Conserved Protein Domain Family
TPD52

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pfam04201: TPD52 
Tumour protein D52 family
The hD52 gene was originally identified through its elevated expression level in human breast carcinoma. Cloning of D52 homologs from other species has indicated that D52 may play roles in calcium-mediated signal transduction and cell proliferation. Two human homologs of hD52, hD53 and hD54, have also been identified, demonstrating the existence of a novel gene/protein family. These proteins have an amino terminal coiled-coil that allows members to form homo- and heterodimers with each other.
Statistics
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PSSM-Id: 461225
Aligned: 18 rows
Threshold Bit Score: 134.122
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006144535  80 LTETEHLEFKSELTKLEVEIVTLRRALAAKERHYWELKRKSDPTALEGFRQNLSKSWHDVQVSNAYMK---------QKT 150
Q3SYU8        41 LTETEAEELRAELAKVEEEIVTLRQVLAAKERHCGELKRKLGLSTLEGLKQNLSRSWHDMQVSNAYKKtqetlsqagQKT 120 cattle
XP_017949722  32 ISEEEKEELKSELFKLENEIVTLRQVLAAKEKHLVEIKQKLGVSMMNELKQNFSRSWHDVQTHSAYKKtqetlsqagLKA 111
Q9I8F4        31 ISEEEKEELKAELAKLEDEISTLRQVLAAKEKHLIEIKQKLGMSLMNELKQNFSKSWHDMQTTSAYKKthetlshagQKA 110 chicken
XP_015215213  31 VSEEEREEIQTELAKLEEEIAALKQVLAAKEKHHAELKLKLGMNPLNDLKQNVSKSWHEVQTSTAYKKtqetlstagQKA 110
XP_022540622  52 ITEEEKEEMHNELTKLEEEITTLRQVLSSKEKRHSELKQRLGITPLSELRHNLSRGWNDMQTSTAYKKtsetlstagQKT 131
XP_003269526  71 LSEEEQEELRRELAKVEEEIQTLSQVLAAKEKHLAEIKRKLGINSLQELKQNIAKGWQDMTATSAYKKtsetlsqagQKA 150
XP_023401105  73 LTEAQQKELNLELTELEAEIVTLRHMLAAKERHCRELKRKLGLTALVGLRQNLSKSWHDVQVSNAYLK---------QKT 143 African savanna...
XP_015212510  72 LTEEEQEELRAELAKVEDEIQTLSQVLAAKEKHVAEIKRKLGISPLNELKQNITKGWQDMTASTAYKKtsetlsqagQKA 151 spotted gar
XP_011490162 111 MTEEEREEIQQELVKLEEEIGTLKQVLSSKEKQQAELRQKLGITPLSELKNNFSRSWHDVQTSVAFKKtsetfstagQKT 190 Japanese medaka
XP_006144535 151 SAALSTMGSAICRKLGD------------------VKKSTTFKSFE 178
Q3SYU8       121 SAALSTMGSAISRKLGD------------------MRNSATFKSFE 148 cattle
XP_017949722 112 TAAITNVGSAIGKKLGD------------------MRNSPTFKSFE 139
Q9I8F4       111 TAAISNVGTAISKKFGDmrshsisysirhsismpaMRNSPTFKSFE 156 chicken
XP_015215213 111 TAALSNVGTAISRKFGD------------------MRNSPSFRSFE 138
XP_022540622 132 TAAFSNLGSAISRKFGDmstqpsysi-rhsvsmptMRNSPSFKSFE 176
XP_003269526 151 SAAFSSVGSVITKKLED------------------VKNSPTFKSFE 178
XP_023401105 144 SAALSTVGSAIRRKLER------------------MK-SATFKSFE 170 African savanna elephant
XP_015212510 152 TAAFSSVGSAITKKLED------------------VRNSPTFKSFE 179 spotted gar
XP_011490162 191 SAAFSTFGSAITRKLGD------------------MRNSPSFKSFE 218 Japanese medaka
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