Conserved Protein Domain Family
C2orf69

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pfam10561: C2orf69 
C2orf69
This family includes C2orf69 from human, previously known as UPF0565, which is an important regulator of human mitochondrial function and may also influence other metabolic pathways.
Statistics
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PSSM-Id: 463147
Aligned: 17 rows
Threshold Bit Score: 310.093
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001998976  21 RIFSVAGFQ-NRANDIVYCPPIV-------------RQQSQHVDDSKAIIYFGGDVQDFPE-------SMETNRDSRGYM 79 
XP_005989576  46 KLPAVVGSEsGRANDLLLVLPTAacprdlretdrapPLQQQQQQQQHHVIYFPGDVQSYHD-------VMAYHSENFRWQ 118
OCA23210      38 RLPAVPGCEaTKCNDVVLRPA------------------RESSQKPQHVVYFPGDVQNYRD-------VMASHPENFRWK 92 
XP_001614480   6 SVHNLAGYN-ERCNTVLYREPIR----------------TNKSYASKYIIFFPGDYSNFFTnsiytsfKLEATNECSDYC 68 
O97301         6 STFKICGYN-EKYNTILYREPIL----------------TSEEYVKKYVIFFPGDYSYFFSnsvytsfKTQSTCECTNYC 68  Plasmodium falc...
OWR43671       5 RLRRVSGYE-GRVNDVIFRPAI-----------------SDAARGAETLVFFGGDVQDYPE-------AMQAHRDNRHYV 59 
XP_001990233  21 RIFSVAGFQ-NRANDIVYCPPIV-------------RQQSQHVDDSKAIIYFGGDVQDFPE-------SMETNRDSRGYM 79 
XP_002073548  21 RIFSVAGFQ-NRTNDIVYCPPIV-------------RQQSQHVEDSTAIIYFGGDVQDFPE-------SMETNRDSRGYM 79 
NP_001034395  63 RLPEVVGAEpQRANDLLLLLP---------------PAPRGPAPPQHHVVYFPGDVQNYYD-------IMSCHPENFQWE 120
XP_311074     56 RINSVKGYQ-NRTNSIIYCPPLL-------------RGNSPK-EKCSAIVYFGGDVQDIPE-------KMESNRDNKNYI 113 Anopheles gambi...
XP_001998976  80 KYNLENSAILLREAFPRSHIIVIRPVRMEFKTFSCFDNFVRGNNAGVPDH------------------------------ 129
XP_005989576 119 RWSLENVAIMLSLRFPNSYIWIVKSSRMHLHKFSCFDNFVESNLFGTPEY------------------------------ 168
OCA23210      93 QWSLEDVADMLSQRFPYSYIWIIKSSRMHLHKFSCYDNFVESNMFGAPKH------------------------------ 142
XP_001614480  69 -YSYEALFWVLSSKYLYDHLVFIKPS-LFVNHFSSFSNFLNPSDVSLSGHghpvtvargtgh-------------vntgg 133
O97301        69 -YSYEALFWILSQRYLYDYILFIIPS-DFSNYFATFSNFLNPCDIPLDNNlyelnrenennydvlnmenkinkksvsfik 146 Plasmodium falc...
OWR43671      60 KWNLESTARMLGESFVDKHIVVVRPSRIEFKSFSCYDNFVPSNNAGVPDH------------------------------ 109
XP_001990233  80 KYNLENSAILLREAFPRSHIIVIRPVRMEFKTFSCFDNFVRGNNAGVPDH------------------------------ 129
XP_002073548  80 KYNLENSAILLREAFPRSHIIVIRPVRMEFKTFSCFDNFVRGNNAGVPDH------------------------------ 129
NP_001034395 121 HWSFENVATILAHRFPNSFIWVVKCSRMHLHKFSCYDNFVASNMFGAPEH------------------------------ 170
XP_311074    114 KWNLENTALLLRESFPQSHIVVVRPMRMEYSTFSCFDNFVRGNNAGIPDH------------------------------ 163 Anopheles gambi...
XP_001998976 130 ------TPMNHALQHLEKLLQN---LSQRLIS-IPENEILDQAA-------QAAAAAAAVAAaAAAAAMT---------- 182
XP_005989576 169 ------STDFGAFKHLCALLTNackLAQNLLLsRRDVNRLNKAAdne--acNSNSVHTTNGCpPEED------------- 227
OCA23210     143 ------STELGAFKHLQSLLTNafsAAQSLLVsQNNKYSVDRDYdls--kmDICPTYTTNGCpEKDNIIh---------- 204
XP_001614480 134 tnpgdaVVPAKSVNHLLCLLLS---LDERLsgg----------------svGSGESGLNGDHtASVNGTP---------- 184
O97301       147 neyinsNIRAKSIKHLLCLLLS---LNNEVLHkDMLNEGNFHKIinnennyNDNNDNNNNDNsNNDNNNNyyyiccdkpl 223 Plasmodium falc...
OWR43671     110 ------TPTHHALLHLERLLKN---VSIRMKT-MSERELLdvlrdvspdssvegcrtavp-------------------- 159
XP_001990233 130 ------TPMNHALQHLEKLLQN---LSQRLIS-IPENEILDQAA-------QAAAAAAAVAAaAAAAALT---------- 182
XP_002073548 130 ------TPMNHALQHLEKLLQN---LSQRLIS-IPENEILDQAA-------QAAAAAAAVAAaAAAAALT---------- 182
NP_001034395 171 ------STNFGAFKHLHALLVNafrLSQNILQsQKSAHGFGKDAkvsarksELQSVPTANGCsSTEREKD---------- 234
XP_311074    164 ------TPMHYSLQHLEELLIN---LTKKLTKpILDQEFLHKLL-------SASSTKGyggdvpckqnnadilqsniydg 227 Anopheles gambi...
XP_001998976 183 ---LSNAT-VNSESSSASVAAaaaaaaaaaaandssqemdidilqvqenvtvdadgavifpivsagstetstatnnggnv 258
XP_005989576 228 ----GTCGhSEKPFCILGSADqy--------------------------------------------------------- 246
OCA23210     205 ---------STIYLGMPSLKDs---------------------------------------------------------- 217
XP_001614480 185 ---CGDSNgEGTHTSAHGRSDhtdgpp----------------------------------------------------- 208
O97301       224 inyLGNELkTEKNIYSKERKNnifmk------------------------------------------------------ 249 Plasmodium falc...
OWR43671         --------------------------------------------------------------------------------    
XP_001990233 183 ---LSNAT-VNSDTGPSSaavndssqemdidilqvqenvtvdadgavifpiisagltatgtttnnttpaadtvnngnnkd 258
XP_002073548 183 ---LSNATsVNTDSTSASLTAassqaandnsqemdidilqvqenvtvdadgavifpivsgssnrinnec----------- 248
NP_001034395 235 ---CECSNnSAMNFVIPSAVGa---------------------------------------------------------- 253
XP_311074    228 gaa----------------------------------------------------------------------------- 230 Anopheles gambi...
XP_001998976 259 nnsnnkdallnnhqesniqqqqqqlqqqqqllqqqqqqpqqtvvkaasapmnnvdhynnttnssndcaadrqpslptqpq 338
XP_005989576     --------------------------------------------------------------------------------    
OCA23210         --------------------------------------------------------------------------------    
XP_001614480     --------------------------------------------------------------------------------    
O97301           --------------------------------------------------------------------------------     Plasmodium falc...
OWR43671         --------------------------------------------------------------------------------    
XP_001990233 259 attnshqe--------------------------lnnqlqqqiaakatvsapannvehynninssidcaalqsslqtqpl 312
XP_002073548 249 --------------------------------------------------------asavpvlstlpaaaattaaaaava 272
NP_001034395     --------------------------------------------------------------------------------    
XP_311074    231 -------------------------------------------------------------------------------g 231 Anopheles gambi...
XP_001998976 339 qprpatptsennplwwrenlnldkSKLVLIGFSKGCVVLNQFIYEFHYLKTltpdDSSMCRLLSRITDMYWLDGGHGGQK 418
XP_005989576 247 ----------------------ssVSFTLIGFSKGCVVLNQLLHELKVAKN----NKELATFIKNIKAMYWLDGGHSGGN 300
OCA23210     218 ------------------------LSITVIGFSKGCVVLNQLLYELQEAIK----DKDIQSFLANIKAMYWLDGGHSGGC 269
XP_001614480 209 ------------------plsplkRRLVLIGFSRGCSVLFALMREANEGQL----------LLPYVDSVYLLDPGFNKRL 260
O97301       250 --------------------niikNKLVLIGFSKGCSVLFSLLRESHEGPF----------FWSYVDSIIFLDPGFNKNI 299 Plasmodium falc...
OWR43671     160 ----repssardplwwreslaldeSSISLVGFSKGCVVLNQIIYEFHYTQTltpgDEHMMRLSGRICDMYWLDGGHAGGK 235
XP_001990233 313 qprpttptsennplwwrenlnldkSKLVLIGFSKGCVVLNQFIYEFHYLKTltpdDSSMCRLLSRITDMYWLDGGHGGQK 392
XP_002073548 273 aqtprqatsdsnplwwrenlnldkSKLVLIGFSKGCVVLNQFIYEFHYLKTltpdDSSMCRLLSRITDMYWLDGGHGGQK 352
NP_001034395 254 ------------------------VSFTLIGFSKGCVVLNQLLYELKEAKK----DKNTDAFLKNIKAIYWLDGGHSGGS 305
XP_311074    232 aedpaepddlaellwwrenlnldkASLKLIGFSKGCVVLNQFIYEFHYYKTltpdDSTMMRLVSRISDMYWLDGGHGGGK 311 Anopheles gambi...
XP_001998976 419 NTWITSRSLLETLTRMGMNIHVHLTPYQVQDDRRPWIRKEEKLFTEMLRRLNAP 472
XP_005989576 301 DTWVTSQEVLRELAQLEVAVYTHVTPYQVHDTMRSWIGKEHRKFVRILRDFNME 354
OCA23210     270 DTWITNPEILKAFALTGIAVHTHVTPYQVRDIMRSWIGEEHRKFVQLLKKYNVK 323
XP_001614480 261 YNTEIESSALEKVAQCGLKIFLHSTPHQVTNKNDVHIHSELLNFLKKLRQHGVG 314
O97301       300 YNINIEKNALEKLSQHKLKISVHCTPNQIMDNTSMNIHEEYIHFVKILKDIHIY 353 Plasmodium falciparum 3D7
OWR43671     236 NTWLTARSLLETIATRGVNIYIHVSPYQIKDESRPWIGREEKIFSSLLKKLGAK 289
XP_001990233 393 NTWITSRSLLETLTRMGMNIHVHLTPYQVQDDRRPWIRKEEKLFTEMLRRLNAP 446
XP_002073548 353 NTWITSRSLLETLTRMGMNIHVHLTPYQVQDDRRPWIRKEEKLFTEMLRRLNAP 406
NP_001034395 306 NTWVTYPEVLKELAQTGIEVHSHVTPYQVFDTMRSWIGREHEKFVRILEEFGVE 359
XP_311074    312 NTWITSRSLLETLCRLCINVHVHVTPYQIQDDHRPWIRKEEKAFTDLLKRLGAA 365 Anopheles gambiae str. PEST
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