6VBU


Conserved Protein Domain Family
BBL5

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pfam07289: BBL5 
Bardet-Biedl syndrome 5 protein
BBS5 is part of the BBSome complex that may function as a coat complex required for sorting of specific membrane proteins to the primary cilia. Mutations in the BBS5 gene cause Bardet-Biedl syndrome 5.
Statistics
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PSSM-Id: 462136
Aligned: 37 rows
Threshold Bit Score: 363.821
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6VBU_5         7 LWEDRDVRFD--VSSQQMKTRPG-EVLIDCLDSVEDTKGNNGDRGRLLVTNLRIVWHSLALPRVNLSIGYNCILNITTRT 83 
Q3SCX0         5 FLYDRCIHFD--IAAAKLNMQKG-EKTLFLWKDVEDIKGNPDQLGSLVISNTRILWWSERNNSVNLSIGLGTIFHIEQKV 81  Paramecium tetr...
ESN92694       6 LWQDRETRFD--VNPSLLNLVRG-EKVILELNAVEDSKGNTGVLGSAILSNLRFIWHSQKFPKVNISLGHNCILSVNCIH 82 
XP_003110993  12 IWQDREIRFD--VDHKLLRMAKG-EFAVAKVEHVEDTKGNNGDKGIMKVTNLRLIWYAMNMPRINISIGWNTITGTQSKT 88 
XP_001746720  12 pWRDREVHFD--IGNKLIALTRG-EFVIDHLDQVEDTKGNNGISGTLTVTNLRLIWTNKKRSNINLSIGLRNVVSIQVKP 88 
EGD78614      17 pWRDHEVRFD--SIATHMQPGPG-EVIIDSLSNVEDTQGNNGVRGKLVVTNLRIMWHAIKKPSVNLSIGLFCISQISVKM 93 
CAM37441      25 FWQDREIHFG--VSAAALKLRENtEHIYAAFNHVEDKKGNEGHSGTLLVTNLRLIWSSARRQAVNISIGYYCVQKLTVQE 102
Q4GYG4        18 LLLDRTIRFDtsLSELQEQTSRG-ERILMRLSPVEDTKGNSGKEGVLYVTNLRFMWHSSHRVRNNLSVGYYGVYNMSVQM 96  Trypanosoma brucei
XP_821922     18 FWFDREFRYNlpDEGLVVQTARG-EVLLSKLSPVEDTKGNNGEEGVLYVTNLRCIWQSKVNPHKNLSVGYYGIQGIEVRE 96 
Q4QGM5        25 FWQDREIHFD--AATPVLKLRENtEHVYATFDNVEDTKGNNGCPGTLLVTNLRLIWRCKQRPNVNLSIGYYCVHKLTVQE 102 Leishmania major
6VBU_5        84 ANSkl---rGQT-EALYVLT--KCNSTRFEFIFTn-------------------------------------lVpGSPRL 120
Q3SCX0        82 TNN------NRTfGTLFRTK--LATGQKYEFHFS---------------------------------------S-QDKKL 113 Paramecium tetr...
ESN92694      83 SQSki---kSSS-DSVIISA--ECSGEKYEFVFSnl------------------------------------iV-DGPSL 119
XP_003110993  89 STSlaarnrGGTnEAIYILAklSSTTTKFEFIFTat------------------------------------sPnSHSKL 132
XP_001746720  89 VESkl---lGNV-KALWIMC--KHKQSKYQFIFThl------------------------------------vP-GSPRL 125
EGD78614      94 VESkl--kgGRT-QALTLVC--KFKKMRFSFVFTyl------------------------------------vP-SSPRL 131
CAM37441     103 MASkl---vGGTtECVTLSA--KYGTRRFQFIFLegngvvgasqgg---------------spssfrrrpskgTaTDQSL 162
Q4GYG4        97 VETrl---rGHA-EALRITA--RYGSNRFEFFFT-----------------------------------------HPSED 129 Trypanosoma brucei
XP_821922     97 ANLrl---rGTT-EVLYITS--RFGSSRYEFVFTqlm----------------------------------rkNcQ---- 132
Q4QGM5       103 AESkl---aGRMtECITLGS--KCGASRFQFIFSvahdvgdigsgsaaststsggaaaqrdcenrsrrrpskgTgGHQRL 177 Leishmania major
6VBU_5       121 ----YTSLIAVHRAYETSKMYRDFKLRS-ALIQNK-QLRLLPQENVYNKINGVWNLSSD---------------QGNL-G 178
Q3SCX0       114 ----YESLINIQRLYTQTMLHREIKVQF-AMISQK-KLNTSEKEQIINQYANTISVAND---------------QQDVsG 172 Paramecium tetr...
ESN92694     120 ----YTSLNSVLRAYVSSKMYREVKLRG-SLFKDD-ALKTYPHEEIFREIHGVLNLSND---------------QGNI-G 177
XP_003110993 133 ----FNTISSINRAYETTKMYRELKMRG-IFIREDgTLRILPQEYIVEIVAGAWNLSTEtvclrldfliyikliQGSL-G 206
XP_001746720 126 ----FTTVPAVHRAYASSTLYRDVKIRApALIRDG-AIEPLPQEEVYDALEGVSNLSGE---------------KGEL-G 184
EGD78614     132 ----FTIIQAVHRAYDSTRLYREVVVRSsTLVSDD-RVAVLPDEEIFDTLDGVWNLSGD---------------KGEL-G 190
CAM37441     163 ----YCTIRAVWNAYESTRVYRELRVRS-AVVQHG-NLLLLDGESVISRTAGVSSVSKD---------------EGRL-G 220
Q4GYG4       130 rrsrLSAVRLVWRAYDTTRIYREVRLRS-CAVRDG-ELLLLKGERLVTRVKGVSNVSSE---------------QGHI-G 191 Trypanosoma brucei
XP_821922    133 ----LFIVPTVWRAYESSRAYRELRMRS-SLVRDG-DVILLPGEQLFTRLEGVTNVSED---------------KGII-G 190
Q4QGM5       178 ----YATIRAVWNAYESTRVYRELRVRS-AVVQHG-NLILLDGENVISRTSGVSSVSKD---------------EGHL-G 235 Leishmania major
6VBU_5       179 TFFITNVRIVWHANMnDSFNVSIPYLQIRSVKIRDSKFGLALVIESSQQSGGYVLGFK-IDpvekLQESVKEINSLHKVY 257
Q3SCX0       173 TLIFTNVRFVWYSATnDLFNISIPWIAVKKISKKTTKGLYTMIIETYQEFGGYYVGYRnID----MDSMIKECNKLHAFH 248 Paramecium tetr...
ESN92694     178 VMIVTNVRVVWYALSnQIYNVSIPYLQIIDVKVKDSKFGRAIVFEITKQGGGYILGFR-IDpvekLQAVFREVRKLYKMF 256
XP_003110993 207 VFVITNIRIVWYAELnTGYNVSVPYLTLYSARVRESKFGMALVLETTASSGEYVLGFK-VDpperLQNLVKTIQTLHKAQ 285
XP_001746720 185 RFIVTNIRFIWYSEQnPLYNVSCPYYTVSHIGGRQSKFGSAVVVKLAGAAGALNLGFR-CDppkrMAKLLKMMQRLHRVY 263
EGD78614     191 TMVVSNIRCIWYSDLdPRFNVTIPYCMMSRIAIRNSKFGKALVVKTAKAARSLTIGFR-IDpadrLQRVAQKMERLHRVY 269
CAM37441     221 TLVVTNIRVVWFAAV-ELFNVSVPYLQFVGLRSQMSKFGQALVIETSSYAGNFVLGFR-IDpeekLNEMYTEISTLWRTW 298
Q4GYG4       192 TFFTTNLRLLWCSDTsAEFNISIPFLQIAAMRIQDTEFGLSLMVETTASVDSYVIGFR-VDpvarLDQLFKECTSLLNAF 270 Trypanosoma brucei
XP_821922    191 VFFTTNVRIVWFAQHaPHINISIPILQLTALRMRPTKYGAAILLETSSYAGSCLIGFR-VDpvdrLRGLFRECVSLWKAW 269
Q4QGM5       236 TFIVTNIRVVWFAAA-EFFNVSVPYLQFVGLRSQMSKFGQALVIETSSYASNFVLGFR-VDpeekLNEMYAEISSLWRTW 313 Leishmania major
6VBU_5       258 SANPIFGVDYEMEEKPQPLeal-----------------------------------tvKqIQDDVe----------iDS 292
Q3SCX0       249 TENPIYGIEIQEKQQPTVQ----------------------------------------R-FDEKVqv--------vqSI 279 Paramecium tetr...
ESN92694     257 THNPNYGIECSVENSMAESkqn-----------------------------------ssK-FSDDAev--------yeDH 292
XP_003110993 286 SMKPIFGVTFIKEKSEKTErke-----------------------------------vtK-EDEEIdiidtneddveiEK 329
XP_001746720 264 HITPLLGIEAEVEEQPTEDlmp-----------------------------------enV-PDDDVe----------iVQ 297
EGD78614     270 HASPIYGVHVDVETAEGEGegag---------------------------------emeT-EDDDIe----------iIQ 305
CAM37441     299 TTRPLLGMKVALHDNMSTAvvpgalesegeapgsdsr-----hgedahrgacspqsrrqT-EGQYV------------LR 360
Q4GYG4       271 KTHPNLGVAVTLQDVTAGNddevsamlgaa------------------egasvgpqpreL-DGENV------------VQ 319 Trypanosoma brucei
XP_821922    270 SARPVLGIAVTLEDAPPREegdanmkhinddgg-------------dgpfsllssqhrkL-DGENV------------VT 323
Q4QGM5       314 TARPLLGMKVELHDDTAKAmvpeslgvggggpggksgsaehphsgripgaagdaqherqM-EGQSV------------LQ 380 Leishmania major
6VBU_5       293 DDhtdaFVAYFad----gNKQQD-REP--VFSEELGLAIEKLKDGFTLQGLWEV 339
Q3SCX0       280 YN----QAARYq------ANENNdIQNdiAYSPELGLAIQKLPADAKLSEFWNI 323 Paramecium tetraurelia
ESN92694     293 GEhsdvFALYCvdgg-----ratnREP--VYNEELGLLIEKLPDGYTLSDLWDV 339
XP_003110993 330 NIrpdpFAAYFdg---qhSTTDEkKLP--VLNQEIGLSMEPIRNGFTLQDLWAI 378
XP_001746720 298 QDkvdtMAAYFssdss----gttgRDP--VFSAELGLAIEPLPAGVSLQDLWRV 345
EGD78614     306 RDdfdvLAAYangrlgqeASEDN-KMP--VYSEELGLAIEPLLPGFTLDALANI 356
CAM37441     361 EApmeaFAAYYad---dgQKGAD-RRP--VYEPSIGLAVEKLRKGATIQSLWDT 408
Q4GYG4       320 EVatdaFAAYYvg---igQKGAD-RKP--EYNASIGLAVEKLRNGVTLQDLWNV 367 Trypanosoma brucei
XP_821922    324 QVetdaFAAYYad---vgQKGTD-RRP--EYDASIGLAVERLRTGVTLRELWTV 371
Q4QGM5       381 EAptdaLAAYYaa---ggRKGED-RRP--VYEPSIGLAVEKLRKGTTIQSLWDT 428 Leishmania major
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