1WOU,1V9W


Conserved Protein Domain Family
TRP14_like
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cd02952: TRP14_like 
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Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a 14kD cytosolic protein that shows disulfide reductase activity in vitro with a different substrate specificity compared with another human cytosolic protein, TRX1. TRP14 catalyzes the reduction of small disulfide-containing peptides but does not reduce disulfides of ribonucleotide reductase, peroxiredoxin and methionine sulfoxide reductase, which are TRX1 substrates. TRP14 also plays a role in tumor necrosis factor (TNF)-alpha signaling pathways, distinct from that of TRX1. Its depletion promoted TNF-alpha induced activation of c-Jun N-terminal kinase and mitogen-activated protein kinases.
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Statistics
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PSSM-Id: 239250
Aligned: 11 rows
Threshold Bit Score: 136.321
Created: 22-Aug-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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catalytic
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic residues [active site]
Evidence:
  • Comment:TRP14 shows disulfide reductase activity and can derive reducing equivalents from TRX reductase 1.
  • Comment:CXXC motif
  • Comment:Disulfide bond reduction by thioredoxin is initiated by deprotonation of the solvent-exposed N-terminal cysteine in the CXXC motif to form a thiolate. The pKa of this thiol must be near physiological pH to achieve maximal catalysis.
  • Citation:PMID 9099998
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                        #  #                              
1WOU_A                           4 YEEVSVSGf---EEFHRAVEQHNg---KTIFAYFTGSKda-gGKSWCPDCVQAEPVVREGLKHIs---eGCVFIYCQVGE 73  human...
1V9W_A                          11 FEEVSVLGf---EEFDKAVKEHEs---KTIFAYFSGSKdt-eGKSWCPDCVEAEPVIREGLKHVt---eDCVFIYCQVGD 80  house mouse...
CAA23057                         2 PEYVPARGfkemENLIKLYENQR----SPIYIYFYGEKdk-dGRSWCPDCVAAEETIMSAFRNHap--aDCMILVVDVGS 74  fruit fly...
REF_WormBase:CE27323_Y71H2AR.1   5 KHYTAQGY----EAFQETLKSIGk--gKRVVALFTGSKilttGESWCPDCVVAEPVVEEVIKDAavaglDVHFVTVFVGN 78  Caenorhabditis elegans...
AAM64350                         5 KLDANPSTl---ESILQELKSDEtnrsKINFILFLADNdpttGQSWCPDCVRAEPVIYKTLEEFp---eEVNLIRAYAGD 78  thale cress...
AAN03825                         2 VVTHNVKGy---DEFTKKMEELEng-dEPVHVLFSGGKde-kGESWCPYCVKAEPVIHDALKKAp---gNSHFVHVDVGE 73  fruit fly...
EAL18807                         2 PLQTAPYP----HVFNALNGPTAp---AVSYIVFYSNIv--dGQMWCPDCRAVENVVKETFDAPd----KPNAAIFWVGN 68  Cryptococcus neoformans var. neoformans B-3501A...
XP_415925                        3 WEEKQVRGy--sEFVQTAQRYHG----RPIFALFCGDKda-eGRSWCPDCVTAEPVVRKELHNMp---dESVFIYCLVGD 72  chicken...
NP_001003456                     4 YEEVAVHGy---EEFCKAVSDRKg---KEIFAYFSGDKde-hGKSWCPDCVKAEPVVRAELPHLp---eGTVFIYCQVGD 73  zebrafish...
AAW26135                         2 SLSTSIRNi---DELLAEVKKHEg---KRIFILFCGTPfp-dGTNWCPDCVKGEPIVKEALKKLp---eNAVFLKAEVGD 71  Schistosoma japonicum...
XP_787642                        2 VLQEKTEGl---DNFLQLLEKHKe--kKTIIALFCGGKnssdGVSWCPDCVSAEPIIEKGLAAAap--eDAVFIYCSVGD 74  Strongylocentrotus purpuratus...

Feature 1                                                                               
1WOU_A                          74 KPYWKDPNNDFRKNLKVt--AVPTLLKY---GTPQKLVESEclQANLVEMLFS 121 human
1V9W_A                          81 KPYWKDPNNDFRQKLKIt--AVPTLLKY---GTPQKLVESEccQSSLVEMIFS 128 house mouse
CAA23057                        75 RESWIGKDNMFRKPPYSv-eGIPTLIRW---KGVERLDGDQllKSSLLELFFE 123 fruit fly
REF_WormBase:CE27323_Y71H2AR.1  79 REVWRDPAVGFRTDPTLkltCIPTLLEVg--NKAKRLLERQiaNKHLVKDFFT 129 Caenorhabditis elegans
AAM64350                        79 RPTWRTPAHPWRVDSRFkltGVPTLVRWd-gDSVKGRLEDH--QAHLPHLILP 128 thale cress
AAN03825                        74 RAYWKDLNCPFRKDPNThliFLPTLLRW---KRPQRLDGERcsNQDLVEMMFE 123 fruit fly
EAL18807                        69 RQEWRTPNNQARTQWNVn--SIPTILRLengKETGRLVEDEilDKARLQAFLK 119 Cryptococcus neoformans ...
XP_415925                       73 RAYWKDPNNEFRKNLKLt--GVPTLLKY---GTPQKLVEEEcfKADLVRMLFT 120 chicken
NP_001003456                    74 RPYWKDSNNDFKKTLKLt--GVPTLLRY---GTPQKLVEEEcfKADLVRMMFT 121 zebrafish
AAW26135                        72 RTTWRDPNNVFRTHPKCqisSIPSLIEF---NTMRRLSDKEvlQPSLVELMFE 121 Schistosoma japonicum
XP_787642                       75 RTSWKDPNNAYRTHPKLqlkGVPTLLQW---DTPKKLGEKDcsNADLVQMFFE 124 Strongylocentrotus purpu...

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