2QJH,6Z9I,7AG7


Conserved Protein Domain Family
DeoC

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pfam01791: DeoC 
DeoC/LacD family aldolase
This family includes diverse aldolase enzymes. This family includes the enzyme deoxyribose-phosphate aldolase EC:4.1.2.4, which is involved in nucleotide metabolism. The family also includes a group of related bacterial proteins of unknown function, see examples Swiss:Q57843 and Swiss:P76143. The family also includes tagatose 1,6-diphosphate aldolase (EC:4.1.2.40) is part of the tagatose-6-phosphate pathway of galactose-6-phosphate degradation.
Statistics
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PSSM-Id: 460332
Aligned: 13 rows
Threshold Bit Score: 143.682
Created: 21-Mar-2022
Updated: 13-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2QJH_I  27 TVIVPMDHGVSNGPIKGL------------IDIRKTVNDVAEG-------GANAVLLHKGIVRHGHRGYGK------DVG 81  Methanocaldococcus ja...
O26679  19 TVIVPLDHGVSIGPVRGI------------IDMAGTIDEVASG-------GANAVLMHKGMVRSGHRGYGR------DIG 73  Methanothermobacter t...
Q8YQT4  74 LSILPVDQGIEHSAGASFapn------piyFDPENIIRLAIAG-------GCNAVATTLGVLGSVSRKYAH------KIP 134 Nostoc sp. PCC 7120
Q8TJ99  10 lMLFAGDQKVEHLNDDFFeegv----peddADPEHLFRIAARS-------KIGVFATQLGLIARYGMDYK-------DVP 71  Methanosarcina acetiv...
P0A991  68 lSILPVDQGVEHSAGASFaan------plyFDPKNIVELAIEA-------GCNCVASTYGVLASVSRRYAH------RIP 128 Escherichia coli K-12
Q19264  60 KVIQYIDLTTLNGDDTAS-------------KVVALAKRAINPvptdpsiHCGSVCVYPQRIADVKKFLASsklnsnITS 126 Caenorhabditis elegans
6Z9I_A  10 RALKLMDLTTLKDDDTDE-------------KVIALCHQAKTPv-----gNTAAICIYPRFIPIARKTLKEqgtpeiRIA 71  Escherichia coli
7AG7_K  36 FAMLAVDQREAMRLMFAAagaktpvadsvlTDFKVNAAKILSP-------YASAVLLDQQFCYRQAVEQNAva---kSCA 105 Salmonella enterica s...
P0A011  21 ISALAFDQRGALKRMMAKhqteep-tvaqiEQLKVLVAEELTQ-------YASSILLDPEYGLPASDARNK------DCG 86  Staphylococcus aureus...
P26425  21 ISALAFDQRGALKRLMAQyqtqep-tiaqmEELKVLVAEELTP-------YASSMLLDPEYGLPAAKHLDK------NAG 86  Streptococcus mutans ...
Q92W65  18 CLDVAIDHGVCNEPSFLSg----------lENMETVVKALTAA-------APDAIQMNYGQADLLQDLPGKd-----KPA 75  Sinorhizobium meliloti
O67506  20 TIIVPMDHGVSSGPIEGI------------VNIREAVEKVAEG-------GANAVVLHKGMVRAGHRGRGR------DIG 74  Aquifex aeolicus VF5
O30128  21 TVIVPMDHGVSMGPIEGL------------KNLAETVNAVAEG-------GANAVVLHKGVVGFGHRGYGK------DVG 75  Archaeoglobus fulgidu...
2QJH_I  82 LIIHLSGGTAISPNPLKKVI------VTTVEEAIRMGADAVSIHVNV---GSDE-DWEAYRDLGMIAETCE--YWGMPLI 149 Methanocaldococcus ja...
O26679  74 LIIHLSASTGLGPDPNHKVL------VTSVEKALKLGADAVSVHVNV---GSER-EPEMLIKLGTVAEICD--DWGMPLI 141 Methanothermobacter t...
Q8YQT4 135 FIAKLNHNELLTFPNQFDQVl-----FADVEQAWNLGAVAVGATIYF---GSEQ-STRQIQEISRAFKRAH--ELGMVTI 203 Nostoc sp. PCC 7120
Q8TJ99  72 YLVKVNSKTHLVGTSQADPFsnlwydVDQVAEFKENSGLNILGVGYTiylGSEY-EAEMLVQAAQVVYDAH--QHGMVSV 148 Methanosarcina acetiv...
P0A991 129 FLVKLNHNETLSYPNTYDQTl-----YASVEQAFNMGAVAVGATIYF---GSEE-SRRQIEEISAAFERAH--ELGMVTV 197 Escherichia coli K-12
Q19264 127 VAGGFPSGQYHLKSK-----------VLEVELSVADGATEIDIVISRasaLDED-WKTVHDEVLACKKACG--SAHLKTI 192 Caenorhabditis elegans
6Z9I_A  72 TVTNFPHGNDDIDIA-----------LAETRAAIAYGADEVDVVFPYralMAGN-EQVGFDLVKACKEACAaaNVLLKVI 139 Escherichia coli
7AG7_K 106 MIVAAD---DFIPGNGIPVDnvvldkKINAQAVKRDGAKALKLLVLWr--SDED-AQQRLNMVKEFNELCH--SNGLLSI 177 Salmonella enterica s...
P0A011  87 LLLAYEKTGYDVNAKGRLPDcl---vEWSAKRLKEQGANAVKFLLYYdvdDAEEiNIQKKAYIERIGSECV--AEDIPFF 161 Staphylococcus aureus...
P26425  87 LLLAYEKTGYDTTSTKRLPDcl---vEWSAKRLKKQGADAVKFLLYYdvdGDEEvNQQKQAYIERIGSECK--AEDIPFF 161 Streptococcus mutans ...
Q92W65  76 LVMRIDMGNPYNRIRHRDMWavlqneAEPLIGALAMDAACVVVNLFMlpdEPDL-FRQCVQNIARVRADCD--KYRMPLM 152 Sinorhizobium meliloti
O67506  75 LIVHLSASTDLSPRKNDKVL------VCTVEEAIRLGADAVSIHVNI---GAEG-EREMLKDFGYVSKVCE--EWQMPLL 142 Aquifex aeolicus VF5
O30128  76 LIIHLSASTSLAPDPNEKVL------VCTVEEAIKLGADAVSVHVNV---GSKT-EAYQLRKLGEISKIAG--EWGMPLL 143 Archaeoglobus fulgidu...
2QJH_I 150 AM-MYPRGKHIQNER-------DPELVAHAARLGAE--LGADIVKTSYT-------------------GDIDSFRDVVKG 200 Methanocaldococcus ja...
O26679 142 AM-MYPRGKKIDDEH-------DPEVVKLAARAGAE--LGADIIKTNYT-------------------GDPDTFRDVVKG 192 Methanothermobacter t...
Q8YQT4 204 LW-CYLRNNAFKQDKdy---hlAADLTGQANHLGVT--IEADIIKQKLPennngygavakatgqsygkTHEKVYTDLTTD 277 Nostoc sp. PCC 7120
Q8TJ99 149 LW-IYPRGAAVKDEK-------DPHLIAGATGVGAC--LGTDFVKVNYPkke--------------geKSAEIFKEAIKA 204 Methanosarcina acetiv...
P0A991 198 LW-AYLRNSAFKKDGvdy--hvSADLTGQANHLAAT--IGADIVKQKMAennggyk------ainygyTDDRVYSKLTSE 266 Escherichia coli K-12
Q19264 193 LAtGELKTLS---------------NVYRASWASIL--AGSDFIKTSTGkesv-----------natlEVAYVMCTAIKR 244 Caenorhabditis elegans
6Z9I_A 140 IEtGELKDEA---------------LIRKASEISIK--AGADFIKTSTGkvav-----------natpESARIMMEVIRD 191 Escherichia coli
7AG7_K 178 IE-PVVRPPRCGDKFd------REQAIIDAAKELGD--SGADLYKVEMPlygk-----------garsDLLTASQRLNGH 237 Salmonella enterica s...
P0A011 162 LE-VLTYDDNIPDNGsvefakvKPRKVNEAMKLFSEprFNVDVLKVEVPvnmkyvegfaegevvytkeEAAQHFKDQDAA 240 Staphylococcus aureus...
P26425 162 LE-ILAYDETITDAAsveyakvKPHKVLDAMKVFSDerFGIDVLKVEVPvnmkyvegfgdgpivhtqdQAANFFKQQDQA 240 Streptococcus mutans ...
Q92W65 153 IEpLVMQPVTEHGGYmv---dgDADKIVTLTRLARE--MGADIVKADPT-------------------NDVDEFHRVVEA 208 Sinorhizobium meliloti
O67506 143 AM-VYGRGPKIENQY-------DPKVVAHCARVGAE--LGADIVKVPYT-------------------GDPETFKLAIEG 193 Aquifex aeolicus VF5
O30128 144 AM-MYPRGDGI-NQF-------DEKAVALAARVGAE--LGADIIKTNFT-------------------GDVESFRRVVDG 193 Archaeoglobus fulgidu...
2QJH_I 201 CPAP---------------VVVAGGPktnTDEEFLQMIKDAM---EAGA--------------AGVAVGRNIFQH 243 Methanocaldococcus jannaschii
O26679 193 CPVP---------------VVIAGGPkieTEEELLQMVSDSV---EAGG--------------AGVAIGRNIFQA 235 Methanothermobacter therma...
Q8YQT4 278 HPIDltryqvlncycgragLINSGGAs--GKNDFAEAVRTAVinkRAGG--------------TGLISGRKAFQR 336 Nostoc sp. PCC 7120
Q8TJ99 205 Agr--------------tkVVCAGGSs-dEAEAFLKKLHDQIh--ISRA--------------QGNATGRNIHQK 248 Methanosarcina acetivorans
P0A991 267 NPIDlvryqlancymgragLINSGGAa-gGETDLSDAVRTAVinkRAGG--------------MGLILGRKAFKK 326 Escherichia coli K-12
Q19264 245 WHELtgk---------kvgFKPAGGI---------KTVDEALsyvALVKdilgdewlnphlfrIGASSLLDDCLK 301 Caenorhabditis elegans
6Z9I_A 192 MGVEkt-----------vgFKPAGGV---------RTAEDAQkylAIADelfgadwadarhyrFGASSLLASLLK 246 Escherichia coli
7AG7_K 238 INMPw--------------VILSSGV---DEKLFPRAVRVAM---EAGA--------------SGFLAGRAVWSS 278 Salmonella enterica subsp....
P0A011 241 THLPy--------------IYLSAGV---SAELFQETLKFAH---EAGAk------------fNGVLCGRATWSG 283 Staphylococcus aureus subs...
P26425 241 TPLPy--------------IYLSAGV---SAKLFQDTLVFAK---ESGAn------------fNGVLCGRATWAG 283 Streptococcus mutans UA159
Q92W65 209 ARCP---------------VLVRGG----GKEDLRSVLDKSAalmKQGA--------------MGMVYGRNIYQH 250 Sinorhizobium meliloti
O67506 194 SPIP---------------VVIAGGPkmkSEREVLEMVQGAM---QAGA--------------AGLSIGRNIFQA 236 Aquifex aeolicus VF5
O30128 194 CPVP---------------VVVAGGPkmgSDEDILRMVRMAM---DAGA--------------RGVAIGRNIFQA 236 Archaeoglobus fulgidus DSM...
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