Conserved Protein Domain Family
Cript

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pfam10235: Cript 
Microtubule-associated protein CRIPT
The CRIPT protein is a cytoskeletal protein involved in microtubule production. The C-terminal domain is essential for binding to the PDZ3 domain of the SAP90 protein, one of a super-family of PDZ-containing proteins that play an important role in coupling the membrane ion channels with their signalling partners. SAP90 is concentrated in the post synaptic density of glutamatergic neurons.
Statistics
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PSSM-Id: 431159
Aligned: 42 rows
Threshold Bit Score: 67.0175
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
GAA91003               13 TELATPgvkrktEMYYgspattlggssssssgsgagagaaggKAKSSTLgSTG----------IGKSKLL-----SSKaK 77 
XP_007872083           11 isLATPsikkksDIYM--------------------------GSEMSKIvSSSer-------kIGENKLL-----SKSaK 52 
WGS:AAWC:PGTG_02219.3  13 nSLATP------EVRG--------------------------IAGSNTApINKr--------kIGENKLLs----SKNr- 47 
EPE04900               13 TALATPgikkknEMYFgspas----------------ssasgSKKPATLgQNG----------IGKSKLL-----SKNaK 61 
XP_013958778           13 TKLATPevkkksEMYYgspas----------------tkasgSKS-ATLgNTG----------VSKSKLL-----SKAaK 60 
EFY90208               12 TTLATPdvkkksEMYYgspaas--------------sskpsgSKS-TTLgQSG----------VVKSKLL-----SKSaK 61 
XP_018162848           14 TTLATPaikkksEIYHgssasas-------------ssspsaSK--PTLgSTG----------IGKSKLL-----SKAaK 63 
KJE91925               11 raLPTT------DPFK--------------------------NKTSKLTgQSSkv-------rVADNKLL-----SKAk- 45 
EOQ99522               11 TKVAAP------DPFR--------------------------NKALGASaSTSkagkteerddLGKNKLL-----SKNr- 52 
EFI98523               11 sQLAAP------DPFK----------------------------SSSSSiKDGsr-------kVGENKLLsrpgsSKNr- 48 
GAA91003               78 ---NPYAAyAS--------------SCEVCKTKTEQ-GRKYCQRCAYQKNACPMCGKGL-TGSSSKNQ 126
XP_007872083           53 kryDPYGV-----------------GCTICKQRTHHlGAKYCPSCAYKQGRCSICGKKIlDTSAYKQS 103
WGS:AAWC:PGTG_02219.3  48 --yTPYASsSSsaskpnqpphsligRCLTCKANVARpSAKYCQACAYKKGLCAMCGKMViDVTYSQQc 113
EPE04900               62 ---NPYAQySS--------------SCDKCKVKVSQ-GHKYCHNCSYKEDVCAMCGKPN------KKA 105
XP_013958778           61 ---NPYAQySS--------------SCTKCKTKITQ-GHSYCQKCAYQTDSCPMCGKPN------KKS 104
EFY90208               62 ---NPYAQySS--------------SCTKCKAKVSQ-GHSLCQTCAYKNDSCAMCGKPN------KKK 105
XP_018162848           64 ---NPYAQySS--------------ACSKCKTKVSQ-GHSLCQSCAYRADSCASCGKPN------KKA 107
KJE91925               46 --yTPYQKfE---------------KCLTCKQTCHMpHHKYCQTCAYKRGICSMCGVAIaDTSSYKQS 96 
EOQ99522               53 --yLPYAAkDGg------------sKCKVCKQATARpDARYCQNCAYKRGKCSVCGVKQmDTTYQKMS 106
EFI98523               49 --fQPYQG-----------------KCKDCKSSVSQnKAKYCHGCAYKKGICAICGKQIlDTTGYVMs 97 
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