1UEA,1GXD,1BQQ,1BR9


Conserved Protein Domain Family
NTR_TIMP

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cd03585: NTR_TIMP 
Click on image for an interactive view with Cn3D
NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by non-covalently binding their active zinc-binding sites. The levels of activated membrane-type MMPs, MMPs, and free TIMPs determine the balance between matrix degradation and matrix formation or stabilization. Consequently, TIMPs play roles in processes that require the remodeling and degradation of connective tissue, such as development, morphogenesis, wound healing, as well as in various diseases and pathological states such as tumor cell metastasis, arthritis, and artherosclerosis. Most TIMPs bind to a variety of MMPs. TIMP-1 and TIMP-2 appear to be multifunctional proteins with diverse biological action. They may exhibit growth factor-like activity and can inhibit angiogenesis. TIMP-3 has been implicated in apoptosis.
Statistics
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PSSM-Id: 239640
Aligned: 15 rows
Threshold Bit Score: 266.978
Created: 10-Apr-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Metzincin-bin..Hemopexin-dom..
Conserved site includes 24 residues -Click on image for an interactive view with Cn3D
Feature 1:Metzincin-binding interface
Evidence:
  • Structure:1BQQ: Bovine TIMP-2 binds human membrane-type 1 matrix metalloprotease
  • Citation:PMID 9724659
  • Structure:1UEA: Human TIMP-1 binds matrix metalloprotease stromelysin-1
  • Citation:PMID 9288970

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1     ##  ###                                                ##                       
1UEA_B      1 CT--CVPp------------HPQTAFCNS-DLVIRAKFVGTPEVaq-------ttLYQRYEIKMTKMYKGfqalgdaADI 58  human
1BQQ_T      1 CS--CSPv------------HPQQAFCNA-DIVIRAKAVNKKEVdsgndiygnpiKRIQYEIKQIKMFKGp-----dQDI 60  cow
AAA21815   10 CT--CSPs------------HPQDAFCNS-DIVIRAKVVGKKLVkeg------pfGTLVYTIKQMKMYRGft---kmPHV 65  human
NP_990818  25 CT--CVPi------------HPQDAFCNS-DIVIRAKVVGKKLMkdg------pfGTMRYTVKQMKMYRGfq---imPHV 80  chicken
AAH81167   29 CS--CSPv------------HPQQAFCNA-DIVIRAKAVTGKEVesgndvygnpiKRIQYEIKQIKMFKGp-----dKDI 88  African clawed frog
AAH60423   27 CT--CAPs------------HPQDAFCNS-DIVIRAKVVGKKLMkdg------pfGTMRYTVKQMKMYRGfn---kmPQV 82  African clawed frog
NP_989629  27 CS--CSPi------------HPQQAFCNA-DVVIRAKRVSAKEVdsgndiygnpiKRIQYEVKQIKMFKGp-----dQDI 86  chicken
NP_003247  30 CS--CAPa------------HPQQHICHS-ALVIRAKISSEKVVpasad-padteKMLRYEIKQIKMFKGfe---kvKDV 90  human
CAG07055   17 CS--CLPa------------HPQQLFCSS-EIVIRAKISGEKIVspgnn-sspymKMIQYEIKMIKMFKGfd---kaKDI 77  Tetraodon nigrovir...
XP_688461   2 CQllCRMladltkkakeksdSCKRSTCRKwDLVIRAKVVGKKEVdsgndiygnpiKRIQYEIKQIKMFKGp-----dRHI 76  zebrafish
Feature 1          #######                 #       # ###                               # ##   
1UEA_B     59 RFVYTPAMESVCGYFHrsharsEEFLIAGKLqd-glLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCeeCTVFPCLSiPC 137 human
1BQQ_T     61 EFIYTAPAAAVCGVSLdig-gkKEYLIAGKAegngnMHITLCDFIVPWDTLSATQKKSLNHRYQMGCe-CKITRCPMiPC 138 cow
AAA21815   66 QYIHTEASESLCGLKLev--nkYQYLLTGRVyd-gkMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCn-CKIKSCYYlPC 141 human
NP_990818  81 QYIYTEASESLCGVKLev--nkYQYLITGRVye-gkVYTGLCNWYEKWDRLTLSQRKGLNHRYHLGCg-CKIRPCYYlPC 156 chicken
AAH81167   89 EFIYTAPSSAVCGVTLeia-gkKEYLIAGKAdgdgkMHITLCDFIEPWDSLTPTQKKSLNQRYEMGCe-CKISRCPSiPC 166 African clawed frog
AAH60423   83 QYIYTEASESLCGVKLev--nkYQYLITGRVye-gkVYTGLCNLIERWEKLTFAQRKGLNHRYPLGCt-CKIKPCYYlPC 158 African clawed frog
NP_989629  87 EFIYTAPSTEVCGQPLdtg-gkKEYLIAGKSegdgkMHITLCDLVATWDSVSPTQKKSLNQRYQMGCe-CKISRCLSiPC 164 chicken
NP_003247  91 QYIYTPFDSSLCGVKLean-sqKQYLLTGQVlsdgkVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCg-CQITTCYTvPC 168 human
CAG07055   78 QYVYTPVFSSLCGVKLdyn-nkAGYLLSGSMwrdgrISVGQCDLVESWDNLSLSQKKNLNYRYQIGCe-CRINTCYTvPC 155 Tetraodon nigrovir...
XP_688461  77 DVVFTAPSSAVCGVTNldtngkKEYLISGKAeangkMHVTLCDLIMPWESMSATQKKSLSQRYQMGCd-CKITRCATfPC 155 zebrafish
Feature 1                 #     #                          
1UEA_B    138 KLQSGTHCLWTDQLlqgsEKGFQSRHLACLPREPGLCTWQSLRSQ 182 human
1BQQ_T    139 YISSPDECLWMDWVteknINGHQAKFFACIKRSDGSCAWYRGAAP 183 cow
AAA21815  142 FVTSKNECLWTDMLsnfgYPGYQSKHYACIRQKGGYCSWYRGWAP 186 human
NP_990818 157 FATSKNECIWTDMLsnfgHSGHQAKHYACIQRVEGYCSWYRGWAP 201 chicken
AAH81167  167 LVSSQDECLWTDWVteknINGRQAKHYACIKRTDGSCSWYRGMAP 211 African clawed frog
AAH60423  159 FITSKNECLWTDMLsnfgYPGYQSKNYACIKQKEGYCSWYRGWAP 203 African clawed frog
NP_989629 165 FVSSSDECLWTDWAmekiVGGRQAKHYACIKRSDGSCAWYRGMAP 209 chicken
NP_003247 169 TISAPNECLWTDWLlerkLYGYQAQHYVCMKHVDGTCSWYRGHLP 213 human
CAG07055  156 VSAGENECLWTDWLldnsLNGEQARQYACIRRSDTTCSWYRGGPP 200 Tetraodon nigroviridis
XP_688461 156 EISAPEECLWTDWVtekiIHGRQSDHYACIKRGDGSCAWYRGVAP 200 zebrafish

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