2GH0,2GYR,2ASK


Conserved Protein Domain Family
TGF_beta_Artemin
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cd19381: TGF_beta_Artemin 
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transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins
Artemin, also termed Enovin, or Neublastin, is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. It acts as the ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. It supports peripheral and central neurons and signals through the GFR-alpha-3-RET receptor complex.
Links
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Statistics
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PSSM-Id: 381651
Aligned: 16 rows
Threshold Bit Score: 167.53
Created: 18-Jul-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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homodimerpolypeptide
Conserved site includes 38 residues -Click on image for an interactive view with Cn3D
Feature 1:homodimer interface [polypeptide binding site]
Evidence:
  • Structure:2ASK; Homo sapiens Artemin forms a homodimer, contacts at 4A.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            # # #   ####         #######      ### ## ##    ### ##   ###### #   #        
2GH0_C         3 GCRLRSQLVPVrALGLGHRSDELVRFRFCSGSCrrARSPHDLSLASLLGAGALRPPPgsrPVSQPCCRPTRYEAVSFMDV 82  human
2GYR_A         1 GCRLRSQLVPVrALGLGHRSDELVRFRFCSGSCrrARSPHDLSLASLLGAGALRPPPgsrPVSQPCCRPTRYEAVSFMDV 80  human
2ASK_A        15 GCRLRSQLVPVrALGLGHRSDELVRFRFCSGSCrrARSPHDLSLASLLGAGALRPPPgsrPVSQPCCRPTRYEAVSFMDV 94  human
Q5T4W7       122 GCRLRSQLVPVrALGLGHRSDELVRFRFCSGSCrrARSPHDLSLASLLGAGALRPPPgsrPVSQPCCRPTRYEAVSFMDV 201 human
XP_015666787 126 GCRLRSHPINVrDLGLGYDSEEVVLFRYCSGTCklARNDYHEVLNHLVQEGIIVPKHn-dHISQPCCRPILYENLSFLDV 204 Protobothrops m...
XP_005170818 139 DCRLERKEMKVrDLGLGYDSDEIVLFKYCVGTCmsARKNYDLALKTLTDNGSVSSRN---VSMQPCCRPTRFETVSFMDA 215 zebrafish
XP_015210613 170 DCRVRIKNLRVrDLGLGYESDEIVRFKYCAGGCqrARSDHDLVLAALVRQGAIKAREg--VSAHPCCRPTRYETVSFMDV 247 spotted gar
PIO24665     100 GCSRQSLQMRVqDLGLGFESEDLIMFSYCSGSCqlQRNTYDITLTSLLKHKMINHGAhgrVSNHPCCRPTSYENVVFLDL 179 bullfrog
XP_015278431  37 HCRLHSLTVKVqDLGLGFQSEEIVRFSYCAGSCesARTNYDLTLQNLVQIDLLMRNKh--LSSNPCCRPVRYEVVSFMDV 114 Gekko japonicus
ETE68407     115 PCRLHSRTINVrDLGLGYQTEEVVLFKYCSGSCdsSRTNYDHVLNYIIQQGLVPAEKn--FISKPCCRPVQFANFSFLDI 192 king cobra

Feature 1                ####      
2GH0_C        83 NSTWRTVDRLSATACGCL 100 human
2GYR_A        81 NSTWRTVDRLSATACGCL 98  human
2ASK_A        95 NSTWRTVDRLSATACGCL 112 human
Q5T4W7       202 NSTWRTVDRLSATACGCL 219 human
XP_015666787 205 HNVWQDLQRVSAAECSCL 222 Protobothrops mucrosquamatus
XP_005170818 216 QTSWQTIKWLSAANCSCV 233 zebrafish
XP_015210613 248 ENSWRTVERLSAAECSCV 265 spotted gar
PIO24665     180 KNKWQVVPQLSAANCSCV 197 bullfrog
XP_015278431 115 QNAWHTVDNLSAAECKCV 132 Gekko japonicus
ETE68407     193 FNVWRNVEKGSAAACDCV 210 king cobra

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