Conserved Protein Domain Family
GPI_EPT_2

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cd16024: GPI_EPT_2 
GPI ethanolamine phosphate transferase 2; PIG-G
Ethanolamine phosphate transferase is involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation.
Statistics
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PSSM-Id: 293748
Aligned: 42 rows
Threshold Bit Score: 342.237
Created: 2-Dec-2014
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative activemetal bindingputative
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  ##                                                         #        
Q758B8      47 EPAFDKLVLVVIDALRADFLfqqnv-------------------shfdFVHELLnRGEAWGFTAYSnpPTVTLPRLKGIT 107  Ashbya gossypii ...
NP_179839   82 SSKYDRLILMVIDGLPAEFVlgkdgkppe-----------kvlkesmpYTQSLLaNGDAIGYHAKAapPTVTMPRLKAMV 150  thale cress
EDQ52916    76 FPRFLAVVLKIVDGMPAEFVlgrgghpsl-----------pelvaampFTHSLIsAGKGLGYHAKAapPTVTMPRLKAMT 144  Physcomitrella p...
KDR12958    56 KPSVGRVVIMVIDALRWDFVegaeg------------------qlnmpYTASLVaGKKACLLTGKArpPTVTMPRIKAMT 117  Zootermopsis nev...
EEC01430    65 KRTPLKLVFVLIDALRFDFVadrs--------------------rslsFLGSMLrDRKALLYRSRAysPTVTLPRIKTLL 124  black-legged tick
EHJ68902    20 NPGENTVILMVIDGLRYDFVtee----------------------ympFTGQLIkNKSACIYVSVAepPTVTMPRIKAMM 77   monarch butterfly
ENN73356    47 RPHFTKTVLIVIDALRWDFVtaq----------------------lmpLAAGLM-NSQGCLSKVSVesPTVTLPRIKALT 103  mountain pine be...
ESO03805    77 KPHFDRLVFIVLDGLRADVIlnlletniqks------nfhkndannlgYLKEFLnAKNTFVFQSVArpPTVTLPGVKALM 150  Helobdella robusta
EEB14563    53 KRSVDKLAIILIDSLRYDFVmensn------------------qvlmpFTTTSIlNNESCLVKIKTesPTVTMPRIKAIT 114  human body louse
ETL91961    53 DAAYDRLVVVLIDALRADMVlgsaamhgiintgenkqqpkgelnahmpFTSSLVtSGRALGYVAHAsvPTVTMPRLKALV 132  Phytophthora par...
Feature 1                                                                                      
Q758B8     108 TGSAPNFLDAilnvaeddsssnlkdQDSWISQFAKHgkKIHFFGDDTWLKLFPeeffqkhdgtnsffVSDFEEVDTNVTR 187  Ashbya gossypii ...
NP_179839  151 SGAIGGFLDVafnfn-----tqallDDNILGQFFRIgwKMVMLGDETWLKLFPglfmrhd-gvssffVKDTVQVDRNVSR 224  thale cress
EDQ52916   145 SGAIAGFLDVafnfn-----tqallDDNLVDQLARAgwKMVMLGDDTWLKLFPdkfmryd-gvnsffVKDTVVVDHNVTR 218  Physcomitrella p...
KDR12958   118 TGTIPSFVDValnlg-----sskilEDNLLLQAVQHdmKLIFYGDETWLKLFPdvftrse-gttsfyVTDFTEVDDNVTR 191  Zootermopsis nev...
EEC01430   125 TGTVPGFGDVllnfn-----advlhDDNLVHQARASgkKTVFYGDDTWLRILPgcfdrye-gttsffVSDYTEVDRNVSR 198  black-legged tick
EHJ68902    78 TGSVSTFADValnfg-----apavqGDSVLRVAKSRglRTILYGDDTWLRLFPglwtesd-gttsffVTDYTEVDNNVTR 151  monarch butterfly
ENN73356   104 TGSVPQYMDVvmnla-----ssevlADSWLHSAKKKglRIVFYGDNTWEKLFPnvftrse-gttsffVWDFTEVDDNVTR 177  mountain pine be...
ESO03805   151 TGTVSSYSDViwnfa-----sgkleEDNLISQLKLLgrRNFFYGDDTWLKLFAedvfissdgvtsffVTDFTEVDRNVSR 225  Helobdella robusta
EEB14563   115 SGSTSNYIDVvmnvm-----tsnyeEDNFIKKAFNNglKILFYGDDTWLKLFPntfyrye-gtssffALDFTEVDDNVTK 188  human body louse
ETL91961   133 TGKPPAFIDIlknfns----aalgeDANLVSLLAASgkRIVFYGDDTWLKLFPetfersd-gtsgfyTRDTVEVDNNVTR 207  Phytophthora par...
Feature 1                                  #                                                   
Q758B8     188 HLPHELQHk-------DWDVLILHYLGLDHIGHKggaaSQFMPPKHREMDAVIRQIYDq-------------vDNRTLLC 247  Ashbya gossypii ...
NP_179839  225 HLPDELNSd-------DWNLLILHYLGLDHVGHTggrnSPLMPAKLKEMDDIVRTMHLrammd------rshdQGQTLLI 291  thale cress
EDQ52916   219 HLNVELAAt-------DWDLLVLHYLGLDHVGHLggrsSSLVAPKLKEMDDVIRRIYDklik--------tsgDRRTLLL 283  Physcomitrella p...
KDR12958   192 HLAAELNTe-------DWRLMILHYLGLDHIGHVegpySPLVRPKLQQMDHIVKRIHHsfltw------dkhfSVPSVLV 258  Zootermopsis nev...
EEC01430   199 HVPSEMEAt-------DWDWLVLHYLGLDHIGHThgpsSSLVDDKLAEMDGILSTMYAslr---------rraNDSFLIV 262  black-legged tick
EHJ68902   152 HLDKVLTPddk--nkpNFDFLVLHYLGLDHIGHLegarSPKIRPKLIEMDEIIKKIYHamq----------qwENVGTLI 219  monarch butterfly
ENN73356   178 NVNLELERs-------DWDVMILHYLGLDHIGHVlgpfHPKMTAKLKEMDDIIFRIQQt-------------mANDTLIL 237  mountain pine be...
ESO03805   226 HLGKLFHVegg--rdwSWDCLFLHYLGLDHIGHLlgphHMQANKKLEEMQGVIKFIKTsldak------dksdNKTSLLI 297  Helobdella robusta
EEB14563   189 NAYKELKRn-------DWDIIILHYLGLDHIGHLegpaGELAKSKLIEMDDIIKNISLhfkal------enerNLKTMLL 255  human body louse
ETL91961   208 HLKEELDPtmqneksgDWDVLVLHYLGLDHVGHLrgprSPLMKDKLQEMDDVMKLVVDsvreqdvqrmkkdgsARSSLIL 287  Phytophthora par...
Feature 1         ##                                                                           
Q758B8     248 VMGDHGMNDLGNHGGSSa-gETSAGMVFISKmlssyprpaaqdgv-sspvtaaedyqffTRIQQVDFVPTIASLFNIPIP 325  Ashbya gossypii ...
NP_179839  292 IVSDHGMTENGNHGGSSy-eETDSLMLFIGLnsnisd----------------yasatnNVAFQVDLAPTLALLFGVPIP 354  thale cress
EDQ52916   284 VASDHGMTEGGNHGGASy-qEADALALFISEsdsinmfmdkrqhestlkqnkgvatssaWPSFQVDVVPTLALQLGVPIP 362  Physcomitrella p...
KDR12958   259 VCGDHGMKNSGSHGGASl-eEVLVPLIVISNicseemts------------gllgdvltGSVLQIDLVPTLSMLLGLPVP 325  Zootermopsis nev...
EEC01430   263 VTGDHGMNAVGNHGGSSe-gEVMTALLFIPTkpwdf------------------gsqdvSTVSQVDIAPTLSLLTGLPIP 323  black-legged tick
EHJ68902   220 VCGDHGMRDAGGHGGASp-sEVLVPLVVIRSkdfkcp----------------ypsgpgPTVSQVDVAPTISWLLNCPLP 282  monarch butterfly
ENN73356   238 VTGDHGMRDAGGNKQPKlerNFLIPSCLGHGgtssaevtvp--------liaighdcenASFQQTDIPANLAVLLGINIP 309  mountain pine be...
ESO03805   298 LTSDHGMTSSGSHGGSTp-dELNTPLVFHAGsflmdsskvkeag---dnllqrgdfglaGTVDQVSVAPTLAFLLGTSVP 373  Helobdella robusta
EEB14563   256 VTSDHGMKDSGGHGGVTp-sEIFVPIVSVGKpckalp-----------------gwpinYTAFQTDIAPTVSALLGLSTP 317  human body louse
ETL91961   288 LCSDHGMSEVGNHGGATl-eESSALLMFMRGdgepmqs--------------sgdvsyeQKRNQEDLVPTISSLFGLPIP 352  Phytophthora par...
Feature 1              
Q758B8     326 KNSLGVFV 333  Ashbya gossypii ATCC 10895
NP_179839  355 KNNVGVLV 362  thale cress
EDQ52916   363 KNSVGALL 370  Physcomitrella patens
KDR12958   326 ATSIGKII 333  Zootermopsis nevadensis
EEC01430   324 KGSYGRAL 331  black-legged tick
EHJ68902   283 GDSVGVIL 290  monarch butterfly
ENN73356   310 ATSIGKLE 317  mountain pine beetle
ESO03805   374 KNSMGVAI 381  Helobdella robusta
EEB14563   318 VKSIGKII 325  human body louse
ETL91961   353 LYSTGLLL 360  Phytophthora parasitica

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