Conserved Protein Domain Family
Claudin_2

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pfam13903: Claudin_2 
PMP-22/EMP/MP20/Claudin tight junction
Members of this family are claudins, that form tight junctions between cells.
Statistics
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PSSM-Id: 372799
Aligned: 14 rows
Threshold Bit Score: 114.057
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q16RP0               16 IIAVALLAIAFSTDNW--LS---YEVKRNNIqtfiakhpd---gasltesfNNRlvyYTRTRGL-FRYCYPKEKPPASSV 86  yellow f...
Q6E5P4               18 CLAWIFVMITTGLNEWrlWY---LDVGNTSV--------------------ITS---GVAWVGI-WRACFYSHVLAKVEN 70  torafugu
Q9VX17               16 IIATALLAIAFSTDNW--LH---YDVWRNQIqsfaakhsdaesllhnmnvkYYY---YTRTRGL-FRICYPKERPPVSAV 86  fruit fly
EFB29180             17 LVGVVLALVAVVTDHW--AV---LSPELDhh-------------------nATC---EAAHFGL-WRICTKRIVMTDSKD 68 
XP_002007879         40 IFAFAFIAIAFATPSW--LV---SDYRITG-----------------------A---KLDKLGL-WVHCFRSLPDVNDDS 87 
Q17AR2               35 VIALVTVLVAFATPSW--LV---SDYRIT-----------------------GA---KLDRLGL-WTHCFRSLPDVNDDY 82  yellow f...
XP_002416528         25 YCSTVLLLISFASPYW--LEs--YQEANAEFvrlglwdvc---frnyrhpsYQY---DETFNGChWVHSYAYQNIRDW-- 92 
WGS:AAEU:GE20527-PA  16 VFSLICFIIAFSTPYW--LV---TDGSLQ-----------------------NP---RFTNLGL-WEVCFNNFQDIHRFF 63 
XP_001861470         16 AVAFLFILIAFVSPYW--LQ---TDGRLE-----------------------NP---KFHNLGL-WELCLNDFQDIHRFY 63 
Q0V9E0               15 ALGILIYLVAFGSDYW--LLakeIEKCSENQetgd-------------natHSV---LLHHEGF-FWRCWFNHAEEENSN 75  tropical...
Q16RP0               87 QIYlspvethcsnidy---fpqteedksspgFNEDIMARLHLARSVIaafilsfVAI-FCAFWTGL-SGCWKRSA----- 156 yellow f...
Q6E5P4               71 CQS----------------------------ISIAAPFAPAEIPVAQ-------VLM-MLAVVAGL-VANICGAVamrlv 113 torafugu
Q9VX17               87 PTYlspiethcsni------dyfpqaedekiANEDATSRLHLARSCIalfiisfVTI-FCAFWTGL-SGCWKRSS----- 153 fruit fly
EFB29180             69 KTCgpitlpgekncs-----yfrhfnpgetsEIFHVTTQKEYSISAAaiaifslGFI-IMGTTCAL-LSFPKKRD----- 136
XP_002007879         88 QRRffvgcrwvyd---------pftkgydeiRGFLLPAFMITTQFFYtltfigmLVS-AIGVLVFFlCAGPDQKYf---- 153
Q17AR2               83 QRRffvgcrwvyd---------pfttgydeiRGFLIPPFMIATQFFYtlctigvILSmIMVLFFFL-CAGPDQKFf---- 148 yellow f...
XP_002416528         93 -------------------------------------LLPGWFMFVQsmmtlalMFA-FTALVLVS-ILLMRFLLrf--- 130
WGS:AAEU:GE20527-PA  64 DNPfngclw----------------vfeeeyYIIHDFLLPGFYISVQlfa-tlcFVM-CLVVIPLT-AAFLRTSRddd-- 122
XP_001861470         64 DTRfsgcmw----------------ifeeeyYILHDYILPGFFIAVQffftlcfTLL-LLGILMTL-LFLVCSKDndr-- 123
Q0V9E0               76 TMEnfwftnqaptkncthaylspfpqnrdnsNSTSYHSALVYRGFWNifmllgvVTA-VIGGFLII-CAAPFTNH----- 148 tropical...
Q16RP0              157 -----------GAITATAILMLtacllAAGAMGLWHTVEFFEKEK--VVGDDYYQSWTTVL-RDNTRISYDWSYIVAWAG 222 yellow f...
Q6E5P4              114 yfsvadrrnmrLVFVLAGMLYL-----LTSGLCLVPLLWNINSVA--KNNTIDFPQEFQLP-SAPVRQQIGSAIGVGIFA 185 torafugu
Q9VX17              154 -----------GAITATSILLLvtcllAAGAMGLWHTVEFFEKEK--VVGEDYFQQWNTVL-RDNTKIAYDWSYIVAWAG 219 fruit fly
EFB29180            137 -----------YLXPAR----------PAGLCIFVSVEVTRQSVK--RM-------IDSEH-TVWIEYNYSWSFACACAA 185
XP_002007879        154 ----------iTLIRSVGYVLL-----GAGVCAAIAVIVFAVFG--------NRNGWMPEH-ANN---WFGWSFVMACVG 206
Q17AR2              149 ----------lKLIRTMGFLTL-----ASGISGGIGVIVFAIFGN--K------DKWMPEH-ANN---WFGWSFILACIG 201 yellow f...
XP_002416528        131 ---------eiIVLMVAFILEA-----ITSIPLFLSVAVFGGMC-----FERS---W---L-QNPIYNHLSWAYALAVVA 184
WGS:AAEU:GE20527-PA 123 --------rymVLLLAIGSCQV-----VGSVFGFIAVVTFGAKGD--------SRDWMPGW-QNN---DMGWSFALGVVG 177
XP_001861470        124 ---------yiMLLLTNGTTMV-----VGAICGLIAVLTFGCYGD--SRD------WMPNW-EHN---GMGWAFALGVVG 177
Q0V9E0              149 -----------RIYKAGGGLFI-----TSGILFALVVVMHVFWVQsvSDIKGYTDTRQQDCsQFTVYVSFGWSFMLAPFG 212 tropical...
Q16RP0              223 VASSLLASILLSG 235 yellow fever mosquito
Q6E5P4              186 SVLSLISGLLFLS 198 torafugu
Q9VX17              220 IGTCLLASILLSG 232 fruit fly
EFB29180            186 FVLLFLGGLALLL 198
XP_002007879        207 TVLTLVAATLFLT 219
Q17AR2              202 AVACGIAASLFLT 214 yellow fever mosquito
XP_002416528        185 FFFHTVAAMMLLG 197
WGS:AAEU:GE20527-PA 178 AVLLLPAGVLYLV 190
XP_001861470        178 VFALFPAGILFIV 190
Q0V9E0              213 IFFCLFAGMLFLL 225 tropical clawed frog
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