Conserved Protein Domain Family
XRCC3
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cd19491: XRCC3 
XRCC3 recombinase
XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.
Links
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Statistics
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PSSM-Id: 410899
Aligned: 31 rows
Threshold Bit Score: 203.677
Created: 16-May-2012
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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ATP binding
Feature 1:ATP binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                          ######                                      #              
NP_005423  89 LDALLRGGLplDGITELAGRSSAGKTQLALQLCLAvqfprq-----------hggleAGAVYICTEDAFPHKRLqqlmaq 157 human
CBN75722   83 LDAAFEGGVrvQGVTEIAGEAGAGKTQLCLQLLLQaqlape----------agglggKSYVLTCGEGDFPSRRLrqmast 152 Ectocarpus silicul...
NP_200554  28 LDGCLRGGIscDSLTEIVAESGCGKTQLCLQLSLCtqlpis-----------hgglnGSSLYLHSEFPFPFRRLhqlsht 96  thale cress
CCA21173   22 IDRLLHGGFrqGLLHEICGEASSGKTQLCLQLLLQmcl-----------------edEAACYVSTEGIGSIKRLhelagi 84  Albugo laibachii Nc14
XP_505243  98 IDTVMNGGFptGTLCEVAGESAAGKSHFLLQLCVNvqlarg-----------egglgKKAVFISTESGLETRRLvqmmdh 166 Yarrowia lipolytic...
EDV08283  107 MDELLGGGIftHGITEIFGESSTGKSQLLMQLALSvqlsep-----------agglgGKCVYITTEGDLPTQRLesmlss 175 Saccharomyces cere...
EIF47724   99 LDSCLNGGIpcGYLIEVSGSSSTGKSNLLMSLAATiqlpvefgglgksvfekekhqxVKTMYISTESSLSTRRLeqimny 178 Dekkera bruxellens...
EDK37692   96 LDQRLNGGAkvGDITEIFGASGTGKSQLLLQMSINsvkl---------------hesSKSVYISTESVIATSRLeemagr 160 Pichia guilliermon...
NP_593627  82 LDETLHGGIpvGQLTEICGESGSGKSQFCMQLCLMvqlpls-----------lggmnKAAVFISTESGLETKRLfelary 150 Schizosaccharomyce...
Q9UUL2     82 LDETLHGGIpvGQLTEICGESGSGKSQFCMQLCLMvqlpls-----------lggmnKAAVFISTESGLETKRLfelary 150 fission yeast

Feature 1                                                                        #            
NP_005423 158 qprlrtd---------vpgellqklrfgsQIFIEHVADvDTLLECVNKKVPVlls---rgMARLVVIDSVAAPfrcefds 225 human
CBN75722  153 yqsr---------------hgvkpeklmeGVCIQNAKTlDDQMMIIMEHLPHimr---sqNVKLVVIDSIAALfrsdmgr 214 Ectocarpus silicul...
NP_200554  97 fhqsnp-----------siyanyndnpcdHVFVQNVHSvDHLFDIMPRIDGFvgnsktrfPLKLIVLDSVAALfrsefdn 165 thale cress
CCA21173   85 yadrhafalkkrrrgftgdtqsgskffldRIFIEHIYEiDELIGLLQSRLPSllt---qkQVTLVVIDSIAALfrpestk 161 Albugo laibachii Nc14
XP_505243 167 vik-----------------lghdnislhHVSFIACKDlEQQDRVFQYNLPNlle---dsSYGLVVIDSLAAHyrseelt 226 Yarrowia lipolytic...
EDV08283  176 rpa-----------------yeklgitqsNIFTVSCNDlINQEHIINVQLPIller-skgSIKLVIIDSISHHlrvelqn 237 Saccharomyces cere...
EIF47724  179 yrdlmqgn-------giedpemlpsmenvLTTSFPIADlESQDRCLFYQIPAmle--rdpGIKLVVIDSITHHvraerrf 249 Dekkera bruxellens...
EDK37692  161 n---------------------aaphimeNIMSVYCSDlEHQDHILYTQLPAlld--lekNVHLVVIDSISHHlrrddhi 217 Pichia guilliermon...
NP_593627 151 lperypk---------adkkdiiiknpgdRVYTILCPDlESQEHIIQYQLPIlfn---rdKIGLVILDSVASNyraelry 218 Schizosaccharomyce...
Q9UUL2    151 lperypk---------adkkdiiiknpgdRVYTILCPDlESQEHIIQYQLPIlfn---rdKIGLVILDSVASNyraelry 218 fission yeast

Feature 1                                                                                 #   
NP_005423 226 q--------------------------------------------asaprarhLQSLGATLRELSSafQSPVLCINQVTE 261 human
CBN75722  215 gr------------------------------------------gdigersrlLGRLSQQMKRLGDrhGAAFVVVNQVTA 252 Ectocarpus silicul...
NP_200554 166 tp------------------------------------------sdlkkrsslFFKISGKLKQLASkfDLAIVITNQVTD 203 thale cress
CCA21173  162 si------------------------------------------qdvserarlMFQIANSIKILCGryNVVFIVTNQVSS 199 Albugo laibachii Nc14
XP_505243 227 sk------------------------------------------gdfssrdkrLLRTLHHLKGLARkhNVAVVFANQISA 264 Yarrowia lipolytic...
EDV08283  238 ksf-----------------------------------------resqenknyLDRMAEKLQILAHdySLSVVVANQVGD 276 Saccharomyces cere...
EIF47724  250 -----------------------------------------------wdrdtyITQTCTFLKQLSLkhGITXIVSNQMTD 282 Dekkera bruxellens...
EDK37692  218 sitsyletrireqeaklselgygadlkrkhdnqlgrffrfspryktsllratyISLLHHHLLQVAQkySIAIVIANQVSD 297 Pichia guilliermon...
NP_593627 219 nrsksh----------------------------------frdldniakrgnqLGKLAMTLRTLAHqhEAAVVIANQVSD 264 Schizosaccharomyce...
Q9UUL2    219 nrsksh----------------------------------frdldniakrgnqLGKLAMTLRTLAHqhEAAVVIANQVSD 264 fission yeast

Feature 1                                                                                     
NP_005423 262 ameeqgaahg---------------------------------------------------------------------- 271 human
CBN75722  253 rfgsstigggggrgq----------------------------------------------------------------- 267 Ectocarpus silicul...
NP_200554 204 lvetsdglsglrig------------------------------------------------------------------ 217 thale cress
CCA21173  200 ifepns-------------------------------------------------------------------------- 205 Albugo laibachii Nc14
XP_505243 265 lpgreltigaeflptllekqlpyfsgwkapvvshtqdgreklvpdat--------------------------pqdfmls 318 Yarrowia lipolytic...
EDV08283  277 kplanspvahrtyvtdydyqlgwlvgwknstilyrqmnsllgassnndeilsdde----------dymliervmstvndr 346 Saccharomyces cere...
EIF47724  283 kpptgifssrndvlykmnvdyqmswlvgwndlgviyrqlmirrrkkrpweiktgeeaaidsydgirypeeqadeneeatn 362 Dekkera bruxellens...
EDK37692  298 qpdfipqmdftadkscldldhqvgilagwdnnvvlnyqvdevpsdqt-------------------------tdysvtkh 352 Pichia guilliermon...
NP_593627 265 riprdydaiglfsldyq--------------------------------------------------------------- 281 Schizosaccharomyce...
Q9UUL2    265 riprdydaiglfsldyq--------------------------------------------------------------- 281 fission yeast

Feature 1                                                              #                      
NP_005423 272 -----------------------------plgfwdervsPALGITWANQLLVRLLADRlree------------------ 304 human
CBN75722  268 ------------------------gtmgvvggsggggsvPAMGLLWSQCINASPSSIPswdvtt---------------- 307 Ectocarpus silicul...
NP_200554 218 --------------------------nlrylyssgrrvvPSLGLAWANCVNSRFFISRsdgsivkdrse----------- 260 thale cress
CCA21173  206 ---------------------------------renrfkPALGLSWSNCIHQRLVLSRd--------------------- 231 Albugo laibachii Nc14
XP_505243 319 ssesdnhpsgspmlsqlssqhslpsfssqqplfpvgskvPTLGQVLANSVDIRVVLKH---------------------- 376 Yarrowia lipolytic...
EDV08283  347 nydffskkkppiienktvernssspisrqskkrkfdyrvPNLGLTWSNHVSTRILLQKsfkastiiqrge---------- 416 Saccharomyces cere...
EIF47724  363 edvdsangtsisvkeqlrsekkqlfeskyktevshirtiPALGMPLLNVIDCRIMLRKrs-------------------- 422 Dekkera bruxellens...
EDK37692  353 gyssnkrqkvdgglfssphvqkpittrhtepqvrtkrqvPALGYQWIKSIQVRILLMKsykeakvitsemdssesvnrge 432 Pichia guilliermon...
NP_593627 282 -----------------------sqwfsgwddtdpnpkiPSLGLVWTNNISTRLALIKktd------------------- 319 Schizosaccharomyce...
Q9UUL2    282 -----------------------sqwfsgwddtdpnpkiPSLGLVWTNNISTRLALIKktd------------------- 319 fission yeast

Feature 1                                                    
NP_005423 305 --------------------------eaalGCPARTLRVLSAPHLPP 325 human
CBN75722  308 ------------------------ldgnlaFASFATCCTVPSVSYFY 330 Ectocarpus siliculosus
NP_200554 261 --------------------kdencsssvsRSAKRRLDIVFSPYLPG 287 thale cress
CCA21173  232 -----------------------------aDTEERHVKVAFSPYIPQ 249 Albugo laibachii Nc14
XP_505243 377 ------------------------------TDSHRTFEVVFSNPYKF 393 Yarrowia lipolytica CLIB122
EDV08283  417 ------------------ahlykggdsasfWQVKRTMKVVYSTFAKP 445 Saccharomyces cerevisiae RM11-1a
EIF47724  423 -----------------------------iPILNEDLIDEFSVDLGI 440 Dekkera bruxellensis AWRI1499
EDK37692  433 ihvagtdmkdtrddymflesaktssgssnkSWMVERFAKIVSNDCFS 479 Pichia guilliermondii ATCC 6260
NP_593627 320 ---------------------------satNNSGRIFRVVYSPNSPR 339 Schizosaccharomyces pombe
Q9UUL2    320 ---------------------------satNNSGRIFRVVYSPNSPR 339 fission yeast

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