2OCC


Conserved Protein Domain Family
Cyt_c_Oxidase_VIIa

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cd00928: Cyt_c_Oxidase_VIIa 
Click on image for an interactive view with Cn3D
Cytochrome c oxidase subunit VIIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 13 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 10 subunits are encoded within the nuclear genome. Found only in eukaryotes, subunit VIIa has two tissue-specific isoforms that are expressed in a developmental manner. VIIa-H is expressed in heart and skeletal muscle but not smooth muscle. VIIa-L is expressed in liver and non-muscle tissues.
Statistics
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PSSM-Id: 238468
Aligned: 21 rows
Threshold Bit Score: 72.6837
Created: 11-Apr-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:Subunit VIIa/I interface [polypeptide binding site]
Evidence:
  • Structure:2OCC_J: Interface with 2OCC_A (subunit I), defined using 3.5A contacts
  • Citation:PMID 8638158

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                      #   # 
2OCC_J      1 FENRVAEKQKLFQEDNGLPVHLKGGatDNILYRVTMTLCLGGTLYSLYCLGWASF 55  cow
Q9VHS2     31 GYFEIRKVQEHFQKKDGKPVFLKGSvvDNVLYRVTVALALVGIGGMGKLFYELSV 85  fruit fly
XP_792390  26 VENKLKESQSKFQAPDGNPIHLKKGgmDYAVYSMTMGLTAVGTLWSCFALFQYAM 80  purple urchin
EAT33984   57 GYKLLKDKQAKFQIKDNLPVWLKGGpmDRMLYLSTVGLSVVGLGSSLAFISMMAL 111 yellow fever mosquito
EAT42464   14 LPDSLRKSMQTFQAKNELPVFLKGGpiDKVLFMTTMALCGVGILGIVRVIYTMGF 68  yellow fever mosquito
AAY66927   27 PLERIKELQKQFTADDGVPVHLKGGklDVFLYQFTMACCAVGLGWTFYNTYMMIY 81  black-legged tick
XP_971661  32 RFHKLKETQKKFGVEDNVPVYLKGGvgDKILYSLTVLITAAGLGMSLESWYRLAN 86  red flour beetle
ABI52771   25 SLERVKELQRLFCADDGVPVHLKRGmvDRVLYQLTMGLCIVATGASFYSIYTWVY 79  Argas monolakensis
ABF18100   31 GYKQLKHIQAKFQKPDGKPVHLKGGpvDQVLFMTTSVLCVVGLLGIGKLIYELSY 85  yellow fever mosquito
DAA03480    3 LPDGLSNKMKVFQAVNELPVFLKGGpaDKILFGITAGLCGLGIVSFVHLVYTMGF 57  fruit fly

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