Conserved Protein Domain Family
Zw10

?
pfam06248: Zw10 
Centromere/kinetochore Zw10
Zw10 and rough deal proteins are both required for correct metaphase check-pointing during mitosis. These proteins bind to the centromere/kinetochore.
Statistics
?
PSSM-Id: 461861
Aligned: 7 rows
Threshold Bit Score: 530.91
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
O43264        27 LTRRVEEIKGEVCNMISKKYS--EFLPSMQSAQGLI--------TQVDKLSEDIDLLKSRIESE-VRRDLHVSTGEFTDL 95  human
O44218        32 VQTRTERFQERVRKHIDENYS--EFMTNHTSPDIFL--------EESSSLGREINDLLETVGTE-GLAALNGSSTQLADH 100 Drosophila pseu...
XP_002634365  11 LEKKLKDGLTSISADIVDKYGnlKVALNINNTAKLIfdrlenleDTAEMSSRELSNLIEQTEKD--------SPEMLAEI 82 
O48626        41 LESHSLRIKSKVQSYLVAHHS--DFSELFSLCQDTV--------SRTRLISDDVSDVLQLVSDRpIDVEIRSVVDEITEK 110 thale cress
XP_001625466  38 MLKKAEEVKAEVFNTIYKEYSyaGFQDLSSSTSELN--------WKVSSLLKEIDATTKKVKGS-ILPDLDAAAEEHANL 108
NP_956435     27 LSRKVEETKEEVTDMINKKYI--EFIPSMEGAEELL--------DQVESVSKDIDLLKSCIENE-VQQNLHDAVTEYAKL 95 
CAF97316      27 MSRKVEETKEELYEMINKRYA--DFLPSLQSSEQLM--------IQVDEVSKEMEALKNCIKNE-VWLDLNPTTKD---- 91  spotted green p...
O43264        96 KQQLERDSVVLSLLKQL-QEFSTAI-----------EEYNCALTEKKYVTGAQRLEEAQKCLKLLKSRKCFDLK-ILKSL 162 human
O44218       101 SRELRELMLGLQVSEHI-LKIDELF-----------QCVEEAKGTKDYLVVLDLVGRLRSLIYGEGEAATQDVVrIFQAL 168 Drosophila pseu...
XP_002634365  83 KTQARSCENLVEFLQSM-KKVEEQLiimrskttnriEWGNAILACKDYLNETNLLLEGIQC-------EGFDMSiPLKHF 154
O48626       111 TKEVKLKRESLDLVNAI-VGICEAL-----------QETKEALKNGRFRFAAERIRELKVVLRIGEEEDGEPVA---YAL 175 thale cress
XP_001625466 109 VQQLKETDMVRVILIRL-GKIHLGL-----------ETLPGTLKSKAFCKAAKLLEDVKEDLEHVP-RAGQEGK-IFIAL 174
NP_956435     96 KQQLEKNTAVIDLLQHL-QEFDTAI-----------EEYHRALQEKNYVVAAKQHGTARACVDALKTWKDTELP-IVRAL 162
CAF97316      92 -RQADRSANSLFYLTSLcLQFHNAM-----------EEFDKALPNKDYVEAANMLERARTSVDSLKVWKLSQVP-LLGAL 158 spotted green p...
O43264       163 ------SMELTIQKQNILYHLGEEWQKL------IVWKFPPSKdtssl--esylqTELHLYTEQSHkeektpmppISSVL 228 human
O44218       169 ecyetiKVKYHVQAHLLQQNMQERFDRLvq---lNCKSFPNSKc-----------VTLLVSKEEGQ---------LHDIV 225 Drosophila pseu...
XP_002634365 155 ------AAEYSVLSYNCRYQLSADYDRA--------MSVPKVSkkqggdksnvsvTVLNLSTPEEQk-------nMNETL 213
O48626       176 --------------------LRKEWSNCfdeiqeVLAKFMENAvrfeld-ssrirIKYQLSVGETAgi------aLSTVL 228 thale cress
XP_001625466 175 ------REELRRLSIQLVNKLDTTWNNC------LLWSIPTSSsldsa--hahlkTQLKLCTYGSE---------ITEVI 231
NP_956435    163 ------SSEITIQRENLIYHLGEEWQKL------AVWKLPSTKteltga-ksflkTALHLNKGGSKvdesvphalLSSIL 229
CAF97316     159 ------SSELTVQRENLIYHLGEEWKRL------IIWKLPPSNdpagp--qsflsVALNLSHACVEgpeakpsalLCCVL 224 spotted green p...
O43264       229 LAFSVLGELHSKLKSFgqmLLKYILRPLASCPslhAVIES-QP-NI----VIIRFESI-MTNLEYPSPSEV----FTKIR 297 human
O44218       226 IALFQERYNPVRLCEF---LLENCIEPLILKP---VGVECnENaEAgt-yVQLSLSYStKESGTASGTSTQlrpnYKQVL 298 Drosophila pseu...
XP_002634365 214 TAMNMIGQLPERLDAWk-tVILNVFCEAIVSSrdgVDVFFvDNpTP----AQTRFLINqKPRGKKDKPMDV-----EKVL 283
O48626       229 EAMEVIGILDYGLAKAadsIFKHVITPAVTHAstfAAVEDlCKsAGevteATLRLEQSsDHKFEDVDGDAM----YSGIL 304 thale cress
XP_001625466 232 NALAFLGRLEQKLKIFgkkLIQFIFRPLIIFPnlkVSVEK-DK-ED----ITISLVRD-TTKCKIVEPGKV----YSKII 300
NP_956435    230 QALSIQGELHKKIKLFgqvLFKYILKPLILYPslvVEVSS-QPeQG----AVLSLQCL-ETKAEHPDPSQV----YTKVL 299
CAF97316     225 QALAIQGELQNKIKLFsqaLVKSMLKPLVVHPslwVNVVE-QQdEG----IVLAFESLqESSKERSTPSQV----YSKLL 295 spotted green p...
O43264       298 LVLEVLQKQL--LDLPlDTDLEnektstvpLAEMLGDMIWEDLSECLIKNCLVYSIPTNsskLQQYE---EIIQSTEEFE 372 human
O44218       299 EHFRLLLQTLsgINHSlSSSQH--------VFSIIGDHVKDRMMHLLVNDCLIPAVPET---MEEYQa-sTLCEDVAHFE 366 Drosophila pseu...
XP_002634365 284 QSMDVFFSKL----SDvLKSHElldacgksFVAMIGHAIQPQLNEMILKDVVAIAAPVTetaEEDQEmflRLLQFGEDFV 359
O48626       305 KVVKFICSSLcfg--------------nvtWIHSFGRLTWPRISELIISKFLSKVVPEDaskLADFQ---KIIERTSQFE 367 thale cress
XP_001625466 301 EVLEVLCTYF-------TPSQDnsglpkisILQYLGNFLWPALSEDLIKDCLAKSIPNTsaqLEKYQ---EVISQTEKFE 370
NP_956435    300 TVLKTLHEHL--FDVSvde---------kkVSEILGGLIWEEMSECIIRECLVHSIPANssqLAEYS---EVIKQTEDFE 365
CAF97316     296 MVLKTLHAHLl--DVSigd---------krLSTILGELIWEEMSGCIIHECLVHSIPNNsseLEKYT---TVIKQTEEFE 361 spotted green p...
O43264       373 NALKEmRFLKGDTTD--LLKYARNINSHFANKKCQDVIVAARNLMTSEIHNTVK----------IIPDski--------- 431 human
O44218       367 QYLAD-SFLINPEVDrgLSQFIEQYGTYYRNRLCSRVLESTREIIQRDLQDMVL----------VAPNnqamd-----vt 430 Drosophila pseu...
XP_002634365 360 ENMKTlGFFSPDA----KLLFSLDTDTIFVTRRCFAIVSKANKLINETYDKLVT----------VGVDdtavkdidllsk 425
O48626       368 AALKElNFVSSSDAEsrLSKYAEDVEVHFASRKKIEILAKARNLLLQcnf------------------------------ 417 thale cress
XP_001625466 371 EELHQlEIVDKLPSS--LTKYAKDVGVHFGNKKCQDLLVTARDLMKDDIYNTVMvdrftdtallVTPQeiqeallgkksk 448
NP_956435    366 SSLKEmGYLAGDSTE--LLKYARNVNCHFASKKCQDVIVAARKLMTSEMHNTVK----------ITPEykl--------- 424
CAF97316     362 KALKDmDFLQRDSTD--LLKYARDINCHFASKKCKDVIVAARKLMTSKMHNTVK----------ITPDykl--------- 420 spotted green p...
O43264       432 -nvPelptpdednklevqkvsnt-------------------------------qyhevmnlepentldqhsFSLPTCRI 479 human
O44218       431 gcdP--------------------------------------------------------------------FLFPRCMV 442 Drosophila pseu...
XP_002634365 426 ahtHaelyakeygndlar-----------------------------------------lwshneesqfpsfFAFQKCTV 464
O48626       418 -tiPqdiamrna-----------------------------------------------------khivcllFSSERCVV 443 thale cress
XP_001625466 449 vknPvntvlkainhnyllvynahffhaeliltwqplairlpssymeyywichqqeiseltksdqeetlseftFNFPTCRI 528
NP_956435    425 -siPkllspsggekerkesskrs-------------------------------ghydqqslenekqlspntLCLPVCRI 472
CAF97316     421 -rlPklpapgpevkvkpeat------------------------------------reeltmenakqlsalsLCLPACRI 463 spotted green p...
O43264       480 SESVKKLMELAYQTLLEATTSSDQCAVQ-LFYSVRNIFHLFHDVVPTYHKENLQKLPQLAAIHHNNCMYIAHHL 552 human
O44218       443 SRSAQDFMKLMERILRQPTEKPGEDEADpLAGVIGMMLQTYIDEVPKVHKKLLESIPQQSVLFHNNCMYFTHWV 516 Drosophila pseudoobsc...
XP_002634365 465 SASTISFVNLLRDNVKAAFACEDEGARAkLALTAENIVRLYVIQSPRKHAELFSSIPNMSAIFYNNCHYISHCI 538
O48626       444 SEAASQLMNLVHKTLEDVCVSSARVASE-FYNAARDSILLYEAVVPVKLEKQLDGLNEAAVLLHNDCLYLFEEI 516 thale cress
XP_001625466 529 SESTKKLMDLAYSTLIEATTSPFQTAVQ-LFYTVRNVFELYCSVVPAYHQDNLATLPQLSALHHNNCMYISHLL 601
NP_956435    473 SESVQQLMDLAIQTLSEAVGSSPQCGVQ-LFYTVRNIFHLFYDVVPTYHKDNFLKLPHLAAIQHNNCMFIAHHL 545
CAF97316     464 SESVQQLMELALHTLCEAVGSSAYCALH-LFITVRNVFQLFYDVVPTYHKENLLKFPHLAAIQHNNCMYLAHHL 536 spotted green pufferfish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap