Conserved Protein Domain Family
TPT_S35C2

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cd21092: TPT_S35C2 
solute carrier family 35 member C2, member of the triose-phosphate transporter family
Solute carrier family 35 member C2 (S35C2 or Slc35c2), also called ovarian cancer-overexpressed gene 1 protein (OVCOV1), is a member of the triose-phosphate transporter (TPT) family, which is part of the drug/metabolite transporter (DMT) superfamily. It may function either as a GDP-fucose transporter that competes with Slc35c1 (S35C1) for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.
Statistics
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PSSM-Id: 411044
Aligned: 26 rows
Threshold Bit Score: 343.868
Created: 23-Dec-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9NQQ7        80 WADYLRRVAPTALATALDVGLSNWSFLYVtvSLYTMTKSSAVLFILIFSLIFKLEELRAALVlvvlLIAGGLFMFTYKST 159 human
NP_647817    149 WRLALRKMAPTGVASAIDIGFSNWGLALVpiSLYTMTKSSTIVFILLFAIAFGLEKKSWYLVsivgLIGTGLLMFTYKST 228 Drosophila mela...
XP_019850680  73 WKNYLKSICPVAIFTSLDIGLSNWSLLYItiSLYTMSKSTALVFILFFGIVIGIEQPRLIQIfvvlLIFAGLVMFTYEST 152 Amphimedon quee...
XP_013078932 112 WSDYIKRVALAGCVSSLDIGLSNWSFEMItvSLYTMSKTTAVIFILFFSLMFKLEKFRWSLLfvvfFIFTGLFLFTFRST 191 Biomphalaria gl...
XP_002156814  77 WSTYIKKCFPTAVSGSLDIGLSNWSIMLStvSLYTMAKSSTIIFIVGFSLLFGLEKLDRYLCaavvLIFIGLCLFTLEDQ 156 Hydra vulgaris
XP_027207385  26 WDVYWRRVMPRCLRPAIDIGLSXWSLEFItvALYTMSKSTALLFILVFAIIFKLEEMRWSVVllvvLIAGGLFLFTYKYT 105 Penaeus vannamei
ELT87927     101 WCDFIKRIAPPGIASSLDIALSNWSFEYIsiSLYTMTKSTVIIFIMFFSIVFKLEKPRWSLIsiigCISLGLFMFTYDST 180 Capitella teleta
XP_030840343 106 WLTYAKIVTPTGITSALDIGFSNWSLVFItiSLYTMCKSSAIIFILVFAIAFGLQKPHWMQViivvLIAVGLFMFTYEST 185 Strongylocentro...
XP_013078933 110 WSDYIKRVALAGCVSSLDIGLSNWSFEMItvSLYTMSKTTAVIFILFFSLMFKLEKFRWSLLfvvfFIFTGLFLFTFRST 189 Biomphalaria gl...
XP_002735463 101 WGLYLKKVAPTGLASSLDIGLSNWSFLFItvSLYTMSKSSAIIFILVFAIIFKLEEFRVSLIavilLIAVGLFLFTYKST 180 Saccoglossus ko...
Q9NQQ7       160 QFNVEGFALVLGASFIGGIRWTLTQMLLQKAELGLQNPIDTMFHLQPLMFLGLFPLFAVFEGLHLSTSEKIFRFQDTGLL 239 human
NP_647817    229 DFNALGFFFILFASLSSGLRWSFAQFIMQKSKLGLHNPIDMIYYMQPWMIASLVPLVIGIEGAGLIAVIEDLHNHTSNEI 308 Drosophila mela...
XP_019850680 153 AFEWEGFILVILASIVTGLRWSTAQLALQKEEYGLSNPVNMIYNLQPVMILTLIPLAFFIDGIHFAISRKLLLAPSPSVL 232 Amphimedon quee...
XP_013078932 192 QFNLKGFVLVMTASVLSGLRWTLAQMVLQKNEIGLHNPIDMMYHIQPWMILSLLPLSAGIELQEMATSDQYFRFSLWSVL 271 Biomphalaria gl...
XP_002156814 157 QFSFYGFCMGVAASLMGGVRWTTSELIMQKKSLGLHNPFDAIYHIQPVMAISMVFLAFSMEGPQLATSELFFRASSLKVA 236 Hydra vulgaris
XP_027207385 106 LFNLFGFILVLIASLLSGLRWTLSQLVMQKSELGLSNPIDMVYHIQPWMTVSLLPLAVIMEGTAIAASEYGFRFTDSSEA 185 Penaeus vannamei
ELT87927     181 QFHLLGFLLVFSASFLSGLRWTLSQLVMQKSKLGVHHPLDMMYHIQPWMMLTLLPLAGGFEGRRLAISPHAFGFHESSLL 260 Capitella teleta
XP_030840343 186 QFNLEGFVLVLAASFLSGLRWSLAQILTQKEETGLRNPIDIIYHLQPVMILGLLPLAIAVEGVRICSTEDFLGFTDIHTF 265 Strongylocentro...
XP_013078933 190 QFNLKGFVLVMTASVLSGLRWTLAQMVLQKNEIGLHNPIDMMYHIQPWMILSLLPLSAGIELQEMATSDQYFRFSLWSVL 269 Biomphalaria gl...
XP_002735463 181 QFNLEGFILVMTASSLSGIRWSMAQLLTQKEEIGLSNPVDLVYHLQPIMIVGLIPLAIAFEGLPVVSTEQFLGYTDQNAF 260 Saccoglossus ko...
Q9NQQ7       240 LRVLGSLFLGGILAFGLGFSEFLLVSRTSSLTLSIAGIFKEVCTLLLAAHll-gDQISLLNWLGFALCLSGISLHvALKA 318 human
NP_647817    309 TWAIARISAGALLAFLMEFSEFLVLCKTSSLTLSIAGIFKDICQLALAVTir-kDHLSVINYIGLIICLAGIVCHlLHKY 387 Drosophila mela...
XP_019850680 233 LTTLILILMAGVLAFLLAMSEYLLVYHTSSLTFSVSGVIKEIIILTISTVfveeGSLSLLKVSGMVLCVMGVATHsVLKA 312 Amphimedon quee...
XP_013078932 272 LTNVGYVLIGAALGFMLEFSEFLLLSYTSSLTLSISSILKEICVLGLAILin-nDKITLINGVGLVICFVGVMVHvCSKA 350 Biomphalaria gl...
XP_002156814 237 LSSFLVILVGATLAFLLIVSEYLIVSNMSSITLSIASIFKEICVLTIAAEfg-gDKWTMFNFIGLVICMCGISLHiVSKL 315 Hydra vulgaris
XP_027207385 186 LHMWGRVMFGAVLAFFMEVSEYLLVCFTSSLTFSISGVAKEIMTLSLAVYiy-nEHLTNINVLGLFFCIIGIILHvVLKA 264 Penaeus vannamei
ELT87927     261 ARDMAILMLGAFLAFMLEMSEFLLVSKTSSLTLSISGIAKEIVTLCLAVVin-kDPMSPINGIGLVVCLLGITIHvILKA 339 Capitella teleta
XP_030840343 266 TLTCTKLLFGACLAFMLAMSEYLLLSRTSTLTLSISGIFKEICTLYIASQk--gDEMSALNFIGMVVCLCGISLHvGLKA 343 Strongylocentro...
XP_013078933 270 LTNVGYVLIGAALGFMLEFSEFLLLSYTSSLTLSISSILKEICVLGLAILin-nDKITLINGVGLVICFVGVMVHvCSKA 348 Biomphalaria gl...
XP_002735463 261 IYSISILSLGACLAFMLGVSEYLLLGQTSSLTLSIAGIFKEICTLYIATQyv-gDILTPINAVGMVICLSGITLHvILKA 339 Saccoglossus ko...
Q9NQQ7       319 LHSRGDGGP 327 human
NP_647817    388 SNMKEMQRQ 396 Drosophila melanogaster
XP_019850680 313 IRLQDEAVR 321 Amphimedon queenslandica
XP_013078932 351 IEMNEKSKH 359 Biomphalaria glabrata
XP_002156814 316 LKDPAYSVV 324 Hydra vulgaris
XP_027207385 265 MHPQKPPPP 273 Penaeus vannamei
ELT87927     340 VHSEDEKEV 348 Capitella teleta
XP_030840343 344 LETKRSSEN 352 Strongylocentrotus purpuratus
XP_013078933 349 IEMNEKSKH 357 Biomphalaria glabrata
XP_002735463 340 ARSKKQGKS 348 Saccoglossus kowalevskii
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