7MQA


Conserved Protein Domain Family
AROS
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pfam15684: AROS 
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Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1
AROS is a family of chordate proteins active in the nucleolus. It has a stretch of polylysines at the N-terminus and in the middle regions and it localizes to the nucleus and especially the nucleolus in high concentrations. It binds to the 40S ribosomal protein RPS19, which is implicated in erythropoiesis. AROS is an active regulator of Sirtuin (SIRT1), an NAD+-dependent deacetylase protein that plays a role in cell survival and hormonal signalling, and AROS regulates the activity of SIRT1 by enhancing SIRT1-mediated de-acetylation of p53 and thus regulates growth of the cell.
Links
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Statistics
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PSSM-Id: 464802
Aligned: 24 rows
Threshold Bit Score: 55.5155
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7MQA_LY       21 DPPGQAKPRGAPV------------KRPRKTKAiQaq--klRNSAKGKVPKSALDEYRKR--ECRDHLRVNLKFL---TR 81 
EFA00824      21 AKVKKSKNNTKDVfnlipdelkitkNISRKGRK-E------KTGVLSTSKKLTVLEAKKTfkSKDEILKENLKKLkeiKN 93 
Q17C35        24 SATSKDKKRKSDDsdimprhhkmvrYVGKKGHK-E------AKDVLRRSESLTVMEARKRiqNRKDNTEDNVRKLlllSS 96  yellow fever mo...
XP_001843707  32 SSKKRKPDAPLATpdlmpqhhkiikYVGKRGKK-E------ARELLRRPESLTVGEARKRlqNRRNHTEENVQKLlllSS 104
XP_016841385  22 DKRKKKKTKSSGAldlipvnhriisKNKKKG----------STVLLKRSSKITVYDAKKQleTKSDPTEENVKRLlllSG 91 
EFN82406       3 KKRKKQDSLYTGTfelipprhrfttEEEKAA----------VIRMLGRSNRLTPQEAKKRlaAQKDRTEENVQRLlslKT 72 
XP_011064123  25 KKKKRKDIRYKGAldliptkhriisKNDKTD----------LDTILGRSSKTTVYETQKRlaTLKDPTDENVQRLllfSS 94 
EEN55191      22 aeGTKGKRKAQNPaeligtnrrgvrKQLRRLQR-Grr--rdDLTVKDKITVSAIEQYKRQ--QKEDHTKDNLRYI---RS 93 
EKC42031      55 kPKGKDKSKGRRSkavedsskrgirKRRKRTAD-HvgkpksSLSKES-----ALETYNRN--KSVDLTEDSLYYLnliSN 126
Q28IC1        21 essskkrNSSSKPkpclsssktgmrKQLRRLKQ-QglrhdqKATAKGRVIRSAVEEFKKQ--SAKDHLQQNLQYM---LD 94  tropical clawed...

7MQA_LY       82 T-RSTVAESVSQQILRQNRGRKACDRPVAKTKKKKAE-GTVFTEEDFQKFQQEY 133
EFA00824      94 VcTIELDKETTEKIIQRAVTRRPVKEK----KKRKKAqTTVFTEEDFKKFEEEY 143
Q17C35        97 A---DIGEEAGAKLVKRAQTGRYVVKADEFLDKKESK-ESVFDEEDFKKFEQEL 146 yellow fever mosquito
XP_001843707 105 A---EIGREASAKMIKRAQTGRYVVKADEFLEKKKKEpASAFTEEDFDNFAKEL 155
XP_016841385  92 N---RLDSDTSEKLLSRASKKLIHKKKE---EKPVEEeRTVFTEEDFKKFEAEY 139
EFN82406      73 N---QLNSNMSNKLLQRAVKNRIKKQ-----EKPKESeKTAFTEEDFKKFEQEH 118
XP_011064123  95 N---RINAETANNLLQRAVGKKYIQQ-----EKLKKSeETAFTEEDFKNFEQEY 140
EEN55191      94 F-KTKVDRHLEEKILEHQRGRLAKNQPKKK-RKTKE--TTVFSEDDFLKFEAEY 143
EKC42031     127 V-GGKPDAKTVNTILEYNKGKLSRNQKKIEEKRKEQ---SIFSDKDFEDFRKEY 176
Q28IC1        95 S-SSVTSKEVVDKILKQNRGRKAKDIEIKQHRQIKE--KSVFSDADFKRFELEY 145 tropical clawed frog
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