3MPR,3L1W,3G6S


Conserved Protein Domain Family
EEP-1
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cd09083: EEP-1 
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Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1
This family of uncharacterized proteins belongs to a superfamily that includes the catalytic domain (exonuclease/endonuclease/phosphatase, EEP, domain) of a diverse set of proteins including the ExoIII family of apurinic/apyrimidinic (AP) endonucleases, inositol polyphosphate 5-phosphatases (INPP5), neutral sphingomyelinases (nSMases), deadenylases (such as the vertebrate circadian-clock regulated nocturnin), bacterial cytolethal distending toxin B (CdtB), deoxyribonuclease 1 (DNase1), the endonuclease domain of the non-LTR retrotransposon LINE-1, and related domains. These diverse enzymes share a common catalytic mechanism of cleaving phosphodiester bonds. Their substrates range from nucleic acids to phospholipids and perhaps, proteins.
Links
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Statistics
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PSSM-Id: 197317
Aligned: 94 rows
Threshold Bit Score: 212.847
Created: 24-Aug-2010
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative catalytic site [active site]
Evidence:
  • Comment:based on other EEP superfamily members with structure; highly conserved in the EEP superfamily
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #                                        #                                 
3MPR_A         8 TVASYNLRnangsd---sargdgWGQRYPVIAQXVQYhdFDIFGTQECFlHQLKDXKEALp---------gYDYIGVGRD 75  Bacteroides the...
NP_194819      6 SVMSFNLHddlpe-----espnsWLKRKDLCLTVITSysPIVLCTQQGVkSQLDYLQQGLp---------aYDQFGISRT 71  thale cress
ZP_07198427    2 RVMTFNLRfendq-----dganaWSCRRDLVVKLIERyaPDILGTQEGRiSPLAYLDAHLt---------kYDIHMPSRV 67  delta proteobac...
YP_001529660  12 SVMSLNVRfglad-----agehsWENRKPAFVELFKQyrPDFIGMQEVNgFQAAFFAGLLs---------dYHAIGKRTP 77  Desulfococcus o...
ZP_05065846   32 RVATYNVHyiwlgraqgdwsvgdWERRKGALQAAFVSldADVVGFQEMEsFGRGQAPQNLtldwlreqnpgYAAAAVGDP 111 Octadecabacter ...
YP_002601873   8 SVMTFNLRfglad-----dgpdcWENRKKGYPLLFEHyqPDFVGFQEVNnFQADFLCRLLd---------gYGFIGRRDT 73  Desulfobacteriu...
YP_002432311   5 SAMTANLRfgrar-----dgehgWEFRKDAFMKLFRTykPDILAVQEANdFQAEHLIQRMe---------dYDHAGFRKN 70  Desulfatibacill...
NP_641025     35 RVMSFNVRvpadt-----dgdkrWQVRRAAMVALIKQthPDVFGTQELVsEQAAFLAEQLp---------dYRWFGQGRR 100 Xanthomonas axo...
ZP_01619868    2 KIVTFNVRfdkpd-----pgnnaWVWRRQVMAQLMAEwdADLVGTQEGKaHQLLDLHRRLs---------nYQTVGVDRQ 67  Lyngbya sp. PCC...
CAO87155       4 TAMSFNIRydkpd-----pdernWRVRREAVAALIAHysPDIIGTQEARaNQLLDLHRLLp---------kYQSLGSDRR 69  Microcystis aer...

Feature 1                                                                                   #    
3MPR_A        76 dg-kdKGEHSAIFYrtDKFDIVEKGDFWLSETPd---vPSKGWD--AVLPRICSWGHFKCKdt---gfEFLFFNLHXDHI 146 Bacteroides the...
NP_194819     72 gpgdaNDEHCTIFFnkEKVELLEGGTFWLSESPsv--pGSTAWG--SAVPCIATWATFQLKgaeppgfSFQIVNTNLDEI 147 thale cress
ZP_07198427   68 id--kTCQYPTLFFrrDRFRILEGKEFWLSKTPgi--hRSKDWD--SAFPRMVSTATLELRes---grIFSVAVTHLDHM 138 delta proteobac...
YP_001529660  78 ap--aGWQDVLIFYh-KNWECRDCDRFFLSDTPd---iPSRMPD--SRWPRQCVMGTFEKEg-----lRMVCVNTHFDFD 144 Desulfococcus o...
ZP_05065846  112 a---vFPSTQPIFYrkDRLTLRDQGWFFFSDTPdv--iYSRTFN--GSWPAFTSWAEFEDRdg----tIFRVYNLHTEYR 180 Octadecabacter ...
YP_002601873  74 sp--eLWQNNLIFYr-KQWTCKAANHLFLSRTPq---kESRLDG--SRWPRQCTLGQFEQGd-----mAVVMANTHFDFA 140 Desulfobacteriu...
YP_002432311  71 ap--dFWQSNILFFk-KPWSLKKHRHIFYSDTPd----EESKWKd-SKWPRQGTLVQLEKGg-----kTLACVDTHYDFK 137 Desulfatibacill...
NP_641025    101 gd--dSDEHMGVFYdaRVLEVVESGDFWLSDTPer--aGSITWG--NVLPRMATWALFERRsd---krRFYLFNTHFPYR 171 Xanthomonas axo...
ZP_01619868   68 gn--gLSEYCAIFYhqQRWRCLKTGDFWLSKTPkl--vGSVTAEweNPVPRMVSWGVFEGVgq---dkPIIIFNTHFDYH 140 Lyngbya sp. PCC...
CAO87155      70 gt--gLDEHCAILYqpSRLKCLEIYEFWLSETPdvigsITEAWG--NPYPRMVTGAKFRTLeg----qTLQFYNTHLDYY 141 Microcystis aer...

Feature 1                                           # #                                          
3MPR_A       147 g--KKARVESAFLVQEKXkelgr--gknlPAILTGDFNvdqthQSYDAFvs-------kgVLCDSYEkcDYRya---lnG 212 Bacteroides the...
NP_194819    148 s--PRARRRSALLTWQHIaslp----ptlPVVYCGGFNtqkesTTGRFLlgrsrehgvvgDMRDAWPs-ARVrknvaliR 220 thale cress
ZP_07198427  139 g--QTARLKQAEIISRWVrek------tvPVILMGDFNdgphsDAHAVLass------qtGLSDVWQvlGHAegk--esF 202 delta proteobac...
YP_001529660 145 ---EPVQVKSAAILLARLekfs---ntalPVLITGDFNagpgsDCHRAFthp------grLTRPFFDv-FDGdn----sG 207 Desulfococcus o...
ZP_05065846  181 s--MSNKQLSVALVAARIaepa----armPVFVIGDFNa----IRGSTTl---------gVLEDANVt-FWPvq----gS 236 Octadecabacter ...
YP_002601873 141 ---ETVQALSAGLVVDFLsefspgsltdlPTVITGDFNsipggAAHRVFld--------nGFEDAFEn-AHA-------Y 201 Desulfobacteriu...
YP_002432311 138 ---PEVQARSARLLLNILedfa----pglPTLVMGDFNakpdsSCRKEFeq--------gGFKDPFDk-RFG-------G 194 Desulfatibacill...
NP_641025    172 dedEPARERSARLILSRIaqlp----atiPVVLTGDFNsdpdkITYPTLt---------aVLRDARAqaSKRsg---peN 235 Xanthomonas axo...
ZP_01619868  141 s--QRARELSAQLISDRLsqfn---adeyLFIVTGDFNaepdsFTRKTLlkpl---tngvVLCDTLAd-IDLde----qM 207 Lyngbya sp. PCC...
CAO87155     142 s--DKAKDLGAKCIQERFcqld---ltkdYLFLTGDFNvnsqrLPRQILtqpl---qseiKLKDALAdlELAe-----qM 208 Microcystis aer...

Feature 1                                            #                                           
3MPR_A       213 TFNNFdpn---------------------sftESRIDHIFVsp--sFHVKRYGVLTDtyrsvrenskkedvrdcpeeiti 269 Bacteroides the...
NP_194819    221 TYHDFkgdkqgtveflklifralclcwdrqtqDLHTDWILYrg-rsIVPVMCEIVNDkidd------------------- 280 thale cress
ZP_07198427  203 THHGFtgv----------------------pkKSRIDWILSsk--pPYAVDARLLHDqfdg------------------- 239 delta proteobac...
YP_001529660 208 TFHKFtgd----------------------avSDRIDWILCrn--mGGPREKRIITDrfag------------------- 244 Desulfococcus o...
ZP_05065846  237 TFHFNrgl----------------------nlFPAIDHIGGsdgisPVGKTFSVRGRfdg-------------------- 274 Octadecabacter ...
YP_002601873 202 TFHGFtgk----------------------drGGHIDWILYrg--gITPLNQKIVRErfsg------------------- 238 Desulfobacteriu...
YP_002432311 195 THHGFtgk----------------------ddGRRIDWILYrggiePVKASRKIIRGrfgg------------------- 233 Desulfatibacill...
NP_641025    236 TFQDFtt-----------------------hpTRRIDWILYr---gLRPSRFATLDDrpgg------------------- 270 Xanthomonas axo...
ZP_01619868  208 TYHEFtg-----------------------kgFAAVDTIYYds--rLNLHQVSVDRTqidy------------------- 243 Lyngbya sp. PCC...
CAO87155     209 SFNNYtd-----------------------tpYLAIDTIYYds--rLQLDWVKVDPSrwln------------------- 244 Microcystis aer...

Feature 1                 ##       
3MPR_A       270 kayeartpSDHFPVKVEL 287 Bacteroides thetaiotaomicron
NP_194819    281 -----lypSSHYPVFAEF 293 thale cress
ZP_07198427  240 -----rypSDHFPYYVDF 252 delta proteobacterium NaphS2
YP_001529660 245 -----ifpSDHFPVYAEF 257 Desulfococcus oleovorans Hxd3
ZP_05065846  275 -----ewaTDHYPVVGDF 287 Octadecabacter antarcticus 238
YP_002601873 239 -----hfpSDHFPVLVEF 251 Desulfobacterium autotrophicum HRM2
YP_002432311 234 -----vypSDHFQVYCEF 246 Desulfatibacillum alkenivorans AK-01
NP_641025    271 -----ilpSDHYPVMAEF 283 Xanthomonas axonopodis pv. citri str. 306
ZP_01619868  244 -----vwpSDHFPVIAQF 256 Lyngbya sp. PCC 8106
CAO87155     245 -----lipSDHYPVIAAF 257 Microcystis aeruginosa PCC 7806

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