Conserved Protein Domain Family
GDWWSH

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pfam15667: GDWWSH 
Protein of unknown function with motif GDWWSH
This family of proteins is found in eukaryotes. Proteins in this family are typically between 135 and 289 amino acids in length. There are three conserved sequence motifs: GDWWSH, RSDF and KRHG.
Statistics
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PSSM-Id: 464790
Aligned: 8 rows
Threshold Bit Score: 293.71
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
A6QQL5        38 QHSKPCVGRGRVYYAKFINTNVRTCNEPVPYIDVKKEPENQGD-WWP-HGKGLENPFQPPYDTKSTQRSDFKKPTCPLVS 115 cattle
XP_006083529  38 PHSKPCVRRRRVYYAKFINTNARTCNEPVPYIDPKIGTENQDD-WWP-HGKEPEHHFQPPYDTKSTQRSDFQKPTCPLVL 115
XP_002812078  38 HHSKPRVGRGRIYYAKFINTNARTYNEPVPYIDPKKGPEIQGD-WWS-HGKALEPVFLPPYDSKSTQRSDFQKPSCPLVL 115
XP_003216202  58 HNPQPI-------HAKFIKTNTKFLNEPVLYMETEDTKRKQGH-WWPtHGAFMQRP-KAPYDPKSTQRSDFQKPPCKLVP 128
EDO36961      57 TNSANRKNKPQPTAVTFLRQNPRFICEPICHVDTSINTEELTHpWWP-NESVERPVTQPHYTFDSTSRDDYRDTSSYIKQ 135
XP_002936967  92 PRSPTRNNMPHPYYARFLRDNSRFLKEPIPHMETASTKHIQSE-WWP-RDEEHVAPHKPSYDMMTTQRSDFLKFSYSSNP 169
XP_014353420  61 KIPHPC-------YAKSIRANTKFYNEPILYIDIKDTTTEKFH-WLR-HETPCKVQHVLPYSKQTTQRSEFQDIKQRPPA 131
XP_003417623  39 QRSKPCVKRGRIYYAKFIHTNARTCNEPVPYIDPKRGPEKQGD-WWS-HGKVLEHSFQPPYDTKSTQRSDFQKPTCPLVL 116
A6QQL5       116 PVKHSKLQ-------KPSYGIVPLVSPDASA-ELQRNFKEHISFIHQYDARKTPNEPIRGKRHGVFVQTEIKP------G 181 cattle
XP_006083529 116 PVKHSKLQ-------KPSCGIVPLASPNAST-ELQKNFIERISFIHQYDSRKIPSEPMRCKRHGVFMQIEIKP------G 181
XP_002812078 116 PVKHSKTQ-------KPSCGIVPLASPGTSA-ELQNNFIEYISFIHQYDARKTPNEPLQGKRHGAFVQREIKP------G 181
XP_003216202 129 AIKYTKR--------QPTHGIVPLTSPRPSPgSLPRLFQEQISFKHNYDSRATPNIPYQGKKCGTFVWTQMKP------E 194
EDO36961     136 HKGYSRYNydstsnsKPTVGLVPGCSTTAS----NPSVIEKISYEHQYNARLDPNHPIRGKRHGCFVWKVSTPvkssgrS 211
XP_002936967 170 QTRYSAKPc-----kSPVCGIVPFAPPRSRT-RLPRLLQEQISFIHNYNARSVTNEPIRGKRHGAFVWTEIKT------E 237
XP_014353420 132 QTRHGSNPy-----kTPASGIVPLATPRGLE-TSSKNLLERMTFHYLCGSSKPSLAPVQRKRHGAFVWTEIKP------V 199
XP_003417623 117 PVKHSRMQ-------KPSSGIVPLASPDASA-EPQSNFIERIFFIHQFDSRKTSSEXLRGKRHGAFVQTQIKP------G 182
A6QQL5       182 SRPTVPERTEVLLNAS-GSCSSEQSKKTEKGNSAESKMISPGLCRQNSQELL-ETKTHLSETDIRVAANASLRRPEKREK 259 cattle
XP_006083529 182 SRPRAPQGTAALLNAP-GPCSSEQPQKTEKGNSAESKMTSPGVGQQTSPELF-ETKTPLSETDVREAATAGPTSPVRRES 259
XP_002812078 182 SRPTVPKGTEVLLNAP-GSHSSEQSKKTEKGNSAESRMISPGLCQQNSQELL-EPKTHLSETDVRQAAKACPSSPESREK 259
XP_003216202 195 ---RVPEGTKAMSCAPrGAGFLEEP-KTEKGSSVGNGVTSSCLCLPESQETApDSDKHLSETDVGPGAKADPRTTEGGQE 270
EDO36961     212 SRSSGPERRSVSYELT-----TDESIGMNNSVNARSSVLSASKSLSNPQEVScAVGKDKDSSSLAACQKDIGQEPEETLT 286
XP_002936967 238 SGPAVPKGTNLFLNTT-GSHSLDQA-ETEKGNSGESSVTSPRRCSHGSQQMF-GSEIHLSKTDLGEGAKSNPSAADREQN 314
XP_014353420 200 SGLIAPKGADAFLNTL-GSGSLEQS-KTKRGNSVEGKVTSPKLCSLNSQQMF-NSGTQLSKTDMKEAAKAYPRIPAKVQT 276
XP_003417623 183 SRPTVPKGTEVVLKAP-GSRSSEQSRKTEKGNSAESRMVSPGLCPQNSQEPL-ESTAYLPETDAREAARARPRSPEREE- 259
A6QQL5       260 TAKVFQIAv-VNALLTRHDPLSPPIK 284 cattle
XP_006083529 260 AAGAPTTA--ADALITRHNPSTPPIK 283
XP_002812078 260 TAGATQTTv-GDALFTRHKPLNPPIK 284
XP_003216202 271 SSEISQTNk-MDVSGPGEKPPSPQKA 295
EDO36961     287 KESVKKSS--PDLRPQRPLPYSPPPD 310
XP_002936967 315 KSGSSQTI--------GRKTLIP-IG 331
XP_014353420 277 SSSISQTAevLDVRSKGEECSVDPIV 302
XP_003417623 260 VAGVFQTTa-VGVLLSGQEPLNPPMK 284
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