_871955    59 MPKV-ELHAHLSGSLSPETIKLIMESdetraeeimkk------------------------------------------- 94  Caenorhabditis e...
Feature 1                                                                                       
1A4M_A       44 ------rniigmdkplslpGFLAKFDYympvi-------agcrEAIKRIa-YEFVEMKAKEGVVYVEVRYSPHllanskv 109 house mouse
ZP_00110911 129 linrwstrnlefagksghdQFFEAFSGfgpisdsmsrrddmvaEVANRAasQHITYLELMLTVQGSEVRQLGRevgwnkd 208 Nostoc punctiforme
AAD52851    180 nlftptpekdyptintvwgRFVQMFFGlwda--------lhylPAAKAFy-WRLLEELYEDNVMYAELRVELFrlyten- 249 Glossina morsita...
NP_494973   383 ntfhrfdkfntkynpvgesTLREIFIKtdny---------vggKYFADLl-KEVLSDLEDSKYQHAEPRLSIYgrskn-- 450 Caenorhabditis e...
NP_296818    96 erdpnvsllkyaiitrdfaSFDRIMATvqghrhp--pggiqneNDLWLVl-QNYLKQCIQDNIIYTEVQQNIRiayviy- 171 agent of mouse p...
2ADA         47 ------rniigmdkplslpGFLAKFDYympvi-------agcrEAIKRIa-YEFVEMKAKEGVVYVEVRYSPHllanskv 112 house mouse
NP_488458    41 ------fedfytrprntldEYLELHTLvesv---------qtvETLPYFiyRLVRGAYIFENLAYLELRYTPYlrtpe-- 103 Nostoc sp. PCC 7120
CAE65987     43 ---------yrlqkpeemkKVFESFGAvnea--------leksENLRIAt-IETCREFCEDGCIYLELRSTPKhtrf--- 101 Caenorhabditis b...
NP_714149    57 qdpdsfrkfyqfnhrgpftEFQAKFNLiials-------kfdpAEISLVa-TRVVENQFLQGVTYGEYRLMYSpletei- 127 Leptospira inter...
NP_871955    95 ---------yklekpenmtGVFDCFPVihai--------lrkpEAIRIAi-RQTIKEFEEDNCVYLELRTSPKetdf--- 153 Caenorhabditis e...
Feature 1                                                                                       
1A4M_A      110 dpmpwnqtegdvtpdDVVDLVNQGLQEGEQAfg--------iKVRSILCCMRhqps--------------------wsle 161 house mouse
ZP_00110911 209 fa----lmhsqllkgGLTKLVILGSQQLAQLerevwktlgcgTLSAQPGCAVtvrylqqttr---------tkspvevfa 275 Nostoc punctiforme
AAD52851    250 ---------grldreQSILQLWEVTEQFKKEhpd------flGVRLIYTVLRgskpgel---------------qeyysr 299 Glossina morsita...
NP_494973   451 ----------ewdnlAKWALTHDVWSPNARWl---------vQIPRLYDVYRaknmvknfddmldnlftplfevtndpss 511 Caenorhabditis e...
NP_296818   172 ---------pslkplEARLRLYDLFSRASQLfls-----qgiTLRFLNCFNKtgssnlqqst--------qqrseeaasw 229 agent of mouse p...
2ADA        113 dpmpwnqtegdvtpdDVVDLVNQGLQEGEQAfg--------iKVRSILCCMRhqps--------------------wsle 164 house mouse
NP_488458   104 ----------hlsqsQRIDKMAEIVKVVGEAssqp---eypiITSQILCMHTrlpye-------------------vnka 151 Nostoc sp. PCC 7120
CAE65987    102 -----------mdyeTYLRTIVGAILEARVLfp-------qmKIFFIVGINRtmnyd-------------------tash 144 Caenorhabditis b...
NP_714149   128 ----------giyekTLAACEGLALGEQKTGgl--------aKGKLVISLHRdgdifqe---------------yliykn 174 Leptospira inter...
NP_871955   154 -----------mtyeDYLQVCIESFEAAKHEfp-------riKTFLIVSLDRrmpfe-------------------taah 196 Caenorhabditis e...
Feature 1                                                                                       
1A4M_A      162 VLELCKKYNqk--tVVAMDLAGDEtieg-----------------sslfPGHVEAYEGAVKNg------------iHRTV 210 house mouse
ZP_00110911 276 QLAYAFELAssekrVVGINLVAPEdnp-------------------ialRDYTLQMQMLQFLkrqf-------pnvKVAL 329 Nostoc punctiforme
AAD52851    300 LKNYTTRQPd---kLVGFDMVGPEdsd-------------------lrlLSFADNLIELSDKt-------------KFFF 344 Glossina morsita...
NP_494973   512 HPELHLFLQq----ISGIDSVDDEskhefvnfdrstpcppeytdlenppYNYYLFYMYRNICalnafrrarglntfALRP 587 Caenorhabditis e...
NP_296818   230 LDEAASFFPn---lFVGLQSAGAEscpe------------------aapTKLTSGYHHAYENg------------fGCEA 276 agent of mouse p...
2ADA        165 VLELCKKYNqk--tVVAMDLAGDEtieg-----------------sslfPGHVEAYEGAVKNg------------iHRTV 213 house mouse
NP_488458   152 IIDLAAQNKn---yVCGIDVAGGDshya------------------drlPEWISLYEYGRSLg------------iNTTG 198 Nostoc sp. PCC 7120
CAE65987    145 ILHIVGVLQlesnvIVGLELSGDPkv---------------------yaKHLVSIFQVARRFhg-----------lGVTY 192 Caenorhabditis b...
NP_714149   175 IMEKNSLIRn---yLVGLDFCYIEegfp-----------------pkgkRKFFQEVNRDNQAekn--------talAILY 226 Leptospira inter...
NP_871955   197 ILGLIGEAQqrtnvIVGVELSGDPhl---------------------dgRRLLKLFVAARRFhg-----------lGITI 244 Caenorhabditis e...
Feature 1       #  #                              #                                             
1A4M_A      211 HAGEv--------gSPEVVREAVDil--ktERVGHGYHTIed-------------------------------------- 242 house mouse
ZP_00110911 330 HSGEltlglvptedLRFHIRQAVEva--qaSRIGHGVDILfeer------------------------------------ 371 Nostoc punctiforme
AAD52851    345 HAGEtn-------sYGGTDLNLVDaillntTRIGLGYALPkh-------------------------------------- 379 Glossina morsita...
NP_494973   588 HCGEa--------gHVSHLLTGYLt----sESIAHGILLRkv-------------------------------------- 617 Caenorhabditis e...
NP_296818   277 HAGEg--------tGFLYLNQTIQal--piQRIAHGFQAIeh-------------------------------------- 308 agent of mouse p...
2ADA        214 HAGEv--------gSPEVVREAVDil--ktERVGHGYHTIed-------------------------------------- 245 house mouse
NP_488458   199 HFYEt---------PSGCYPQLLPy----lMRIGHGIQIPlly------------------------------------- 228 Nostoc sp. PCC 7120
CAE65987    193 HLAEt--------kDYTDDTLDYMlt--ipDRIGHGTFLHtn-------------------------------------- 224 Caenorhabditis b...
NP_714149   227 HVGEsfqdksilsaSRWVLESAEWg----aHRLGHAIALGlhpsekmkdeiteprserldqlqlyydrkeeldsyfevps 302 Leptospira inter...
NP_871955   245 HLAEvl-------qNMADVEDYLNlr---pDRIGHGTFLHtdpyteyltn------------------------------ 284 Caenorhabditis e...
Feature 1                                                                                       
1A4M_A      243 ---------------------------------eaLYNRLLKE-----NMHFEVCPWSSYLTGawd-------------- 270 house mouse
ZP_00110911 372 --------------------------------pfeLMEQMRRL-----GVLVEICLTSNEVILnvq-------------- 400 Nostoc punctiforme
AAD52851    380 ---------------------------------pvLMKIVKAR-----EIPVEVCPISNQVLHlvn-------------- 407 Glossina morsita...
NP_494973   618 ---------------------------------pvLQYLYYLT-----QIGIAMSPLSNNSLFis--------------- 644 Caenorhabditis e...
NP_296818   309 ---------------------------------vpTIHAIQEK-----NITLVMAPAINLVLGaslhqysglekisktmi 350 agent of mouse p...
2ADA        246 ---------------------------------eaLYNRLLKE-----NMHFEVCPWSSYLTGawd-------------- 273 house mouse
NP_488458   229 ---------------------------------peLLPDVARR-----GQCLEVCPTTYIQTGtlqd------------- 257 Nostoc sp. PCC 7120
CAE65987    225 ---------------------------------kkLVEIVQFYkiplgRFIILSCVIFFSELClssnvyt-------ktv 264 Caenorhabditis b...
NP_714149   303 rekigneidslkhketvkfnispsfleecigfqnyCISKIKQT-----NAIIESCPSSNEYIGmvv-------------- 363 Leptospira inter...
NP_871955   285 --------------------------kykiplgenLIQLHLIF-----LFFLEICLSSNVYSKttt-------------- 319 Caenorhabditis e...
Feature 1                              ##                                                       
1A4M_A      271 -pktTHAVVRFKND-KANYSLNTDDPLIFks------------tLDTDYQMTKKdmg-----ftEEEFKRLNINAAKSSf 331 house mouse
ZP_00110911 401 --gdQHPFREYWKA-GVPMTLASDDEGISri------------dLSHEYLLAATryg-----lgYKDLKRLARNSLEYSf 460 Nostoc punctiforme
AAD52851    408 -dlrNHPGAILLAN-NIPMVISNDAPAFWgv-----------qgLSYDYYYTIMslas--nkagLSTLKQLVFNSIKYSa 472 Glossina morsita...
NP_494973   645 --yqRNPLPEYLQK-GLNVSLSTDDPLQFhyt---------keaLMEEFSIAAQvwk-----lsSCDMCELARNSVMQSg 707 Caenorhabditis e...
NP_296818   351 nnldEHPFFALFRDhKLSVTLSSDNPQMGgtsvqntmlllsgfsADEDSHLTHVtss----pltFKEIIQLNVEAIVSSf 426 agent of mouse p...
2ADA        274 -pktTHAVVRFKND-KANYSLNTDDPLIFks------------tLDTDYQMTKKdmg-----ftEEEFKRLNINAAKSSf 334 house mouse
NP_488458   258 irqlKLVFDRCFDA-GVDIAICTDNAGLHnv------------rLPFEYENLLTydi-----inFEQLQACQDAAFRHAf 319 Nostoc sp. PCC 7120
CAE65987    265 pspaDSHFKYWRDR-GIPVSINTDDKGIFpa-----------ssLSEEYFKVAKvmlsrltsrsFGTSASCSRTAGVFRd 332 Caenorhabditis b...
NP_714149   364 -npeSHPILRFAKN-DMKFTISTDDPGIFgt------------sIKEEFSKAAKig------lsTEVLETVRRNSFLFTs 423 Leptospira inter...
NP_871955   320 -nyrNSHFNYWRKR-GVPVFICTDDKGVIpg-----------atLTEEYYKAAItfd-----lsTEELIGINQDALLNSf 381 Caenorhabditis e...
Feature 1                             
1A4M_A      332 l---------peEEKKELLERL 344 house mouse
ZP_00110911 461 apgn---slwksPEFKEMVPTC 479 Nostoc punctiforme
AAD52851    473 lpe-----eekkTAEKNLEKQW 489 Glossina morsitans morsitans
NP_494973   708 f---------edKVKIHWLGPN 720 Caenorhabditis elegans
NP_296818   427 v---------dvDTKIMLLNSI 439 agent of mouse pneumonitis
2ADA        335 l---------peEEKKELLERL 347 house mouse
NP_488458   320 aw-------pygERPASLLNEL 334 Nostoc sp. PCC 7120
CAE65987    333 krevafpiagksPKVVSLADAC 354 Caenorhabditis briggsae
NP_714149   424 e---------ilSGKKSSSEFE 436 Leptospira interrogans serovar lai str. 56601
NP_871955   382 a---------ykYNVTDLTETF 394 Caenorhabditis elegans

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