Conserved Protein Domain Family
MCM_bind

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pfam09739: MCM_bind 
Mini-chromosome maintenance replisome factor
This entry is of proteins of approximately 600 residues in length containing alternating regions of conservation and low complexity. The Arabidopsis protein is a replisome factor found to bind with the mini-chromosome maintenance, MCM-binding, complex and is crucial for efficient DNA replication. The family now spans the full-length proteins.
Statistics
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PSSM-Id: 462870
Aligned: 39 rows
Threshold Bit Score: 547.24
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q55CZ6        45 FENVISEDQIYKSIPLVSTINQCDLNSGKLVKIRCMIQDIFDPQFCPSFNKIKNIETNE-IRLEASKYKDKINLN----D 119 Dictyostelium d...
Q501D5        44 FRHYFSDESAISQVPILDSSSIKWVQPKTLVRFRGMIQDMLGNEFYAGAYKDD-------STWRTNKYSDVSQFPe--gS 114 thale cress
XP_006365988  44 FRKFLYDDGGLSQVPVLNPSSIARLKSNTLVRFRGMIQDMLGNELYVGMYKDG-------ETWRTNKFGDFFQFPmatgS 116
XP_002274437  48 FRQFLFDNGGLSQVPVLNSTNFKRVQPNTLVRFRGMIQDMLGNELYVGVYKEG-------PNWRTNKFMDVSQFPm--gS 118
EEF41557      44 FRHFLFDQSNLSQVPILNPASLRWIQPNTLVRFRGMIQDILGNEFYVGAYKDG-------SVWRTNKFMDVSQFPi--gS 114
XP_003522508  44 FQHFLSDPSRLSQVPLLTPATIQWVKPNTLVRFRGMIQDMLGNEFYVGAYKDG-------SVWRTNKFMDASQSLt--aS 114
XP_009406879  48 FRDFLFEQGGLSQVPILDASTIRWVQPNTLVRFRGMLQDMLGNELYVGAYKDG-------STWRTNKFTDVAPSPm--pP 118
XP_015694686  43 FRSFLFEQGGLDKVPVLDESNLGLIKPNTLVRFRGMVQDMLGNEFYVGAFKDG-------STWRTNKFSDSSPFSm--pH 113
XP_004968309  51 FRSFLLEEDGLDKVPVLNASNLGLIKPNTLVRYRGMVQDMLGNEYYIGAFKDG-------STWRTNKFTDFSPFSm--pH 121
XP_004346868 104 YLELLNDPSNYHRIPLVNNTPVSLLKPNTLVRFRCMIQDT-ADELSMGVAAFSVTDAAQqTRILSGLYRD---------- 172
Q55CZ6       120 CEELIFDSFDS--STFDKTILYCIPIPCENKWVnn-nnNnnnnnnnnnnnnnNNNNNNGNEQISSSLLNKKKRNIddadm 196 Dictyostelium d...
Q501D5       115 STEI---------QVWERRLLYCVPVPGKNQWTecs----------------sqELKNRFLDL--TGQNREKRVRv---- 163 thale cress
XP_006365988 117 SPDM---------RVWERRLLYCVPVPGQNSWIeys----------------seSLLNPSSIS--SSPQREKRHRe---- 165
XP_002274437 119 RPDM---------RVWERRLLYCVPVPGQNSWVeps----------------seAVINCYRNG--TSQQREKRQRd---- 167
EEF41557     115 SPDM---------RIWERRLLYCVPVPGLNSWAdsa----------------seVAGDTCMNW--TSQQRDKRGRm---- 163
XP_003522508 115 SADM---------RIWERRLLYCVPVPGLSPWTqvs----------------teEFGHLSMDR--TSENREKRRRe---- 163
XP_009406879 119 AFET---------QLWERHLFHCVPVPGQNSWTmep----------------spSPGERNMSSS-ASQHGVKRGR----- 167
XP_015694686 114 PCDS---------HLWERHLFHCVPVPGQNSWThes----------------spGPDVRRMSSCLTSEQREKRKR----- 163
XP_004968309 122 PCDS---------HLWERHLFHCVPAPGQNSWTmes----------------spGPDLRRMSSCLATELREKRKR----- 171
XP_004346868 173 -HESIDECDHGseSLISRQTFVGIPIPGEAPWVqehhqAlal--------yhGAVSSDPVATPAATPSVRSKRGY----- 238
Q55CZ6       197 kNENDEENKKSKDQKSTTTTtTTts-----kEGEEEGEEGEQLTKSKKLLTNNKIDINKIFN-YPIPidsndeNNLKTPF 270 Dictyostelium d...
Q501D5       164 dEEMTDSMDSSTLEAGRNGSpfkk---mkvgEAT--SSASESQVPQTSGIPPATS-------------------ADSLPC 219 thale cress
XP_006365988 166 dDTAMDDIDMQVTNEEVQAS-TSnkkm-redGIT--SNSSNLGDTPTADIGSATSVLPYF-------------DRNSLPC 228
XP_002274437 168 dNTATDPMELHVSDDEFQGS-SSnkkl-regELP--FESSKAQDFVSESACSSVSMVPTF-------------DKDSLPC 230
EEF41557     164 dFEAADHKDSHre-----------------dGHP--SPYSDSQDCKTAGACSSKIMLSDI-------------NKNSFPC 211
XP_003522508 164 dDESSD---MPVSGDEVQNS-PNtkrm-regEHS--SLASNSRGAATEIASSGTSLVSGL-------------DSNSPPC 223
XP_009406879 168 --NTEDDMDLNVSYNGDEGS-SNmkkq-kedESTCQSSGSSEDLVKHGGDLLLKNGD-----------------SSCLSC 226
XP_015694686 164 --GAEND-AMEVSENCNGEA-SCtkkp-kddDAQI-SNSSPEVSMNEEHVPEMNGGDHHI-------------PGSSFSC 224
XP_004968309 172 --DGDKD-DMDVSENGHEES-SAlckkpkedDVHV-SSGSNEVA---EGVPEMNRGD-HI-------------PGSSFSC 229
XP_004346868 239 -EEDDEPAEPSLMLPTSNIVpPSva-----kRVQSVADRAQLDRVTSQQANTPLSVADALSTcFPVPy-----QQAGPVC 307
Q55CZ6       271 IVNIYDDDiifdennKavTFKINEIIEFVGVVAkFNPTLQHQSS-NSSDqgettttiidLMSMLDVDEISTI-------- 341 Dictyostelium d...
Q501D5       220 LVKIYDSP-------Es-DLKLNDVVEFLGVLT-FDPIVMMDTD-TLDE----------NSDALSEAESVQM-------- 271 thale cress
XP_006365988 229 LVKIYDSP-------Es-DLKLNDVFEFIGVLT-FDPEFSVDKNvDNDI----------LGYLGDDDTQTQM-------- 281
XP_002274437 231 LVKIYDSP-------Es-DLKLNDVFEFVGVFT-FDPELVV-KD-DTDE----------FS-DLCDDVLANL-------- 280
EEF41557     212 LVKIYDSP-------Es-ELKLNDVFEFVGVLT-LDSDLAMEKD-DHDD----------LSNDFGDDVSIHL-------- 263
XP_003522508 224 LVKIYDSP-------Ds-ELKLNDIFEFVGILT-SDLELEEDNE-DCD-----------LSDGISEDPLCHL-------- 274
XP_009406879 227 LVKIYDMP-------Es-HLKLNDVFEFIGIYT-FDPELAGHKD-NSDD----------LMYDLFEDPMAHL-------- 278
XP_015694686 225 LVKVYDMA-------Es-QVKLNDVAEFIGVYT-FDPELASPSD-NSDD----------IMFDLIEDVTAQL-------- 276
XP_004968309 230 LVKVYDMP-------Ds-QVKLNDVIEFIGVYT-FDPELAAPSD-NPDD----------IMLDLIEDVIVQL-------- 281
XP_004346868 308 HIKIYHGY-------D--DVKVASVLDVVGILT------------------------------FEQDHFEEPvfeheefr 348
Q55CZ6       342 PDTLIPQFHAITYRYLDpykfnHLNPFSidtnttinnnnnnnnnnnnnnnnnnnnnnnnnnnNNNPNNNNPNNNNLNNNL 421 Dictyostelium d...
Q501D5       272 PSGKVPRLHCLIHRKLEtqhflHGSSLL-----------------------------------------PEPKSPQIFKE 310 thale cress
XP_006365988 282 PPTKVPRLHCLIHKKLSnqdfiTGSPTL------------------------------------------ELK-SHLVKE 318
XP_002274437 281 PPSKVPRLHCLIHRKLAvhdfiSNSPVM------------------------------------------EVK-PHLVKQ 317
EEF41557     264 PPNKVPRLHCIIHRKLAvadflHSSPII------------------------------------------EPK-PHFIKA 300
XP_003522508 275 PPSKVPYLHCFIHRKLAvhdflQHNPIV------------------------------------------EPR-PNLVRE 311
XP_009406879 279 PPSKVPRLHCLICRKLViqdflPNSPVI------------------------------------------EPL-PNMIRK 315
XP_015694686 277 PPSKVPRLHCLVWRSLSahdflSRSPAV------------------------------------------EPS-PILLKG 313
XP_004968309 282 PPSKVPRLHCLVWRKLSphdfiSRPPVV------------------------------------------EPS-PSILKG 318
XP_004346868 349 PSSLVPRIHCITFTMPK-----STNPLVph-------------------------------aQSAVFAGERLAIAAQAQM 392
Q55CZ6       422 IRNELIKFI-KLFIVDELLSEYLLFHLISKVYSFTSGLSIGNFSMNIsi----------pnDKEFQRLPQLIELLYEILL 490 Dictyostelium d...
Q501D5       311 IRESLMKYLtGLLGNDHIAAQFLLLHLLSKVHGRVDNVAVGKLSLNLih----------lnKESMSIFGTQLSGALKSLL 380 thale cress
XP_006365988 319 IRETLLRHLtTILGNDGVAANLMLLHLLSKVHARVDSTAVGKLSLNLtc----------fnKETLSVYGHRLNLALKNLL 388
XP_002274437 318 IRESVLGHLtAVLGNDGLAAHFMLLHLLSRVNGRVDTLAVGKLSLNLtc----------fnKESVSVFGNQLTLAIMNLL 387
EEF41557     301 MREALLRHLtAILGNDGVAATFMLLHLLSRVHARVDNVAVGKLSLNLtc----------lsKESISIFGTQLSIAVKNLL 370
XP_003522508 312 IREALLRHLtAVLGNDDFATHFMLLHLLSNVHARADDLAVGKLSLNLtc----------fsKEIVSVFGKPLSAALKNLL 381
XP_009406879 316 IRESLLLHLsAVLGNDEVAAQYLLLHLLSRIRAQVDVITVGKLSLNLtg----------ftRESASIFGCQLTNAVEELL 385
XP_015694686 314 IRQSLLSHLtLVLGNDELAAQCLLLHLLSRLRNKVDVVTVGRLSMNFtg----------fnRESVSVFGNQLNNLIQRLL 383
XP_004968309 319 IRQSLLSHLtLVLGNDELAAQCLLLHLLSRLRNRVDLVTVGRLSLNFtg----------fnRESASIFGNQLYSLIQKLV 388
XP_004346868 393 LRSHAVDVFaNILLGDQLAAEYLLLHLLSNVYVRRQLMACGKLSLNIsnipdlaesgmpsiaSSANGLVNALARTVGALV 472
Q55CZ6       491 ARSYRFSMSLENLNDMDVVPYKDYDRNRIVSGLLQLPKGTNLILDETQLTEGKVESQGIKVLNALNTLSIQQKVEYDFKY 570 Dictyostelium d...
Q501D5       381 PFTQSIPLTIEYLNTASFGPKKDYGINRLMPGVLQIADGTHLILDETELQPGTLNSVGVENANLLKNLLECQKVEYDFQY 460 thale cress
XP_006365988 389 PFTHCVPLTVDYLNKIPLAPKKNYQTNRLASGILQLAEGSHLTIDETQLQEGRLNPIGLENARVLQSLLEQQKVEYDFTY 468
XP_002274437 388 PFTHRIPLTVDYLNSASLAPKKDYQLNRLVTGVLQLAEGSHLTIDETQLKAGTLNSVGVENARLLKNLMQLQKVEYDFKY 467
EEF41557     371 PFTSCIPLTVEYLNRSSLAPKKDYQSNRLMPGVLQLADGSHLIIDETQLETGTLNSVGVDNARLLKNLIEFQKVEYDFTY 450
XP_003522508 382 PFTFYIPLTVEYLNTVSLVPKKNYDTNRLETGVFQLAEGSHLIVDETKLEAGTLNSVGVENTRLLKNLMELQKVEYDFKY 461
XP_009406879 386 PFTRAIPLTIEYLNNATLQPRKDNKTGRLVAGVLQLAQGTHLTIDETRMQNGTLNSNGVENARLLKHLLEWQKVEYDFEY 465
XP_015694686 384 PYSQTIPLSIEYLNTATLQPRKDNHSGRLVTGVLQLPQGTHLTFDETLLQSGSLTSKGVENTMLLKNLMESQMVEYDFEF 463
XP_004968309 389 PYSQAIPMSIEYLNTATLQPRKDNKSGRLVTGVLQLPQGSHLTFDETLLQTGSLTSKGVENTMLLKNLMESQKVDYDFEY 468
XP_004346868 473 PNSLLLPLTVNNLNTLRFRPFKNHTLGKLESGVFQLPHHTHLLVDETSLQPAQLEPRGTENCNTISNLLQWQSLEYDFEY 552
Q55CZ6       571 HPIEIQTDLPTISISFGKS-LIKGTTQISINKSIqlptineinQQLIhsyNNDKLNQFRNYINHCKNLSFKIssptttti 649 Dictyostelium d...
Q501D5       461 YKMEMATDVQMLIFSEGKSnIMPADLVLPLQPSQvnsl---------eviTPETAETWRCYLATCKSLSHSI-------- 523 thale cress
XP_006365988 469 YKMDMPADIQLLVLSEGKSnILPADLVLPFRPLSvdaa---------qdvEIEVLQSWRWYLATMRSLSHSI-------- 531
XP_002274437 468 YKMEMAADVQLLILSEGKSnILPADLVLPFQPSSvdst---------epvATEALEAWRWYLVTLRLLPNSI-------- 530
EEF41557     451 YKMEMAADVQLLILSEGKSnILPADIIIPFQPSSasss---------evvVTDSLNAWRWYLATVRSLPHSI-------- 513
XP_003522508 462 YKVDMATDFQLLVLSEGKSnILPADVIVPFRPSAtscs---------eavTAEALEAWRWYLATVRQLSHTI-------- 524
XP_009406879 466 YNLEMAADVQLLIISEGKSnILPADLVLPFCPKSvds----------vnaTGEKLQAWRWYLATMRSLQHSS-------- 527
XP_015694686 464 YKLEMATDVQLLTLSEGKSnILPSDLIVPFRPSSvpa----------vnaSSEELESWRWYLATVRSFPQST-------- 525
XP_004968309 469 YKLDMATDVQLLTLSEGKSnILPSDLVVPFRPSSvpt----------idaGSEELENWRWYLATVRSLPQST-------- 530
XP_004346868 553 HNITFNTDLQVLITSSGKS-MFPADCHVPLEPVTsgvvdvlaqMDAA------TLERLRLYLTMARDFDYSF-------- 617
Q55CZ6       650 aeSDDATRHIQEDFVKSRQLDSKMTTDVFHYWLTLSRLVALSFNDQYIKIDKWNIMKSLEEKR 712 Dictyostelium discoideum
Q501D5       524 --GQELQQVVENDLVAARQTDRSLGSQDLSRLLTMARMMSVSYGETTLSLEHWQMVLELERLR 584 thale cress
XP_006365988 532 --TQEMQKVVEDDLVAARQADRSLGSLDFSRFLTMGRLVSLSFGETTLTLEHWQMAKELERLR 592
XP_002274437 531 --DPELQKVIEDDLVAARQADRTLSSQDFSRLLTMGRLMSLSYGETSLSLEHWQMVKELERLR 591
EEF41557     514 --ESEIQKVIENDLVAARQADRSLGSQDFSRLLTMGRLISASFGETSLSLEHWQMVKELERQR 574
XP_003522508 525 --EPEMQKVVETDLVAARQADRSLSSQDLSRLVTMGRLMSLSYGETSLSLEHWQTVKELERLR 585
XP_009406879 528 --EPETSQILQDEMVAAMQEDRSLGCSGLTRWLTMAELMSASFGEKCLTLEHWQMIKELERLR 588
XP_015694686 526 --ETETYQTIQDEMVNAMRDDRNLGCSELSRWLTMAQITAASFGETSLSMEHWQMVKELERLR 586
XP_004968309 531 --EPETYQMIQDEMVSAMRDDRSLGCSELSRWLTMAQIMASSFGEKSLSLEHWQMVKELERLR 591
XP_004346868 618 ---EQLESEVQNDFVAMRRADRTVTQETFSQLLVVSRLLSLSYGQPQLTPACWQRAKELEQLR 677
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