Conserved Protein Domain Family
CDK5RAP3

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pfam05600: CDK5RAP3 
CDK5 regulatory subunit-associated protein 3
This family contains several eukaryotic sequences such as CDK5RAP3 (also known as C53 or LZAP) which serves as a probable tumour suppressor. Initially identified as a CDK5R1 interactor controlling cell proliferation. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation. It also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. It has been shown to bind Wip1 and stimulates its phosphatase activity.
Statistics
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PSSM-Id: 461688
Aligned: 44 rows
Threshold Bit Score: 289.58
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005845265  23 LPI-DVQYTKLSEWLVDRKQVPADWNRKLQAIQAKAAAAVRELPpG------------FLGQFE-GgedAPLDYFQAQRV 88 
EEY59584       7 LPI-DIQYKQLLEALVDRRIVPNKWLEQHKQIRDAIAALYLELPlAse---------aLSKFRSkKpshEDLNYFDCKFI 76 
XP_009122300  10 LPI-DITFSRLGEWLVDRKRIPADWRKKVAAIRVRISKEFSSLPkEid---------pYFQTID-P---DVIGYLEAKRI 75 
EEF30042      10 LPI-DITSSRLGEWLVDRKRIPSDWRKRIAAIRARISKELSSLPkDid---------pYIQTLE-P---EGIGYLEAKKI 75 
ERN11638      10 LPI-DIAFSRLGEWLVDRKKIPGDWRKRLSSNHKQISSSFASLPkDld---------tYFQTLD-S---DSIGYLEAKKI 75 
XP_009394999  10 LPI-DIAFARLGEWLVDRKRIPQDWRKRLTAIRARISSALPSLPrDld---------pFLQTLD-P---EEIGYLEAKNI 75 
EER88322      10 LPI-DIAFGRLQEWLVDRKRVPHDWRKRLAGIRARVASAFAALPrDlh---------pSLLALD-P---EEIGYLEARKI 75 
XP_006656040  10 LPI-DIAFGRLQEWLVDRKRVPQDWRKRLAGVRARVAAAFASVPrEld---------pSLLALE-P---DEIGYLEAKKI 75 
EGG18868     239 IPIvDIPGAKILDWLVERKKVPMHWKRNNGNLIKLIEDTMTSNP---------------SQLLK-DlkiENIDYFKCLEV 302
EFA79352      70 LII-DLQGSKIMEWLLDRKKLPQHWKRNAVHLKKLIDEAIRTSPpTnvklpeshrlddDDETVGh---sDRLNYFKCQTV 145
XP_005845265  89 LAKL-SETAE--KSLLGSL-KGAAGEWDKVVRAYEYNLIYLAEAAQTLCRNADFEIPFLKKQAAKCQQQLADLEKRKAEA 164
EEY59584      77 FQCLeQSDEGasKNFFGQYtSPVLKRWSALIRQYQKNNVFAAETARIIAQNTAFEIPFLKKSIQQNEKQVADNNRKMADL 156
XP_009122300  76 YEIL-LKTTPesRNIFGRL-SGASGVWEAIVRAFEKDHVYLGEAAQIIIQNVNYEIPYLKKQVQKVQQQMSELDRKEADI 153
EEF30042      76 YDTL-VKTTPesRNIFGRL-SGAAGAWEAIVRSFEKDHIYLGEAAQIIIQNVTYEIPYQKKQVQKIQQQLAELERKETDI 153
ERN11638      76 YEIL-LRSTPqtRNIFGRL-SGSAGEWESIVRAFEKDYIFLGEAAQIMVQNVNYEIPYQKKQVQKVRQQLADLERKEADI 153
XP_009394999  76 YSIL-LNSTTesRNIFGRL-SGSAGEWESIVRSFEKDHIFLGEAAQIMVQNVNYEIPYQKKQMQKVQQQLAELERKETDI 153
EER88322      76 YGIL-LDSNTetRNIFGRL-TGSAGEWESIVKAYDKDHVFLGEAAQIMVQNVNYDIPYQRKQMQKTQQQLAELDRREADI 153
XP_006656040  76 YGIL-LESNTesRNIFGRL-TGSAGEWEAIVKAYEKDHLFLGEAAQIMVQNVNYDIPYQRKQMQKTQQQLAELDRREADI 153
EGG18868     303 FKYFeSQPSGnsKTLLGYYsNINTQKWNDVIKAYHKDQLYIGENCQRLTQSLNYDIPNMKKTIEKTMKSLEESNKKEIEL 382
EFA79352     146 LQDClDAPNGsaKTLFGGYsNNATQKWNDVIKAYQKDYLYIGESCQTFTQSINYDIPNLKKIVEKSTRSLEDYTRKDQEY 225
XP_005845265 165 GRSAAAAAAEFQQAreCSALGIDCSNIRGGLLGLTAELPALAAAAVEALQAegVSQGMQYYASVAGSQQQE--------- 235
EEY59584     157 TRSIAEYKRKLETS--CADMGIAGENFREELRRLPMELPSLFDGVAKAICSdeIATAIEYHQALQAYLHDCeipvvvtes 234
XP_009122300 154 KRSVALSATKYEEA--CRELGLQGNNVRRELLETANSLPTTFAKILEVINSesVSAAMEYYSAYVKDVHTEk-------- 223
EEF30042     154 KRSASLSAAKYMEA--CQELGLQGNNVRSELLETAKSLPSTFNQILEVINSdsMLKAIEFYSTFVRDVHTEk-------- 223
ERN11638     154 KRTANISAAKYADA--CQELGLQGINVRMELVETAKSLPATFRKILEVLNDdsVLQAIEYYKNFVAVAHTEk-------- 223
XP_009394999 154 KRNAALSAAKYSEA--CQELGLQGNNVRLELLEAAKTLPSTFSKILEVLNSdsMFKAMEYYQNFVKDVHTEk-------- 223
EER88322     154 KRLAALSATRYVEA--CQELGLQGINVREELIESAKTLPSTFSKILEALNSdpVSNAMEYYTTFVKDCHTEd-------- 223
XP_006656040 154 KRLAALSASRYAEA--CQELGLQGINVRQELIESAKTLPSTFTKILEVLNSdpVSKATEYYTTFVRDCHAEd-------- 223
EGG18868     383 TKSRETAINTFKKA--CSDIGIKGDKIRDEILELPNGLDKLFEKAIQLLQDgrILGMIRFYKQFAQTNTCE--------- 451
EFA79352     226 TKSRSSAQSALKKA--CQDLGIKGEKIREEIEELPKNLESIFDSVINLVNNgtLLKSINFYREVINATNCE--------- 294
XP_005845265 236 ------QGEAALLPVLAEVREG---------RTEAPAAaaaaeaparsasgdgg------daaaadsggsaatglQLDWd 294
EEY59584     235 isssssKKKKKSKKQVEAAEEPevttdepfeLVLAPHKffaaieelrnasnel--------vettatldfeaeaaEISWd 306
XP_009122300 224 -----dKPARVVLENLKDIREN------------PPSLsvlgafealdgdnv---------qssenangtdvaadSIDW- 276
EEF30042     224 -----dKSSWIVLWNLREIREN------------PPTLnvsagpeildimnlqls----hnetshvrgdmdvtadNIDW- 281
ERN11638     224 -----eKTAGVVLPNLTNLYAN------------PPSLnisvrhealassevssktkssysvdgnqlcdvdvsmdQIDW- 285
XP_009394999 224 -----eKSPGSVLENLRHLHEN------------PPSLyvsmsaevqnslsdmsms--dvhvsagtpmdtilpmgGIDW- 283
EER88322     224 -----mGNCVSVLHKLKELQAN------------PPSLhvsvyneiksslvea--------peshgqidsnvaddDIDW- 277
XP_006656040 224 -----kENCKSVLQNLKQLQAN------------PPSLhisvcnevetslgetska-hgsnvtgeeniasnmsadDIDW- 284
EGG18868     452 -------LKEEIFSYLLLVNKHgnisigereMILNPSIivkskkdqnvdsn-----------nsgsdlvaltapaTIDWd 513
EFA79352     295 -------LNGELLALTNFLIQHgnitlgereAILDPTykvpkrvntte----------------saqqqqqqqqpQLNFd 351
XP_005845265 295 lgaalgaaggeeaggGGAAVPAAGISWDldasdlaaaaedggddaagagggaaggiswevevdpadvaaaadvaadvaae 374
EEY59584     307 is----------ldgSGTAE-VGEIDWGietvaste-------------------------------------paeitvd 338
XP_009122300 277 ----------------DITLDTAEIDWDvsmveevdggndlgsye------------------ivdasdipenkveggpe 322
EEF30042     282 ----------------DISVDSTQIDWDigateeiddgsnglgpyeivnasdilqsssqneavesdlnssskgednlhpe 345
ERN11638     286 ----------------DVSVETSQIDWDigtveetevsigevgkdeipnatdelqvqvmdkaippenklpkildedtglq 349
XP_009394999 284 ----------------NISVDDTQIDWDvdaveqleesgnsfgsyeiidynvdl-kdsengkdllydntsskktegvvpe 346
EER88322     278 ----------------DISVDANEIDWDigaveqpveesgngfgsyeiidan-----ielagsenynvsvadkslnkdla 336
XP_006656040 285 ----------------DISLDDNGIDWDigaveqpveesgngfgsyeiidan-----velagsenynfgisddpsvnkss 343
EGG18868     514 fsve-------esgsQLDEKAAASINWD---------------------------------------------------- 534
EFA79352     352 i------------dtNVGGAAAGGINWEiddq--------------------------------------------ltai 375
XP_005845265 375 VAPAEIAW-------------------------DIDISGVGEESEQQeqqlagarqqgagageadgpsaAAAAAAAADEP 429
EEY59584     339 DAPVEIDW-------------------------DITTSDAVEP-VNEvsapeaa-----------dvvepvpIT-TGQAT 380
XP_009122300 323 VDVSEISW-------------------------DVSVETPQVEEIADssslesg------------qekqiqSIDQVLGS 365
EEF30042     346 ISVSEISW-------------------------DISVEPPQIDVVDDvdspntg---------lenqkyVPDSLTHNSGV 391
ERN11638     350 NSNEEICW-------------------------DISIENSSMDILEEaavqdvp----------sddqfdVNMLASSEGD 394
XP_009394999 347 ASESEICW-------------------------DISLENPQVDMLEDavvpvvg------------idkpnpTETSQSES 389
EER88322     337 sSESGICW-------------------------DITADSSE----EIasiqnap---------------sefeqpQSQMI 372
XP_006656040 344 sSEPGICW-------------------------DITDDNPE----ENatmqnap------------------esgqpqSS 376
EGG18868     535 ------EFtvvleedgttnsssvaddfsmmdtiEIVEEANTISSPILest-----------------ttITDNIKFMDNA 591
EFA79352     376 QEPAEIKWdedfsvidsstsqdivddfsmmdaiEIIDESNSPVLLSAsdasqqqi------tldggdnsGSGNTKVIDNP 449
XP_005845265 430 AtirRLIEDAAYRARLLDDLYELRAFLMQRCRELSGRSsELL----LAAAAEGGLHVSADQATDMVGAVDEALARFGGDK 505
EEY59584     381 Rv--GLLDDNEFRTRVLNDLLELRAFLRQRLVELSGSD-SVAfanqFQGSSSLLEQQSTAKIEELQAAVDGAVSLLTSKR 457
XP_009122300 366 GeerSQLLETEYRNKILDDLYEVKAFLNQRLVELRNEDtLSLqhhvQAVAPMVLQQYSPEIIEPMVVDISMAISLLTNKK 445
EEF30042     392 KeerSQLLGTEYRNKLLDDLHEMKAFLNQRLAELRNEEtLSLqhqvQSVSPLVLQQYAPDAIETMLSDVFLVISLLTNRK 471
ERN11638     395 AeerSQILDTEYRNKLLDDLFEVKCFLSQRLFEMKSEEtSSLqhhvQAVCPFVLQQYTVDAIQLMSSRISSAISMLTNRK 474
XP_009394999 390 FeerSQLLETEFRNKILDDLFEVKSFLNQRSIEMRSEEtSSLqhqvQAVAPSVLQQYSPDVVQLMISEISSALSMLTDRK 469
EER88322     373 TedrSRLLEKEYRNDILDDLLEVKSFLTQRLGEMRNADtSSLqhqvQAVSPFVLQQHAPDSLENMLVEVSSAISLLTNQK 452
XP_006656040 377 AeerSQLLEKEYRNNILDDLLEVKAFLTQRLGEMRNADtSSLqhqvQAVSPFVLQQYAPENLENMLAEVSSAISLLTNQK 456
EGG18868     592 Ne--SIMSDKIFRNRLLDDIYEMDIFLKQRAVEMNQPes------eFSAIHMMQESITLDQCEQYSKLIGDIISQLSSSK 663
EFA79352     450 Fe--SILGDRTLRNQFLDELYELEIFLKHRSVEMAAPeh------vFGIDQINVESTNLDQCKQYLKQVTEIITLMTNHK 521
XP_005845265 506 LKQLIALRTSSHYLDRLAAGLQQKAAQEAK---AAAEAEARRGGIQSQLMADSAKLAVLVKHTRQAKEEVERALSAKLG- 581
EEY59584     458 LQQLVLIKTSERYLDRHVASLEMLTKHMDKcgrEIHALEDKNVDLIDATKNVQPQINALVATTKKLKKELEAALPPLFKg 537
XP_009122300 446 TRDLVMILNSKRFLDRLVSELEEKKHREVKlkeSLKDVGRRRMELQNSLSSIWPKQEAALVKTRALKELCETSLSSIFEg 525
EEF30042     472 TRDLIMILNSKRFLDRLVNTLEEKKHHELKlkeGLKDLAAKRMELHNSLSSSWPKQEAALAKTRELKKLCEGTLSSMFDg 551
ERN11638     475 MQDLIMILNSKRFLDRLVSMLEQRKSHEVKlkeSLKDLSARRMELNNMLSLSWPKQEAMLLKTRELKKLCETTLSSMFDg 554
XP_009394999 470 MRDLIMILNSKRFLDRLVLTLEEKKNHEVKlreSLNDLSVRRVELQNTLSSSWPKHEAAIAKTRELKTLCETTLSSLFDg 549
EER88322     453 TLDLIMILNSKRFLDRLVSTLEEKKHHEVKlreGLGDLSVKRMELQNALSSSWPKQEAAITKTRELKKLCESTLSSVFDg 532
XP_006656040 457 TLDLIMILNSKRFLDRLVSTLEDKKHHEVKlreGLGDLSVKRMELQNALSSSWPKQEAAITKTRELKKLCEATLSSVFDg 536
EGG18868     664 VNNILELKSSSKLVDRMALQFTQKIGTITKyqqLIKDLLQKREDLNTTLTETKTKLESQTKETKQLRLQLQELLVDIMDg 743
EFA79352     522 IKHILEIKSSKKYIDRLVLQFNQKQGNIAKytqMIADLDLKRKEVNQTLTESRKKLDQLIKDTRVLKTKLEGILVDVLDg 601
XP_005845265 582 RRINVMG 588
EEY59584     538 YKVNIVG 544
XP_009122300 526 RPVNIRG 532
EEF30042     552 RPVNIIG 558
ERN11638     555 RPVNIIG 561
XP_009394999 550 RPVNIIG 556
EER88322     533 RPVHIIG 539
XP_006656040 537 RPVHIIG 543
EGG18868     744 KHINIMm 750
EFA79352     602 KKANLMi 608
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