1DQX,2F84,1EIX,1LOL,1VQT,1DBT,2CZ5


Conserved Protein Domain Family
OMP_decarboxylase_like
?
cd04725: OMP_decarboxylase_like 
Click on image for an interactive view with Cn3D
Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two domains: the orotate phosphoribosyltransferase (OPRTase) domain that catalyzes the transfer of phosphoribosyl 5'-pyrophosphate (PRPP) to orotate to form OMP, and the orotidine-5'-phosphate decarboxylase (ODCase) domain that decarboxylates OMP to form UMP.
Links
?
Statistics
?
PSSM-Id: 240076
Aligned: 169 rows
Threshold Bit Score: 114.195
Created: 11-Jul-2006
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
active sitedimer interface
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1DQX; Yeast Orotidine 5'-phosphate decarboxylase with bound transition state analog 6-hydroxyuridine 5'-phosphate
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1          # #                                                                          
1DQX_D       32 LCASLDVrtt---------------------------------------------------------keLLELVEALGpk 54  baker's yeast
YP_634047    21 FCLGIDPsrdlltrwgl------------------------------------------pdnarglrdfCERVADAAGss 58  Myxococcus xanth...
2F84_A       18 LCIGLDPdekdienfmknekennynnikknlkekyinnvsikkdillkapdniireekseeffyffnhfCFYIINETNky 97  Plasmodium falci...
Q8YSY4       18 LFVGLDPnpemmpgryss-----------------------------------------qdiidglwdwLQFIIAETAdf 56  Nostoc sp. PCC 7120
NP_924025    18 LFVGLDPnpemlperygr-----------------------------------------tasiaalrdwMRALVEQTAas 56  Gloeobacter viol...
CAI72962     18 LCLGLDPrdeqvekfsktaeferlfqlnv-------------------dkkenwykldknstyvklklyCLHILDNTLdh 78  Theileria annulata
ZP_00517498  18 LILGLDPnpemmpqdqhthq-------------------------------------gqeslilaletwLKWVIEQTAel 60  Crocosphaera wat...
ZP_01085405  18 LITGLDPnpemlqtwtrhna-------------------------------------gsgsflaqarrwIKAVIEATSds 60  Synechococcus sp...
YP_720317    18 LYLELDPnpeslpkqaegknipakyl------------------------llkhpekdnqeliqdwwewLHFLITQTEky 73  Trichodesmium er...
CAF26551     16 LCIGFDPshhilqswnl------------------------------------------sfdykglkdfCDILLAAVVgh 53  Bartonella quint...

Feature 1           # #                                   # #                                   
1DQX_D       55 iCLLKTHVDIltd------fsmEGTVKPLKAlsakynflLFEDRKFADIG-NTVKL--QYSAgvyri-aewadITNAHGV 124 baker's yeast
YP_634047    59 vAVVKPQSAFferhgpeglqvlQELMRRFKSvg----tlTLLDVKRGDIG-STMEA--YAETvfgegsayeadAATFTAY 131 Myxococcus xanth...
2F84_A       98 aLTFKMNFAFyipygsvgidvlKNVFDYLYEln----ipTILDMKINDIG-NTVKN--YRKFifey---lksdSCTVNIY 167 Plasmodium falci...
Q8YSY4       57 vCAYKPTLGFyealgvpglellQKTLAAIPShi-----pIILDAKHSDLNtSTIFAk-TVFTqwg------vdAITLSPY 124 Nostoc sp. PCC 7120
NP_924025    57 iCAFKPTLGFyqalgpagidllLEVLEWIPPhl-----pVILDAKHGDLN-TGTQL--ARTFfedw----gvdAVTINPF 124 Gloeobacter viol...
CAI72962     79 vCCVKPNLAFflsrltdgvqvlVELCNYLREln----vpVLLDCKLGDIG-TTTEY--YKKFvfee---lradSCTVNTL 148 Theileria annulata
ZP_00517498  61 vCAYKPTLGFyealgsegldllLKVIQVIPDdi-----pIILDAKHGDINtSTVFAktIFENwq-------vdAVTVSPY 128 Crocosphaera wat...
ZP_01085405  61 vCAYKPSLGFyqalgp-iglelLREVRELVPle----lpLILDAKHGDLN-SSSAL--AHYLfrdl----gvdAVTLSPL 128 Synechococcus sp...
YP_720317    74 vCAYKLSLGYyqsfgipglqllQQTLKTIPSei-----pIILDAKHSDLKtSTVFAq-SIFAdlq------vdACTILPY 141 Trichodesmium er...
CAF26551     54 vGIIKPQVAFfelygveglqalKELIENAHEqg----llVIADAKRGDIG-STVEA--YGKAwlgsssafkadAITVNAF 126 Bartonella quint...

Feature 1                                   ##                                                  
1DQX_D      125 vgpgIVSGLKQAaeevtkeprGLLMLAELSCkgsl--------stgeYTKGTVDIAKSdkd---------fvIGFIAQrd 187 baker's yeast
YP_634047   132 lglgALLKTLERara---sgaAAFLVVRSSNpegtslqmsrgedgrtVAEALADGLRAfnekpg--qdaapvAGAVMGat 206 Myxococcus xanth...
2F84_A      168 mgtnMLKDICYDeekn--kyySAFVLVKTTNpdsaifqknlsldnkqAYVIMAQEALNmssylnl-eqnnefIGFVVGan 244 Plasmodium falci...
Q8YSY4      125 tgqdHVAPFLVYpd------kAVFILCSTSNpgaealqq-yptrespLYLQVVQESKNwgt--------peqLGLEVGtt 189 Nostoc sp. PCC 7120
NP_924025   125 agqdAVAPFLLYpr------kGVFVLCHTANpaaqamqa-hpgqqppLYQQVVREARGwgl--------peqLGLEVGtv 189 Gloeobacter viol...
CAI72962    149 lgsdVLKSFCSDssnn--fvnDLFVLAKCSNessqefqsallkdgtpLYLRVIQQSEKflenn----scnckFGYVVGsn 222 Theileria annulata
ZP_00517498 129 agqdHIAPFLVYpd------qGVFILCHTSNpgavilqe-yptdeapFYLQVIKEAKTwat--------peqLFLEIGtt 193 Crocosphaera wat...
ZP_01085405 129 agqdIAAPFLLYpd------rAVVLTCHSSNpgarvvqh-hpdeddpLYITIVRETQLwgt--------pehLLLEVGts 193 Synechococcus sp...
YP_720317   142 tgfdLVVPFLLYpg------kAVFLLCATANasagvlqq-ypnqeqpLYLKLVVEAQRwat--------pekLGFEVGim 206 Trichodesmium er...
CAF26551    127 lgfdALIPLIKIaee---tatGVFVVVQSSNpegkpirn-arignqtLSVHLAQRICDynsqssgkhhsvgpIGAVIGat 202 Bartonella quint...

Feature 1                          #                                           ##               
1DQX_D      188 mggr-----degydWLIMTPGVGlddkgdalgqqyrTVDDVVSTg------------sDIIIVGRGLFAKgrd---akVE 247 baker's yeast
YP_634047   207 lpdsdrgvierlggALLLTPGIGaq---------gaGFDDLKRLfagr-------eaqVIPTATRSVLEAgpdtaalrQA 270 Myxococcus xanth...
2F84_A      245 sydemnyirtyfpnCYILSPGIGaq---------ngDLHKTLTNgyhk------syekILINIGRAITKNpy----pqKA 305 Plasmodium falci...
Q8YSY4      190 naevlarirqvapeRMIMVRSIWae---------ggNLNRILEVglnt------dgngLLIPVPQDMLASanlskeiqSL 254 Nostoc sp. PCC 7120
NP_924025   190 rpeilarvraaapeRLIMVRSLWaap--------pgALASMLAAglda------agagLLVPVPQECLGAdtpglsvaAL 255 Gloeobacter viol...
CAI72962    223 cvdeir-riresyeCYLLVPGIGsq---------ggDLEQTLRYglnk------nkggLIVPISRSITDTdv----clKF 282 Theileria annulata
ZP_00517498 194 nlevikkvrylapeRLLLMRSIWsk---------gnDIHEILKVslnp------mgqgVLIPIPQDFLKSk-------DL 251 Crocosphaera wat...
ZP_01085405 194 dpavlarvrreapeRFLILRSLWge---------eeRLEALLQAglna------sadgLLLPLPQHLLVEegmaagtrAL 258 Synechococcus sp...
YP_720317   207 pdilgk-irqvapeRLILIQGDIae---------enDINNPQKLnqllaaglningegLLLPIPPKLLGTaepktaikSL 276 Trichodesmium er...
CAF26551    203 lgneskdtieqlknSLFLVPGVGaq---------ggTIKQLADQfpqr------lwqnIIPSVSRSITDAgrn---vvDL 264 Bartonella quint...

Feature 1           
1DQX_D      248 GERY 251 baker's yeast
YP_634047   271 LERH 274 Myxococcus xanthus DK 1622
2F84_A      306 AQMY 309 Plasmodium falciparum 3D7
Q8YSY4      255 RAEI 258 Nostoc sp. PCC 7120
NP_924025   256 RCEI 259 Gloeobacter violaceus PCC 7421
CAI72962    283 LIVF 286 Theileria annulata
ZP_00517498 252 KEKV 255 Crocosphaera watsonii WH 8501
ZP_01085405 259 RQQI 262 Synechococcus sp. WH 5701
YP_720317   277 ISTI 280 Trichodesmium erythraeum IMS101
CAF26551    265 KNII 268 Bartonella quintana str. Toulouse

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap