1P87,3BCH,1VI6,1PNS,2HGR


Conserved Protein Domain Family
RPS2
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cd01425: RPS2 
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Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ribosomal protein S1 to the 30s ribosomal subunit. In humans, most likely in all vertebrates, and perhaps in all metazoans, the protein also functions as the 67 kDa laminin receptor (LAMR1 or 67LR), which is formed from a 37 kDa precursor, and is overexpressed in many tumors. 67LR is a cell surface receptor which interacts with a variety of ligands, laminin-1 and others. It is assumed that the ligand interactions are mediated via the conserved C-terminus, which becomes extracellular as the protein undergoes conformational changes which are not well understood. Specifically, a conserved palindromic motif, LMWWML, may participate in the interactions. 67LR plays essential roles in the adhesion of cells to the basement membrane and subsequent signalling events, and has been linked to several diseases. Some evidence also suggests that the precursor of 67LR, 37LRP is also present in the nucleus in animals, where it appears associated with histones.
Links
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Statistics
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PSSM-Id: 100106
Aligned: 170 rows
Threshold Bit Score: 88.7929
Created: 12-Dec-2003
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:rRNA interaction site [nucleic acid binding site]
Evidence:
  • Structure:2HGR: RPS2 contacts 16s rRNA in the 30s ribosomal subunit, contacts at 4.5A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                            ##        #   ##                                            
1P87_B         8 MLKAGVHFGHQTry----wNPKMKPFIFGAR---NKVHIINLEKTVPMFNEALAELNKiasrkgkILFVGTkr------- 73  Escherichia coli
YP_316599      5 LIKTRNYKLFKYn------LLKLQIYSNESSfniSTFSNNVLEQIEAYLKQVLKIIFEyhmyqfkILFIGFp-------- 70  Thalassiosira p...
YP_052907     20 LFKSKNFYGESLke----tKKKNLPFIYGFR---HNYSIINLKATIFFLQKALFLIKLcikknkkILIIGDsfdikflls 92  Saprolegnia ferax
YP_448641     13 FIGSSGYLVPRSvnenikiSKTMHPYLLGKR---NSYYFYNLEKSLYGIRASLEVLKNiiedngeILFVSDlp------- 82  Desmarestia vir...
NP_150383     13 FIGSSGYLVPRPqneyvkiSKTMHCYLLGKR---NNFYFYNLEKSLYGIRATLEVFKNivakegkILLISNs-------- 81  Pylaiella litto...
ABX45183      20 FLRSEFYIGCKKsr----wNPLLIGFIYKLR---KKIYILNLEYTVFQLRRSLNMIKNiirnrgqILMVMIkk------- 85  Polysphondylium...
YP_001876557  22 LVRNEFYIGGQKar----wNPLLVGFLYKIR---KGMLIINLEYTIFQIKNGLNLIKNivrnrgkIMILVLkk------- 87  Dictyostelium f...
XP_001712991  10 LIYSQNYIGAAYv------DFRMKNHIIKQKn--NLNNKINLFTTYKNLIYLPSLLFSiss-mrkLAIIDTkc------- 73  Bigelowiella na...
P46753        12 LVASDLFLGYHIan----wNPRTNFFLIGKY---KNTNIFNLNYTYFLAKKFIVFLSElfvnkghLWLVNEnfsl---fn 81  Acanthamoeba ca...
YP_665647     21 FFKLSAHIGNKKw------HPTMSSNLIASR---NAVYILDISKTIKGLFNALDVISSivsqkghILFINSnp------- 84  Nephroselmis ol...

Feature 1                              # ###  ##                                                 
1P87_B        74 aASEAVKDAAlsc--dqFFVNHRWLGGMLTNwktvrqsikrlkdletqsqdgtfdkltkkealmrtreleklenslggik 151 Escherichia coli
YP_316599     71 vVSKLKQMRLmhftnhdFISEKSWISGIFRNrfsiltyltliqsqn-------------------------fsknlklll 125 Thalassiosira p...
YP_052907     93 eSKKINFTQKnk---niILKNDIWINGLLTNktvsnf------------------------------------------- 126 Saprolegnia ferax
YP_448641     83 aLKYAFGKNPn-----iNCINLKRSSLANSGd------------------------------------------------ 109 Desmarestia vir...
NP_150383     82 -LTLESRFALe-----sNINYLKWKRGSLSKsq----------------------------------------------- 108 Pylaiella litto...
ABX45183      86 kISNLVKTLLkks--kqGYVDYKYYNGSLIHfkeskkllyqkstgnievd-----------------lkektfikmlgyk 146 Polysphondylium...
YP_001876557  88 kINNIVKILLtkn--kqGYVVYKYSHGSLMRfrrmrrlfelkrmgyligk-----------------lrpitflklkgyv 148 Dictyostelium f...
XP_001712991  74 iSRKAIKQICial--ncRGIFKNYIPGNFSNrqik--------------------------------------------- 106 Bigelowiella na...
P46753        82 rSSELYQLYSlfp--eiTFLNSKWCKGMLSNykyvsi------------------------------------------v 117 Acanthamoeba ca...
YP_665647     85 lYNKLLQKTCelt--eqSYVNNRWVGGTLTNwpiiskeietykkvvtqlhlytsl------fyvstpryekmkksfqgfq 156 Nephroselmis ol...

Feature 1                               #  #                                                   
1P87_B       152 dmgglPDALFVIDa-dHEHIAIKEANNLGIPVFAIVDtnsDPDGVDFVIPGNDDa------IRAVTLYLGAVAATVRE 222 Escherichia coli
YP_316599    126 svktkPHLVVVFNq-kVETNVINEFYKAGIPILSFNCkplNMPKITYKTLGNFKfvetnlrTAYFFLFYSILKRPPLT 202 Thalassiosira pse...
YP_052907    127 lkhnkINLIILLKsktKENYLLTEFNHKNIPIITLNNtnsNIDYINYPIFSNTKn------LKSLFFLIYLIRKTFLK 198 Saprolegnia ferax
YP_448641    110 -----SDLIFLSG---VRKENLVEAHRKCTPLVGVGSf--TMSKIAYPFNLNIDs------ILLSYWFFNAIYATCDR 171 Desmarestia viridis
NP_150383    109 ----dVDLVFLSG---VNRENLVEAHRKCLLLSGVGSs--TMSKIAYPVNLNIEs------PLLSDWFLGALYTSYIQ 171 Pylaiella littoralis
ABX45183     147 nlqkkPSAVIITQt-nKSDWLIRECNRLKIPTICFIDsntMSLLYTYSIVGNSNt------NKHLNLILLFIYHAIFQ 217 Polysphondylium p...
YP_001876557 149 alrrpPALLVLTTg-nKQEDIYRESLYAGIRVLSFIDtntMTLWQSHTVVGNSKt------NKNINLILLLINYAIFF 219 Dictyostelium fas...
XP_001712991 107 -sfmlPEAAIVAEp-kNDPRIIRELSNINIPIIGICNtdtNISFIDWVLPSNTNs------KFSNAMIFYLIGRLLKR 176 Bigelowiella natans
P46753       118 kpakfPHSIFVPNi-qNNHYVINESFIINIPSIAIVDsidNPSNVFFPIPGNSKs------LKSLFFFYMVIAKSLFY 188 Acanthamoeba cast...
YP_665647    157 tpiskPDLLIVLNp-sKNKEAINEAWVLNIPVIAIVDsdtNLSKITYPIPGNNSs------YEFIYYCLNIIVKTITN 227 Nephroselmis oliv...

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