Conserved Protein Domain Family
RNA_pol_3_Rpc31

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pfam11705: RNA_pol_3_Rpc31 
DNA-directed RNA polymerase III subunit Rpc31
RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.
Statistics
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PSSM-Id: 463324
Aligned: 89 rows
Threshold Bit Score: 36.1939
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ERT01182      22 APWS-DD--LTm--kADSR---PVELFPAY-SAPMAAPLTQQECQAVDYFLLVREQTHSTPL-YTQTRtwkslegagsgg 91 
XP_011405594  17 EGLGvPP--GErippPSLE---PSPLFPPLdKRPLDLTDNELYVELLGKKSSLRVAMQDSVF-YLRKSqrd--------- 81 
NP_001102938  14 FNIEaVG--FSrgekLPDVvlkPPPLFPDTdYKPVPLKTGEDEDYMLALKQELRETVKRLPY-FIETPee---------- 80 
2_pfamImport   1 FNIDaLG--IGrgnmPEARv-gPSPLFPSTdFKPVPLKAGEDEDYMLALKQEMRGTMQRLPY------------------ 59 
4_pfamImport   1 FNVEaLG--IGrgsmPESNvtrKKPTFQNTdFKAVPLKAGEDEDYMLALKQEMRGTMQRLPH-HIKHLsn---------- 67 
7_pfamImport   1 FNVEaLG--IQqgeaLPGPvlqPPPSYPALeTVTAPIYPSLKFGETLQYKKDFLNFYTRLRVdYEEVAts---------- 68 
XP_001984653  16 EQMQaLGcvGKdmpqVQSA---PPPTFPPVlNKPITLETTASQNYQLLWKEDFLNRMRDSPY-YIISAsqe--------- 82 
ETN67765      16 EQLQsLGvtSKeiqtVTSAa--PPPVFPVLlSKPVSLESSVDRNYKILWKEDFISYLRESAY-FTTKKcs---------- 82 
Q16WK0        16 EQLQsMGvtRNemqaVSSAa--PPPLYPILqSKPVPLESNADRDYKILWKEDFISYLRESPY-YTTVKss---------- 82  yellow fever mo...
XP_007253929  13 FNIEaLG--LNrgsmPETQr-gPRPMFPEVeFKPVPLKAGEAEDYMLALKQEIRGKMKGLPF------------------ 71  Mexican tetra
ERT01182      92 pggggasgkaygqdqinrqygvrnKATVDPF-TS----VPMYSHRFQ-TTERALP-DLS--GRPFSKALFPP-ELWPTL- 160
XP_011405594  82 ------------------------------heLN----IVRYSDKYKtKDETDIMeILA--STPSWQQRLPK-ELHPKT- 123
NP_001102938  81 ------------------------------kqDD----IERYSKRYM-KVYKE---EWEpdWRRLPREMMPR-KKCKKA- 120
2_pfamImport  60 --------------------------------------------------------NIK-----------PQ-------- 64 
4_pfamImport  68 ----------------------------ksVeTE----VERYTERYL-KQKLMEDkDWSpeWSLLPKELMPQkKKTCTK- 113
7_pfamImport  69 ----------------------gnKRRFDS--TS----ISATQNK---KERPQLN---------YEWTRFPV-ELRP--- 104
XP_001984653  83 -----------------------------kqkSS----VKDWREKAL-ERLKNKA------EPEFNYKAMPR-EVNTTS- 120
ETN67765      83 -------------------------------klS----VQRYSDKVI-NVIENDPkTKH--DGDFLWSCMPA-ELMPNF- 122
Q16WK0        83 -------------------------------kGP----VQRYSDKVI-NVIENDPkRKC--EGDFLWSIMPA-ELKPTFk 123 yellow fever mo...
XP_007253929  72 --------------------------NIKP--RSsknnVEKYKEKYV-KEYSKIC-DEE--WTPd-WNRLPK-ELMPQK- 116 Mexican tetra
ERT01182     161 -DGNDDgrlgkgGAGAKNM-RDRv------lALSDVTSLRTAEDifqtkkaeDSADGESGTHKALEQLEKFKNVGLDNED 232
XP_011405594 124 ------------KRTIKKA-QRHkkalkptsGTQFGTSKLNIAD------------TTSPPLGDTITVGSIDLINIRAGY 178
NP_001102938 121 -DPKSKa-----AKATSKG-TT---------LMNSTDVLKKIEE-----------LERRGE--GERSDEENDEKEGSKEK 171
2_pfamImport  65 -------------------------------------SNKAGEE-------------------GGELANKDDPEKSDEET 88 
4_pfamImport 114 ------------PGSKKKT-VKIs-------GKDAADMLNKLDN-------------NLLLTLFQNLAKKDEGNPEKSDD 160
7_pfamImport 105 ------------GTTKRPK-KIP---------KVKIKAMADIDKm-------LAQLEQKENAMFNADESVVKVEKPQDED 155
XP_001984653 121 --------------RKRRA-AEP--------RPKLVAKKTNIED-----------------RLKQLEQKELKSSGDNEND 160
ETN67765     123 ----------------KRA-KQMn-------AASKPKRPRTVED-------------IDATLQALEQKENTAAKAEGAKK 165
Q16WK0       124 rTKSAAn-----GASKGAK-KSK--------VVDINAKLSELEQ-------------------KESFLDDTDVKKEKASD 170 yellow fever mo...
XP_007253929 117 ------------KKIIRKTdSKK------------SKSLSSNDK--------------EVLLSKLDELEKKGDDKSDEEK 158 Mexican tetra
ERT01182     233 N-VEFDLVEDEGDYD---EVEDEEY-DDDEEGDYNAEAAFDNGDD 272
XP_011405594 179 T----EGEEEVGEEE---EEEVYDEeEEEEQGDYQL-SYFDPGGD 215
NP_001102938 172 E----KDEEEDGEEDa--EQEEYDEeEQEEENDY-INSYFDNGDD 209
2_pfamImport  89 E----KKPRNEDEEEi--EEEEYEEeDIEEENDY-IESYFDNGED 126
4_pfamImport 161 EtEKKTGNAEEDEED---IEEDIEEeDVEEENDY-IDSYFDNGED 201
7_pfamImport 156 N----EDEEGMGEEE---VEHDSDq-EMDEGTDYNS-NYFDNGES 191
XP_001984653 161 E--VKQESDSEHEDEpedPEAALDD-EMDEENDY-ANDYFDNGEA 201
ETN67765     166 E---KSETDDENEED---LEEEIVDeEMDDDNDY-GNNYFDNGEA 203
Q16WK0       171 S----EDEKDDEEQE-----EEVADeEMDDENDY-GNNYFDNGEG 205 yellow fever mosquito
XP_007253929 159 EeSGKKKAGEEDEEEv--EGEEFDEeLEE-ENDY-IASYFEDGDD 199 Mexican tetra
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