Conserved Protein Domain Family
ApoL

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pfam05461: ApoL 
Apolipoprotein L
Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes located in close proximity to each other on chromosome 22q12 in humans. 22q12 is a confirmed high-susceptibility locus for schizophrenia and close to the region associated with velocardiofacial syndrome that includes symptoms of schizophrenia.
Statistics
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PSSM-Id: 461657
Aligned: 31 rows
Threshold Bit Score: 387.393
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007503451 171 LSEDEAWERFFADS--SSMREKATQLSETLygLFGDKVLDDTNGqDGSLSDEDKIFLKEFPKKKMELEERIQDLHAIADQ 248
Q9BWW9        51 VNLCQSWKINNLMS--TVHSDEAGMLSYFL--FEELMRCDKDSMpDGNLSEEEKLFLSYFPLHKFELEQNIKELNTLADQ 126 human
XP_005625974  55 LFDAKAWEMLVQRS--GLDRDEANILYHML--MEELMQNKEASM-LENLSEEEKIFLFWFPLQKNNLKKNIRELHALADQ 129
Q9BQE5        29 LTDDEAWNGFVAAA--ELPRDEADELRKALnkLASHMVMKDKNR-HDKDQQHRQWFLKEFPRLKRELEDHIRKLRALAEE 105 human
O95236       100 LTNNEAWKRFVTAA--ELPRDEADALYEALkkLRTYAAIEDEYV-QQKDEQFREWFLKEFPQVKRKIQESIEKLRALANG 176 human
Q9BPW4        56 LTSDEAWKRFVRVA--ELPREEADALYEALknLTPYVAIEDKDM-QQKEQQFREWFLKEFPQIRWKIQESIERLRVIANE 132 human
XP_013008670  33 LTDDVAWEIIVETT--DLTRKEADAVREALtdLQADC---------DEDFQARKRFLNEFPNVKKEMQEHIAKLYALAER 101
EHB14171      33 LTHSGAWEVFVEMA--KLTREEADALREALnvCTADT---------DEDLRARERYLKEFSEMKMELQKQIAQLHALADR 101
XP_022280190  36 LINHETWEKFVAET--SLSREDADALREGLndLEGDMDIEDEGQ-------AREKFLNVFPQVKVELEGYIKRLRECADE 106
XP_009008383  58 RTDSEAWQRFVAVAvaGLPRDEADALYEALktLTTHEDIDDKDK-RQKDRQFREWFLKNFPQLRRDIQESIREIYALADR 136 white-tufted-ea...
XP_007503451 249 VDKTHKKCIITNVVAGSTSIISSIVTIMGLALAPVTAGGSLILSASGFGLGALAAITSLSSSVIERVGNLTAKERVSNHK 328
Q9BWW9       127 VDTTHELLTKTSLVASSSGAVSGVMNILGLALAPVTAGGSLMLSATGTGLGAAAAITNIVTNVLENRSNSAARDKASRLG 206 human
XP_005625974 130 VDAKHKMLTKTSLVASSSGTVSGVMSILGFALAPVTVGGSLMLSAAGLGLGVAAVATNTLTSILERNSNSAARDRASRLV 209
Q9BQE5       106 VEQVHRGTTIANVVSNSVGTTSGILTLLGLGLAPFTEGISFVLLDTGMGLGAAAAVAGITCSVVELVNKLRARAQARNLD 185 human
O95236       177 IEEVHRGCTISNVVSSSTGAASGIMSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLT 256 human
Q9BPW4       133 IEKVHRGCVIANVVSGST----GILSVIGVMLAPFTAGLSLSITAAGVGLGIASATAGIASSIVENTYTRSAELTASRLT 208 human
XP_013008670 102 IDKVHKGCTITNVVASTGGAVSGILTMLGFALAPVTAGGSLVLSATGMGLGTAAAVTGVSASIVDHSNKVSAQAEARQLL 181
EHB14171     102 IDRIHRNCTVSNMVSSSAGAASGVLTILGLALAPVTAGSSLLLSATGMGLGAVSAMTSAAAAIVEQSSVSSAKAEARCLV 181
XP_022280190 107 VDQVHEGCTITNIVASSTGAATGPLGIHGLGLVPVIGGLSPETLVAGVGLGAASDATQVTTSIVEGSHESPATAE----- 181
XP_009008383 137 IEKVHRDSTISNVVSSATGTPSGIMSILGLVLAPFTGGTSLALTAARAGLGTLSVVARFITSAVEHSHTSSAQAEASRLS 216 white-tufted-ea...
XP_007503451 329 GTk---gQVAMVVLCKEAPQVVSVAQRCVslgnQVLEEInKNIRAFRLAKANTRLTTSAKTLMTTGSLSTRSARKVEKAF 405
Q9BWW9       207 PL-----TTSHEAFGGINWSEIEAAGFCVnkcvKAIQGI-KDLHAYQMAKSNSGFMAMVKNFVAKRHIPFWTARGVQRAF 280 human
XP_005625974 210 PVp---aMTVHDSSEERGCSEISAALLCIdkcvRAFKNL-KELRAYQMAKANSGFMAKVNKFMAMGHIPFWRTGGLQRAV 285
Q9BQE5       186 QSgtnvaKVMKEFVGGNTPNVLTLVDNWY----QVTQGIgRNIRAIRRARANPQLGAYAPPPHIIGRISAEGGEQVERVV 261 human
O95236       257 ATsidrlKVFKEVMRDITPNLLSLLNNYY----EATQTIgSEIRAIRQAR------ARARLPVTTWRISAGSGGQAERTI 326 human
Q9BPW4       209 ATstdqlEALRDILRDITPNVLSFALDFD----EATKMIaNDVHTLRRSK------ATVGRPLIAWRYVPINVVETLRTR 278 human
XP_013008670 182 TSrldtgKEVLQVVGQATPKVVAASKKCV----QTFQSIeKNLYALKVAQSNPRLLARANRFIKTGKISARSGKQVQKAF 257
EHB14171     182 TNskdtaKELAQSVGQVELDVVLKSVQGI----SVLKGMkKSIHALKLARADARLLANANRFTGTWKIPFRKGERVQKAF 257
XP_022280190 182 -TtldkeEVVAKVLHENWSSISSLALDSM----KVLARAaRDIRNLRLGRFTCQPVVAAAGFLTANTALGLGWAQVKRVV 256
XP_009008383 217 GTsidklKEFSELTHEMXPNSRSCVTDFY----IATEVIgEQVRAMRGAR------ASAQHPRQT---SAQNGADLVLTS 283 white-tufted-ea...
XP_007503451 406 GGTALAMTKGSRMMSAMTTGAFVLVDMITVIHDLNHLLEGAKAEMAGELREQAQELEGKLEELSQ 470
Q9BWW9       281 EGTTLAMTNGAWVMGAAGAGFLLMKDMSSFLQSWKHLEDGARTETAEELRALAKKLEQELDRLTQ 345 human
XP_005625974 286 GASVMPMTKVARLLGAAGAGLSLMQDLRSLQQSWTHLEEGAKAETAEELRAVAGALEQELDQLTQ 350
Q9BQE5       262 EGPAQAMSRGTMIVGAATGGILLLLDVVSLAYESKHLLEGAKSESAEELKKRAQELEGKLNFLTK 326 human
O95236       327 AGTTRAVSRGARILSATTSGIFLALDVVNLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQ 391 human
Q9BPW4       279 GAPTRIVRKVARNLGKATSGVLVVLDVVNLVQDSLDLHKGAKSESAESLRQWAQELEENLNELTH 343 human
XP_013008670 258 GGTTLAMTKGTRLMGAATAGLFALVDVYSLVQDSVHLHNGAKTESAAELRQEAQVLEEKLEELTE 322
EHB14171     258 GGTAQAMSKGARMMGAAVAAVFLLVDVYSLVQTSKHLQKGAKAESAEELRQQAQVLERKLEELIG 322
XP_022280190 257 RGSLRAIARGARVVGTASLGLFILMEAVSLVFKSGNLHEEAKTWSAESMREEAQELNRKLELLKE 321
XP_009008383 284 GPTNWLAGRGGRMVSTASTGILLVLEVVNLVYESKHLLEGANSQSAEQLRQQAQMLEANLK-Vls 347 white-tufted-ear marmoset
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