Conserved Protein Domain Family
Phospholip_B

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pfam04916: Phospholip_B 
Phospholipase B
Phospholipase B (PLB) catalyzes the hydrolytic cleavage of both acylester bonds of glycerophospholipids. This family of PLB enzymes has been identified in mammals, flies and nematodes but not in yeast. In Drosophila this protein was named LAMA for laminin ancestor since it is expressed in the neuronal and glial precursors that surround the lamina.
Statistics
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PSSM-Id: 461479
Aligned: 17 rows
Threshold Bit Score: 508.795
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_011270802  60 AYGTFE-DGLMTTGW---------GVFEVKT---NSAFKDAEQLYAAGFLEGALTYNRIYDHYQNMFTYFFPNASdpSVQ 126
EDQ87028      54 ARASYF-PGVNETGW---------ADLTVEAl--TGVCNSSEAAYAMGLLEGALSQPLIYDAFLNFEASNGYLDKghLPS 121
Q57ZQ0        68 AIVNVS-NTFNKTGWdvvtavandGFMHLPGeaePSAERVLLAYKAVGFGEGYATYESMKASINNTFEGPEGLSAllSDA 146 Trypanosoma brucei
Q9XWV2        53 ATAYFH-DEVNQTGW---------AFLEVDVi--SPKIPHYLQGYAAGFAEGRATRHLIDLHIINTVNGYCDGAKhfCDE 120 Caenorhabditis ...
EFX77541      57 AGAQFT-NAINQTGW---------ANFEVWT---NGNFPDSVQSKAAGFLEGYLTHELIYFSYLNTLQDYCKGRDgyCSK 123
O62146        82 AVARWQ-NAVNTTGW---------TFLEVET---KENYCPQLQAYSAGYLEGLLSKTVLTYHLKNAQEDYCKNFTgyCSR 148 Caenorhabditis ...
Q9BL07        73 ALGKYS-NQVNTTGW---------GILEIET---FASHSYDVQAYGAGVAEGELTRLQIYYHYRNTIETMCNNHTlfCKR 139 Caenorhabditis ...
EFA78500      63 AWCLYG-NEMMTTGW---------GYISIQT---NGAYNDTQQASAAGYLEGYVSAEMIYQNWYNMYVNEYKKS---VND 126
Q54ZI6        55 AWGYFK-DEMNKDGW---------GKLSIET---VSTVSDNIAFKAAGYLEGYLTWEYIYKFSGNYFNSFFNTSNikEIP 121 Dictyostelium d...
EGD78150      59 ALASHNlPAYNMTGF---------AKLHVQTkpsTSVQNDNLAAFSAGYVEGLVTADMIYNTYLNLEPE--------HDP 121
XP_011270802 127 l-YRNWFNQQDAWTRRNVQL----NPqvsFWVQTGSILAQFDGLVAGYNAV-AASSRK--L--DVFAFQVLNGNGDILDL 196
EDQ87028     122 k-LQAFVDAQLKYISDQWSRnp-aDP---FWRQAGHLLAQARGVQDGYm---LTAPQQqqL--QPDQILILTLAGDLEDL 191
Q57ZQ0       147 pqAQHWIEEHVRYMDAAKFEss------aFYTQLRNMLALIDGMVAGYNAR-APADER--L--DRMKLLMYNMQAEIGDI 215 Trypanosoma brucei
Q9XWV2       121 --LGEFMVDNLKWMEQEIREnp-eDE---YWQQVNLTVNQLFGLIHGYENQlGAEIDFkqI--AVHPIFMIQIAGDLEDL 192 Caenorhabditis ...
EFX77541     124 --LRTFLATNTKWVNKMYTKlrntSP---FWHQVGLFYEQMEGLAAGW--EkAAVNTGhsM--GTYGFMWFNIFGDMEEF 194
O62146       149 --LSDFLTENQKWIQSSLETvapdDL---YWGAVNRTYHQVSGLIDAY----EGREFKprItyELHPILYLNLNGDFYDL 219 Caenorhabditis ...
Q9BL07       140 --LYIYLQQNLDWMRSQVQAnpptDP---FWRQVNLTFAQLTGIYDAY----SKRNLTpeIgfDLHPIYMMQLAGDMFDL 210 Caenorhabditis ...
EFA78500     127 k-AIAWIDSNNRYMQQQVAEnl-dDP---YWQQVGLVMTQVASLFQGYND--ATTDPSqsL--EFYDILLMNMDGDMIDL 197
Q54ZI6       122 teTLTFVSDNWEYMMERVNSssttDP---YWIQIRNAMSQQIGLYEGYNAA-AGEDYQ--K--TFIEIYMINLYGDMGDI 193 Dictyostelium d...
EGD78150     122 k-VMAFVQQNYNWTMDKIKHnp-qDP---FWTQVALVYQQLNGLVAGYN---AAGQKK--L--TFTDMLLLNLLVDLPTI 189
XP_011270802 197 MNVLqpstrpswndmt--pqqaqleasrrGHCSGFIKMLPGFEDILISHSSWFTFTATNRIYKHYNFQl-----NDQATA 269
EDQ87028     192 ASALvdyvaplh---------nefpdyehMHCSGLVKLTISRDDLFTGHTTFNAYWCMLRIYKHYIVP----------GV 252
Q57ZQ0       216 VRATspaevlddmr------qmmprwfvdTHCSAFVKVVK--DDIYFGHATWSSFNTMLRQYKTYAFG------------ 275 Trypanosoma brucei
Q9XWV2       193 AMKFkkpenpk------------kvfsgpGHCSALVKLLPKNEDILFSHVTWSSYGTMLRINKKYSFK---------TGD 251 Caenorhabditis ...
EFX77541     195 EQMFapqkagkdwr-----lnkvgrrhmfASCSALIKVLPDASDIYTSHVTWNGYESMIRILKKYNFEvhrtaaEDSAVI 269
O62146       220 EKKLnktrdp-------------afeqtgGKCSGLIKVAPGNADLFISQVTMSGFQNMLRVIKLYKFG------YDRQFY 280 Caenorhabditis ...
Q9BL07       211 NKLLnktadp-------------meypegGRCSGFVKLAPGNKDMFMAHVSMSSLSWMQRVLKIYKFG------YDVNEV 271 Caenorhabditis ...
EFA78500     198 APALnisfdaataaalppkqhlenfmrktGHCSSLIKLTDDLTELYAGHTTWSSFYEMVRMFKIYTFAf-----SSSSLS 272
Q54ZI6       194 Vtltttpnnefipm---drkeveqlmattGHCTSIIKLTNNCSDLMSAHTSWADFSVMIRIYKRINIPv-----ASTPY- 264 Dictyostelium d...
EGD78150     190 ELALypgkrpnvtamt--qqelkdfmadtTHCSAMVKVTDDLSDLMFTHTTWCPYSQMLRIFKVYHLPy-----STTAGT 262
XP_011270802 270 -AKRTSFSSYPAYLSSLDDFY-IMDSGLVMIQTTNNVFNMSLY--DLVRPE-SLLAWQRV-------------RLANTMA 331
EDQ87028     253 pGNVVSFSSRPGDLHSKDDYF-QTSANLTVIETSLTVFNKSLY--NTLQPN-SVPCWMRSqlsltsstfgglpQIANRLA 328
Q57ZQ0       276 -GRFVTMSSYPGLAHSVDDWY-MTHKRLAVMETTNVIHNATLL--RNHVGSsSVATFLRA-------------MIANFIA 338 Trypanosoma brucei
Q9XWV2       252 pGQIYSFSSYPASITSTDDFV-LTSAKLAILETTIGNYNEKSL--DLITPN-TVLTWIRA-------------EIAHRTA 314 Caenorhabditis ...
EFX77541     270 pGHSMSFSSYPGLLYSGDDFS-VISSGLVSMETTIGNNNVELF--KYIKPTgQVLEGVRS-------------MVANRLA 333
O62146       281 pGYASSFSSYPGLLYSSDDFA-LQTSGLAVIETTISVFNTSLF--ENTKPVgQLPTWIRA-------------IVSNQLA 344 Caenorhabditis ...
Q9BL07       272 pGHIVTFSGYPGVLISTDDYT-ITSAGLTSIETTIAIFNQTLYtdKFMKPEgQVHCWIRS-------------MISNLLS 337 Caenorhabditis ...
EFA78500     273 rSATTMFSSYPASLSSIDDFY-LLDTGLVVVETTNGMMNNNLY--YLVTPS-SVLSWIRV-------------IIANRMA 335
Q54ZI6       265 -GSETLFSSYPGLLVSIDDFYqIRPSKLHLTETLNTILNQTLY--QQINAQ-SFMYWVRN-------------LVANRLA 327 Dictyostelium d...
EGD78150     263 kTSTVMFSGYPALLESLDDYY-ITSERMAIMETTNGIFNNTLY--DMVNPS-TLPYWVRV-------------IVATRMT 325
XP_011270802 332 HDG-REWSHIVAQfNSGTYNNQYMVVTLDQIKL-GQ--AVLD-GALWVVEQIPGY-----VESADVTPIL-RAGYFSSFN 400
EDQ87028     329 TSS-DTWMEFFAReNSGTHNNQWIVSNYNLFTP-GT--DLPA-HAVSMLEQMVAV-----IETSDLSAVInQEGYIASYN 398
Q57ZQ0       339 VDA-PSWVSNFSReSSGAYNNQWMVLNMGAVESeAMfkNMAP-NTFWVLEQLPGTapplgITSKDMTSVLnTTGYWASYN 416 Trypanosoma brucei
Q9XWV2       315 SSG-LQWAEAFGRhNSGTYNNEWVVVDYKQFHRgKE--VQPEtGIIHVVEQMPGH-----IVHSDKTAHLfRETYWPGYN 386 Caenorhabditis ...
EFX77541     334 SSGiKKWTEVFSRhNSGTYNNQWMIVDYKLFKP-FK--PLRD-GLFWVLEQLPTL-----IESRDATDVLrSQSFWPSYN 404
O62146       345 RDA-REWCKLYSLyNSGTYNNQWAVLDYKKFKP-NQ--PLPKnGLFYVLEQMPGK-----IVYSDLTWFVeKYSYFPSYN 415 Caenorhabditis ...
Q9BL07       338 RTG-KQWVDMFGRyNSGTYNNQWTVLDWKQFTP-EK--ELPDkDVLWISEQTPGY-----YETRDMTWYLkKYTYFASYN 408 Caenorhabditis ...
EFA78500     336 SNG-ANWCTTFGReNSGTYNNQWIIVDYNKFES-GV--DAHD-GMVYVLEQIPGY-----VEYDDVTNIV-RTGYWPSYN 404
Q54ZI6       328 NNG-FQWVSIFVEnNSGTNNIQFVVLDYKLFTPyST--ELQS-DLLWIVEQYPGG-----YQAADVTLTLwEQGYWPSYN 398 Dictyostelium d...
EGD78150     326 NTG-REWHERFYQyQSGTYNNQWMTIDYKLFVP-GQ--PLPH-GIFWVSEQIPGA-----YVLEDKTMDL-QRSYWPSYN 394
XP_011270802 401 VPFFERVFDMSGYPAMVAkygvsfthDLAPRAEIFRRDSNTVVDFSSLKQLMRSNSYktdpysgg--------------- 465
EDQ87028     399 IPRSPVIFEISGYAAQgy------syENDTRARIFRRDQHTVTSLNSMSALLNANDYendplarg--------------- 457
Q57ZQ0       417 RPYFPNVYNLSGTLKMQEeygdfysyKNYSRARIFERDQGSVVDIESMKRLMRYNNYtkdpfslipnctgavgmdddgnv 496 Trypanosoma brucei
Q9XWV2       387 QPYYKQIIRFSDTDKMVEkfgdwysyDKTPRALIFKRDHNTVTDMSSMIALMRSNNYtkdplskcdcn------------ 454 Caenorhabditis ...
EFX77541     405 SPYFPTIFNLSGVPALVEeygdwftyDKTPRALIFNRDQSKITDMDSMIRMMRYNDYrndplsrcekce----------- 473
O62146       416 IPFFKEITEISGFIGQAAkmgdwfkwGASPRAKIFERDHGNVHDLDSLTALMRYNDYkndefskckcn------------ 483 Caenorhabditis ...
Q9BL07       409 IPFLPKVSEISGFDNKARqfaw-fdwGGSPRARIFDRDHSKVTDIDSLTKLMRYNDYtheefarckctp----------- 476 Caenorhabditis ...
EFA78500     405 VPYFEYIYNVSGFNNT-QsygnffsySGNPRAMIFRRDANNVYTFEQYQAELRYNNWehdplsag--------------- 468
Q54ZI6       399 RPYFEEVFDILGYPYYVEkfgdlftyEYNPRANIFRRDHSKLETLQDMMNIIDYNQYktdpfsmg--------------- 463 Dictyostelium d...
EGD78150     395 VPYYPWIYNVSNYPAAARahgddytyQLAPRAKIFRRDAGAVESVDDLKTFIRMNHFeqhdplap--------------- 459
XP_011270802 466 --------spanavcsRYDLI----Angg-------------spDGCYDTKATNYARA----RLLQADALNGPTTA-NSt 515
EDQ87028     458 --------dpcnqisaRCDLPkagnAsgn------------pyaFGGIDCKVTGRAQV----LQQEARVAGAPSHA-IQ- 511
Q57ZQ0       497 tnvckppysamlsiaaRGDLN----PpgnateygplvrsvghvnSGAIDAKIATWTGMvknpESYTAHVVCGPTTD-NQ- 570 Trypanosoma brucei
Q9XWV2       455 -----ppysaenaiacRSDLN----Plngtypf----kslgfrdHGAIDVKVTNSKLI----NSLQFTAVSGPPGGvTKd 517 Caenorhabditis ...
EFX77541     474 -----pkysgenaisaRNDLN----Pangtypf----halshrsHGATDCKVTSHQLM----TSLDFIAVGGPTFD-SL- 534
O62146       484 -----ppysaeagisaRGDLN----Pangtyef----pgqghvnHGALDYKGTNVELM----KKLQFVAQGGPTWG-KV- 544 Caenorhabditis ...
Q9BL07       477 -----npytgeggisaRGDLN----Tpggtyev----esmgfrdHAGLDFKGTNYEMF----KKMRFRAWGGPPYD-PL- 537 Caenorhabditis ...
EFA78500     469 --------nsgnaissRFDLV----Tksdpnnp-----ylnkdaFGGIDSKAVNHAMV----RNMQVAAQSGPTYD-QQ- 525
Q54ZI6       464 --------ypgnsinaRFDIKggslPsgnpiys-----wfyhgtHGGIDGKAINYDMV----NSFTAVARNGPTVT-SDc 525 Dictyostelium d...
EGD78150     460 --------tadsaiaaRRDLD----Ptap-------------raDGAIDAKIVNAAMV----LDMSVTAIAGPTHD-TQ- 508
XP_011270802 516 lPAY----SWSA---FANlPHVGLPETYNFDFITV 543
EDQ87028     512 -PVFaftpEWSSv------AHAGMPTQLNFTFRQV 539
Q57ZQ0       571 -PPF----QWVDgmfDPMpPTYGLLKLYNFSFVVM 600 Trypanosoma brucei
Q9XWV2       518 vPIF----DWKTsplREKvPHFGQPDRWNFAPVTY 548 Caenorhabditis elegans
EFX77541     535 -PAF----RWSEsdfVNL-SHIGHPDLWKFEPVQT 563
O62146       545 -PSF----KWSEfdfKDKvNHVGHPDEWKFNTLVH 574 Caenorhabditis elegans
Q9BL07       538 -PVF----DWNHtnlTNV-RHFGQPDVWNFTYVDL 566 Caenorhabditis elegans
EFA78500     526 -PPF----NWKQgd--wTyTHVGMPEIWQFPWMIM 553
Q54ZI6       526 -PPF----NWND---WSLiSHQYMPQIYNFTWISI 552 Dictyostelium discoideum
EGD78150     509 -PVFswtgMWAN---ETRgKHYGHAQRFGFDWHVI 539
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