Conserved Protein Domain Family
Gla

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pfam00594: Gla 
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).
Statistics
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PSSM-Id: 459861
Aligned: 87 rows
Threshold Bit Score: 29.4217
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015219956  86 LEELKMGNLERECMEEKCSYEEAREVYEHDEATNEFWTNYN 126
NP_001229297  57 FEEFKKGNLERECMEEICSYEEVREIFEDDEKTKEYWTKYK 97 
P00743        45 LEEVKQGNLERECLEEACSLEEAREVFEDAEQTDEFWSKYK 85  cattle
XP_003214643  49 LEEMRRGNLERECLEETCIYEEAREALESDVKTDIFWAQYK 89 
XP_013002920  68 LEELRKGNLERECVEEQCSYEEAFEALESASATDAFWAKYT 108
ABV53442      49 FEEMRKGNLERECVEEQCSREEAYEALESPSETDAFWAKYT 89 
XP_022263877  45 LEEMKKGNLERECMEETCSFEEAREVFEDTAKTMEFWNKYK 85 
XP_023599269  52 LEEIFEGNLEKECYEEICVREEAREVFEVDETTDEFWQRYM 92 
XP_012996780  45 LEELFEGNLEKECYEEICVHEEAREVFEDDDATGAFWREYR 85 
7_pfamImport   1 LEELKQGNLERECMEEACNHEEAREIFEDEAKTKEFWNKYF 41 
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