4EOZ,1CS3,2Z8H,3M8V,3B84,3LBZ,5DAD,6I2M,4U77


Conserved Protein Domain Family
BTB

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pfam00651: BTB 
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BTB/POZ domain
The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Statistics
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PSSM-Id: 395526
Aligned: 83 rows
Threshold Bit Score: 63.8156
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4EOZ_C   16 LGGLWEN---SRFTDCCLCVagQEFQAHKAILAARSPVFSAMFEHEmees------------kknRVEINDVEPEVFKEM 80   human
O74881  608 LTSYENYk-qSFSDVTIYCGt-SMFHSHKFILCARSSFLRKLLLQKkkssvsniiyieeitqshsTIRVEDIPPLAVAIL 685  Schizosaccharomyces...
Q08605   24 IQLLRCHg--DLVDCTLAAGg-RSFPAHKIVLCAASPFLLDLLKNTpckh------------pvvML--AGVNANDLEAL 86   fruit fly
Q9W0K7  117 FDQLLQNe--CFVDVTLACDg-RSMKAHKMVLSACSPYFQTLLAETpcq--------------hpIVIMRDVNWSDLKAI 179  fruit fly
P42284   22 FDTLLENe--TLVDCTLAAEg-KFLKAHKVVLSACSPYFATLLQEQydkh------------pifIL--KDVKYQELRAM 84   fruit fly
P17789   23 FDQLLHAe--TFTDVTLAVEg-QHLKAHKMVLSACSPYFNTLFVSHpekh------------pivIL--KDVPYSDMKSL 85   fruit fly
Q86B87   22 FHESLCRg--DLVDVSLAAEg-QIVKAHRLVLSVCSPFFRKMFTQMpsnt-----------haivFL--NNVSHSALKDL 85   fruit fly
O77459   23 IGAAFRGe--HPADLTIVCEnkVKLHAHKLVLAAASPLIRNLLEDThlsd------------csttVYFPDVNATYFKFL 88   fruit fly
Q19838   23 LQAKRRAgdfSTCDVKIQLKt-GFDMVHSVVICAHSDVFSETFDNQrap--------------yqpFNMTDFDPDSVRRV 87   Caenorhabditis elegans
Q10225  296 LNQPSDQy--SFHDAYLQSYt-HRYPVHRAIMCRCEYFLDMLAGPFlesn------------qelpVLSLPFSSSVVEIV 360  Schizosaccharomyces...
4EOZ_C   81 MCFIYTGka-------pnLDKMADDLLAAaDKYALERLKVMCEDALCSNL 123  human
O74881  686 LHYLYTDtllspwhldsrFSPLKENLSKLaNLLELPHLAEVLPFSVSRQP 735  Schizosaccharomyces pombe 972h-
Q08605   87 LEFVYRGevsv------dhaqLPSLLQAA-QCLNIQGLAPQTVTKDDYTT 129  fruit fly
Q9W0K7  180 VEFMYRGeinv------sqdqIGPLLRIA-EMLKVRGLADVTHMEAATAA 222  fruit fly
P42284   85 MDYMYRGevni------sqdqLAALLKAA-ESLQIKGLSDNRTGGGVAPK 127  fruit fly
P17789   86 LDFMYRGevsv------dqerLTAFLRVA-ESLRIKGLTEVNDDK-PSPA 127  fruit fly
Q86B87   86 IQFMYCGevnv------kqdaLPAFISTA-ESLQIKGLTDNDPAPQPPQE 128  fruit fly
O77459   89 LDFLYSGqtc-------itSRDVNYLHDLlLLLQIKSDSWKTTDSAYLSS 131  fruit fly
Q19838   88 FDWMYSGeid------ipETTIADVLAVA-SYLRVTMLQRQIEQKILNHN 130  Caenorhabditis elegans
Q10225  361 LKFLYTDktd-----iapELALDVVYVADmLSLDKDRSLKSLASIVITKQ 405  Schizosaccharomyces pombe 972h-
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