Conserved Protein Domain Family
Meckelin

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pfam09773: Meckelin 
Meckelin (Transmembrane protein 67)
Members of this family are thought to be related to the ciliary basal body. Defects result in Meckel syndrome type 3, [MIM:607361], an autosomal recessive disorder characterized by a combination of renal cysts and variably associated features including developmental anomalies of the central nervous system (typically encephalocele), hepatic ductal dysplasia and cysts, and polydactyly. Joubert syndrome type 6 [MIM:610688] is also a manifestation of certain mutations; it is an autosomal recessive congenital malformation of the cerebellar vermis and brainstem with abnormalities of axonal decussation (crossing in the brain) affecting the corticospinal tract and superior cerebellar peduncles. Individuals with Joubert syndrome have motor and behavioral abnormalities, including an inability to walk due to severe clumsiness and 'mirror' movements, and cognitive and behavioural disturbances.
Statistics
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PSSM-Id: 462892
Aligned: 25 rows
Threshold Bit Score: 754.144
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015791560  197 SSQC--IPCHASMKN-------CS-----CPKDHy--TLYGGLCLp--NGNLITEKVDLYKV-------TYENGEQV--- 248 
CAP31878      125 GAFC--DYCAEGFSKndd--geCKkcdysCPGKK-----------------FTNSDKVYTRI-------KLQNGVEM--- 173 
A0DDG3        113 REQC--VPCPDKLMIyt----------gsCECPQtgyIKSYDRCIl-sTQKTIGSLIFDSSY-------IVEYETDQkia 172  Paramecium te...
A0BV64         89 TNLC--QQCPNNQVNvs---gkCS-----CSASS---LASDNYCVg-lYINVFSDDISQVLG------------------ 136  Paramecium te...
XP_001317146   34 IFDC--VDCG----TednytypCVp---eCESPN---ELIGTICVnstEFAELKANVTTNTSknfrfynLVNQTENKafq 101 
EAY23261       48 TQTCeySSCEDGYDRye----------saCIKTDtyeRIYTTIANqetDLLTFTNPKTTDTS-------TTVLNLQYsde 110 
CBZ12062      173 SGAC---RCSAGFTMlyd---------gsCVPTE----AYESMAAa----aSGTSTALSPPN-------IDNSGAAGplt 225 
Q4DL05        214 TGEC---VCASGYTTlyd---------asCVPTE----VYNGVVVa----aVGATTTFQPLN-------LNNKGILGpsv 266  Trypanosoma c...
XP_002428855   45 LNQC--LPCKRFFATgq---pkCE-----CDKGQ---INVEGYCVs-nVLENSSGEKNIYGI-------TYENGIKV--- 100 
NP_495591      97 DAFC--GNCASGFYRndn--gyCTkcetsCSEMN-----------------STNSDQVYTRI-------KLQNGVEM--- 145  Caenorhabditi...
XP_015791560  249 NSAFFMEN---LQSSIYQCQYQGNRSACQLLANLCTFlnyNLYetssfggfiginsvkSKANACTEFLKLS--KLPS--- 320 
CAP31878      174 KSNYIENH---LSTEAKSCSER-NVQSCEALANICVLqnfEAG---------------FSLNACGLLENIKrsfnp---- 230 
A0DDG3        173 SSYMLSRY----QYAITMCYYYSSINACQLLANLCVLqlfDLT-----------------KPICSIFLDELssKIPAs-- 229  Paramecium te...
A0BV64        137 ------------PKAYDGCNLYNDMVSCQQLANLFILkrsTVS---------------TEKDFTYLYNAVLtfQNKKn-- 187  Paramecium te...
XP_001317146  102 TSYNNNTYnklVESITVLNYQSKAPQQREFLANVCAAnhfSLK-----------------SQACTLATSFAdiMTAKqyd 164 
EAY23261      111 TFKKILYYgviAKSSPY------DVKAKEFFANLCTAnhfKPD-----------------SAVCNLFRFGCneTGDSqyg 167 
CBZ12062      226 RVFPAQTY---SLGAALLCSRG-NSTACNLLANLCVVmdyQVT-----------------AMPCALYQHIKqsKPCDdpw 284 
Q4DL05        267 TSVVVRSY---AMDSAVQCMRG-MAVGCSLLFNMCVLmmyDVD-----------------SLPCKLYLSVRdkRTSYr-- 323  Trypanosoma c...
XP_002428855  101 ESKFFKDN---LIRDVTLCKMG-NQTACQSVANMCVMllyKEEee-----------eeVKSGPCTIFTEKN--RISErk- 162 
NP_495591     146 KSIYIENH---LSTDAKLCSER-NIQSCEAMVNMCVLqnfESG---------------SSLNACGLLENIKrlfnp---- 202  Caenorhabditi...
XP_015791560  321 -------VPFLIYG-DNG--VNE---LKKANVISKMFKI-----DSR--LELIAARYNVHGTLVDYSPLKLGELQLCQSE 380 
CAP31878      231 ---wqnaWDALANTd-----DSE---LEKENVIDHQYLFk---dDSR--FELFFARYDVNGTFDGFFTSETIPLLLCGDF 294 
A0DDG3        230 -------APALFPS---VntETI---NIYQTAFPQTMKLddsdsKGRryLNYAIQKYDLDGNLISDSTLR-SEFILCPHS 295  Paramecium te...
A0BV64        188 -------MPSIIHEvSTTvtSVT---LIEDTPIQMQVNFkedraTSLnrMPFYVMEYYIDGSVSELKPLQ-NQFQLCSSS 256  Paramecium te...
XP_001317146  165 ynfwpknDLFLTYI---NrdDNE---IFKENIILSKFSAgr-------iINITFARYSFDGEFLGFKVLE-LDTERCRHK 230 
EAY23261      168 yeywrkgVPFLYYNg----tQSE---IVDEDIFKSTYPPkr-------dISIQLARYSPDGDFLGFKELT-IDFERCSIK 232 
CBZ12062      285 ce-tidgLPWLYYTrSNAdvLSN---VTTEYRLSARQK-----------LQLVVSVFDLYGNWLGYQSVV-SQVNPCFLK 348 
Q4DL05        324 ------rLPPLFDGdNTDtyTSDdgvLLATTNITAAGDP----------MTFLVAVYDWRGNLKGLRHVS-EVLNLCCIS 386  Trypanosoma c...
XP_002428855  163 ------iIPWIYYS-Eg--eAST---ILSRKKISTQFNLypesvMNH--LNLTGIIYYPDGRLKGVGKIFEHTLQLCP-S 227 
NP_495591     203 ---wqntLDALATTd-----DSE---LENENVIDHQYLFr---pDSS--FELFFARYDVNGTFDGFFTSEDIFLHFCDDS 266  Caenorhabditi...
XP_015791560  381 PDSLDSGFYFGTNYYQKCEIDLRTLWDTkaSSiSSIlLYDLYLL-DDDQEPNTVYPIPVIVTNLMENG------EAVNK- 452 
CAP31878      295 LDPF-APFVFGRRFYKECKIRKEAYSDSflERk----LFEVYLKfTDEQGRPKLYPMHVLNSAIRVNGql---pNFANK- 365 
A0DDG3        296 PGDEINSRAFGLNMKISCTLDLDAFLQN-----YEMyMYELSVTaIRDDNTIVPQNVYFLVNNLKDKDg-----NLPNT- 364  Paramecium te...
A0BV64        257 YGDTDLASNFGVSYKNDCNVDFTKYLNSn----YQTvFYSVWIKd--IDGSFIQVPIKIADYDGNGNGetedqyGYTNT- 329  Paramecium te...
XP_001317146  231 QETENIWRKFGSNYYSSCAINIYEEMNFtsNE-----FYDPFIQdNMVGSYPVLRPIPVLDMSFADESg-----NLTNLi 300 
EAY23261      233 NSNAQIWRSFGSNLYNDCYINLYEELNKtsQE-----FYEPFIVdNTVDGEQVIRPLPALDLNYA---------STTSQs 298 
CBZ12062      349 NTELQTFFAAGDTRATSCHVNWHWFLRA-----NRTlFYEVYLRh--PFNASRLMPVPLLI-------------DYSNYg 408 
Q4DL05        387 DADMSSFFKVGSNRRLRCFFDWYKLLQDa----GPTyFFELFMRd--FTNTSRLVPVPVVM-------------DYTTGn 447  Trypanosoma c...
XP_002428855  228 LWKLKSSFRFASKYSKTCEIPVEQLLSK--ET-E---FIDVFLSy-KEEDEELLYAIPILILNIKNEG------TISNR- 293 
NP_495591     267 LNPF-APFLFGRRYQKECKIRKATFTDPrlERk----LFEVYLKfSDEQGHSKLYPVHILNSAVRVNGql---lNFANK- 337  Caenorhabditi...
XP_015791560  453 --GDDEQKRRLVR-----------------RFYLAEALIGIElk-kDGISDT-PlessksseafkgssklsegssDYMRY 511 
CAP31878      366 ----DRNRWILTR-----------------RFYLVDDYTL------QFDNST-----------------------RLLRF 395 
A0DDG3        365 --DKATQNSIFVK-----------------RIFLVDTLTSKKdytsPAET---P---------------------EYIRY 401  Paramecium te...
A0BV64        330 ---------KFLW-----------------RFFMVDNLKS-------------P---------------------SEIIY 349  Paramecium te...
XP_001317146  301 --NNGTSNLYYAR-----------------RFFLMDNSTTD----------------------------------DIIQY 327 
EAY23261      299 lnRQDERYHVLTR-----------------RFFLAENYTSN----------------------------------DYIQY 327 
CBZ12062      409 fePATFHDPWLYRgravasngamseggfrrRFYAYDNVGGSS----DALLRSlP---------------------SYVTA 463 
Q4DL05        448 ihPQSLRDGTLRRamat---------gyrrRFYLYDTLTDCKldvpQVTETT-P---------------------CYVTA 496  Trypanosoma c...
XP_002428855  294 --VSDQMQWQLVR-----------------RFFLVDKISGVEqvegQNQSLI-P---------------------KVTRY 332 
NP_495591     338 ----DRNRWVLTR-----------------RFYLFDDYSM------KFDNSS-----------------------KLMRF 367  Caenorhabditi...
XP_015791560  512 AQSITINIAISKTDGSGSIYTPWIKITYGTVTKED------------------YIn---GIKVPIEFCINYSADQSKNAR 570 
CAP31878      396 AAKIGINVVLQR-DRDGYINPPYLTIEYDDTTEEN---------------------------LENSLEVMYHKDPSGYDQ 447 
A0DDG3        402 ASKIQI-VILPSQDSYEQIYVPYVYVEYSIVRNSGe----------------------sFGYADFEFALQISPDPTNYWV 458  Paramecium te...
A0BV64        350 AKSIRL-ISYLSTKEDDKTFLPYFYVIYSEPISITti--------------------enEKYYPVKYGHYYYQAKTSFYT 408  Paramecium te...
XP_001317146  328 LVNFTL-IFTTSSTKADNITTPKIIVRYKQFPRSIleas----------tpsyEKlketTSQPAYEFNVVYSKDMKSFWD 396 
EAY23261      328 LTNFTL-VFETRMRNKTYMYVPYVAVDYIQVLKSSlker----------spsfKPlteeIYQPHYEFNVEYTMDLSDFWN 396 
CBZ12062      464 LRSASL-VLGADHRDDRYVATPLLVLQYASKMVSTiadaaptddleeerqtplNTsgqpDYTLHCQMRSYYLSSTDSVSQ 542 
Q4DL05        497 LRHVVFALEVVDVYRDHHSLKPVVYLQYASGLKKAhn--------------gdLTartaNNIVEGGVSVLFIASSS-VDK 561  Trypanosoma c...
XP_002428855  333 AKSITLKVRLVGNDNSGKIYVPYLEIEYGEFTGEE------------------VTr---GNSVKHFFKIDYEI-ENSFSH 390 
NP_495591     368 AAKIGINVVLQK-ERDGYINPPYLTIEYDDSTDEI---------------------------FENSLEIIYHKDSSGYDQ 419  Caenorhabditi...
XP_015791560  571 DLSICQGVFCGFAVLIALFRAWAWTKRQGK-QAVD---PVTISEFLLISISFLADAFFLVCLGFSIHSFIIYKQQS-VIH 645 
CAP31878      448 KLTICLSIVVPLSLFWSALCSYSWGRRQGKpSAVD---ASSILYFFVCEVSVLGDVFFIIFGLIAFWITFAYKSQTyASY 524 
A0DDG3        459 TIIILFAIYNVIIILVWLFRIYVWTKANPSsSIREnymLQLIKNMAQLLIDSWTDWMFYFLFFMTAYWFIFFKFQNtPFL 538  Paramecium te...
A0BV64        409 VASALLIVAHIFIIIVWFIRIYVWTKRNPSyTGQNdwcMYLTIRSFYVLLDTWAEVIFYYLAIFTGYLFCFFKFQQ-TIY 487  Paramecium te...
XP_001317146  397 VAAIVFSMIFILGLFVFAYTAFVSIKKHGN-GGFG---LYLILTLLGNLLDQIGNIFVVMVYGYSIYYFFFFKLQS-DLA 471 
EAY23261      397 GVLATIIVFLFLLVVALVWRLITFCKRHNA-EGLS---SYIMLGSFAYILDYISNWFFVCFFLISTYYWFFYKLQY-STF 471 
CBZ12062      543 GLKVAVIVLCALCFFSAWVRTYGWMRRRQY-LVLD---SFAVLRFFVYLCNHISNMFFLAVAVASWYMFIAYKGQS-SLS 617 
Q4DL05        562 GMMITMIIFCLLCICSAWIRTYGWMRRRQN-VMLS---IGAVIRFMVYFCNHIGNLFALVVSLASWYIFVLYRAQKpNLS 637  Trypanosoma c...
XP_002428855  391 TLEVYMGVFSGLAVVWSGIQTWSHTKRSGR-VAID---FLTVLNLLIFTCGNLANVFFFIIFCACLNFFVFFKGQS-VIH 465 
NP_495591     420 KLIIALSIIIPMSLFWSALCSYSWGRRQGKpSAVD---ASSILYFFVCEVSILGDVFFVLFGFIACWTTFAYKSQTyVLY 496  Caenorhabditi...
XP_015791560  646 GLLP--ST--SFESTIRIYLYIAFALKCVKILHDLIILSHTNIFLIDWERPRvitvtkrsrpeeterktvnddgilsank 721 
CAP31878      525 NMLS--E---DQERSLFHYIISALVLKFFGLLFTMGALVFQETFFIDWERQKlk-------------------------- 573 
A0DDG3        539 LMLN--QNepSNYLPFYGLFYTIFALRLIQTLAIIYAQSSISIYFIDWETTE---------------------------- 588  Paramecium te...
A0BV64        488 ILMPdlSDyaNNYRPFEILFYMMFACRLISMFNLILRQADVQVFFIDWEKSE---------------------------- 539  Paramecium te...
XP_001317146  472 VYLP--YG--EEFRFLIAFISTAFVFKALASIIKLLLVTGHQFFIIDWSQED---------------------------- 519 
EAY23261      472 YSFP--YS--KEFPYLIPFVWTAFVVKFFAVLLRLWQITTTDLFFIDWETPH---------------------------- 519 
CBZ12062      618 RAMR------LGDAYVNAMLYVAVTGKGVTVLYRLAEQCNADYFVIDWERSK---------------------------- 663 
Q4DL05        638 MFLS------DNYVFLEAMLYAATAAKGIAVVYKIVEQCNADYFVIDWERSK---------------------------- 683  Trypanosoma c...
XP_002428855  466 VLLP--RE--NQETDMKLYIIFAFVLKVVEIGRLLYNQISIDVFFIDWERPR---------------------------- 513 
NP_495591     497 NMLS--Y---DQEKFLFHYFIASLVLKFFGLLFTMGALVFQETFFIDWERQKlr-------------------------- 545  Caenorhabditi...
XP_015791560  722 kASASISsaGAGTRKSsASgnassigltekisqdklhfahcPAVSIWRTYFVANEWIKLCTYRRIKTSLHLFLVLLFLIG 801 
CAP31878      574 qTDEHGMplSRDLNKStEA----------------------EPVVVWRTYLIANEWNELQQYRKTSLALQIIMMTLLMEY 631 
A0DDG3        589 -IHRPVEkrRQEELEEnEIlvta--------------nkikSKVSVWRTLLVANEFNELSTVRTVSVEWTLIILGFVLIG 653  Paramecium te...
A0BV64        540 ----VLRprELAEKLDnNVlrmv--------------eqaqSKQSAWRMILIANEFNELQIYRIVSVEWTLLFVGFFLEG 601  Paramecium te...
XP_001317146  520 --------------KNvDE------------------------SKVWHRLLVANEFFKISTVRYYNMPFTIMIVVLLQVA 561 
EAY23261      520 ---------------SdDK-----------------------TVSSWRRITVAKEWLRVTLVHSYSIPFTLITIVFIQNG 561 
CBZ12062      664 -----------GQLLReNKv---------------------VPVSMWRSTFVANALNELQALRYWCPLLTMTIVLLFLLG 711 
Q4DL05        684 -----------GQLLReNRi---------------------LPVSMWRSTFVANELNELQVLRQWRPLLSMTIVLFFLVG 731  Trypanosoma c...
XP_002428855  514 --ARNVVprVGGQTETdEE----------------------QPISIWRTYFVANEWNEIQTKRKINVYIHLIITIFILKI 569 
NP_495591     546 qTDEHGMplSRDLHKStEA----------------------EPVVVWRTYLIANEWNELQQYRKTSLALQVITMILLMEY 603  Caenorhabditi...
XP_015791560  802 FGLENLATSDTQNNLKRDSGQ-RFVPESQTCRLAIGSLVFFLLGLAQLGWHRMFQERMY-KNKLDEFVDLCSVSNVSLFC 879 
CAP31878      632 FQIKNYALVEPGFE--RNSADsATTLSILLSTLAITVSLYLFLAFIQVFLRVLIVERIV-TDPFHNFVDLCSVSNISVLS 708 
A0DDG3        654 LGFQKRFIESPDLI-----ETqPFVPENPILKYFLVQFVYLMIGLGQLILRRILNIWQ--PYPYENFVDLCTIANVSIFI 726  Paramecium te...
A0BV64        602 LNWINLGQEQPNLS------LdKTIPKNYVLQYFLCTFLYMAIGLAQIIIQKLFDIWF--PILVEDFVDLCAISNVSILI 673  Paramecium te...
XP_001317146  562 IKLELFASPIPDTDLV------FTGIYAMILQVGWLAIVFIALFVFELLFCK-LYWLIF-TSPFKKFTNICLSQNISVLI 633 
EAY23261      562 FNVDLISQAIPDTLLK------DVGFSPMVLRVGWLTFLWVILGFVQWIWCEFFYWHFG-SDPFLNVVDLCSTSNISTMV 634 
CBZ12062      712 LDYQNMSASVPRGS----RQVdGMTVSFDTLRIAIDTFFWVAVALVMYLFEYQIYYRFVvVHPLQAFVDLCSVSNISIII 787 
Q4DL05        732 LNYLKYTESVPVTS----GADeAGTYSLTVMRIALGTFFWVSVSLVLNILEFQIYYRFFcVHPLQAFVDLCSVSNISIMI 807  Trypanosoma c...
XP_002428855  570 IQLENWSSSSPELYIIKSSSLhDNNDFSFTCFFAVGNLVFLFIYILQRLYVGFFHERYI-KDGIQQFVDVCSMANISVFI 648 
NP_495591     604 FQVKNYALVEPEFE--RDAFDsSTTLSTLASSLAVTIFVYLSLALLQVLVRVLIVERIV-TDPFHNFVDLCSLSNISVLS 680  Caenorhabditi...
XP_015791560  880 LLYQRFGFYIHGRSPNGRADVNMKEMHELLKR-------EEDDLCSKRGLLPNT--------DQQTFEMLLPTSINDQCN 944 
CAP31878      709 LTHSLYGYYIHGRSVHGKGDAGMSEMNEFLQR-------ERNNLCGFRGLETGS--------ELQTFIVNLPQMFRSKYD 773 
A0DDG3        727 LDDNLHGYYIHGENPLGFSEGGIPHLQECLRN-------ESKNKGKNRGLVKDGyd-----sQLCTYELFVPPEFKHQFE 794  Paramecium te...
A0BV64        674 LDDVLHGYYIHGENPIGYAEGSSEHLANCLHY-------EALGKGKKRGFIQESslqhsddvDLQTFELFLPMRFREAYE 746  Paramecium te...
XP_001317146  634 TDSTVHGHYIHGLT--KDTEKSMIELQLSASQrlntkpaEQQNSQTQSFIMIDM--------KSNCFETYFEPELSRRIF 703 
EAY23261      635 IESPQHGYYVHGRCVHAHADESMFRLTTNLAK-------EALGVASGRGLTPED--------KSQVYEVFYEKSFRLKFI 699 
CBZ12062      788 LLEQQWGFYIHGESIHAHADVSMEEFQSNLFL-------EAQGNLPVRGLGGQS--------KCQSLEVYLGPYTRQYLY 852 
Q4DL05        808 LPETQWGYYIHGESIHAHSDVSMEEFQQNLYL-------ESQGNLPVRGLGGQS--------KCQTFEVFMGIYMRQYLY 872  Trypanosoma c...
XP_002428855  649 LALENYGFYIHGRSAHGFADTNMENILCQLER-------EEENLVGYRGLLPGS--------EQQTFEMTVPTQLRAYYR 713 
NP_495591     681 LTHSLYGYYIHGRSVHGKGDAGMSEMNEFLQR-------ERNNLCGFRGLEPGS--------ELQTFTVNLPNLFRSKYD 745  Caenorhabditi...
XP_015791560  945 RI-RALLTTYSQGAERMQgvggh---------------lfkvDLEKVVPTYVM-LTKFLSGYIEHAFK--DADYTVK-DK 1004
CAP31878      774 EI-SAISKQTTSGVVGHeav--------------------taKMNATVEAHSQ-MNSFLKKFVDHSIS--DIDYVVR-DR 828 
A0DDG3        795 VN-YQGIRNYKEKREMKSl----------------------gIENVELQKFK--IEQFLKSKINEVKKvdKRANFIR-TK 848  Paramecium te...
A0BV64        747 KVyNQELKQKTDNAQYQNyneirvl----------rqgvpdgLDMALVQAIKDtFSFYLKDVLTQVRT--NFAKCVR-DK 813  Paramecium te...
XP_001317146  704 DI-YNSVSAQVGGSLFKqaa--------------------asLAQVCIGIYSD-LNKFLQQFFTPGAT--NFKLELHyEI 759 
EAY23261      700 EV-FYSVMNNTGSKLFKvna--------------------seIPHACIDAFSE-LNKLFTRFFDMSQS--EHRAEVQlEV 755 
CBZ12062      853 MC-YIEMHIENQRSLLKRerainpaqwhyi-rflfcfsrqlcVYTQTALAIRDrINYAFQQSVRRAES------TVL-VK 923 
Q4DL05        873 MC-YAEIEAEYQRSSGKAlapirpgrqwhllecvlgfsrksrVYNTEILAIKTrINSVLKQSVRSAEG------TLL-MK 944  Trypanosoma c...
XP_002428855  714 KA-LAPLKNMSKAVKRLPasnster-----------skikneTVDRSVEAYKN-MNRFLSAYLEHALK--DLDYEVR-EK 777 
NP_495591     746 EI-FAVSKQTTSGVVGHeai--------------------taKMNATVDAHSQ-MNSFLKKFVDHSIT--DIEYVVR-DR 800  Caenorhabditi...
XP_015791560 1005 SNVESILAFELAE-PGE---------RGFLYN-----------D-NGHSFDQLLFCGNEFKLFTFEFMLFIFIDLITHNF 1062
CAP31878      829 PFLESLLDMEMSDtSIT----------GSFTRseitnendkkiDhVEIAYSRCFVYGNEWAWTSFECLGFTVFYIWSGSI 898 
A0DDG3        849 ETAQRYFDYPPDElAYDdfn---ksqVPYFYK-----------D-PDYQYRRVFFSGYEMYFLVTDIIIFTFFVLVTQNV 913  Paramecium te...
A0BV64        814 LPVQRFFDYPPADlEENyfk---dqsMPVFFR-----------D-PDQSFKSMFFCGHEFFFLITDTMIFNFWMILTNNT 878  Paramecium te...
XP_001317146  760 PVARRIFGMAPT--ITD---------SSILDK-----------T-SGEHYRFMLFYGLQVRLYFTYSLLFCIIDMFLKNP 816 
EAY23261      756 PITQYVFGLSPK--IED---------RSILSK-----------D-DDREFRKTMIHGAQWSLYILAIILFVGVDMHTHNS 812 
CBZ12062      924 FMLQKWLDFPPNVmYMNgpqrgdhcgKDLFFI-----------D-DVQSYGRAFLCGLDFDLFVLYAALFAAIDAALHNF 991 
Q4DL05        945 FIFHRWFDLAPNIlYMNgpqsgdksgKDLFFV-----------D-DVLAYGNAFLYGLDVDLFVLYTMLYASVDASMHNV 1012 Trypanosoma c...
XP_002428855  778 LFTEYLLGIEFGD-SGE---------KGIFYS-----------D-NGHSFDSILFYGNEFSLLTFDVILFSFILVLFQDY 835 
NP_495591     801 PVLESVLDMEMSDsSIT----------GTFTR-----------DpVEIAYSRCFVYGNEWAWTSFECLTVTVFYLWSGSL 859  Caenorhabditi...
XP_015791560 1063 VAAATFTFLIIEIIKSIYIVAYKRNIVKKALIDERFLM 1100
CAP31878      899 YLAGAVVYVISHIIRMVFGYLSTNHLIKTSLVDQRFLV 936 
A0DDG3        914 ALSILLQYFVTKSFEWLKQEWQKSNISEKTKIDKRFLI 951  Paramecium tetraurelia
A0BV64        879 YLSLMLTYLISAGIFNFRQWVGERNLADQSKIDSRFLI 916  Paramecium tetraurelia
XP_001317146  817 VVAGFIVLVVDYLVLKFVRFRCKQNLAKKSLLENRFLY 854 
EAY23261      813 MIAAFVVFIVDFLITFVFKMRARAKIAKNALIDTDYLM 850 
CBZ12062      992 YVAMVLAFAVEVVVHFYRVREGLANLSQKTMIDDRFFL 1029
Q4DL05       1013 WVALVITFALELSIRWYRMSEGVANISSKTLIDDRFFI 1050 Trypanosoma cruzi
XP_002428855  836 LTASIVTGFFSHLLVVVRDLGGRKNLAKKTLIDERFLI 873 
NP_495591     860 YLAGFVVYVISHLIRLIFGYLSTNHLIKTSLVDQRFLV 897  Caenorhabditis elegans
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