Conserved Protein Domain Family
SIP1

?
pfam04938: SIP1 
Survival motor neuron (SMN) interacting protein 1 (SIP1)
Survival motor neuron (SMN) interacting protein 1 (SIP1) interacts with SMN protein and plays a crucial role in the biogenesis of spliceosomes. There is evidence that the protein is linked to spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis(ALS) in humans.
Statistics
?
PSSM-Id: 461493
Aligned: 152 rows
Threshold Bit Score: 42.8258
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
ETW83753      32 PSNFE--GEPEDGMQYLFTVRRETRQLPAVKRApnpy----------etaPPEPALPSAS------TFIASTIAPSPPSQ 93 
CEO98648      33 TGD----APPASADEYLLRVRMEARRIPFVVSK------------------PVPADVKVK------AGVRVVPRCVPMSP 84 
PIA18481      23 GDHTQ---APTSGEQYMLRVRLETESIPRVVVApnre----------qllHDNHLNLSTS------PVPSTTPNPERLPD 83 
ORX94526      29 TADVDldGPPTTGEEYLRMVRMEANNRPSVFIAknk------------psTSIPTSIPKT------PREAEKVKGQPVs- 89 
RGB42109      33 GNSLPn-RPPATGEEYLRMVRSEANKRPNVVIA-----------------------KNQI------NKSKEVRMAGWV-- 80 
PVV04967      22 QASLD---SDFSALSYLNSVRLEANSFPKVLLPkdtslidsvssnktnnsTSLLSSLPQD------LLHTSKEFKNKNNF 92 
XP_006679188  71 PTSLRsnEPPSSGFQYLLSVRKEAEAAQQVVIA------------------DIPEEVLNVpialniFDRRQQLFEFANTL 132
KND01348      33 EPLLApgAPPASGLQYLRMVRAEANACQQVVTVslp------------aeKLHSPIPPNV------FDVRKEYFGTKASG 94 
OLL25797      36 DENITt-DVPLDGFDYLRMVRNQARKAPSFTFS-----------------EKQQAHMPTP------AVEQESRETKASg- 90 
XP_007872758  44 DDSLP-----LDGVSYLKKVRIEAKHRP-IIKA------------------VEAPPTAMT------ITQISEPKINNKAE 93 
ETW83753      94 KSH----------------IPSEQWRS-TFTRRFVNFRKNT---SQPTIHVYmpmpraRGQKLMPDKKERDRWWEFFAGS 153
CEO98648      85 SAS----------------MPRPDWAV-RFAVRFAELRQSLa--RVIARFGIe-----EHAEGLPHSNNASAWRARFVDE 140
PIA18481      84 IL-----------------RPSVGWLD-AFARYFTQEQTGFr--LLLDKTTI------PLEFSIPNSDRLREWKNFCYSI 137
ORX94526      90 ------------------rVPSPEWRE-AFKLRFSRLRKTVe--ERRKTIKSs-----SRIEGLPGIKDETAWLGLLYGD 143
RGB42109      81 ---------------------KRGWANqMELDNFDQNSNNLvneEWEKIFLMk----fDLIRQFPARNDEAGWLKFCYGi 135
PVV04967      93 DPK---------------------WAD-DFNSTFSQWNESFq--DYLSLLDA----------DFFHVNNELFWKKLLFDD 138
XP_006679188 133 MPSpnqsgdsvlsnhtvhlMPSSNWIL-TLIQESNKLRDIMt--AYRKSKQAfqa-gkKICHNLPPISDSNQWHVFCYGi 208
KND01348      95 DESyip----------enlRPSADWLN-NFLERFNALHDEVa--KRRQIVRKs----vSSRFFRPNLYNERGWKRFCYGD 157
OLL25797      91 --------------------iYEEWQI-QFLARFRELRRTMs--SILMSKSN-----------FPSTQNS--WLGFVALS 134
XP_007872758  94 EIY------------------SSVWEE-KFLKSFIKLRRNLn--LQTKSVIL-----------RPLPKDKIEWRRLILEE 141
ETW83753     154 Pasvwdppraakqpkqrevrrlgnddhavppfhrtnaygsstdewvvgtvteeqla-----emhdgtrvsdtdprqgafa 228
CEO98648     141 Sr------------------------------------------------------------------------------ 142
PIA18481     138 Ddgt---------------------------------------------------------------------------- 141
ORX94526     144 Sskaetpa------------------------------------------------------------------------ 151
RGB42109     136 iespnfvegkg--------------------------------------------------------------------- 146
PVV04967     139 Dpasgga------------------------------------------------------------------------- 145
XP_006679188 209 aqnqtgsdssg--------------------------------------------------------------------- 219
KND01348     158 Pienapqepsanmelppnapvhepsvsedvpesvpeltpenvveiqehedakdpsdsdilkkrkreldeeegdtsqkskr 237
OLL25797     135 N------------------------------------------------------------------------------- 135
XP_007872758 142 Le------------------------------------------------------------------------------ 143
ETW83753     229 sgslqastgnmsgandgvselqsasspspplvprePT----PTLLQY-IDHRMSVHLLMYFTHWFNLHLEwldsast--- 300
CEO98648     143 ----------------------------------lPS----LSEIAA-LDQVRTRSILRHLASVVRCDTSstg------- 176
PIA18481     142 ---------------------------------ttKT----IVYALAsVDQMMAIRLIKWMTAWMTIDR----------- 173
ORX94526     152 -----------------------------eaqpllPY----ASVVLK-MDQKTTLALLEYHIDWLDEDSLtknqvsiask 197
RGB42109     147 -----------------------lenegdvnemtlPR----VSIVSR-IDQTTTITLLLYHTKWLSNGIT---------- 188
PVV04967     146 ------------------------------agntsPSkelsMKLLAG-LNRKSILRIIEWFTNWLRCDS----------- 183
XP_006679188 220 -----------------------nivlyenstrtlPS----LSMIGA-LSHETVLRLVQMHTLWLEESGT---------- 261
KND01348     238 lqtqsaepthdeqakklppsgkqasetdiviggkePL----LNLICN-LEQGEVLKVLKYHTNWLSDDD----------- 301
OLL25797     136 -----------------------------------PT----YKNLRS-TSNPVAIQFLSLSAYWLENE------------ 163
XP_007872758 144 ----------------------------------pPS----ISLLNS-INQCTALNLLKWNTEWFSYN------------ 172
ETW83753     301 --appahiPTESHARWIFTLLGRVDAFCTADEISGLRGLARVClGLVRARrergdg------dvkgksTEAHRGMG---- 368
CEO98648     177 ------avVPEPVVIWIWSALLRLDKPLLPDTAATLRELYRSI-ATRRAN------------------ADPSNHQS---- 227
PIA18481     174 --------LRRIEGIWIWYLILRLDSLLDHDDTHVLRELCRRL-ISIRANighnig-------qnaeaQSAHFHDE---- 233
ORX94526     198 sakewikaNIHAKAQWLFALLLRVDKLLTSDSISTLRELCRQW-GAIRTNlarpla-------ktipsQTNGTGEQ---- 265
RGB42109     189 --------IAQS--QWLFALLLRVDKLLTPNQMATLRQLCKKC-IQIRQK------------------TDEEDLIT---- 235
PVV04967     184 --------LTYKQSFSIFVLLLTLDTLLSNQEIYVLRSLSRKl-IEIRSN------------------SISPNIPS---- 232
XP_006679188 262 --------ITPDKSKWIFALLMRLDSLLTGDEISLLRDLSKVC-LRLRSDtirdlitkhtaqkddsisSTDTNSIRrdhr 332
KND01348     302 --------ISEEQCQWIFALLLRLDTLLHGDEVSIIRDLCRKC-RGIRSHm----------------iDLDAGDPR---- 352
OLL25797     164 --------YTPQLAKWIFAFLVRVDDTLEFEEVSVLRDLAKKS-WDLKDT---------------------GEIGF---- 209
XP_007872758 173 --------SPEQQIMWIFFLLIKIDMVMTSDELSILRELCKKC-LFLRNS------------------KKNLPLHI---- 221
ETW83753     369 EVACWMVVCIVVGMWGQQ 386
CEO98648     228 VALFNIVLTIIHHCFGQS 245
PIA18481     234 IAAINILIAAVTRGYRQY 251
ORX94526     266 IASLNMLISIVIDYFGQL 283
RGB42109     236 LASLDMIIIIVRKYFGQK 253
PVV04967     233 SVYTNILISTISTTFGQK 250
XP_006679188 333 IVSCTMVISIVHHIFGQK 350
KND01348     353 AATLNMIVAIVSHIFGQR 370
OLL25797     210 RAICEMVIVIVSEIFGQH 227
XP_007872758 222 QSNIDMVISIVGNIFGQK 239
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap