3NMN,3QN1


Conserved Protein Domain Family
PP2Cc
?
smart00332: PP2Cc 
Click on image for an interactive view with Cn3D
Serine/threonine phosphatases, family 2C, catalytic domain
The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.
Links
?
Statistics
?
PSSM-Id: 214625
Aligned: 85 rows
Threshold Bit Score: 34.2729
Created: 13-Jul-2011
Updated: 16-Jan-2013
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
3NMN_B         4 SLFEFKSVPLYGF--TSICGRRPEMEDAVSTIPRF------L--------QSssgsmldgrfdpqsaAHFFGVYDG---- 63  thale cress
O25181         6 AFGASIRGVYHAY-------ARLPNQDAFLIRKN----------------QK---------------GLLLVLCDG---- 43  Helicobacter py...
T16245       223 SVSLYEKNPISGV------NAGEPIADVWGVVGR----------------NN---------------NGVMALADGv--- 262 nematode
NP_388355      7 NEHIQTLVYQLNK------EGKSICGDSFFMKAD----------------DK---------------ELICAVADG---- 45  Bacillus subtil...
AAC84035     574 TDCHSTAACYFGL----FPAQPYRLNVAVAQTPRygsavagdstgywdgpGG---------------RKVVALSDG---- 630 Heliobacillus m...
XP_640588    389 FYARTISTYPHLP------NHPKREGDPICDHFCvq------------iqAS---------------RIIAAVADGcnwg 435 Dictyostelium d...
AAB68888     100 PKDRDDLIYQKLK--DSI--RSPTGEDNYFVTSNn---------------VH---------------DIFAGVADGvgg- 144 baker's yeast
YP_003560636 327 NLSKLVPGTSENM--LEQQQYVRKIRDVTANRVEQ------FsnvfqalsKS---------------FTQNGFYDEkpsa 383 Bacillus megate...
NP_109935      2 DSTNQNLFASLSK----KGPVRKENQDFSVVTFNR------Fg------------------------qLMSLVCDGlg-- 45  Mycoplasma pneu...
NP_072770      1 ---mQAANDHFFTglSKKGPVRKENQDFYGFSFNQ------Nn-------------------------LLIVVCDGlg-- 44  Mycoplasma geni...

3NMN_B        64 ---------HG--GSQVANYCRERMH--LALAEEIAKEKPMLcdgd-------twlEKWKKALFNSFLRVDSEIESVAp- 122 thale cress
O25181        44 ---------LG--SKKDSQIGAKKLC--ESVEKALNAIDIQ---------------GCNLALLNKVIFSIWECLLYPLev 95  Helicobacter py...
T16245       263 --------nWGegARLAARCAIRGAI--DHLNTRVIKDSLadttkssamifgdfnlEEVFHEMLAAFHSAHSLIlq---- 328 nematode
NP_388355     46 ---------LG--SGSLANESSAAIK--DLVENYa--------------------sEDVESIIERCNQAMKNKR------ 86  Bacillus subtil...
AAC84035     631 ---------SGv-GPRAARESASTLSmlEHLCRVGIFP---------------------GEALHSVNSLVALATEE---- 675 Heliobacillus m...
XP_640588    436 -----srpaEA--ATRASISFVDFMS--KALSSEIQTVQD------------------AGNHILSAFNYAHNRIVEGKsd 488 Dictyostelium d...
AAB68888     145 ------waeHGydSSAISRELCKKMD--EISTALAENSSKETl-------------lTPKKIIGAAYAKIRDEKVVK--- 200 baker's yeast
YP_003560636 384 dkevdyflsSV--TERTCQFCFKKEQ--CWAQQFDT----------------------TYEYMKEIMLEVDNGTLEQNpr 437 Bacillus megate...
NP_109935     46 -------gyKG--GKMASALVSEVFT--KSFTVFDFHSQ-------------------TERAVKQWFEITLIEARRTLeq 95  Mycoplasma pneu...
NP_072770     45 -------gyKG--GKIASNLVGKLFL--SLFEGFEFNQWDETtv-----------kKWFENTLIQARFQLENCFQTVYea 102 Mycoplasma geni...

3NMN_B       123 ---------------------------------------------ETVGSTSVVAVVFPSH------------------- 138 thale cress
O25181        96 r---------------------------------------------nalSTLQLVFIGKEK------------------- 111 Helicobacter py...
T16245       329 --------------------------------------------eGGMLTTLCVALVAPVRrgn---------------- 348 nematode
NP_388355     87 ------------------------------------------------GATASILKINFEQr------------------ 100 Bacillus subtil...
AAC84035     676 ----------------------------------------------ESFATVDMAVIDVSTa------------------ 691 Heliobacillus m...
XP_640588    489 i-------------------------------------------weAGTTTLLGGVLVELQqseaskpepssqlgrsgvn 525 Dictyostelium d...
AAB68888     201 ----------------------------------------------VGGTTAIVAHFPSNGk------------------ 216 baker's yeast
YP_003560636 438 liremdkhcvkskkvidvieheltyfkanqhlkaqiqesrrivaeQLHGVSEVMGNFAKEIkrerenlnvqeeqilealr 517 Bacillus megate...
NP_109935     96 yfqti---------------------------------krnqvqfARMATTLVLSIISKQN------------------- 123 Mycoplasma pneu...
NP_072770    103 q-----------------------------------------iqfARMASTLVLGILTKSD------------------- 122 Mycoplasma geni...

3NMN_B       139 -------------------------------------------IFVANCGDSRAVLCRGKTa--LPLSVDHKP------D 167 thale cress
O25181       112 -------------------------------------------AFIGKVGDGLLAVLGKe----HRLLREDKQd------ 138 Helicobacter py...
T16245       349 ----------------------------------------gwaLCVCNVGDSLCFVYNrhy-gvREVTLGSHDi------ 381 nematode
NP_388355    101 ------------------------------------------qFTYCSVGNVRFILHSp-----SGESFYPLPi------ 127 Bacillus subtil...
AAC84035     692 ------------------------------------------eAEIFKLGASPSYLKRGQr---VQIVQNSSLp------ 720 Heliobacillus m...
XP_640588    526 kpviganfanltgsgivsnglsasvnnagsivkdinappskwgFICASVGDCKAFHYSASSkkfTDITKNNRGnv---dD 602 Dictyostelium d...
AAB68888     217 -------------------------------------------LEVANLGDSWCGVFRDSKl--VFQTKFQTVg------ 245 baker's yeast
YP_003560636 518 nfgmeinqieiyslepgnvdiemwvpychgrgecekiiapmltdilgesivvkneecakypqgychvsfgctkayvvdtg 597 Bacillus megate...
NP_109935    124 -------------------------------------------IWTFWVGDSRAYLINSYQs--LQITEDHNL------- 151 Mycoplasma pneu...
NP_072770    123 -------------------------------------------IYIFWIGDSRAYLLFENQa--KLVTKDHNLynqlvaM 157 Mycoplasma geni...

3NMN_B       168 REDEAARIEAAGG--KVIQWngaRVFGVLAMSRSIGDRYLKPSIIPDPEVTAVKR--VKEDDCLILASDGVWDVMTDEEA 243 thale cress
O25181       139 --------------lVHFTTp--FDRN-TLLTWEVL---------ERKKI-----------DALFLCTDGLDESLIDARR 181 Helicobacter py...
T16245       382 ----------------------dQMRDMRDAGGALGPVDGRn---PQLHNLTCSMtfVEEGDVVFITSDGVSDNFDPVVG 436 nematode
NP_388355    128 ---------------------------sGYLSGKP---------QKYKTHTAt----YEKGSKFIIHTDGLNVPDIRSHL 167 Bacillus subtil...
AAC84035     721 ----------------------------LGILKNLEvesi--------------nlsLLPGDRLILVSDGIFDARRELNS 758 Heliobacillus m...
XP_640588    603 PKDPGGRLGP-------------YVANGQPDLRNLCLHFLp----------------CNENDIIVLISDGVHDNLDPQTV 653 Dictyostelium d...
AAB68888     246 ---------------FNAPYq-lSIIPEEMLKEAERRGS--KYILNTPRDADEYSfqLKKKDIIILATDGVTDNIATDDI 307 baker's yeast
YP_003560636 598 vahaakgggfvsgdsysmielnagkyalaisdgmgngerahyessetlqllkqilqtgieetiaiksinsilslrtndei 677 Bacillus megate...
NP_109935    152 ----YNQLLQMHAtpDVIAS---YKDKLLALTATVSKDQERql----kYSFRCDV--VNAWDFLLLCSDGLYNFLDPNCF 218 Mycoplasma pneu...
NP_072770    158 NADEKLLLSY-------------SNQL-LALTNTISKETKRPLVYGFYNTKIEQQ------EFLLLCSDGLYNFVEKELF 217 Mycoplasma geni...

3NMN_B       244 CEMARKRIllwhkknavagdaslladerrkegkdpaAMSAAEYLSKLAIQR---------GSKDNISVVVV 305 thale cress
O25181       182 LDFVKDIIsef-----------------------khkKKASKKCYVLLKNH---------KFYDDTSLIIA 220 Helicobacter pylori
T16245       437 KFCVIK-------------------------------KSEHENKENAHLPP-----------REDRTLDVT 465 nematode
NP_388355    168 ------------------------------------KKGQSVEEISNSLKmy------ttSRKDDLTYILG 196 Bacillus subtilis subsp....
AAC84035     759 QDWLIPlleql---------------------tlddAKELAQRILQEALQhn------dgKAKDDATVVVI 802 Heliobacillus mobilis
XP_640588    654 GWTPRDlqlnye------------------nwsdmePDKALEAKTKYTQEFlkkklrthdQEQDPITAKFI 706 Dictyostelium discoideum...
AAB68888     308 ELFLKDNAartndelqllsqkf-vdnvvslskdpnyPSVFAQEISKLTGKNys------gGKEDDITVVVV 371 baker's yeast
YP_003560636 678 fstldlamidlqdanvnflkigstpsfikrgdkvikiqasnlpmgiieefevdvvneqmkaedllimmsdg 748 Bacillus megaterium QM B...
NP_109935    219 YEVITSap---------------------------nLKKAVTQLAKLSLDN---------ASNDNITLNLI 253 Mycoplasma pneumoniae M129
NP_072770    218 FEIITNSKn---------------------------LKQAVFNLYRKSIEN---------ASNDNITAALV 252 Mycoplasma genitalium G37
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap