Conserved Protein Domain Family
Fucokinase

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pfam07959: Fucokinase 
L-fucokinase
In the salvage pathway of GDP-L-fucose, free cytosolic fucose is phosphorylated by L-fucokinase to form L-fucose-L-phosphate, which is then further converted to GDP-L-fucose in the reaction catalyzed by GDP-L-fucose pyrophosphorylase.
Statistics
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PSSM-Id: 462323
Aligned: 42 rows
Threshold Bit Score: 313.818
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBJ29017      126 SGGDSQRSPTQCVCGKAWSALNScgdsg-----sgrcNTPMDLL---LEHLSRLFSGGSSgSLePGTLVVTACDVMLlvp 197 
XP_003290380   36 NGGIHQHAPLVNLCTKSFSMLPLnnkfv-----gdspVYPIDILlsnLNVILPHA---------QPGFMVCSTESLI--- 98  
1_pfamImport    1 LILHTGRDFPWSSCSRAFCWLPLes-----------aDQSVHAPlccLDLLLDRLGRQVCpGS-PPGVWVCSTDMILhip 68  
4_pfamImport    1 LILHSGRDFPWSSCSRAFCWVPApe----------epNCRVQAPvccVDLLLDRLSTNICpGS-PPGVWVCSTDMILnip 69  
XP_003227902   90 LILHMGRDFSFDDCSRAFTCLPLed-----------pSAPVEALtcnLDNLLATLTCQICkGS-PPGVWVCSTDMLLtvp 157 
XP_004175035   89 LILHMGRDFSFDDCGRAFTCLPAed-----------pGAPAEALvcnLDSLLGTMTHRLCvGS-PPGVWVCSTDMLL--- 153 
Q7TMC8         91 LILHMGRDFPFDDCGRAFTCLPVen-----------pQAPVEALvcnLDCLLDIMTHRLGpGS-PPGVWVCSTDMLLsvp 158  house mouse
EEC42659       94 AGGESSRCPTQMILGKAWTSLPTmssvgspgvatcrlQTPVHVW---LRICERLFRGIP-----NGSIVVLAADTLLrlp 165 
XP_003417207   91 LILHMGRDFPFDDCGRAFICLPVen-----------pQAPVEAVvcnLDCLLDIMTHRLGpGS-PPGVWVCSTDMLLsvp 158  African savan...
XP_023208122   91 LILHTGRDFPWSSCSRAFCWLPEek-----------pGQKVQAPvcvLDLLLDRLSTQICpGS-PPGVWVCSTDMIL--- 155  southern plat...
CBJ29017      198 pevaatadwSF--------DQQSGaagGVAGLAIAADAAkYASNHGVYCLDGGg--------gGGGQeSHGITGVRKYLQ 261 
XP_003290380   99 ---------FLdlndknlnSPSSWqkpGVSVITMDVGPD-YYTNHGVCRLNEK-------------------DEILEIAY 149 
1_pfamImport   69 pdfvlswegFS----------------GVRVLALPGDVS-YALNHGVYLSDQQ-------------------GRVRDIVY 112 
4_pfamImport   70 pdftlswngFS----------------GVRVLALPGDAS-YAADHGVYLSDPQ-------------------GQVRDIIY 113 
XP_003227902  158 svpkidwhgFT----------------GARVVAMPGSFS-YAKQHGVYLADGQ-------------------GFVQDIIY 201 
XP_004175035  154 ---------TVpst--pgiNWDGFq--GVRVIAVPGSPA-YARNHGVYLTNEQ-------------------GLVRDIIY 200 
Q7TMC8        159 pnpgiswdgFR----------------GARVIAFPGSLA-YALNHGVYLTDSQ-------------------GLVLDIYY 202  house mouse
EEC42659      166 d--------------skfaIDWEAhadTVFGLAVPAPLA-TASNHGVFVLPPMrtnavpgasdQSSEpVIQVEPCHDVLQ 230 
XP_003417207  159 pnpgiswdgFR----------------GARVIALPGSSA-YARNHGIYLSDSQ-------------------GFVLDIYY 202  African savan...
XP_023208122  156 ---------SVpth--cvlSWEGFs--GVRVLAVPGDVS-YAADHGVYLSDSQ-------------------GRVRDIIY 202  southern plat...
CBJ29017      262 KPSREEAEASGAFLNPggmaapknesgnpnhdpsanPEVAIDSgVVVFSGAATRALTSLA------HSEtfkgctsrg-- 333 
XP_003290380  150 KRSAEYLSNNGFISKE--------------------DKASIYTgLVFFCQKTTEKLLYLHntp-plDSCtylgvds---- 204 
1_pfamImport  113 KGREEQLV--PAVMPD--------------------GKVPLVSgPVFFSSLVSEKLLLTHvtp-plDGCtylglds---- 165 
4_pfamImport  114 RGTREQIQ--QAVMHD--------------------GKVPLVSgPVFFSRSISEKLLQAHvtp-plDGCtylglds---- 166 
XP_003227902  202 QGSEDQIQ--RCVGSD--------------------GKVPLVSgIVFFSSEAAEQLLATHvip-plNACtylglds---- 254 
XP_004175035  201 KGTEAQIQ--QCAGPD--------------------GTVPLVCgIVFFSSDAAEQLLATHvvp-plDACtymglds---- 253 
Q7TMC8        203 QGTKAEIQ--RCVGPD--------------------GLVPLVSgVVFFSVETAEHLLATHvsp-plDACtymglds---- 255  house mouse
EEC42659      231 KPSQSTLQA-HCQFKQng-----------------qACAWIDTgVIVFLPTTATILRRLAfddellSRCtastlqsmqnr 292 
XP_003417207  203 QGTEAEIQ--RCARPD--------------------GRVPLVSgIVFFSVETAERLLATHvsp-plDACtymglds---- 255  African savan...
XP_023208122  203 RGTREEIQ--RALMPD--------------------GKVPLVSgPVFFCRSVSEKLLQTHvsp-plDGCtylgvds---- 255  southern plat...
CBJ29017      334 ------------vaggasalrLELYSDLLLALRTGGGTGESAegtldayleACGHVLPPDHDV----SKARREIWDALSG 397 
XP_003290380  205 ---------------gsqllkFGVFPDILCAMTKHETLESYL---------NQPCFPGSNKKLv---EGARKIVWKTFRD 257 
1_pfamImport  166 ---------------gapplqISLFLDVLKCLCSDVTQDRFVsed---rtgCSSPVGPQGATV----RRGREELWRILRG 223 
4_pfamImport  167 ---------------gapplqVSLFLDLLKCLCSDLTQDQFVted---ragCSSPVGPEGASV----RRSRAELWRLLRG 224 
XP_003227902  255 ---------------gappiqLSLFFDILLSMARGVSEEAFVnglg-prtgGSGDNTQSEAAL----WSARAVLWKTLHT 314 
XP_004175035  254 ---------------gappiqLSLFFDIVLCMAGGMTEEDFV-------------KGGGDASV----RNARSVLWTALRG 301 
Q7TMC8        256 ---------------gaqpvqLSLFFDILLCMARNMSRENFLa-------gRPPELGQGDMDVasylKGARAQLWRELRD 313  house mouse
EEC42659      293 hladgdspesalikaqdasfrFDLYTDLLQALPMVASMDDRLdng---kvtQGPSYAVLRESF----RSCR--------- 356 
XP_003417207  256 ---------------garpvqLSLFFDIVLSMARNVSKEDFLv-------gRPPEMGQGDVGIaaylQGARAELWRELRD 313  African savan...
XP_023208122  256 ---------------gapplqISLFLDLLKCLCSDLTQDQFVneg---ragCSPTDGLQGATV----RAGRAELWRILRG 313  southern plat...
CBJ29017      398 FP--LGALLLQGATFVHLGTTP-ELMEMLTLRLPEFIEPy---GLTARASSVVGAACsV-En----------DPPAVVVN 460 
XP_003290380  258 IE--LHSIKIK-GNYYYFKNPM-DFLNFIHNNGKYQISRkmhsFIATKS-----------------------PCNGVVIN 310 
1_pfamImport  224 TP--LTVAYVPGGCYDYLTLSG-KQHVE---------------RLSRDWTDRN-----V-Lshiqk--ergvDPGARIIN 277 
4_pfamImport  225 ETctLLYSYVPGGCYDYLTLSG-KHHVQ---------------RLCCDWMNRN-----T-LshiqfqresavRDGGRVIN 282 
XP_003227902  315 MP--LIMAYVPDGSYDYMTSSA-SDHIH---------------HLTTSVGNAHGGSFsK-VahshveepgllEEGCSVTN 375 
XP_004175035  302 FP--LSMACIPNASYDYMTASAsDHIRSLTLLPSSASHL----RFCKTAHSHV-DQPcL-L-----------EDGSSVTN 362 
Q7TMC8        314 QP--LTMVYVPDGGYSYMTTDA-TEFLH---------------RLTMPGVAVA-----Q-IvhsqveepqllEATCSVVS 369  house mouse
EEC42659      357 ----LSVMTIPSGRFLHLGTTR-ELLDFYTHGCHSNTE-----PLTASMSPPQALCReF-Gtslalt-------rrleaf 418 
XP_003417207  314 QP--LTMAYVPDGSYSYMTSLA-SELLH---------------SLTVPSTPRA-----Q-TvhsqveelellEPGSSVVS 369  African savan...
XP_023208122  314 AP--LSLVYVPGGCYDYLTLSG-KQHVD---------------RLTSDWTVGNTLSHiQvNen-------llSEGARIIN 368  southern plat...
CBJ29017      461 SSLHGAGVVAGGAVVEHCYFDr-DGWE-VGAGSLISGIRSLEEDChl--rLRGGMCLQQTDLDRASPEEta--srFVVSL 534 
XP_003290380  311 SILLGNGKCSDTSIIYSSVLS--GNWS-VGEDSIVFGAKSLSAny----hIKDRMIVNEIRLKPIKMKHssnetpRALLV 383 
1_pfamImport  278 SVLEEDVAVATGAVVQHCHLK--GPLK-VPAGCLLSGLSSAASQClrqldLGADIIVQGHHIQLGDLKL------RVYTV 348 
4_pfamImport  283 GVLEGDIAVATGAVVQHCHLQ--GPLE-VPSGCLLSGLPLMTSQClrqlqLADDIIIQGHRIEVGGLKL------SVYTV 353 
XP_003227902  376 SLLEGAVFVGPGTAIQHCCLK--GPLQ-IHSGCLLTGLDGDSSEAlrghhLK-DVVIQGHAVRLKGLSC------KVFTL 445 
XP_004175035  363 CVLEGAVQLAAGSVIQHCHLQ--GPLV-IGPGCLLSGLDVDSSPAlrgcpLR-DVVLQGHHVRLRDLPC------RVFTL 432 
Q7TMC8        370 CLLEGPVHLGPRSVLQHCHLR--GPIR-IGAGCFVSGLDTAHSEAlhgleLH-DVILQGHHVRLHGSLS------RVFTL 439  house mouse
EEC42659      419 TLVGPYGQIDPSAIIMHSSIQdsLSMEsVGSLPMV---------------IPDNTIVQQVRRVPQDEADtc---aCTLVV 480 
XP_003417207  370 CVLEGPVWLGPGSVLQHCHLR--GPIH-ISTGCFLSGLDIAQSEAlhgmeLR-DLILQGHHMRLHGSLG------RVFTL 439  African savan...
XP_023208122  369 SILDGGVTVATRAVVQHCHLQ--GPLD-VPSGCLLSGVDVSASAClrrlaLSSDIIIQGHRIQLGELKL------NMYTV 439  southern plat...
CBJ29017      535 FGARDDIKAHYSADRA----RVCGATWEAFFGYTGATAEDVWGGIEEGDR-KLWSARLFPVLTR 593 
XP_003290380  384 LGIQDDLNLYFTDPNA----TIANRTWEEFLKTSGIAPEELWSKGLPR---ILRTARLFPIIVD 440 
1_pfamImport  349 MGAQDPLEASFGDRGA----SFLNQSWSRFCSRTGIQPEEVWLKPEQR---SLLEARLFPVFSP 405 
4_pfamImport  354 TGAQDVLEASSEDSGA----SFLNHGWSLFFSRTGIQSEELWVRGERR---SLLAARLFPVLHP 410 
XP_003227902  446 SGRHNRWESLAE-EDG----TYLNARWSDLFLRTGIRREDLWSGDVLPGRgCLLNAHLFPVLHA 504 
XP_004175035  433 TGRLDDWQSPVE--KA----TYLNVPWAEFFQRTGLREGDLWDAEMPRGSrCLLSARLFPVLHA 490 
Q7TMC8        440 AGRLDSWERQGA---G----MYLNMSWNEFFKKTGIRDWDLWDPDTPPSDrCLLTARLFPVLHP 496  house mouse
EEC42659      481 LGVDDKIKSLDG---------LYGRPLQDFMSWAGLSESDLWDEEADHK--MVWNARLHPSIKP 533 
XP_003417207  440 TGRLDNWE-----RQGtgtyLNMP--WSEFFQKTGIRDWDLWDPDTPPTErCLLSARLFPVFHP 496  African savanna elephant
XP_023208122  440 TGAHDDLQVPFNDSGA----SFLNQTWTVFFSSSGIKPEELWVKGEHC---SLLEARLFPVLHP 496  southern platyfish
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