1B2W,1F58,1LIL,1RHH,2ADG,1QLR,1IQD,1NFD,1AQK


Conserved Protein Domain Family
IgC1_L

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cd07699: IgC1_L 
Immunoglobulin light chain Constant domain; member of the C1-set of Ig superfamily (IgSF) domains
The members here are composed of the immunoglobulin (Ig) light chain constant (C) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determine the type of immunoglobulin: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.
Statistics
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PSSM-Id: 409496
Aligned: 15 rows
Threshold Bit Score: 109.083
Created: 7-Jun-2009
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
  next features
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1RHH; human light chain IgC domain forms a heterodimer with the CH1 domain of the heavy chain, defined using 4.0 A contacts.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1            ###             # # # ##                     ####          ###              
1B2W_L       112 APSVFIFPPSDeql-ksgTASVVCLLNNFYprEAKVQWKVDNALQsgNSQESVTEQdskdSTYSLSSTLTLskadyekhk 190 human
1LIL_A       112 APSVTLFPPSSeel-qanKATLVCLISDFYpgAVTVAWKADSSPVkaGVETTTPSKqs-nNKYAASSYLSLtpeqwkshr 189 human
1RHH_A       113 APSVFIFPPSDeql-ksgTASVVCLLNNFYprEAKVQWKVDNALQsgNSQESVTEQdsrdSTYSLGSTLTLskadyekhk 191 Homo sapiens
2ADG_A       112 APTVSIFPPSSeql-tsgGASVVCFLNNFYpkDINVKWKIDGSERqnGVLNSWTDQdskdSTYSMSSTLTLtkdeyerhn 190 house mouse
1QLR_A       113 APSVFIFPPSDeql-ksgTASVVCLLNNFYprEAKVQWKVDNALQsgNSQESVTEQdskdSTYSLSSTLTLskadyekhk 191 human
1IQD_A       112 APSVFIFPPSDeql-ksgTASVVCLLNNFYprEAKVQWKVDNALQsgNSQESVTEQdskdSTYSLSSTLTLskadyekhk 190 human
1NFD_E       113 SPKVTVFPPSPeel-rtnKATLVCLVNDFYpgSATVTWKANGATIndGVKTTKPSKq--gQNYMTSSYLSLtadqwkshn 189 house mouse
1AQK_L       116 APSVTLFPPSSeel-qanKATLVCLISDFYpgAVTVAWKADSSPVnaGVETTKPSKqs-nNKYAASSYLSLtpeqwkshk 193 human
NP_001087883 141 EPALLVFPPYTddneskdSSTLTCHISKLEvsLVNVNWLIDGTTVqdGVTTSNPVRes-dNTFSMSSYLTLsskdinkdr 219 African clawed ...
AAG31698     135 PPVLTILRPSSreelsssKVTLLCLINHMSvaFADVRWLVNGNSVteGVFTGSAEQqp-dHKFKSSSSLTIqrsewdkdr 213 zebrafish
Feature 1                        ##   
1B2W_L       191 VYACEVTHqglsspVTKSFNR 211 human
1LIL_A       190 SYSCQVTHeg--stVEKTVAP 208 human
1RHH_A       192 VYACEVTHqglsspVTKSFNR 212 Homo sapiens
2ADG_A       191 SYTCEATHktstspIVKSFNR 211 house mouse
1QLR_A       192 VYACEVTHqglsspVTKSFNR 212 human
1IQD_A       191 VYACEVTHqglsspVTKSFNR 211 human
1NFD_E       190 RVSCQVTHegetveKSLSPAE 210 house mouse
1AQK_L       194 SYSCQVTHeg--stVEKTVAP 212 human
NP_001087883 220 LYSCMIKQegssafISKGVKL 240 African clawed frog
AAG31698     214 ELTCEATVas--ktSRASIRK 232 zebrafish

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