6O58,6K7X


Conserved Protein Domain Family
MCU

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pfam04678: MCU 
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Mitochondrial calcium uniporter
MCU functions with MICU1, an essential gatekeeper component of calcium-channel transport, to facilitate Ca2+ uptake into the mitochondrion.
Statistics
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PSSM-Id: 461389
Aligned: 85 rows
Threshold Bit Score: 117.744
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6O58_A       118 EDRGIDRVAIYSPDGVRVAASTGidLLllddfklvindltyhvrppkrdLLSHENAATLNDVKTLVQQLYTTL------- 190
XP_018468504 101 PDEARVFARVLDDAGVVLIFRD----------------------------------KVYLHPDKVVDLIRRAMpl----- 141
XP_004980118  98 HAEAEELARAMDDAGVVLLFRD----------------------------------KAYLHPEKVVDLVRRAVpl----- 138
XP_001419914 173 AEETAIKVKLLEECGAVLILED----------------------------------MVYLHPRDVTSAVLRVL------- 211
XP_002503501   9 DEAQDETLATLQKAGVIIKLDD----------------------------------VVYTNPGQLTRDVLAVL------- 47 
XP_003392651 111 VEDPDAALADLEAAGVVVVLDG-------------------------------G-SMVHLRPVLYLETLEMICnvarpss 158
Q387B7       112 VEDTDKALQLLCESGVVVSISD-------------------------------G-AAVHLRPVQFLQMHNDAAdasdak- 158 Trypanosoma brucei
Q4CZP7       108 VENSDEALRLLEESGSVVSLSN-------------------------------G-EGVHLRPLQFAHMYEDLTgegeek- 154 Trypanosoma cruzi
CAM38980      48 DAEAVKYIDTLKRAKMVVVVED----------------------------------YVYTDVKAVIDAVHLKSglp---- 89 
ESK91690     193 AASAAEFLICISREKEKELDSDE--QT----------------------PEDGSETVISVRVPTFADR------------ 236
6O58_A       191 ------------------CIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGLAYMATQFGILAR 252
XP_018468504 142 -----------------eETP-----------EEDQI-KEEFNKLRTMKEEIDVLAHRQVRRILWGGLATAVVQIGLFVR 192
XP_004980118 139 -----------------aLGP-----------ENDPR-KKEFKQLQEKKEEIDKLAHKQVRRILWSGLGFFMCQVGLFFR 189
XP_001419914 212 --------------------PGVPSKVYGITDADLQAMTNEFETMKENYKVARRRAEARSRTIISSGLIVLCLQLATFVR 271
XP_002503501  48 --------------------PRVPSYVYGVSDAELVSLEADLAAQEAEVTAAAERARWRSNVVVGSGLALMCTQLVVFMR 107
XP_003392651 159 sgnetsetnskpsvavrsFMVEEAERRVATLTEREKAMRNRLQPAIA-------RAARWRRTVWGAALLYAGAQLAIISR 231
Q387B7       159 ------------vktpfeDYIRAAQNRLADAEAEEMAMRVALQPAID-------NAAKRRRLLWSGALCLMAVQLAVISR 219 Trypanosoma brucei
Q4CZP7       155 -------------gstlaFFLEEATKRLKAAQAEEAAMRSELQPALM-------RAAKWRRVVWGGALCFSGAQMAIISR 214 Trypanosoma cruzi
CAM38980      90 ---------------lvpSTSKGFMCFHHMMSESLAAFNRECSLAME-------RAVRREKEFWAFTALVSGIQMLVLAY 147
ESK91690     237 ---------------------------TRFLRRRLDVINAELSSMEGLKCQCDKEAHRGARRMAVGGFGMLIVYWGAVAR 289
6O58_A       253 LTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQL 320
XP_018468504 193 LTFWEFSWDVMEPITFFVTATSIIVGYAYFLITSRDPTYQDFMKRLFLSRQRKLLKSQHFDVERFKEL 260
XP_004980118 190 LTFWEFSWDVMEPIAFFTTASGLLVGYAYFLVTSRDPTYQDFMERLFLSRQRKLCAAQKFDMERYMEL 257
XP_001419914 272 LTYYEFSWDVMEPLSYFVGLCNAILVYVYYLWNRRDFSFETWQNSLAGKYADSHLRRSGFDLDRYVAL 339
XP_002503501 108 LTYVELSWDVMEPISYFVGVFNAILVYIYFMVYKRDFSFNDWTSRMQTSYTKSAVSKKGIDWERYKKI 175
XP_003392651 232 LTYFDLDWDIMEPVSYMITVANTLFFFLYYLRFNEEHSYTAFDQRFLPRKV-RQYAPRDFDWAAYADV 298
Q387B7       220 LTFVDLDWDIMEPVSYFLGSGTSILFLIYLLRNGRVKSYKEYEEKAAASRV-RLHAPADFEWRKYDAV 286 Trypanosoma brucei
Q4CZP7       215 LTFFDFDWDTMEPVSYFLGTGTSLLFFLYFLRHGRSHTYEDYDRTTLPKKL-RKYAPPGFDWEKYEAI 281 Trypanosoma cruzi
CAM38980     148 LTFQVYGWDVMEPVTFFVTTATALCSYAYFLCFRTEHSYESVDDNFLPHLLMKELSALRVDANKVIHD 215
ESK91690     290 LTFWDYGWDVMEPITYLSGLSTVICGYLWFLYRGREVSYSSVLDSSISARREALYKTKGLDIERWVEL 357
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