1YE8


Conserved Protein Domain Family
NTPase_1
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pfam03266: NTPase_1 
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NTPase
This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme. The sequence carries both a Walker A and Walker B motif which together are characteriztic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue.
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Statistics
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PSSM-Id: 460869
Aligned: 28 rows
Threshold Bit Score: 180.13
Created: 21-Mar-2022
Updated: 13-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1YE8_A         2 KIIITGEPGVGKTTLVKKIVERL---GKRAIGFWTEEVRdpETKKRTGFRIITt-EGKKKIFSSKFf-----TSKKLVGS 72 
Q9HJH0         7 KIGITGPVGSIKSEALQKIIDMLkndNLNVQGVLVSKVT--NNGKLTGYTIEDieSKRKAQFCFDNf-----VSRVKIDK 79  Thermoplasma ac...
Q9VP84         8 TIILTGPPGVGKTTLVHKICSALqdrGRILQGFYTEEMRgeGTSQRIGFDVVTl-AGKRAILSRKNpg--dqLRRPKVGE 84  fruit fly
XP_001626430   7 HVLLTGPPGIGKTTLCSKVKQALasrGVPTQGFYTEEIRgpGGGARVGFDVVTl-DGGRGPLARVKttg-skQRGPSVGS 84 
XP_021336237  19 HVFLTGVPGVGKTTLVKKVCDTLs--GLSVSGFYTEEVR--EHGRRVGFDVVTv-SGDRGRLSRVSsgsaagGREYRVGQ 93 
ALO23619       4 HVFLTGPPGIGKTTLIQKVTQALkssDVPIDGFYTEEVK--EGGRRRGFDVVTl-SGKRGPLSRVSsdsstsRRECRVGQ 80 
Q9CQA9         4 HVFLTGPPGVGKTTLIQKAIEVLqssGLPVDGFYTQEVR--QEGKRIGFDVVTl-SGAQGPLSRVGsqplpgKPECRVGQ 80  house mouse
Q9WXP3         2 KILITGRPGVGKTTLIKKLSRLLq----NAGGFYTEEMR--EGEKRIGFKIITl-DGEEGILARTDl-----PSPYRVGK 69  Thermotoga mari...
O67322         2 KIIITGEPGVGKTTLVKKIVERL---GKRAIGFWTEEVRdpETKKRTGFRIITt-EGKKKIFSSKFf-----TSKKLVGS 72  Aquifex aeolicu...
Q5TDF0         4 HVFLTGPPGVGKTTLIHKASEVLkssGVPVDGFYTEEVR--QGGRRIGFDVVTl-SGTRGPLSRVGlepppgKRECRVGQ 80  human

1YE8_A        73 YGVNVQYFEELAIPILERAYr--EAKkdrrkVIIIDEIGKXELFSKKFRDLVRQIXhD-PNVNVVATIPIRD--VHPLVK 147
Q9HJH0        80 LGVDTKILEEILIPSLQKARe--TAD-----VIVIDEIGKLENTTKKVHAEIEETL-K-CGKPLIVTLHKRS--RNPVLQ 148 Thermoplasma ac...
Q9VP84        85 YSVFVQDFDSLALPVLGTQDsqpEPD-----LLVVDEVGKMELLSKRFESAMADLL-K-KKRALLVTIPEKS--TLALVE 155 fruit fly
XP_001626430  85 YLVDIQSFEQLALPAITKTv---GSG-----IIIIDEIGKMELFSQTFSRAIQDLF-DgGHSPILATVPIARqkPIHLVE 155
XP_021336237  94 YVVDLQSFESLALPLFRNMQegsGKQ-----LFVMDEVGKMELFSQPFIRAVRQIL-EkSCCSVLGTIPVPKgkPLALVE 167
ALO23619      81 YVVDVVSFEQLVLPVLRNVNq--GSDaa-kkICVIDEIGKMELFSQAFIQAVRQML-AgSGTVVLGTIPIPKgkPLDLVE 156
Q9CQA9        81 YVVNLDSFEQLALPVLRNAGs--SCGpk-hrVCIIDEIGKMELFSQPFIQAVRQML-StPGIIVVGTIPVPKgkPLALVE 156 house mouse
Q9WXP3        70 YYVNLKDLEEIGVRSLERAFq--EKD-----LIIVDEIGKMELLSRKFREVVEKIF-D-SEKDVIATIKKS---SDPFVE 137 Thermotoga mari...
O67322        73 YGVNVQYFEELAIPILERAYreaKKDrr--kVIIIDEIGKMELFSKKFRDLVRQIM-HdPNVNVVATIPIRD--VHPLVK 147 Aquifex aeolicu...
Q5TDF0        81 YVVDLTSFEQLALPVLRNADcssGPGq---rVCVIDEIGKMELFSQLFIQAVRQTL-StPGTIILGTIPVPKgkPLALVE 156 human

1YE8_A       148 EIRRLpgAVLIE----LTPEN-----------------RDVILEDIL 173
Q9HJH0       149 EIKSLegVRVFD----ITPIN-----------------KNILPFKVM 174 Thermoplasma acidophilum DSM 1728
Q9VP84       156 QLRKSagSKIYQ----VTKFN-----------------RNALAGEIT 181 fruit fly
XP_001626430 156 QLKQRsdVTLLE----VSKCN-----------------RNTLQDKVV 181
XP_021336237 168 ELRSRadVKIFM----VTKEN-----------------RDVIFDDIV 193
ALO23619     157 EIRSRkdVEVFT----VSKEN-----------------RNNILQDIL 182
Q9CQA9       157 EIRKRrdVKVFN----VTRDN-----------------RNSLLPDIv 182 house mouse
Q9WXP3       138 KIKNRndVVIFE----LNEKN-----------------RNSLLNEIL 163 Thermotoga maritima MSB8
O67322       148 EIRRLpgAVLIE----LTPEN-----------------RDVILEDIL 173 Aquifex aeolicus VF5
Q5TDF0       157 EIRNRkdVKVFNspycVIEDQskfsscvsqstltepgwRQKLLQSLL 203 human
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