Conserved Protein Domain Family
Cohesin_load

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pfam10345: Cohesin_load 
Cohesin loading factor
Cohesin_load is a common cohesin loading factor protein that is conserved in fungi. It is associated with the cohesin complex and is required in G1 for cohesin binding to chromosomes but dispensable in G2 when cohesion has been established. It is referred to as both Ssl3, in pombe, and Scc4, in S.cerevisiae. It complexes with Mis4.
Statistics
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PSSM-Id: 463053
Aligned: 49 rows
Threshold Bit Score: 304.625
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDK42881      360 KVSYFLQESTKFIHAAHEHLAYYHEKINLENYWKLIKAAIRCLLLVLKkyNRSMTDFQKVSAIYSLAWIYSEETENFDKA 439 
Q6CNT3         26 QLDLIYHLSKQYTLTAHDVVTEIETELELRQYYTLINQAIRCLRYLKDg-GFQLSLEQDFQITNDLVTLLIEETHRIDLA 104  Kluyveromyces...
XP_003647107    9 QRSLVYQRSRQYLAHAHSVASKVRSETQLRQYYTLIQEAIRGFEYLKN--ELQLTIAQDLQVTLDLVRVLLDETHEVELA 86  
XP_001646299   14 RPELVYGLAHEYLEQAYKLSGKVSDEVQLQQYYTLISMGIKCLQRLKL--EYSLTVEQDAKITLELVHVLLNETNNLSLA 91  
Q6FQF3          4 SAQELWELHEEYVTCAHNCVSKVQNRDQLRQYYQLIGAGVTCLVTIKE--KYSLSMEHDAQVTLALVSLLVDETADYDAA 81   [Candida] gla...
CCE79525       85 IVDLLLTNSDFYLKKAHQTVPHSNTPQGVSTYQKFVKLSIKSLLILIRryDKALNPYLESVIYLKLASIYYEETDNLNRA 164 
XP_001387408   10 VVENLFMTSDFFLQKAHKIVLNIYSEQGMNEYFKMIKISIKSLVIIARkyAQHLTPRKESILYYKLARLFLFETENIDKA 89  
Q6BID2        149 VVNNLVISSDYFLNRAHETVLDTNSMNGSKTYFKMIKISIKSLLLLIRkySKCLNPYLELIIYFKLARIYFIETENINRA 228  Debaryomyces ...
CCE43614      639 KVAYFVQTSQELIHKAHESLVVDKSFQSVLNYYKFIRGAIKCLLILVKkyPKDLTPHQLASLYYKIAKLYLTETESFDLA 718 
EMG49796      170 RFEYFIELSDYFRNRAHKD----VSTLPLDTYYKFIKLSLKCLTILDK--RHSLDMNQKFLVYYKLAQIYIEETENLEIG 243 
EDK42881      440 QEYANKAIQICRSQGPSMIkyEFYCQLLLILII----VKTGGt--ASALDYLAEITN-LYETRGKQ---E---FVDCLLL 506 
Q6CNT3        105 EQYFSALRERLQSTTWVNE--KMYVDYVLLCKIp--lYKNDPshnKIALRNLSKLIS-KLDTSL---------WKVLFQY 170  Kluyveromyces...
XP_003647107   87 EQYLNGIRTRLQPTTLTDD--KYLVDFYLLYHIp--mLKRDPg-nKLLLKNLGRLIG-TFNKSD-----P---WRLVFQY 152 
XP_001646299   92 EDYLSSLRERLKNHKLGVLneKLHCEFIALYEIp--mKYSSEyyyKMSTRSCDSLLE-YLKTLESTqevQe-fWVPLFSF 167 
Q6FQF3         82 EMYISSLQERLKNDKYSDDleVYRLVCHFMNFYtiplKRKSQfhmNIALKNCNELVTyMENALESGsmqPyseWLVVFKF 161  [Candida] gla...
CCE79525      165 DDYANKAIAITTRNNFSSL--KFAAEVLAAKVL----ERSRP---GLALNYLSDKIK-SYNSSGSM---H---LGNLLAI 228 
XP_001387408   90 DENIYKSGTIAKRNKFTDL--IFVSDYLSAQIK----ERNNK---TVFVNFINERVT-YYENLELH---H---YVTMLQL 153 
Q6BID2        229 DDYVNKAISIATRNNLIKV--KFICEFLAAQIL----EKSNP---KLSLNYINERIS-NFKMIGLH---S---LGSLFAL 292  Debaryomyces ...
CCE43614      719 EAYALKTQTISRDHSIVEF--EFYCDLLLIDIY----EKINIs--TIGAFALRREAY-YEEAGYHL-------LSNCMKM 782 
EMG49796      244 EKYLNQAIALSSN--LNDLknMFNCELMVCHLI----EKVNP---KTLINYLIAKIQ-FYQEKRLN---E---LVDCLEL 307 
EDK42881      507 MRIHYLLAT----DYSIALVNLQRMLKRQNKM------HPILYTVASIYLAGLLTyRGDP----KNAIMVLTNIK-YNFE 571 
Q6CNT3        171 FRLQLIPGN------ERKLADYRDILFVIKNHe-----QFHFVVMCSFINYCLde-------giSIPADMW-----VYFS 227  Kluyveromyces...
XP_003647107  153 CRIAILDMNkssrNISSITADYAEMLNSTTSLepgaegEINGFLLCSYVTFLLNRtLLVSnddlEKLKLLKTKSDrISVK 232 
XP_001646299  168 INIWLNIKIg---KKNLIRSKFNNLLEKSSKLn----hEWEAFIILAYVSFLLDErYTVPpdviEKLNEInt-------- 232 
Q6FQF3        162 VVLTLSILTn---KHGRLHERYKELIEYENVPk-----IWKYILVLHYVDYRLKQrKPIEqdilSSLSEITVETAg---- 229  [Candida] gla...
CCE79525      229 LKTGILLQE----DYSAGLVALQSLSALDIV-------DPATKVFCLLLQANLHLtd-----asPVVAISLCNEEsTLFE 292 
XP_001387408  154 LKIESLLTY----DANTAVIILQSLAQSEKI-------DELTKVHCMLSLSNLHLyRGSPsislSIVNEIDKILDslg-- 220 
Q6BID2        293 LKIDNLLSQ----DPNTGLIVLQSLCQDPQI-------DNTTRALCFIYQSNLHLyRGSPkhslELLNHAEKLMYghe-- 359  Debaryomyces ...
CCE43614      783 VRIKYLMIS----DASFALVNLQRLVNDPKL-------DPTVKKIAIVYLAGLHNhRGNpa-avADLLRGfe-------- 842 
EMG49796      308 IKIKYNLVH----NPDTALSSLTLLIGKTQ--------NQTIKAFCLIQSANLHLhRASPvtalDLINHAGKIIEd---- 371 
EDK42881      572 ----PNSPLHALFLLNKLLAVMC-TNDYYGATKVMSKLYDLKNRSdaLKWRNWHPDGD----IELNITERdetnfnsnFN 642 
Q6CNT3        228 emdtAHVKLKIWKILLELLVLI---FKDINITDKLTELKSFFDNN--KD----KIDSP-----LESIHLF--------DT 285  Kluyveromyces...
XP_003647107  233 --------IKIWAMLLELLIAI---YQDENITLLLYDFKEFFGRH--KETLNTGRDSIl---LQIK------------PG 284 
XP_001646299  233 --nrFSPTLVAWRMVLELMMQIY---KEENITNKLNEFKEFFNQQ----KSNLENRDN----YCIKFD----------DS 289 
Q6FQF3        230 ------AKLYAWRLISELLMDIY---NDRNITEQLNRFKLFFKEC--KD----KLDGS----LEVNVD----------SK 280  [Candida] gla...
CCE79525      293 hl-qSYPQLMAMCLLHKLCGHLQ-AGYLKQGKEMINKISDFVQNQqnTGWRWWSEDGIi--nITIGITFD--------ET 360 
XP_001387408  221 --neTPRQMAAMSAITRYYGEIQ-MNNVDEASKIMKSINSLIANEqnLSWSSWREDGKf--kIEIPIQPE--------AN 287 
Q6BID2        360 --enYPIQLQAILFLLKYSVYIH-TDDSAGSKDVMQFISNFILTEqlKHWNSWKEDGTfkikIDIPSSNG--------LN 428  Debaryomyces ...
CCE43614      843 --vnISQPFAAYILMTRLLASVS-LNNVSESKHLLKELMSLSNDGekSHWNQWSINGD----IKFHIGGE--------SG 907 
EMG49796      372 ---nNIESLKLSLLMAQFVAYIHlNKDSKKIIGKVSKFVGRDDNA----NGKIe--------LSIDVPKL---------D 427 
EDK42881      643 SGFKFIVP-WLRVNDLLAVAYFINGLMFIGHKRD----Y-AEKNFHRATRQLERVKEDLKsn-----rNPSFTVQTLKEQ 711 
Q6CNT3        286 VSLKLDFP-VFGYKDVKNLLLFFQSVSYLPNCFDkrsnF-SVKFLPKTISTTGKLLSSL---------DEKCSLSKLNSL 354  Kluyveromyces...
XP_003647107  285 LKLKVEVP-FFNSADCKNILLLFQSVSYLPTCYSkssnF-STKFLPKVLRTSEELKQNV---------ARKASLSKLYSI 353 
XP_001646299  290 NRINITLPlIFNYKDLKNILLLLQSISYLVNCYDknanF-STKFLPKVQSTTKKLIDSLNdks---tsEN--SLSYWDAK 363 
Q6FQF3        281 AKLQLKLEpIFHYKDLKNILLLLQSVSYLLNGYDkk-aNfSIKFLPKVQTTTQLLLEGIRn-------DSANSILTVDNK 352  [Candida] gla...
CCE79525      361 YSARYGIP-WINSDEFVILFYMLSGVLLLRTNNKk--rK-AKQIFEKCLEMVSNKLSETGernqhkttMIAFSMWHYYEK 436 
XP_001387408  288 TLIPTYLS-WLNSDEFVIMFYFLTGIHYMSEAANgk-kK-SKKVFDRCLQIVEKQLLELGsv----nnKRNLSITDLSNK 360 
Q6BID2        429 SDLSYRVT-WLNSDEFVIMFYFLTGVHFLPEIYNkk-yK-SKKVFQKCLQILDNQLHELRgmg---ntERCFPLNQLTKK 502  Debaryomyces ...
CCE43614      908 LELDFVIS-WLPVVDFKIMLYFLSGVAYLHLTGD----R-SKLCFEKAIALIQSAQDDLEmnr---nlAKHLSAHESRQR 978 
EMG49796      428 HTFRIDFD-WITTGELAILAHLLTGVALLSDSRN----K-AKICFEKALKNLSKVEKSNK--------LGSMSLDEYVRK 493 
EDK42881      712 YVKVRYFKFIIRYYLQY-------HAFVVDNWDATc-lNEFTtVARNALESKMEHTC-LKVQHPLVYYLQALWYLKKGD- 781 
Q6CNT3        355 HKFYHTLLDLVKFYQTCesi--ilHGMVADDNTTS---------PYQDLLQAWNAQL-RGQVKTASAIYYSILHNDLGNr 422  Kluyveromyces...
XP_003647107  354 GSIYDHIKELCQFYQAWeqm--ilNGPIENNLPQL---RNSDyYDLLESMNSHLLIP-RKSIKHVYNLYESLLKSKDSEv 427 
XP_001646299  364 INWYKSIISYCNFYQLWeqliltpQKLINNDFSEIsntSQNSfDSYHTLMEGITSQI-KGDGTLSLDQYSTVVRSKNAT- 441 
Q6FQF3        353 VSWYTTILKYVSFYKLWdyv--llKGITHEYKRNC---LEIPqKDHQLFLELIGRQS-KLTSTGGSEELQQLTEQYTDL- 425  [Candida] gla...
CCE79525      437 ILFLETVRYKINFYETF-------MDFLEGRFSSTg--FTELrNVYHNLRFVSTDVInYSIHNTEVYYTYALFFQYYGK- 506 
XP_001387408  361 IIRLKFIKYSTKIYQAW-------IGFLNGEFKDInylNEFMsDYNNRRFSDEEFCE-YSLLLPKTYYLFALYYHYKGD- 431 
Q6BID2        503 IIRLSFIRYYINYYQVW-------MNFLDKNFTNIdplNEFLeNYNNSKFSDEELCY-YKLLIPNIFYLFGIFFQYKGD- 573  Debaryomyces ...
CCE43614      979 ELKLRYYRYSVQYYRQW-------QLFLNGDSKIVy-lNEFM-NANNRLFTREEYTM-FKPIYTYVHYMFALYYHSRGD- 1047
EMG49796      494 SKKLKYLRVLIKYYQTI-------NNFVISKYTIDp-lNEFM-QSTHKEMDESDYII-IKGFYRMIYYCFAMYYHHNAD- 562 
EDK42881      782 ---IQAAKYHFvkVRNLTRDvcledekqalQQMRCGVGCe------------sFMPqgkfNELYLYSSLHL--VIlleYe 844 
Q6CNT3        423 elkLLSLLHLY--AITLAEI-----------SECDTGND--------------DLHtlttKANQLVSQLDL--LLntsVf 473  Kluyveromyces...
XP_003647107  428 --rLIAFMHCFilTISQLSQc---------NEEPDQFSR--------------LIQqannTWNQIIKNMEH--TP---M- 476 
XP_001646299  442 ---VEIRMISLlnSFIIKSSe---------GIKNEQSHQ--------------SVSdshnIWQQVEKLLEE--SD---L- 489 
Q6FQF3        426 ---AGDSSVHY--EVKLSSLlncyiilsslVSEDIDKAK--------------NISrcndVWMSIQSIFDN--CD---L- 480  [Candida] gla...
CCE79525      507 ---ISRSKYYY--LKILSEVlngksspkttLSFSKMASKge-----------tQNRkwlhSEIYGFSLINLksIIdfeI- 569 
XP_001387408  432 ---IQAAKYYYlkVKNLTSEfnsaansdvvSSNCSVVGLgn----------vaMVPksefSELYVFSSVHL--LVlvqFe 496 
Q6BID2        574 ---LKAAKYYYmrVRSFTLYe---------QEPSNTIEYssilqsslgvggetFQSkgqfSELYIYSTLHL--VM---L- 635  Debaryomyces ...
CCE43614     1048 ---LQAAKFYYlkVRNMTGIlydndasmslQQMTNGLGGd------------sIRPqgkfSDLNVYSTFHL--II---L- 1106
EMG49796      563 ---LQAAKYYYlkVIESNKAvnpryaaeqlSLGIPCES---------------ISPvgkfDELSVYANLNL--VI---L- 618 
EDK42881      845 VADIMRQGD-----KQLRTFCD-------KLIGLrnsiadeiela------kggskgkgkssDMF--------Q----AN 894 
Q6CNT3        474 SASTVWRST-----KLLLVIMG-------RFEPF----------------------------TKN-------------PQ 500  Kluyveromyces...
XP_003647107  477 VNNNTWLCT-----IATLWVLS-------KFEPF---------------------------------------SnhplPN 505 
XP_001646299  490 KENSIWECT-----LTILWVTT-------HFKPFt---------------------------DQP--------L----PC 518 
Q6FQF3        481 RDNSLWNVT-----ILMVWIIS-------HFEPF---------------------------------------TanplPS 509  [Candida] gla...
CCE79525      570 YRIPEDSRKvg--sSSLNRLLElkdivdnDLNSI----------------------------VMNnnsnlsnkFlsnfTN 619 
XP_001387408  497 LSQLMKQAP-----GQSTDAIN-------DCFKL----------------------------CNRlhnelngaF----GD 532 
Q6BID2        636 TEFEVYQITk----SSHTNIIN-------DRDDTyrfrshlyldltkifdqkdkktsnsfnmNLA--------G----SS 692  Debaryomyces ...
CCE43614     1107 LDYEVNEIMskeenDESKLAVE-------KLTAIennllddfaqv------nkppkngpfqcCFV--------I----NN 1161
EMG49796      619 LHFETDKLK-----QNTPSYLP-------DIKNQ----------------------------CLN--------N----LE 646 
EDK42881      895 FMMTNTLALMTT-------DLilcilQDTSNIIPSNELRKMLTAISHKSA----FYFIYF-----LITFALATEMVASVd 958 
Q6CNT3        501 ASNQNTLLLNEL-------EQy----FAGNSLLPADDL--PTSKAPVKIK----KSLLLH-----IWLNYIAGSMSINE- 557  Kluyveromyces...
XP_003647107  506 DNDEERQLYLKK-------LEn---yYTANSLLSSDQSAQPSSFKLK-------KCLLLH-----FLLNFLGGTIFVSD- 562 
XP_001646299  519 TDEERSHYLEK--------LRvyynsNKIQGLNDVEISVLKEEGKYLKLK----KGLLLR-----ILLNYLGCSLFEHD- 580 
Q6FQF3        510 TDEEKSSKLEAFk------------gYYQNNKYNVIDKKDAGMHNNLKVK----RGLLLH-----VLLNYIGARLFEQD- 567  [Candida] gla...
CCE79525      620 SYFSGTYHVLNQ-------IQa---yQQNDSLASLENRIFHGSDLKNHLAyvdnNEFVPS-----FLSALVKFTMYIISk 684 
XP_001387408  533 RSTSNSFTSNFAkcndllkMThsilvNISDEEQQNSTFLQELSQVYNKYE----LKVCFP-----FVFNVVKHLLFVSTt 603 
Q6BID2        693 QTLIITYNLLLS-------IYdnnysGSGKVNAESSEYPQILYDAMKGSN----SMHSFP-----YLISLIHYVTYLLSt 756  Debaryomyces ...
CCE43614     1162 RLLQMTLEIVMR-------MV---------HNLEPDFNVKNVMQMLGEIG----DRTTFY-----FIYFFLTYVLVLNIs 1216
EMG49796      647 EAFKQSETTTSNt------FNlnftsNSDILFVTYNFILKIVLSSGIDLNfqtkIEQLLSklgpkSSFAFLGIILMYVLn 720 
EDK42881      959 qetILHEGMRVLPPSQTkvieendenlqqsesspssvtttigtststststknnvganetssisqsfSKSETADSC--RV 1036
Q6CNT3        558 ---LDQRCVLSSTCFKLakq--------------------------------------------qylPYLRYLVGI--WN 588  Kluyveromyces...
XP_003647107  563 ---IQERCNLSASCFQMckq--------------------------------------------qhmPVIRYIGGI--WH 593 
XP_001646299  581 ---LESICKISEVCFNLskl--------------------------------------------qdmPVIRYIIGL--WH 611 
Q6FQF3        568 ---LEEMTKISERCFRManisiedasyskksskqprvgsln---ttdieeseldhptnmnvegnqgiWAIRYIMGL--WS 639  [Candida] gla...
CCE79525      685 tieEKMKWLEHSLAEVQ--------------------------------------------------INSASHNSLivHT 714 
XP_001387408  604 sleEKNKYLSEFLTLIS--------------------------------------------------IPAKTDFERivFT 633 
Q6BID2        757 slaDKELALKMCLSLVSm------------------------------------------------eNCSDNERIV--NL 786  Debaryomyces ...
CCE43614     1217 --sTSDKTRYIKRCLHMlpqpktevv--------------------------------etpvgkeqvSTSESVDSC--RV 1260
EMG49796      721 ---FKNQDHLSVFKDRL--------------------------------------------------KDEDTEDIC--KL 745 
EDK42881     1037 FLLRSIHVIMMQ-NGEHY 1053
Q6CNT3        589 LMNNTIAMNSKEvALTKA 606  Kluyveromyces lactis
XP_003647107  594 LINCTVAMKNKEvAVTRA 611 
XP_001646299  612 LISCTSAMKSKEvTITRA 629 
Q6FQF3        640 LMNYTVGMRQKEvIYTRN 657  [Candida] glabrata
CCE79525      715 FILSEYY-NLLLiRNELD 731 
XP_001387408  634 FILKSLLLH-FKsTGEND 650 
Q6BID2        787 FILKDYSLQLHE-EGDYD 803  Debaryomyces hansenii
CCE43614     1261 FLLRSLM-EVDEsNGLHT 1277
EMG49796      746 LISKGFMKHFKEv-GEHD 762 
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