Conserved Protein Domain Family
LicD

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pfam04991: LicD 
LicD family
The LICD family of proteins show high sequence similarity and are involved in phosphorylcholine metabolism. There is evidence to show that LicD2 mutants have a reduced ability to take up choline, have decreased ability to adhere to host cells and are less virulent. These proteins are part of the nucleotidyltransferase superfamily.
Statistics
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PSSM-Id: 428243
Aligned: 34 rows
Threshold Bit Score: 135.582
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
P36044        490 TKANGIISWLSHGTLYGYLYNGMAFPWDNDFDLQMPIKHLQLLSQ-YFNQs-----LIL----EDPRQgn---------g 550  Saccharomyces...
Q1G8I9         45 CQKYDIPWYLSGGSLLGAVRHQGYIPWDDDIDLMMYRKDFERLCE-VASQ------EFTe--pYFFQTeetdtg-sirgh 114  Lactobacillus...
Q03SH4         23 CHQLGLPYFLMGGSLLGAIRHQGFIPWDDDVDVGLLRADYDQLLA-AAPT-------HLadspYFLQTptsden-yglsy 93   Lactobacillus...
Q03GP1         22 CDKHDIKYMLIGGTLLGAIRHGGFIPWDDDVDLGMTRENYDEFAR-VAPVe-----FQNt--hYFMQTadtdpn-fafsy 92   Pediococcus p...
wustl:BD1384   43 AKENNIPYWIDGGSLIGIVRHKGFIPWDDDLDISLLKKDYLRLIKeISMYcemhndVAL----FYN-------------- 104 
Q832Q2         24 CRSNNLHYTLFYGTLIGVERHKGFIPWDDDIDIVMPRPDYELLIKiLKND-------SN----YQLLSfetrkh-frypf 91   Enterococcus ...
Q8CWR1         24 CKKHDIPYFLSYGTMLGAIRHKGMIPWDDDIDISLYREDYERLLK-IIEEe-----NHPr---YKVLSydtssw-yfhnf 93   Streptococcus...
jgi:HSM_0545   24 CAKNDIQYSLGGGTLIGAVRHKGFIPWDDDIDVYMHRDHYQKFVN-IWKS------ETHd--kYELSLaedihgmfpgem 94  
P14184         24 CERYKISYSLGGGTLIGAIRHKGFIPWDDDIDVYMHRDEYQRFVDvWFQE-------THeh-yNMETAedilaq-ytgem 94   Haemophilus i...
Q9CIZ2         24 CRENGIEYTLAGGSLIGAIRHGGYIPWDDDIDIELTRPHYDHLISvLMDQ-------LPn--eKYALLhykvre-tylpf 93   Lactococcus l...
P36044        551 RYFLDVSDSLTVRINGNGKnnidarfidvDTGLYIDITGLas--tsAP-SRDYLnsyieerlqeehldINNIPesngETA 627  Saccharomyces...
Q1G8I9        115 AQLRNSATTAILKSEEYFHyq-------fNQGIFIDIFPLd----nVP-DDPEErq----------afVKSVN----QLK 168  Lactobacillus...
Q03SH4         94 AKLLDRRTYIEEKRNVNNA----------RKGIFIDIFPLd----rIPqDTSAQ---------------QKQStkfqLLN 144  Lactobacillus...
Q03GP1         93 MKVLDTNTYIEEKNNVNDA----------HKGIFIDIFPFd----kVP-RQPEI--------------RQAVYnrfkIND 143  Pediococcus p...
wustl:BD1384  105 EPLVEHTCNFFASKKVFSRtqg----scvLVPVKIDIRPVncivknKD-N----------------------ViennI-- 155 
Q832Q2         92 AKLVDPNTVAHSKQYFGGEd--------kDLGVFVDIFPId----gIP-DTQKErn-----------eLRKITeqyrLNL 147  Enterococcus ...
Q8CWR1         94 ASILDTSTVIEDHVKYKRH----------DTSLFIDVFPId----rFT-DLSIVdk-----------sYKYVA----LRQ 143  Streptococcus...
jgi:HSM_0545   95 TKIFDKNTLIIDTKGR-------------KSGIFIDIFIYd----sVP-NAPAV--------------IYKVMkk-hRRL 141 
P14184         95 AKIFDCRTQITDAKGR-------------KSPMFMDIFIYd----gVP-NEPKI--------------IYPLMkk-hRRI 141  Haemophilus i...
Q9CIZ2         94 AKLYDTRTSFTSKIDNLNR----------GTGVFLDIFPMd----iLP-DNEEErq-----------vFKKEFlkkaIQL 147  Lactococcus l...
P36044        628 TLPDKvddglvnMATLNITELRDYITSDENKN-HKRVPTDTDLKDLLKKELEELPksk-tieNKLNPKQRYFLNEKLKLy 705  Saccharomyces...
Q1G8I9        169 HRARQfyn--ycNGYPNKNLSGLKQFLLYTKFfFEKKKSGGRNIYYDRFAKEITK-------YDDQATQEVMMVMLGT-- 237  Lactobacillus...
Q03SH4        145 TRILL--------QLRYHLVDNPLRKLQGPLS-SEQLTSVNALKAERQAVMTQYQaeitlpqVKNLSSQYAY-------- 207  Lactobacillus...
Q03GP1        144 AAILV--------RLGYNIIKTPFRKAPNEKP-LELFMSVAKLKERRENIMRLYDnep-fhhYKNYASQYAY-------- 205  Pediococcus p...
wustl:BD1384  156 --------------------YRDTANYIIFGK-SYGYMKKTLSHKNEQMDFLEYYnyk-yglVDSGLENVIMVHPYFEF- 212 
Q832Q2        148 MDTLGl-----sYARSFHLSKALIKLITRYPN-HFKVKKVGNNQYWRDLYQTEAKkt---pfGATKHCGYLEWIHIDWG- 217  Enterococcus ...
Q8CWR1        144 LAYIK--------KSRAVHGDSKLKDFLRLCS-WYALRFVNPRYFYKKIDQLVKN-------AVTNTPQYEGGVGIGKEg 207  Streptococcus...
jgi:HSM_0545  142 KLRF---------SSCRKRWYKANNESLIQSI-FFRLSQYLFNKMMLNLKQFQDK-------YPIDEAEYIGLVLSDYGg 204 
P14184        142 KLRF---------SSCKKRWLRAKENTVQKAI-LNKLSHFLFSKMQKNLAQFQIK-------YPIKQCDYIGLVLSDYGg 204  Haemophilus i...
Q9CIZ2        148 TASNPhg----lDFASSSKKIYFWGKLVLWMP-QHIRFYGKYRILAEKLDEFMQK-------YRNSDNQLISYLYTGY-- 213  Lactococcus l...
P36044        706 ncrNNH-FNSFEELSPLINTVFHGVPALIPHRHTYCLHNEYH 746  Saccharomyces cerevisiae S288C
Q1G8I9        238 ---EKC-CWKREYVANPVRVPFELLSLPIPKDYDPLLTKQYG 275  Lactobacillus delbrueckii subsp. bulgaricus ATCC 11...
Q03SH4        208 ---AKE-VFTVAELSDLTTVPFEHLQVQVPRNYATILTRMYG 245  Lactobacillus brevis ATCC 367
Q03GP1        206 ---DKE-VLSQSELIELTTHKFESIEVSIPKHYDRILKRMYG 243  Pediococcus pentosaceus ATCC 25745
wustl:BD1384  213 ---SNTfELTYNDLFPLKMLQFENMLLPVPNNYDYLLKELYG 251 
Q832Q2        218 -------VFPNEWFLEYEDVEFEGHKFMAIKNRKQFLTLRYG 252  Enterococcus faecalis
Q8CWR1        208 ---MKE-IFPVDTFKELILTEFEGRMLPVPKKYDQFLTQMYG 245  Streptococcus pneumoniae R6
jgi:HSM_0545  205 --wKKS-YMPKKYFNSVVYLDFEESKFPVMNGYHEHLTMYYG 243 
P14184        205 --wQKS-YMPKEYFNHVIYKEFEGRQFQVMNGYHEHLTQYYG 243  Haemophilus influenzae Rd KW20
Q9CIZ2        214 ---KKA-IFPKEIWEEYEDVKFEGLTARKLKNHEEYLTRQYG 251  Lactococcus lactis subsp. lactis
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