Conserved Protein Domain Family
Wtap

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pfam17098: Wtap 
WTAP/Mum2p family
The Wtap family includes female-lethal(2)D from Drosophila and pre-mRNA-splicing regulator WTAP from mammals. The former is required for female-specific splicing of Sex-lethal RNA, and the latter is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. The family also includes the yeast Mum2p protein which is part of the Mis complex.
Statistics
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PSSM-Id: 465345
Aligned: 35 rows
Threshold Bit Score: 88.1208
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q8I5B2        63 KKREHVYLACISSLEKEVCRIHTYLNE------------WR---SMHSyEDeekkSstgkstvninslRNILIDPCIN-L 126 Plasmodium falc...
XP_018653139  62 KYHEQLNSYLARYINADFSLAQMEyilpakrakfskvhasttsgYSSNsIGtdanSl-----------ITLKHFFEPS-M 129
EFN58948      66 ALGAREAGLQATAAQTAAENLQLRRAL------------HV---ARQAaEPsv--------------vQLRQLLLDPA-V 115
ESS30735      45 EHKKREHLQLSLIASLEAQLAETRASV------------SE---YRAChDVas--------------nRLRTVVVDPA-V 94 
EDL47670      28 EFKKREHVYLACISSLEKEICQTHTYL------------NE---WRNMhMYedeeGkapked-lininSLRNLLIDPS-M 90 
Q4UHF7        19 DVESVKSYCLSIISTLQKELQNRKSSL------------CDirlLGDShEK--------------------------AiE 60  Theileria annulata
EDO05896      17 NPADIMAYFMTIISAQQKEIQKTKALV------------KD---FRTVhNLdgiyEk----------nASINAMIDPV-I 70 
ESK96121       5 LASTRELELEILLREKDQQISELGDQI------------TR---LRQYlSSpaha----------gpsTADPLTLPPPlV 59 
EED84719     132 LPSAREIELETLLRERDAQVAELTDEV------------TQ---LRQYlSTqpg------------ppTADSISLPPAlV 184
XP_007391706   3 LPTPRELELETLLRQRDVQLTDLTDEV------------TH---LRQYlANqpv------------ptVTDPISLPPPlV 55 
Q8I5B2       127 EIKELRHKIYEITKKCNIAEEKLQGCNFDAQSIAGQRLINKCKKLQEENYELGKTIEENNLQSLSIQITKLKQHIVFYKN 206 Plasmodium falc...
XP_018653139 130 NLVYKKLHEITKEAQNKYRQSNDDMLAWKFSPESSIGKSLMSRIRQLLSANEELGRVNQTDRVARLESEAELQTTCMKEF 209
EFN58948     116 NREFAGLRAELEARTRELAAAQLELKALKFGPEP-----LLAKLDRQQDEIANLRRQVGESRAQQLERTVAALREQLEEM 190
ESS30735      95 SLEIKTLRRKLFDTETLLRRAKEQLAAQNFSGQSVMGQRLINKCKTLQEENNELGRSLAETHLQPLTVEVAGLKKHVAFL 174
EDL47670      91 NLEIKELRQKIYEVTRKWNLAEEKLQGFNFDAQATAGQRLISKCKKLQDENYELGKTLEENTLQPLSIQIINMKEQMLFY 170
Q4UHF7        61 NNEILELKAKLDKYSTENTKLKEQLNTKQFSSQSVLGRYLIDKVRLLKVENEELSKALLENHIQPLFIELNKEKELNKLM 140 Theileria annulata
EDO05896      71 NCEILHLRKLLKEKEVELKTAKEALDAQNYNPQSTIGTTLLERCKLLITENEELGRIVLENKVQPLTMDLYKEREANKVL 150
ESK96121      60 SLLLPHLNRARNLENEGGSS--S----------NSTMTALTQRVRLLQEENEEMYGILKEGEIGTLKEEVQSLRRLVQKL 127
EED84719     185 SLLLPHIN---DRSSQS--S--S----------NTVTAALVQRTKVLQQENDELYELLKSGETGKLKEDVRALRRVVQKL 247
XP_007391706  56 SLLLPHIN---DQSSATSSSALS----------STVVQALTQRVKVLQEENDELYELLKTGETGRLKEDVRSLKRVVQKL 122
Q8I5B2       207 ELRVLKELNADIDEDNELLSQQLSE 231 Plasmodium falciparum 3D7
XP_018653139 210 IKTNEDIEGVLEEAYTDLEGLQSSL 234
EFN58948     191 QRVHAELEQHSFAVDQQAERLAEQL 215
ESS30735     175 RGELRQLRELNSDMDRDNETMALQL 199
EDL47670     171 KNELKILKELNADIDEDNELLSQQL 195
Q4UHF7       141 EKRLKELHVLNVKLRKDNSYLSHKS 165 Theileria annulata
EDO05896     151 KKQLKALHQYNIELEAEAEVMSKNL 175
ESK96121     128 EGALKESHQVIQSLSTELEKSSDAF 152
EED84719     248 EGALKESHQVISSLSSELEKSHETI 272
XP_007391706 123 EGALRDSHQAINSLSEELDKAQATI 147
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