Conserved Protein Domain Family
CHZ
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smart01082: CHZ 
Histone chaperone domain CHZ
This domain is highly conserved from yeasts to humans and is part of the chaperone protein HIRIP3 in vertebrates which interacts with the H3.3 chaperone HIRA, implicated in histone replacement during transcription. N- and C- termini of Chz family members are relatively divergent but do contain similar acidic stretches rich in Glu/Asp residues, characteristic of all histone chaperones.
Links
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Statistics
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PSSM-Id: 198150
Aligned: 13 rows
Threshold Bit Score: 29.3011
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EGA75307      93 EEEEDDLAEIDTSNIITSGRrtRGKVIDYKKTA-EELDK 130 Saccharomyces cerevisiae AWRI796
NP_175099    380 KNISRELEGIDTNNIVWNSR--RRSSTSFAPPP-KPKVT 415 thale cress
XP_003360801 487 REEAAEVASLDVTNIISGSGrpRRRTA-WNPSGdAAPPG 524 pig
EDL17467     469 REEAAEVAALDVANIISSTGrpRRRNA-WNPSG-EGTSP 505 house mouse
NP_192571    410 KERTKELEGIDTSNIVSSSR--RRSSASFVPPP-KPIKA 445 thale cress
NP_003600    484 REEAAEVASLDVANIISGSGrpRRRTA-WNPLG-EAAPP 520 human
NP_956117    429 REEAQELAELDMSNIITTQGrpKRR-AA-AAVW-PPAQN 464 zebrafish
XP_757741     99 IEDEEELAEIDTSNIVWTGRr-RNAPLDYSSEE-ALKQA 135 Ustilago maydis 521
NP_593688     58 DEEPEDYSAIDPTNIMC-STrtRRKKIDFTKVL-EEGQN 94  Schizosaccharomyces pombe 972h-
XP_381612     57 EADEDGLEEIDLNNIVE-GRrtRGAQIDFAKAA-EQHPA 93  Gibberella zeae PH-1
EGO56531      58 EAEEDNLEEIDPSNVIS-GPrtRQKEIDYAKAA-QDLPA 94  Neurospora tetrasperma FGSC 2508
XP_001385568  89 EDVEDDLAEIDTANIITTGRrtRRKVIDFAKAA-KELDA 126 Pichia stipitis CBS 6054
XP_750489     61 DDDHDNLEPISEANIISGGRrtRGKTIDFQEAA-EKLKA 98  Aspergillus fumigatus Af293
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